GREMLIN Database
MURA1 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
UniProt: P70965 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (400)
Sequences: 7668 (4705)
Seq/√Len: 235.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_N283_R4.4261.00
15_T254_K4.0721.00
345_D356_N3.7581.00
43_C227_K3.4211.00
252_L283_R3.3801.00
250_N285_I3.1601.00
181_T218_E3.1401.00
157_K185_E3.1151.00
402_D405_Q3.0271.00
43_C229_H2.7931.00
39_K75_N2.7231.00
206_K218_E2.7071.00
17_K254_K2.7001.00
36_S222_K2.6821.00
245_A273_V2.6701.00
152_R179_E2.6421.00
200_I205_G2.6171.00
321_T356_N2.5721.00
114_P120_G2.5581.00
41_V227_K2.5541.00
400_Y406_K2.4951.00
367_A391_T2.4931.00
289_E319_S2.4631.00
246_I379_L2.4581.00
274_T285_I2.4291.00
338_E341_R2.3681.00
47_T52_Y2.3431.00
56_E59_R2.3151.00
278_E281_G2.2831.00
365_E391_T2.2711.00
159_Y185_E2.2711.00
242_V314_L2.2631.00
251_V410_L2.2611.00
66_H73_T2.2311.00
41_V73_T2.1921.00
365_E389_R2.1821.00
39_K73_T2.1771.00
157_K183_T2.1371.00
43_C71_E2.1351.00
349_E352_S2.1301.00
164_S167_A2.1201.00
360_Q385_E2.1041.00
130_G171_L2.0961.00
317_R383_V2.0481.00
381_G388_T2.0341.00
47_T67_F2.0101.00
41_V71_E2.0051.00
181_T216_K1.9971.00
13_N250_N1.9951.00
294_D325_T1.9391.00
338_E377_L1.9371.00
172_I197_A1.8871.00
32_S40_S1.8821.00
323_M354_I1.8371.00
64_D75_N1.8111.00
125_D129_K1.7731.00
137_E150_K1.7721.00
344_G361_L1.7651.00
35_A38_E1.7101.00
276_K283_R1.7061.00
25_V45_V1.7041.00
30_A54_I1.6981.00
252_L281_G1.6961.00
291_K319_S1.6941.00
155_G178_A1.6891.00
55_N72_V1.6701.00
7_R387_H1.6681.00
252_L278_E1.6651.00
347_K354_I1.6571.00
313_A376_A1.6501.00
339_F344_G1.6331.00
342_M388_T1.6071.00
321_T354_I1.5951.00
129_K133_A1.5901.00
347_K356_N1.5891.00
183_T216_K1.5761.00
238_G307_M1.5741.00
205_G223_L1.5731.00
108_H148_E1.5621.00
278_E283_R1.5541.00
185_E214_T1.5431.00
342_M364_A1.5251.00
336_A346_I1.5211.00
38_E225_G1.5111.00
55_N65_V1.5091.00
183_T214_T1.5001.00
378_I403_F1.4991.00
28_V199_Y1.4961.00
201_N210_A1.4931.00
241_M265_I1.4911.00
154_Q179_E1.4871.00
67_F72_V1.4721.00
208_R218_E1.4641.00
110_R146_E1.4571.00
85_P88_Y1.4361.00
139_K148_E1.4311.00
29_I58_L1.4221.00
294_D323_M1.4211.00
210_A215_I1.4181.00
407_L412_A1.4171.00
366_V377_L1.4041.00
101_P170_N1.3991.00
15_T252_L1.3951.00
312_M335_H1.3781.00
96_V145_I1.3681.00
59_R65_V1.3671.00
336_A348_I1.3611.00
118_A121_S1.3571.00
266_A269_E1.3521.00
203_M226_V1.3471.00
292_P321_T1.3461.00
231_I260_H1.3321.00
327_T331_N1.3281.00
316_L344_G1.3221.00
16_V410_L1.3191.00
