GREMLIN Database
RAPB - Response regulator aspartate phosphatase B
UniProt: P70962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (317)
Sequences: 1767 (1624)
Seq/√Len: 91.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_E239_Q4.6511.00
275_D278_A4.4591.00
147_A163_A4.3931.00
196_N199_K4.1771.00
228_G244_F4.0591.00
188_S204_L3.4851.00
107_G123_Y3.4431.00
350_Q353_E3.3981.00
143_H162_H2.9791.00
155_Q158_F2.9451.00
244_F265_S2.8551.00
115_N118_S2.8351.00
163_A186_V2.5301.00
341_A345_F2.4571.00
245_E266_L2.4551.00
160_M187_I2.4451.00
267_T283_Y2.4231.00
201_L227_I2.3891.00
103_H122_F2.3391.00
106_R110_E2.3391.00
231_Y239_Q2.3251.00
110_E115_N2.3071.00
224_L243_Y2.3021.00
239_Q242_E2.2381.00
224_L246_K2.2301.00
309_Y314_N2.2091.00
185_F226_N2.1911.00
184_H203_H2.1731.00
278_A281_R2.1471.00
346_S359_E2.1351.00
201_L231_Y2.0811.00
144_F186_V2.0621.00
199_K202_E2.0141.00
301_K305_L1.9971.00
143_H165_Q1.9811.00
270_L278_A1.9581.00
241_A269_V1.9401.00
241_A270_L1.9391.00
302_Y309_Y1.9371.00
187_I191_Y1.9051.00
150_F158_F1.9031.00
227_I231_Y1.8871.00
263_L282_Y1.8751.00
241_A266_L1.8741.00
146_V150_F1.8561.00
266_L270_L1.8501.00
123_Y145_K1.8451.00
201_L230_C1.8341.00
241_A273_K1.8311.00
100_Y126_A1.7901.00
228_G243_Y1.7871.00
310_V313_V1.7761.00
160_M190_N1.7751.00
188_S207_A1.7681.00
192_I204_L1.7511.00
181_I207_A1.7191.00
353_E356_Y1.7041.00
184_H206_D1.6911.00
205_D227_I1.6661.00
342_A358_Y1.6361.00
110_E118_S1.6311.00
267_T286_G1.6091.00
107_G126_A1.5931.00
238_D273_K1.5901.00
167_L184_H1.5721.00
270_L275_D1.5641.00
107_G122_F1.5451.00
227_I243_Y1.5281.00
248_L263_L1.5251.00
266_L282_Y1.5191.00
241_A245_E1.5161.00
225_Y265_S1.4991.00
221_G247_A1.4981.00
334_I338_A1.4861.00
118_S121_S1.4801.00
201_L205_D1.4761.00
144_F183_C1.4561.00
147_A166_A1.4420.99
204_L226_N1.4280.99
311_E314_N1.4110.99
228_G240_A1.4100.99
191_Y199_K1.4040.99
103_H125_K1.4020.99
201_L234_K1.3910.99
269_V273_K1.3840.99
146_V162_H1.3780.99
338_A357_F1.3730.99
139_R143_H1.3630.99
326_E360_K1.3580.99
32_K35_E1.3540.99
189_G204_L1.3460.99
160_M191_Y1.3320.99
318_I321_V1.3210.99
140_A170_Y1.3110.99
188_S203_H1.2970.99
126_A142_F1.2960.99
48_Q51_L1.2870.99
248_L262_A1.2780.99
80_Y83_L1.2730.99
342_A361_A1.2710.99
265_S268_R1.2660.99
164_V187_I1.2650.99
345_F353_E1.2590.99
248_L266_L1.2580.99
356_Y360_K1.2540.98
237_L269_V1.2460.98
305_L309_Y1.2420.98
158_F161_N1.2390.98
267_T282_Y1.2350.98
281_R285_K1.2100.98
34_K38_D1.2050.98
150_F155_Q1.1930.98
39_L42_E1.1920.98
143_H166_A1.1900.98
224_L247_A1.1740.98
