GREMLIN Database
ECFT - Energy-coupling factor transporter transmembrane protein EcfT
UniProt: P70972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (236)
Sequences: 5394 (4306)
Seq/√Len: 280.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_W247_T6.4011.00
25_K131_T4.2521.00
174_E215_R3.5871.00
24_T242_W3.2231.00
92_P105_G3.1881.00
22_P240_L3.0561.00
28_T253_L3.0341.00
15_S18_H2.9991.00
25_K130_T2.9781.00
64_S68_K2.7961.00
176_D180_K2.6081.00
193_P196_E2.4901.00
92_P104_E2.4181.00
178_I208_L2.3941.00
14_T19_R2.3671.00
95_F102_V2.3301.00
93_I96_Q2.3261.00
93_I101_K2.2961.00
93_I103_Y2.2581.00
179_M183_M2.2461.00
20_L249_V2.1811.00
247_T251_V2.1731.00
178_I182_Q2.1131.00
29_I127_L2.0921.00
258_A262_F2.0491.00
171_L212_A2.0371.00
96_Q101_K2.0171.00
52_T123_I2.0021.00
24_T250_I1.9861.00
147_L152_L1.9581.00
49_G119_Y1.8491.00
94_I107_L1.8451.00
180_K183_M1.8291.00
81_F114_S1.8101.00
148_K155_H1.7711.00
243_T246_D1.7331.00
23_R139_G1.7021.00
174_E177_K1.6711.00
132_T135_E1.6521.00
36_V48_L1.6341.00
55_V126_L1.6041.00
20_L24_T1.5711.00
68_K71_K1.5391.00
94_I104_E1.5381.00
244_G248_S1.5361.00
242_W250_I1.5311.00
92_P96_Q1.5271.00
108_V112_F1.5151.00
184_A225_A1.5121.00
159_L228_Y1.4941.00
175_T208_L1.4851.00
36_V119_Y1.4621.00
174_E211_S1.4571.00
43_Q47_L1.4501.00
71_K75_W1.4421.00
90_E105_G1.4281.00
85_I102_V1.4121.00
135_E238_R1.3821.00
153_P156_E1.3701.00
29_I123_I1.3621.00
223_M228_Y1.3621.00
62_P65_F1.3591.00
45_Y119_Y1.3551.00
165_L169_P1.3301.00
195_K199_K1.3121.00
35_I257_A1.3051.00
159_L163_I1.3021.00
160_M164_S1.2851.00
193_P197_R1.2671.00
245_K248_S1.2661.00
85_I110_G1.2651.00
104_E108_V1.2551.00
254_I257_A1.2471.00
16_L58_L1.2121.00
229_Q232_E1.2021.00
43_Q46_A1.1971.00
17_V59_T1.1871.00
242_W246_D1.1821.00
166_R170_T1.1661.00
39_A44_T1.1641.00
175_T204_L1.1621.00
199_K203_P1.1581.00
30_F34_C1.1521.00
41_N44_T1.1441.00
152_L157_L1.1371.00
80_T84_H1.1371.00
96_Q99_F1.1311.00
248_S252_S1.1241.00
182_Q203_P1.1181.00
106_G110_G1.1151.00
175_T179_M1.1151.00
35_I39_A1.1091.00
220_A224_E1.1031.00
67_M71_K1.1001.00
54_G57_S1.0981.00
82_L86_L1.0841.00
32_F123_I1.0731.00
166_R208_L1.0711.00
27_I250_I1.0681.00
169_P220_A1.0681.00
196_E199_K1.0631.00
19_R245_K1.0541.00
194_V198_V1.0471.00
115_L119_Y1.0451.00
169_P207_P1.0301.00
186_G207_P1.0251.00
42_V108_V1.0221.00
46_A50_L1.0171.00
83_L87_M1.0061.00
109_Q113_I1.0021.00
170_T219_L1.0011.00
164_S223_M1.0001.00
221_V224_E0.9991.00
105_G108_V0.9951.00
167_F219_L0.9931.00
26_L127_L0.9841.00
75_W79_F0.9831.00
84_H113_I0.9741.00
