GREMLIN Database
YBAC - Probable aminopeptidase YbaC
UniProt: P70981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (266)
Sequences: 56207 (46187)
Seq/√Len: 2831.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_I62_T5.3361.00
110_Y134_T4.6851.00
69_R92_D4.4461.00
94_I124_V3.0891.00
264_K292_E3.0361.00
302_E305_L2.9461.00
110_Y133_Y2.9091.00
289_F309_T2.8541.00
139_S266_D2.7401.00
108_K133_Y2.6841.00
291_F309_T2.6111.00
259_V313_H2.5731.00
138_I306_F2.5101.00
20_K75_Y2.4601.00
124_V128_R2.3621.00
101_L109_L2.3171.00
15_S20_K2.2601.00
94_I131_L2.2351.00
118_S140_Q2.2101.00
111_L121_A2.1811.00
264_K290_Q2.1751.00
94_I128_R2.1251.00
22_M73_L2.1061.00
278_Y286_K2.1011.00
60_Y311_S2.0681.00
102_A131_L2.0451.00
91_K127_Q1.9691.00
94_I102_A1.9511.00
123_H127_Q1.9281.00
25_I64_V1.9221.00
271_A290_Q1.9171.00
294_S302_E1.8861.00
26_N65_H1.8711.00
110_Y314_A1.8511.00
125_L135_Y1.8271.00
23_L100_L1.7951.00
110_Y136_Y1.7921.00
61_F110_Y1.7681.00
121_A135_Y1.7631.00
53_Y307_A1.7591.00
56_E307_A1.7521.00
34_L64_V1.7461.00
259_V289_F1.7141.00
87_N127_Q1.6971.00
34_L106_K1.6961.00
39_H71_S1.6931.00
309_T312_R1.6901.00
66_W93_T1.6521.00
68_Q120_L1.6251.00
39_H68_Q1.6241.00
276_Q280_E1.6081.00
308_N312_R1.6051.00
124_V132_F1.5981.00
17_G95_Q1.5971.00
38_L93_T1.5911.00
258_C281_L1.5561.00
38_L68_Q1.5401.00
90_I123_H1.5391.00
34_L62_T1.5331.00
22_M67_D1.5231.00
85_T88_H1.4981.00
128_R131_L1.4931.00
250_S253_S1.4681.00
59_Q311_S1.4621.00
136_Y310_L1.4561.00
93_T124_V1.4461.00
44_T48_G1.3671.00
124_V131_L1.3671.00
305_L309_T1.3601.00
115_S296_H1.3451.00
38_L121_A1.3401.00
37_F63_V1.3371.00
19_T69_R1.3091.00
123_H126_Q1.3061.00
114_H299_H1.3061.00
21_Q92_D1.3061.00
136_Y259_V1.2921.00
42_P49_Y1.2911.00
137_G140_Q1.2891.00
122_L137_G1.2851.00
56_E59_Q1.2801.00
271_A275_K1.2621.00
305_L308_N1.2601.00
164_A168_S1.2571.00
262_S274_S1.2531.00
67_D72_G1.2511.00
64_V100_L1.2381.00
56_E311_S1.2211.00
291_F294_S1.2041.00
112_A138_I1.1871.00
37_F112_A1.1751.00
275_K279_Q1.1751.00
27_G62_T1.1691.00
100_L104_F1.1601.00
35_L61_F1.1411.00
281_L286_K1.1381.00
261_I291_F1.1251.00
252_P280_E1.1161.00
276_Q279_Q1.1101.00
40_G115_S1.1071.00
60_Y315_R1.1011.00
109_L132_F1.0971.00
106_K109_L1.0941.00
126_Q250_S1.0921.00
66_W100_L1.0911.00
102_A128_R1.0871.00
114_H297_T1.0811.00
278_Y288_W1.0781.00
112_A310_L1.0741.00
262_S288_W1.0731.00
101_L106_K1.0661.00
306_F310_L1.0651.00
262_S290_Q1.0541.00
287_R309_T1.0531.00
28_V62_T1.0491.00
259_V287_R1.0471.00
38_L111_L1.0341.00
262_S271_A1.0151.00
36_L101_L1.0111.00
210_L213_M1.0071.00
213_M217_N1.0031.00
304_S308_N1.0031.00
16_I95_Q0.9991.00
21_Q74_S0.9991.00
33_P110_Y0.9981.00
206_S209_V0.9971.00
275_K278_Y0.9961.00
87_N123_H0.9921.00
90_I120_L0.9881.00
23_L104_F0.9871.00
36_L109_L0.9861.00
61_F314_A0.9831.00
109_L131_L0.9821.00
311_S315_R0.9821.00