315_L322_S1.3091.00
292_P322_S1.3061.00
320_G357_G1.3061.00
128_L140_V1.3011.00
312_M324_I1.2991.00
92_M95_S1.2891.00
241_M253_V1.2831.00
18_V253_V1.2781.00
195_D228_H1.2741.00
97_L169_E1.2691.00
367_A392_E1.2681.00
243_A382_L1.2681.00
237_A256_A1.2621.00
52_Y67_F1.2601.00
63_A74_V1.2551.00
83_E110_R1.2521.00
349_E354_I1.2491.00
242_V264_L1.2441.00
29_I55_N1.2391.00
342_M380_A1.2311.00
66_H75_N1.2301.00
271_M293_I1.2271.00
336_A353_V1.2241.00
201_N206_K1.2231.00
42_I230_I1.2211.00
268_M273_V1.2201.00
56_E60_H1.2131.00
35_A40_S1.2101.00
276_K285_I1.2101.00
406_K409_A1.2091.00
28_V230_I1.2051.00
17_K255_G1.2051.00
45_V51_V1.1931.00
297_T326_E1.1901.00
138_I147_A1.1901.00
208_R216_K1.1901.00
241_M268_M1.1851.00
184_L187_V1.1741.00
25_V51_V1.1621.00
110_R148_E1.1611.00
179_E221_E1.1591.00
132_E137_E1.1551.00
139_K150_K1.1471.00
381_G390_V1.1371.00
40_S199_Y1.1351.00
346_I353_V1.1341.00
136_A153_L1.1261.00
42_I74_V1.1241.00
374_G396_L1.1211.00
317_R358_P1.1071.00
254_K281_G1.1051.00
57_V88_Y1.1031.00
134_M156_A1.0971.00
268_M314_L1.0941.00
189_K213_G1.0931.00
38_E224_H1.0911.00
172_I217_I1.0901.00
246_I383_V1.0891.00
26_L54_I1.0841.00
175_A182_T1.0841.00
243_A379_L1.0831.00
344_G358_P1.0771.00
402_D406_K1.0711.00
202_G226_V1.0681.00
197_A207_I1.0641.00
59_R64_D1.0631.00
32_S74_V1.0591.00
241_M284_V1.0491.00
57_V89_V1.0491.00
366_V388_T1.0371.00
374_G395_H1.0331.00
239_T375_A1.0331.00
209_G212_T1.0311.00
137_E148_E1.0281.00
258_P277_D1.0271.00
63_A76_A1.0181.00
140_V143_G1.0181.00
257_V260_H1.0171.00
53_T56_E1.0171.00
40_S226_V1.0161.00
267_K295_I1.0141.00
53_T90_R1.0111.00
129_K132_E1.0101.00
271_M318_A1.0101.00
158_I161_D1.0091.00
245_A288_K1.0071.00
321_T357_G1.0061.00
313_A380_A1.0041.00
180_G219_G1.0021.00
7_R10_Q1.0011.00
269_E277_D0.9981.00
267_K311_M0.9981.00
110_R150_K0.9921.00
242_V307_M0.9921.00
197_A210_A0.9911.00
333_F353_V0.9901.00
169_E196_L0.9901.00
128_L132_E0.9871.00
35_A225_G0.9811.00
362_Q385_E0.9801.00
240_F400_Y0.9791.00
149_V152_R0.9751.00
267_K270_E0.9651.00
242_V268_M0.9631.00
296_K326_E0.9621.00
153_L178_A0.9611.00
236_E406_K0.9601.00
12_L243_A0.9581.00
315_L324_I0.9571.00
405_Q408_A0.9561.00
384_A388_T0.9501.00
68_E71_E0.9491.00
108_H146_E0.9451.00
238_G310_Q0.9361.00
28_V42_I0.9331.00
59_R67_F0.9321.00
364_A388_T0.9311.00
126_Q162_F0.9301.00
286_G290_L0.9271.00
392_E395_H0.9251.00
307_M310_Q0.9231.00
58_L63_A0.9211.00
186_N191_P0.9191.00
160_L171_L0.9141.00
341_R364_A0.9031.00
228_H231_I0.9031.00
49_S397_D0.9011.00
45_V72_V0.9001.00