197_R200_A0.9741.00
182_Q200_A0.9721.00
69_G80_T0.9651.00
108_V111_I0.9601.00
171_L175_T0.9531.00
98_G101_K0.9511.00
31_L257_A0.9441.00
133_P165_L0.9431.00
131_T136_I0.9391.00
202_V206_V0.9391.00
97_I101_K0.9321.00
155_H231_G0.9271.00
244_G247_T0.9231.00
178_I207_P0.9211.00
253_L257_A0.9201.00
22_P139_G0.9161.00
94_I105_G0.9151.00
196_E200_A0.9121.00
256_L260_L0.9121.00
57_S60_R0.9091.00
163_I219_L0.9091.00
179_M204_L0.9071.00
90_E93_I0.8961.00
194_V197_R0.8911.00
229_Q234_R0.8881.00
81_F110_G0.8861.00
17_V55_V0.8861.00
57_S63_F0.8851.00
72_P75_W0.8781.00
64_S67_M0.8691.00
94_I97_I0.8681.00
46_A49_G0.8671.00
252_S256_L0.8671.00
133_P171_L0.8611.00
93_I97_I0.8571.00
163_I223_M0.8561.00
249_V253_L0.8411.00
21_D24_T0.8381.00
36_V123_I0.8351.00
42_V46_A0.8261.00
137_T158_A0.8251.00
25_K135_E0.8231.00
45_Y115_L0.8231.00
75_W78_L0.8140.99
90_E103_Y0.8120.99
160_M219_L0.8120.99
73_I77_V0.8110.99
170_T174_E0.8070.99
77_V81_F0.8070.99
147_L151_K0.8060.99
214_K218_E0.8050.99
171_L187_V0.8010.99
206_V214_K0.8000.99
137_T162_S0.7970.99
84_H110_G0.7930.99
42_V112_F0.7920.99
97_I100_F0.7880.99
138_D240_L0.7850.99
247_T252_S0.7830.99
24_T247_T0.7770.99
28_T32_F0.7770.99
71_K79_F0.7740.99
44_T47_L0.7720.99
35_I44_T0.7690.99
155_H229_Q0.7690.99
63_F67_M0.7670.99
167_F220_A0.7660.99
241_V244_G0.7650.99
56_V66_L0.7640.99
24_T249_V0.7620.99
95_F99_F0.7610.99
259_L262_F0.7590.99
33_V37_F0.7570.99
188_D197_R0.7400.99
29_I124_T0.7380.99
52_T55_V0.7380.99
117_F121_I0.7350.99
173_E176_D0.7350.99
184_A222_A0.7330.99
251_V255_V0.7240.99
200_A204_L0.7210.99
69_G129_L0.7170.99
148_K151_K0.7160.99
150_L153_P0.7160.99
216_A219_L0.7140.99
220_A223_M0.7120.99
24_T246_D0.7110.99
126_L130_T0.7100.99
127_L136_I0.7080.99
49_G53_I0.7080.99
35_I256_L0.7040.98
95_F101_K0.7020.98
48_L119_Y0.7010.98
29_I114_S0.6990.98
21_D240_L0.6980.98
178_I204_L0.6970.98
94_I102_V0.6970.98
247_T250_I0.6950.98
114_S118_V0.6910.98
131_T135_E0.6910.98
21_D139_G0.6890.98
149_K152_L0.6860.98
148_K158_A0.6840.98
210_V213_F0.6840.98
177_K218_E0.6830.98
23_R240_L0.6820.98
151_K158_A0.6800.98
158_A169_P0.6740.98
248_S258_A0.6730.98
135_E240_L0.6730.98
77_V114_S0.6720.98
211_S217_E0.6710.98
217_E221_V0.6700.98
176_D179_M0.6690.98
63_F259_L0.6680.98
20_L245_K0.6650.98
155_H230_G0.6630.98
112_F116_R0.6630.98
241_V246_D0.6620.98
105_G109_Q0.6610.98
59_T130_T0.6610.98
33_V120_L0.6600.98
243_T247_T0.6580.98
17_V20_L0.6560.98
177_K180_K0.6560.98
166_R174_E0.6540.98
27_I254_I0.6530.98
15_S78_L0.6510.97
127_L131_T0.6480.97
236_K239_K0.6470.97
76_I117_F0.6460.97
