GREMLIN Database
4OT - 2-hydroxymuconate tautomerase
UniProt: P70994 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 62 (59)
Sequences: 459 (312)
Seq/√Len: 40.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_K30_E3.5681.00
21_V52_A3.4931.00
29_K39_I2.2381.00
25_T36_E1.9990.99
4_V28_V1.9730.99
13_T16_Q1.9580.99
46_M51_Y1.9230.99
14_D49_D1.8830.98
6_V24_V1.8590.98
7_K44_E1.8470.98
20_L28_V1.8230.98
53_V58_L1.7450.97
26_E36_E1.5740.95
27_A31_T1.4840.93
45_E50_H1.4430.92
32_T40_V1.4040.91
26_E30_E1.3680.90
17_K43_I1.3550.90
5_T44_E1.2470.85
3_Y42_F1.2430.85
22_E26_E1.2120.84
24_V27_A1.1470.80
41_V52_A1.1460.80
10_E47_R1.1390.80
35_S38_K1.1370.80
22_E30_E1.1160.78
17_K50_H1.0690.75
7_K46_M1.0550.74
3_Y7_K1.0420.73
19_N31_T1.0210.72
18_R57_R1.0020.70
3_Y51_Y0.9980.70
22_E56_K0.9950.70
3_Y53_V0.9410.66
8_M43_I0.9220.64
20_L24_V0.9200.64
21_V57_R0.8830.61
42_F46_M0.8480.57
23_K31_T0.8120.54
4_V41_V0.8010.53
19_N23_K0.7910.52
29_K38_K0.7880.52
6_V45_E0.7630.50
5_T46_M0.7620.50
18_R35_S0.7600.49
14_D18_R0.7520.49
47_R50_H0.7440.48
39_I57_R0.7330.47
42_F51_Y0.7270.46
53_V59_S0.7210.46
16_Q43_I0.7190.46
40_V58_L0.7120.45
25_T29_K0.6990.44
29_K33_G0.6860.43
40_V51_Y0.6660.41
29_K36_E0.6630.41
21_V41_V0.6630.41
14_D57_R0.6610.40
5_T22_E0.6460.39
25_T39_I0.6380.38
8_M17_K0.6340.38
49_D57_R0.6290.38
50_H54_A0.6260.37
19_N22_E0.6260.37
25_T55_G0.6230.37
29_K54_A0.6140.36
28_V41_V0.6140.36
3_Y40_V0.6080.36
34_A45_E0.6000.35
15_E37_E0.5990.35
13_T17_K0.5970.35
13_T45_E0.5930.34
36_E39_I0.5890.34
4_V8_M0.5880.34
14_D56_K0.5720.33
6_V43_I0.5680.32
40_V53_V0.5670.32
34_A38_K0.5580.32
9_L12_R0.5490.31
17_K45_E0.5450.31
2_P25_T0.5440.30
27_A54_A0.5440.30
8_M26_E0.5290.29
15_E48_K0.5270.29
14_D20_L0.5180.28
32_T36_E0.5120.28
4_V24_V0.5020.27
20_L31_T0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ej9B 3 0.9516 99.6 0.318 Contact Map
3ej9A 3 0.9839 99.5 0.343 Contact Map
4u5rA 3 0.9839 99.5 0.362 Contact Map
3abfA 4 1 99.5 0.363 Contact Map
3mb2A 5 1 99.5 0.366 Contact Map
2x4kA 4 0.9677 99.4 0.369 Contact Map
4m1aA 4 0.871 99.4 0.37 Contact Map
3m20A 5 0.9516 99.4 0.377 Contact Map
2opaA 4 0.9839 99.4 0.381 Contact Map
4x1cC 5 0.9839 99.4 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.