234_R264_L0.8930.99
55_N59_R0.8920.99
340_R345_D0.8910.99
27_P30_A0.8900.99
382_L412_A0.8840.99
269_E274_T0.8790.99
127_H170_N0.8780.99
199_Y203_M0.8770.99
44_D229_H0.8740.99
176_A205_G0.8720.99
292_P318_A0.8710.99
292_P320_G0.8710.99
369_T392_E0.8710.99
290_L318_A0.8630.99
368_A374_G0.8590.99
324_I353_V0.8580.99
117_C371_L0.8540.99
271_M290_L0.8530.99
101_P173_M0.8500.99
12_L249_G0.8480.99
201_N209_G0.8430.99
318_A322_S0.8380.99
39_K76_A0.8370.99
83_E88_Y0.8370.99
229_H255_G0.8290.99
210_A214_T0.8280.99
129_K161_D0.8260.99
103_L136_A0.8240.99
335_H373_A0.8240.99
161_D267_K0.8230.99
277_D282_L0.8210.99
30_A102_L0.8200.99
244_A247_T0.8180.99
34_L102_L0.8180.99
192_E234_R0.8140.99
155_G179_E0.8130.99
316_L358_P0.8130.99
312_M353_V0.8120.99
317_R359_V0.8120.99
187_V190_E0.8110.99
18_V237_A0.8090.99
36_S39_K0.8090.99
381_G407_L0.8040.99
241_M244_A0.8030.99
202_G228_H0.8000.99
128_L138_I0.7980.99
81_Q85_P0.7950.99
248_E287_P0.7940.99
67_F70_N0.7890.99
201_N207_I0.7880.99
16_V253_V0.7870.99
200_I223_L0.7820.99
18_V240_F0.7800.99
325_T349_E0.7780.99
119_I330_E0.7780.99
368_A390_V0.7780.99
248_E286_G0.7760.99
33_L58_L0.7760.99
245_A268_M0.7750.99
126_Q161_D0.7750.99
55_N74_V0.7740.99
246_I313_A0.7740.99
96_V124_I0.7740.99
275_I284_V0.7720.98
38_E76_A0.7680.98
310_Q379_L0.7670.98
178_A182_T0.7650.98
155_G182_T0.7650.98
112_A148_E0.7640.98
24_A199_Y0.7630.98
393_L396_L0.7620.98
55_N67_F0.7610.98
181_T219_G0.7610.98
25_V230_I0.7590.98
176_A223_L0.7570.98
245_A284_V0.7570.98
243_A412_A0.7550.98
273_V290_L0.7540.98
312_M355_I0.7530.98
19_E406_K0.7520.98
198_N202_G0.7510.98
199_Y226_V0.7490.98
100_G149_V0.7490.98
246_I317_R0.7490.98
19_E236_E0.7480.98
81_Q84_A0.7470.98
265_I269_E0.7460.98
348_I352_S0.7460.98
70_N401_V0.7460.98
189_K192_E0.7440.98
82_T86_F0.7430.98
186_N190_E0.7410.98
44_D255_G0.7380.98
89_V119_I0.7370.98
271_M314_L0.7350.98
267_K293_I0.7300.98
29_I74_V0.7300.98
293_I322_S0.7270.98
397_D404_H0.7270.98
59_R66_H0.7270.98
187_V191_P0.7240.98
49_S53_T0.7240.98
171_L184_L0.7230.98
175_A184_L0.7230.98
378_I396_L0.7190.98
113_L145_I0.7180.98
29_I72_V0.7170.98
264_L307_M0.7140.97
363_G388_T0.7140.97
271_M315_L0.7140.97
21_A25_V0.7130.97
31_A199_Y0.7110.97
39_K225_G0.7100.97
80_L83_E0.7070.97
89_V113_L0.7060.97
155_G180_G0.7060.97
198_N201_N0.7060.97
394_K397_D0.7060.97
119_I145_I0.7040.97
82_T85_P0.7030.97
237_A253_V0.7020.97
32_S76_A0.7000.97
134_M158_I0.6980.97
17_K44_D0.6980.97
162_F328_V0.6970.97
84_A87_E0.6960.97
316_L339_F0.6950.97