295_A301_E0.9821.00
113_G121_A0.9801.00
275_K290_Q0.9771.00
19_T75_Y0.9671.00
68_Q116_W0.9651.00
54_Q65_H0.9641.00
208_A211_F0.9641.00
45_P49_Y0.9581.00
294_S301_E0.9571.00
64_V104_F0.9511.00
291_F305_L0.9501.00
94_I127_Q0.9371.00
45_P48_G0.9341.00
275_K288_W0.9301.00
52_H307_A0.9181.00
138_I299_H0.9171.00
83_S88_H0.9171.00
56_E304_S0.9111.00
168_S172_R0.9091.00
33_P133_Y0.9011.00
88_H91_K0.8981.00
211_F215_T0.8971.00
207_L210_L0.8951.00
138_I298_P0.8931.00
134_T257_P0.8881.00
24_M46_Q0.8861.00
289_F312_R0.8821.00
42_P71_S0.8761.00
289_F305_L0.8761.00
214_L217_N0.8731.00
26_N54_Q0.8721.00
261_I309_T0.8711.00
167_L170_L0.8581.00
206_S210_L0.8561.00
204_R207_L0.8541.00
125_L132_F0.8521.00
168_S171_T0.8491.00
28_V31_K0.8471.00
35_L112_A0.8471.00
44_T49_Y0.8451.00
166_I170_L0.8451.00
35_L63_V0.8451.00
224_M228_L0.8401.00
135_Y258_C0.8371.00
294_S298_P0.8351.00
33_P61_F0.8321.00
260_F286_K0.8301.00
264_K293_N0.8281.00
123_H250_S0.8281.00
16_I19_T0.8281.00
165_S169_F0.8271.00
212_Q215_T0.8191.00
165_S168_S0.8161.00
227_F230_G0.8151.00
47_I50_V0.8131.00
207_L217_N0.8131.00
101_L124_V0.8071.00
224_M227_F0.8051.00
95_Q102_A0.8001.00
36_L93_T0.7991.00
114_H139_S0.7981.00
67_D73_L0.7971.00
34_L61_F0.7951.00
38_L66_W0.7941.00
91_K95_Q0.7901.00
113_G118_S0.7871.00
207_L211_F0.7851.00
134_T313_H0.7831.00
274_S288_W0.7821.00
207_L213_M0.7801.00
291_F302_E0.7801.00
211_F214_L0.7801.00
90_I127_Q0.7801.00
179_W183_I0.7781.00
236_K239_T0.7771.00
90_I124_V0.7751.00
182_D185_H0.7741.00
255_K284_P0.7701.00
22_M74_S0.7651.00
111_L124_V0.7641.00
185_H189_R0.7621.00
183_I190_F0.7611.00
183_I187_I0.7601.00
166_I172_R0.7581.00
91_K94_I0.7541.00
185_H188_Y0.7541.00
25_I28_V0.7521.00
136_Y314_A0.7511.00
43_G47_I0.7491.00
105_S108_K0.7481.00
46_Q73_L0.7461.00
163_K167_L0.7461.00
89_F116_W0.7461.00
95_Q103_H0.7441.00
31_K34_L0.7381.00
227_F231_L0.7371.00
139_S262_S0.7341.00
21_Q69_R0.7321.00
68_Q89_F0.7311.00
247_A250_S0.7311.00
206_S211_F0.7301.00
281_L285_E0.7291.00
61_F315_R0.7261.00
264_K271_A0.7251.00
263_G298_P0.7201.00
61_F311_S0.7201.00
307_A311_S0.7191.00
55_K58_E0.7161.00
87_N91_K0.7151.00
132_F256_V0.7151.00
179_W182_D0.7141.00
35_L314_A0.7121.00
265_H293_N0.7101.00
261_I306_F0.7061.00
163_K168_S0.7051.00
209_V213_M0.7031.00
164_A167_L0.6941.00
68_Q71_S0.6911.00
222_R225_H0.6871.00
125_L256_V0.6871.00
272_E275_K0.6861.00
69_R89_F0.6841.00
186_L190_F0.6831.00
152_Y155_I0.6811.00
223_N226_S0.6791.00
208_A212_Q0.6791.00
39_H66_W0.6741.00
46_Q50_V0.6731.00
52_H55_K0.6691.00
64_V106_K0.6681.00
17_G88_H0.6651.00
111_L132_F0.6651.00
42_P116_W0.6631.00
139_S298_P0.6631.00
164_A171_T0.6611.00
215_T218_E0.6591.00
227_F232_R0.6581.00
32_N110_Y0.6571.00
266_D296_H0.6541.00
249_T252_P0.6531.00
113_G117_G0.6511.00
303_P307_A0.6511.00
308_N311_S0.6511.00
210_L214_L0.6511.00
114_H138_I0.6451.00
42_P48_G0.6441.00
