GREMLIN Database
YWHA - Uncharacterized HTH-type transcriptional regulator YwhA
UniProt: P70993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (127)
Sequences: 21985 (16108)
Seq/√Len: 1429.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_S95_T3.0251.00
50_S95_T2.9181.00
126_E136_K2.7581.00
81_E95_T2.5761.00
85_N93_W2.4501.00
52_T91_T2.4211.00
123_T126_E2.3371.00
129_T132_A2.2451.00
84_R92_V2.0351.00
46_Y104_A2.0321.00
52_T55_D1.9781.00
129_T133_I1.9671.00
38_R77_E1.9011.00
122_L133_I1.8861.00
85_N91_T1.7791.00
46_Y96_L1.7291.00
126_E129_T1.6791.00
53_I71_L1.6551.00
78_G99_S1.6091.00
38_R73_H1.5611.00
99_S103_A1.5571.00
35_N38_R1.5231.00
71_L94_I1.5191.00
48_H59_E1.5181.00
130_F133_I1.5131.00
75_E82_R1.4881.00
126_E132_A1.4831.00
72_N76_Q1.4651.00
14_A135_A1.4561.00
41_I70_A1.4551.00
99_S102_G1.4241.00
103_A106_Q1.4201.00
32_K110_N1.4121.00
46_Y101_R1.3491.00
72_N89_R1.3381.00
133_I136_K1.3071.00
55_D58_K1.2761.00
50_S93_W1.2711.00
14_A131_L1.2511.00
44_I59_E1.2441.00
102_G106_Q1.2211.00
63_S66_A1.1971.00
53_I92_V1.1941.00
32_K106_Q1.1941.00
54_K64_P1.1791.00
54_K58_K1.1621.00
41_I67_T1.1341.00
62_L66_A1.1321.00
132_A136_K1.1271.00
53_I67_T1.1041.00
50_S83_S1.0991.00
125_E129_T1.0971.00
53_I94_I1.0761.00
49_G101_R1.0521.00
48_H51_C1.0451.00
127_K131_L1.0371.00
79_F103_A1.0251.00
51_C55_D1.0201.00
68_T72_N1.0151.00
98_E101_R1.0091.00
27_E30_V1.0071.00
32_K107_M1.0071.00
33_H77_E0.9921.00
51_C59_E0.9901.00
55_D59_E0.9891.00
31_P110_N0.9871.00
110_N113_Q0.9791.00
65_S68_T0.9741.00
77_E99_S0.9681.00
72_N75_E0.9671.00
53_I64_P0.9631.00
122_L137_L0.9631.00
96_L100_G0.9581.00
98_E102_G0.9511.00
82_R92_V0.9421.00
16_T19_L0.9421.00
49_G95_T0.9391.00
66_A69_T0.9391.00
84_R89_R0.9301.00
71_L80_I0.9251.00
46_Y105_E0.9191.00
63_S69_T0.9151.00
39_G107_M0.9031.00
45_I80_I0.8921.00
111_R115_I0.8891.00
37_V70_A0.8811.00
77_E103_A0.8731.00
115_I118_M0.8671.00
83_S93_W0.8661.00
79_F99_S0.8651.00
126_E133_I0.8641.00
46_Y108_I0.8631.00
131_L135_A0.8581.00
48_H55_D0.8581.00
71_L75_E0.8571.00
40_F60_V0.8561.00
62_L67_T0.8561.00
113_Q116_D0.8521.00
81_E97_S0.8511.00
86_N93_W0.8481.00
101_R105_E0.8451.00
69_T73_H0.8411.00
124_A128_K0.8411.00
109_E113_Q0.8281.00
44_I51_C0.8241.00
42_L104_A0.8241.00
44_I60_V0.8161.00
16_T20_K0.8121.00
88_D91_T0.8091.00
85_N88_D0.8091.00
39_G111_R0.8061.00
96_L101_R0.7971.00
11_L131_L0.7941.00
19_L23_K0.7881.00
106_Q110_N0.7881.00
18_Y134_I0.7811.00
25_L114_L0.7791.00
53_I68_T0.7761.00
75_E81_E0.7701.00
123_T127_K0.7651.00
37_V66_A0.7611.00
128_K131_L0.7611.00
109_E112_Q0.7241.00
15_L19_L0.7231.00
44_I56_I0.7211.00
73_H76_Q0.7201.00
125_E128_K0.7201.00
74_L79_F0.7181.00
128_K132_A0.7181.00
27_E36_N0.7171.00
102_G105_E0.7141.00
41_I60_V0.7131.00
113_Q117_G0.7131.00
41_I56_I0.7121.00
45_I51_C0.7111.00
75_E80_I0.7071.00
129_T136_K0.7061.00
112_Q116_D0.7031.00
44_I48_H0.6981.00
20_K24_Q0.6921.00
117_G120_E0.6881.00
114_L117_G0.6871.00
72_N82_R0.6831.00
38_R70_A0.6791.00
67_T71_L0.6791.00
57_L64_P0.6771.00
25_L28_A0.6701.00
57_L67_T0.6651.00
14_A17_K0.6641.00
23_K27_E0.6641.00
45_I96_L0.6631.00
69_T72_N0.6621.00
15_L18_Y0.6601.00
42_L46_Y0.6561.00
106_Q109_E0.6511.00
22_T25_L0.6491.00
23_K26_D0.6461.00
119_F127_K0.6441.00
43_R47_R0.6401.00
40_F44_I0.6171.00
39_G104_A0.6171.00
122_L136_K0.6161.00
25_L117_G0.6151.00
84_R88_D0.6101.00
17_K21_S0.6021.00
122_L127_K0.5951.00
12_D26_D0.5851.00
43_R108_I0.5821.00
73_H77_E0.5821.00
83_S86_N0.5791.00
97_S100_G0.5701.00
132_A135_A0.5671.00
56_I94_I0.5671.00
78_G81_E0.5641.00
104_A108_I0.5471.00
26_D111_R0.5391.00
123_T136_K0.5381.00
119_F123_T0.5321.00
24_Q28_A0.5321.00
54_K57_L0.5311.00
105_E109_E0.5281.00
111_R114_L0.5271.00
108_I112_Q0.5271.00
116_D120_E0.5251.00
105_E108_I0.5221.00
35_N73_H0.5111.00
34_V103_A0.5081.00
21_S25_L0.5071.00
11_L130_F0.5071.00
95_T101_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bj6A 2 1 99.9 0.265 Contact Map
4rguA 4 0.9712 99.9 0.27 Contact Map
3fm5A 4 1 99.9 0.276 Contact Map
1s3jA 2 0.9928 99.9 0.279 Contact Map
2rdpA 2 0.9712 99.9 0.282 Contact Map
2gxgA 2 0.9568 99.9 0.287 Contact Map
3deuA 2 0.8993 99.9 0.287 Contact Map
4yifA 2 0.964 99.9 0.287 Contact Map
3cjnA 2 0.964 99.9 0.287 Contact Map
3e6mA 2 1 99.9 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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