95_S398_R0.6950.97
241_M245_A0.6950.97
58_L99_M0.6930.97
195_D198_N0.6910.97
333_F348_I0.6860.97
83_E86_F0.6850.97
60_H85_P0.6850.97
104_A136_A0.6840.97
240_F406_K0.6820.97
345_D358_P0.6800.97
333_F352_S0.6760.97
309_S335_H0.6760.97
24_A195_D0.6760.97
11_K249_G0.6750.96
201_N208_R0.6740.96
47_T70_N0.6700.96
28_V228_H0.6700.96
20_G230_I0.6690.96
87_E112_A0.6690.96
296_K325_T0.6670.96
25_V46_P0.6660.96
12_L251_V0.6660.96
100_G127_H0.6660.96
244_A286_G0.6660.96
325_T352_S0.6650.96
245_A290_L0.6640.96
172_I215_I0.6640.96
342_M384_A0.6640.96
243_A407_L0.6630.96
382_L407_L0.6610.96
82_T108_H0.6610.96
76_A105_R0.6570.96
404_H408_A0.6560.96
158_I184_L0.6560.96
160_L184_L0.6530.96
83_E87_E0.6520.96
248_E288_K0.6520.96
99_M131_F0.6520.96
247_T382_L0.6510.96
160_L163_P0.6500.96
174_A178_A0.6490.96
166_G193_I0.6490.96
36_S224_H0.6490.96
12_L412_A0.6490.96
244_A251_V0.6460.96
137_E151_G0.6460.96
364_A386_G0.6450.95
309_S373_A0.6450.95
63_A77_S0.6430.95
84_A89_V0.6430.95
256_A282_L0.6420.95
238_G264_L0.6400.95
58_L65_V0.6400.95
198_N228_H0.6390.95
297_T308_Q0.6380.95
24_A27_P0.6360.95
97_L166_G0.6340.95
258_P282_L0.6320.95
14_G410_L0.6320.95
277_D281_G0.6300.95
122_R372_R0.6290.95
192_E195_D0.6270.95
332_R370_D0.6270.95
100_G113_L0.6260.95
316_L359_V0.6260.95
81_Q87_E0.6260.95
122_R332_R0.6250.95
265_I277_D0.6230.95
124_I145_I0.6190.94
244_A253_V0.6190.94
33_L63_A0.6180.94
36_S76_A0.6160.94
232_P253_V0.6160.94
134_M182_T0.6150.94
153_L180_G0.6150.94
35_A76_A0.6140.94
203_M223_L0.6130.94
240_F403_F0.6120.94
363_G384_A0.6120.94
103_L131_F0.6110.94
273_V284_V0.6100.94
16_V240_F0.6080.94
247_T286_G0.6080.94
313_A377_L0.6080.94
323_M349_E0.6060.94
131_F136_A0.6060.94
82_T88_Y0.6040.94
89_V95_S0.6040.94
182_T219_G0.6040.94
124_I128_L0.6040.94
209_G213_G0.6030.94
126_Q163_P0.6030.94
61_L103_L0.6020.94
316_L361_L0.6020.94
199_Y228_H0.6010.93
103_L111_V0.6010.93
269_E275_I0.6000.93
242_V310_Q0.5990.93
341_R367_A0.5990.93
80_L88_Y0.5980.93
246_I314_L0.5970.93
270_E299_P0.5960.93
125_D143_G0.5960.93
396_L404_H0.5940.93
16_V406_K0.5940.93
378_I404_H0.5920.93
206_K220_V0.5920.93
89_V96_V0.5910.93
132_E138_I0.5900.93
312_M336_A0.5890.93
175_A200_I0.5860.93
26_L30_A0.5860.93
68_E73_T0.5860.93
274_T287_P0.5850.93
126_Q129_K0.5850.93
240_F407_L0.5850.93
273_V287_P0.5840.92
363_G386_G0.5840.92
96_V113_L0.5830.92
132_E140_V0.5820.92
344_G380_A0.5810.92
27_P97_L0.5810.92
103_L113_L0.5800.92
339_F380_A0.5790.92
335_H376_A0.5790.92
140_V147_A0.5770.92
141_G146_E0.5760.92
38_E75_N0.5750.92