241_V247_T0.6460.97
26_L139_G0.6400.97
120_L164_S0.6360.97
73_I118_V0.6360.97
28_T249_V0.6360.97
182_Q207_P0.6340.97
127_L224_E0.6310.97
215_R218_E0.6300.97
66_L70_L0.6290.97
166_R219_L0.6270.97
77_V84_H0.6230.97
184_A226_R0.6230.97
84_H106_G0.6230.97
248_S255_V0.6230.97
31_L254_I0.6210.97
66_L122_L0.6210.97
182_Q204_L0.6180.97
85_I106_G0.6150.96
50_L54_G0.6150.96
215_R219_L0.6140.96
216_A220_A0.6100.96
31_L253_L0.6040.96
251_V258_A0.6030.96
55_V97_I0.6000.96
52_T119_Y0.5960.96
84_H88_T0.5960.96
120_L124_T0.5920.96
61_V129_L0.5910.96
120_L167_F0.5880.95
23_R27_I0.5880.95
173_E177_K0.5840.95
97_I111_I0.5840.95
32_F36_V0.5830.95
76_I103_Y0.5820.95
133_P137_T0.5800.95
45_Y49_G0.5790.95
251_V254_I0.5770.95
159_L182_Q0.5770.95
224_E227_G0.5760.95
147_L161_M0.5750.95
18_H25_K0.5740.95
16_L19_R0.5740.95
121_I134_I0.5730.95
167_F210_V0.5730.95
133_P169_P0.5710.95
52_T122_L0.5700.95
167_F170_T0.5700.95
245_K256_L0.5690.95
116_R175_T0.5680.94
90_E94_I0.5670.94
111_I114_S0.5660.94
248_S251_V0.5660.94
121_I125_T0.5640.94
58_L259_L0.5630.94
182_Q224_E0.5620.94
158_A161_M0.5620.94
35_I123_I0.5610.94
16_L60_R0.5610.94
33_V124_T0.5610.94
57_S258_A0.5600.94
246_D249_V0.5570.94
35_I38_L0.5550.94
227_G230_G0.5550.94
70_L73_I0.5520.94
160_M215_R0.5480.93
138_D236_K0.5470.93
188_D200_A0.5470.93
182_Q186_G0.5460.93
59_T126_L0.5410.93
134_I138_D0.5410.93
245_K252_S0.5370.93
107_L111_I0.5370.93
160_M228_Y0.5360.93
91_G104_E0.5320.92
51_F256_L0.5320.92
217_E226_R0.5300.92
64_S71_K0.5300.92
38_L261_F0.5290.92
88_T106_G0.5280.92
156_E230_G0.5250.92
86_L102_V0.5250.92
125_T129_L0.5240.92
40_N45_Y0.5240.92
147_L160_M0.5240.92
15_S59_T0.5230.92
247_T257_A0.5220.92
170_T226_R0.5210.92
90_E96_Q0.5190.91
124_T168_I0.5150.91
62_P129_L0.5140.91
120_L216_A0.5100.91
114_S120_L0.5100.91
250_I254_I0.5080.91
251_V262_F0.5070.90
92_P95_F0.5060.90
32_F48_L0.5060.90
147_L205_L0.5060.90
104_E109_Q0.5060.90
69_G73_I0.5040.90
170_T215_R0.5030.90
101_K104_E0.5030.90
33_V160_M0.5020.90
16_L245_K0.5020.90
70_L80_T0.5000.90
95_F98_G0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4huqT 1 0.9208 100 0.114 Contact Map
1rh5C 1 0.1208 16.7 0.945 Contact Map
2ww9C 1 0.0792 12.1 0.948 Contact Map
2wwbC 1 0.1358 12 0.949 Contact Map
2l0eA 1 0.117 4.4 0.958 Contact Map
4g35B 1 0.0642 3.7 0.96 Contact Map
3mqpB 1 0.0943 2 0.965 Contact Map
1hgvA 8 0.1736 1.6 0.967 Contact Map
1lbjA 1 0.0792 1.5 0.967 Contact Map
4p02B 1 0.2377 1.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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