228_L231_L0.6431.00
62_T106_K0.6421.00
109_L124_V0.6421.00
214_L218_E0.6411.00
163_K170_L0.6411.00
26_N58_E0.6411.00
119_I141_V0.6401.00
36_L111_L0.6401.00
293_N302_E0.6391.00
115_S297_T0.6371.00
190_F193_E0.6371.00
107_S131_L0.6371.00
169_F172_R0.6371.00
26_N55_K0.6331.00
122_L142_V0.6311.00
166_I169_F0.6301.00
126_Q253_S0.6281.00
32_N133_Y0.6261.00
222_R226_S0.6261.00
226_S231_L0.6231.00
134_T314_A0.6211.00
166_I171_T0.6211.00
136_Y261_I0.6191.00
46_Q49_Y0.6191.00
213_M216_G0.6181.00
28_V32_N0.6171.00
112_A136_Y0.6141.00
274_S278_Y0.6131.00
118_S137_G0.6131.00
236_K240_D0.6121.00
32_N61_F0.6121.00
86_I123_H0.6111.00
206_S214_L0.6101.00
42_P115_S0.6101.00
273_I276_Q0.6101.00
50_V65_H0.6081.00
189_R192_V0.6081.00
35_L110_Y0.6061.00
42_P45_P0.6051.00
34_L109_L0.6041.00
209_V212_Q0.6041.00
33_P108_K0.6021.00
163_K166_I0.6021.00
226_S229_N0.6011.00
187_I192_V0.6011.00
101_L131_L0.6001.00
238_L241_E0.5981.00
89_F120_L0.5981.00
24_M65_H0.5931.00
68_Q93_T0.5911.00
239_T242_L0.5871.00
54_Q307_A0.5871.00
22_M46_Q0.5851.00
70_G84_M0.5811.00
15_S18_N0.5811.00
109_L133_Y0.5771.00
150_T153_Q0.5741.00
122_L140_Q0.5721.00
136_Y313_H0.5711.00
94_I101_L0.5701.00
204_R208_A0.5691.00
53_Y56_E0.5691.00
36_L66_W0.5681.00
261_I289_F0.5681.00
44_T47_I0.5671.00
189_R193_E0.5671.00
37_F65_H0.5671.00
223_N227_F0.5651.00
212_Q216_G0.5651.00
226_S230_G0.5631.00
181_Q184_Q0.5621.00
116_W120_L0.5611.00
225_H229_N0.5601.00
260_F288_W0.5561.00
32_N62_T0.5521.00
91_K128_R0.5501.00
90_I94_I0.5491.00
25_I104_F0.5471.00
287_R312_R0.5471.00
260_F281_L0.5471.00
32_N60_Y0.5451.00
164_A170_L0.5421.00
207_L218_E0.5411.00
224_M230_G0.5411.00
31_K62_T0.5401.00
46_Q65_H0.5381.00
163_K169_F0.5331.00
187_I190_F0.5271.00
182_D190_F0.5271.00
265_H294_S0.5271.00
211_F217_N0.5261.00
32_N108_K0.5261.00
100_L105_S0.5251.00
299_H306_F0.5241.00
164_A169_F0.5241.00
260_F278_Y0.5231.00
307_A312_R0.5221.00
17_G91_K0.5221.00
277_Y281_L0.5211.00
125_L254_I0.5211.00
254_I281_L0.5191.00
312_R315_R0.5181.00
43_G48_G0.5181.00
248_F280_E0.5181.00
233_F237_H0.5161.00
272_E276_Q0.5161.00
297_T300_I0.5151.00
187_I191_C0.5151.00
222_R227_F0.5131.00
139_S263_G0.5091.00
48_G52_H0.5071.00
184_Q188_Y0.5071.00
292_E305_L0.5061.00
133_Y136_Y0.5051.00
38_L120_L0.5031.00
182_D186_L0.5021.00
232_R236_K0.5021.00
224_M229_N0.5011.00
137_G260_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.8711 100 0.248 Contact Map
3oosA 1 0.8648 100 0.255 Contact Map
4inzA 1 0.8805 100 0.257 Contact Map
3om8A 4 0.8333 100 0.264 Contact Map
2pujA 4 0.8616 100 0.273 Contact Map
3wmrA 1 0.9119 100 0.277 Contact Map
2wueA 4 0.8679 100 0.28 Contact Map
1mtzA 1 0.8994 100 0.281 Contact Map
1q0rA 1 0.9088 100 0.281 Contact Map
2xuaA 2 0.8176 100 0.281 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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