181_I211_A1.1730.98
120_I150_F1.1710.98
235_G272_K1.1630.98
145_K148_E1.1460.97
302_Y318_I1.1290.97
188_S230_C1.1280.97
212_L220_I1.1250.97
280_I284_E1.1220.97
355_V359_E1.1190.97
263_L285_K1.1190.97
352_K356_Y1.1180.97
351_Y354_A1.1080.97
208_Y220_I1.1040.97
30_A34_K1.1030.97
243_Y247_A1.0970.96
207_A223_A1.0940.96
284_E301_K1.0930.96
203_H207_A1.0750.96
110_E122_F1.0730.96
315_L319_Q1.0710.96
280_I308_L1.0690.96
140_A166_A1.0670.96
167_L180_R1.0620.96
126_A129_M1.0620.96
103_H126_A1.0580.96
107_G149_V1.0540.96
232_D244_F1.0410.95
35_E39_L1.0400.95
30_A33_L1.0350.95
271_F283_Y1.0320.95
127_E143_H1.0300.95
338_A360_K1.0210.95
124_R146_V1.0180.95
346_S358_Y1.0170.95
31_V40_D1.0140.95
147_A162_H1.0050.94
101_Y105_F1.0040.94
120_I146_V0.9930.94
39_L45_E0.9910.94
228_G247_A0.9900.94
120_I149_V0.9880.94
302_Y314_N0.9880.94
189_G226_N0.9840.94
140_A147_A0.9820.94
301_K304_F0.9780.93
247_A262_A0.9750.93
229_N244_F0.9670.93
187_I203_H0.9640.93
270_L282_Y0.9630.93
217_P220_I0.9440.92
34_K41_I0.9430.92
245_E278_A0.9430.92
302_Y306_Q0.9390.92
104_L145_K0.9330.92
96_G99_E0.9330.92
127_E142_F0.9330.92
83_L86_T0.9310.92
170_Y183_C0.9310.92
169_T173_H0.9220.91
345_F350_Q0.9130.91
229_N265_S0.9130.91
82_E86_T0.9070.91
144_F182_Q0.8990.90
147_A186_V0.8990.90
157_H194_Y0.8980.90
232_D272_K0.8900.90
35_E38_D0.8870.90
354_A361_A0.8870.90
340_D343_S0.8860.89
120_I124_R0.8820.89
120_I153_M0.8820.89
35_E42_E0.8820.89
108_M123_Y0.8800.89
141_E145_K0.8670.88
244_F259_L0.8660.88
166_A183_C0.8630.88
198_E234_K0.8600.88
33_L38_D0.8600.88
206_D209_R0.8590.88
109_Y113_Q0.8560.88
169_T216_Q0.8550.88
67_Y71_D0.8550.88
248_L259_L0.8500.87
164_V168_E0.8500.87
124_R162_H0.8490.87
285_K334_I0.8450.87
287_I291_Q0.8430.87
185_F223_A0.8430.87
131_A139_R0.8420.87
33_L37_I0.8400.87
53_Y57_I0.8400.87
55_Q58_S0.8380.87
200_A279_A0.8380.87
208_Y224_L0.8370.87
282_Y286_G0.8270.86
151_Y163_A0.8260.86
181_I188_S0.8230.86
160_M194_Y0.8220.86
77_Q80_Y0.8200.86
123_Y142_F0.8190.85
264_F286_G0.8190.85
207_A210_L0.8190.85
343_S358_Y0.8160.85
165_Q168_E0.8140.85
144_F148_E0.8100.85
119_A123_Y0.8060.85
33_L39_L0.8040.84
32_K40_D0.8000.84
37_I44_M0.7960.84
80_Y84_I0.7950.84
106_R122_F0.7920.83
230_C234_K0.7870.83
107_G111_F0.7860.83
305_L313_V0.7840.83
40_D44_M0.7830.83
150_F153_M0.7810.83
37_I40_D0.7800.83
315_L341_A0.7770.82
283_Y300_A0.7760.82
53_Y56_L0.7750.82
325_M337_F0.7730.82
116_Y120_I0.7730.82
143_H263_L0.7720.82
264_F268_R0.7700.82
310_V314_N0.7650.81
31_V35_E0.7640.81
158_F193_D0.7630.81
283_Y287_I0.7610.81