46_P236_E0.5730.92
192_E198_N0.5720.92
47_T72_V0.5720.92
190_E193_I0.5690.91
316_L383_V0.5690.91
265_I275_I0.5660.91
244_A248_E0.5650.91
368_A395_H0.5640.91
154_Q180_G0.5640.91
286_G289_E0.5620.91
324_I355_I0.5620.91
363_G381_G0.5610.91
295_I311_M0.5600.91
141_G144_F0.5590.91
322_S355_I0.5590.91
117_C121_S0.5590.91
244_A249_G0.5580.91
239_T310_Q0.5570.91
195_D231_I0.5550.90
256_A260_H0.5540.90
198_N210_A0.5530.90
22_K122_R0.5520.90
340_R344_G0.5520.90
152_R178_A0.5510.90
308_Q333_F0.5510.90
194_V209_G0.5500.90
8_G11_K0.5480.90
308_Q324_I0.5480.90
128_L147_A0.5470.90
130_G134_M0.5450.90
361_L380_A0.5440.90
369_T395_H0.5430.89
26_L95_S0.5420.89
258_P281_G0.5410.89
326_E330_E0.5400.89
331_N334_M0.5380.89
374_G404_H0.5370.89
197_A215_I0.5370.89
342_M366_V0.5370.89
292_P319_S0.5370.89
18_V256_A0.5360.89
35_A75_N0.5350.89
49_S52_Y0.5340.89
311_M314_L0.5340.89
57_V98_V0.5340.89
43_C70_N0.5330.89
40_S225_G0.5320.89
201_N205_G0.5310.88
84_A88_Y0.5300.88
235_I371_L0.5300.88
205_G221_E0.5300.88
101_P104_A0.5290.88
29_I54_I0.5290.88
160_L215_I0.5280.88
263_S266_A0.5280.88
26_L399_G0.5280.88
375_A403_F0.5270.88
341_R377_L0.5260.88
256_A281_G0.5260.88
166_G169_E0.5250.88
47_T69_N0.5250.88
80_L87_E0.5240.88
40_S203_M0.5230.88
327_T351_R0.5220.88
187_V192_E0.5220.88
52_Y56_E0.5200.87
315_L355_I0.5200.87
342_M361_L0.5200.87
176_A220_V0.5190.87
21_A231_I0.5190.87
340_R346_I0.5150.87
38_E226_V0.5140.87
266_A270_E0.5140.87
275_I282_L0.5140.87
317_R361_L0.5140.87
127_H130_G0.5130.87
57_V99_M0.5130.87
333_F336_A0.5110.86
393_L404_H0.5110.86
194_V198_N0.5110.86
86_F365_E0.5100.86
296_K327_T0.5100.86
190_E209_G0.5100.86
206_K221_E0.5080.86
267_K300_H0.5080.86
153_L174_A0.5080.86
313_A316_L0.5060.86
218_E221_E0.5050.86
61_L82_T0.5050.86
54_I399_G0.5050.86
97_L329_F0.5040.86
337_E340_R0.5040.86
91_K116_G0.5040.86
313_A339_F0.5030.86
126_Q164_S0.5020.86
289_E359_V0.5010.85
64_D67_F0.5010.85
121_S330_E0.5010.85
340_R347_K0.5010.85
332_R372_R0.5000.85
265_I282_L0.5000.85
142_N362_Q0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.945 100 0.155 Contact Map
2pqcA 1 0.9427 100 0.191 Contact Map
3slhA 4 0.9495 100 0.205 Contact Map
3zh4A 1 0.9404 100 0.21 Contact Map
3r38A 2 0.9748 100 0.216 Contact Map
1rf6A 1 0.9266 100 0.222 Contact Map
1ejdA 4 0.9564 100 0.226 Contact Map
4fqdA 2 0.9381 100 0.231 Contact Map
2yvwA 1 0.9518 100 0.235 Contact Map
5bq2A 4 0.9564 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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