104_L108_M0.7580.81
347_H360_K0.7570.81
355_V358_Y0.7560.81
30_A37_I0.7540.80
224_L228_G0.7520.80
41_I45_E0.7490.80
314_N317_M0.7470.80
182_Q185_F0.7410.79
87_L90_N0.7390.79
191_Y196_N0.7370.79
31_V34_K0.7370.79
111_F123_Y0.7320.78
220_I224_L0.7320.78
33_L42_E0.7310.78
188_S339_L0.7300.78
151_Y190_N0.7280.78
36_E40_D0.7270.78
305_L310_V0.7250.78
346_S355_V0.7250.78
357_F361_A0.7240.78
171_K213_L0.7200.77
225_Y262_A0.7200.77
233_D236_E0.7180.77
337_F341_A0.7170.77
53_Y60_R0.7160.77
201_L208_Y0.7110.76
39_L43_Q0.7070.76
35_E50_L0.7060.76
121_S125_K0.7060.76
84_I87_L0.7030.76
197_Y237_L0.7010.75
57_I60_R0.6980.75
226_N229_N0.6940.75
62_Q71_D0.6940.75
317_M321_V0.6930.75
154_K159_S0.6920.74
357_F360_K0.6910.74
304_F308_L0.6910.74
147_A159_S0.6910.74
41_I51_L0.6900.74
353_E357_F0.6900.74
81_R84_I0.6850.74
226_N265_S0.6820.73
63_I66_D0.6810.73
98_S102_F0.6770.73
108_M145_K0.6750.73
309_Y318_I0.6730.72
286_G290_A0.6720.72
37_I50_L0.6720.72
264_F267_T0.6710.72
48_Q54_Y0.6700.72
122_F126_A0.6690.72
38_D42_E0.6690.72
127_E146_V0.6690.72
107_G147_A0.6680.72
302_Y321_V0.6670.72
31_V41_I0.6670.72
239_Q243_Y0.6660.72
50_L82_E0.6630.71
342_A354_A0.6620.71
61_H196_N0.6610.71
35_E43_Q0.6590.71
268_R283_Y0.6590.71
320_E324_Y0.6570.71
75_E81_R0.6560.70
30_A43_Q0.6510.70
276_S280_I0.6510.70
127_E139_R0.6500.70
104_L126_A0.6500.70
228_G231_Y0.6460.69
260_P267_T0.6440.69
191_Y203_H0.6420.69
242_E277_E0.6410.69
62_Q65_L0.6390.68
246_K249_P0.6370.68
107_G279_A0.6360.68
167_L183_C0.6350.68
34_K37_I0.6340.68
185_F204_L0.6320.68
111_F149_V0.6310.67
205_D243_Y0.6310.67
160_M316_N0.6290.67
260_P290_A0.6260.67
99_E129_M0.6230.66
50_L53_Y0.6220.66
267_T301_K0.6220.66
182_Q286_G0.6210.66
31_V39_L0.6190.66
317_M320_E0.6180.66
163_A187_I0.6180.66
321_V324_Y0.6170.66
171_K206_D0.6170.66
31_V45_E0.6160.66
306_Q314_N0.6150.65
333_Y336_E0.6120.65
274_Q294_N0.6110.65
172_A175_F0.6110.65
278_A282_Y0.6110.65
165_Q182_Q0.6100.65
75_E78_L0.6090.65
256_L262_A0.6090.65
237_L273_K0.6080.65
351_Y356_Y0.6070.64
148_E186_V0.6040.64
268_R272_K0.6020.64
112_E115_N0.6010.64
185_F207_A0.6000.64
123_Y261_K0.6000.64
83_L90_N0.5990.63
34_K42_E0.5980.63
30_A36_E0.5960.63
31_V36_E0.5950.63
264_F283_Y0.5950.63
208_Y223_A0.5950.63
171_K180_R0.5940.63
128_K131_A0.5930.63
32_K37_I0.5930.63
126_A140_A0.5930.63
164_V191_Y0.5920.63
30_A41_I0.5920.63
79_Q83_L0.5920.63
77_Q125_K0.5910.62
35_E40_D0.5890.62
107_G200_A0.5880.62
347_H351_Y0.5880.62
344_Y351_Y0.5870.62
232_D237_L0.5870.62
211_A214_E0.5870.62
30_A44_M0.5850.62
166_A207_A0.5840.62
119_A149_V0.5830.61
131_A356_Y0.5830.61
197_Y201_L0.5800.61
55_Q62_Q0.5790.61
180_R347_H0.5780.61
91_Q98_S0.5770.61
38_D43_Q0.5770.61
31_V50_L0.5770.61
144_F166_A0.5750.60
61_H65_L0.5740.60
268_R271_F0.5730.60
33_L40_D0.5710.60
192_I230_C0.5710.60
121_S215_G0.5710.60
180_R184_H0.5700.60
60_R64_M0.5680.59
36_E44_M0.5660.59
299_L303_K0.5640.59
263_L286_G0.5630.59
280_I301_K0.5630.59
354_A357_F0.5620.59
34_K43_Q0.5610.58
229_N232_D0.5610.58
211_A216_Q0.5600.58
351_Y355_V0.5600.58
63_I68_V0.5590.58
284_E288_A0.5590.58
198_E202_E0.5590.58
159_S190_N0.5580.58
345_F358_Y0.5570.58
200_A230_C0.5570.58
87_L277_E0.5550.58
56_L81_R0.5540.58
330_L337_F0.5540.58
315_L321_V0.5540.58
216_Q273_K0.5530.57
212_L246_K0.5510.57
319_Q351_Y0.5510.57
66_D71_D0.5490.57
245_E270_L0.5470.57
95_S98_S0.5450.56
142_F145_K0.5450.56
207_A247_A0.5440.56
345_F357_F0.5430.56
52_L58_S0.5430.56
304_F307_A0.5430.56
57_I62_Q0.5420.56
149_V153_M0.5410.56
356_Y361_A0.5410.56
302_Y308_L0.5400.56
313_V317_M0.5400.56
291_Q296_F0.5370.55
204_L233_D0.5370.55
227_I266_L0.5370.55
316_N319_Q0.5370.55
141_E144_F0.5370.55
342_A346_S0.5350.55
212_L327_E0.5350.55
186_V267_T0.5330.55
224_L263_L0.5330.55
180_R204_L0.5330.55
233_D289_I0.5330.55
147_A187_I0.5320.55
83_L240_A0.5320.55
248_L255_Q0.5310.54
162_H166_A0.5300.54
190_N194_Y0.5290.54
49_L56_L0.5280.54
163_A183_C0.5270.54
225_Y228_G0.5260.54
164_V199_K0.5260.54
349_E356_Y0.5250.54
151_Y186_V0.5250.54
228_G265_S0.5250.54
343_S347_H0.5240.53
100_Y130_L0.5230.53
99_E103_H0.5230.53
36_E41_I0.5200.53
232_D240_A0.5200.53
203_H210_L0.5180.53
58_S62_Q0.5170.52
256_L319_Q0.5160.52
57_I87_L0.5160.52
59_Y64_M0.5160.52
184_H210_L0.5150.52
126_A138_E0.5150.52
146_V266_L0.5140.52
87_L242_E0.5130.52
240_A244_F0.5130.52
48_Q53_Y0.5110.52
123_Y127_E0.5100.51
122_F125_K0.5090.51
314_N325_M0.5080.51
219_L223_A0.5080.51
161_N165_Q0.5060.51
100_Y141_E0.5050.51
341_A357_F0.5050.51
120_I123_Y0.5030.51
33_L44_M0.5030.51
125_K128_K0.5030.51
211_A223_A0.5030.51
34_K44_M0.5020.50
121_S161_N0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i1aA 2 0.939 100 0.222 Contact Map
3q15A 2 0.9682 100 0.223 Contact Map
3ulqA 1 0.9735 100 0.232 Contact Map
4gyoA 2 0.9443 100 0.236 Contact Map
4gpkA 3 0.9125 100 0.283 Contact Map
1w3bA 2 0.8435 100 0.359 Contact Map
4ui9C 2 0.8674 100 0.384 Contact Map
3dssA 1 0.7268 100 0.385 Contact Map
4l9pA 1 0.7401 100 0.385 Contact Map
3sf4A 1 0.8382 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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