GREMLIN Database
YWMC - Uncharacterized protein YwmC
UniProt: P70960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (178)
Sequences: 9685 (6473)
Seq/√Len: 485.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_S119_N4.5591.00
69_S115_L3.7841.00
36_N76_Q3.0631.00
65_S115_L2.8901.00
38_A78_K2.8871.00
36_N149_K2.5211.00
43_A81_V2.4541.00
40_L136_A2.3981.00
210_T213_D2.2891.00
136_A151_V2.2411.00
166_I196_A2.0101.00
39_V64_I2.0071.00
110_N113_S1.9761.00
57_F61_K1.9311.00
55_S58_N1.8991.00
150_V180_N1.8501.00
191_K207_P1.8451.00
170_K174_K1.8151.00
129_I153_L1.7951.00
86_G135_E1.7951.00
128_P131_K1.7621.00
137_K172_L1.7481.00
46_S156_D1.6741.00
41_L60_A1.6401.00
41_L64_I1.6301.00
144_D147_G1.5951.00
64_I118_L1.5531.00
58_N61_K1.5421.00
78_K106_F1.5331.00
40_L151_V1.5311.00
127_T156_D1.5161.00
81_V121_I1.5061.00
181_V198_A1.4681.00
61_K118_L1.4661.00
135_E138_S1.4641.00
158_E190_Y1.4621.00
192_G196_A1.4461.00
191_K195_N1.4191.00
137_K175_D1.4171.00
38_A80_S1.4151.00
141_D175_D1.3921.00
46_S127_T1.3921.00
43_A121_I1.3761.00
171_E174_K1.3751.00
165_P169_A1.3641.00
68_A118_L1.3581.00
80_S132_A1.3471.00
102_N105_G1.3471.00
81_V103_V1.3321.00
68_A114_F1.3191.00
38_A136_A1.2931.00
181_V194_L1.2611.00
68_A77_V1.2601.00
183_G194_L1.2481.00
112_Q116_N1.2391.00
127_T157_G1.2331.00
166_I170_K1.2301.00
137_K171_E1.2221.00
133_L151_V1.2111.00
66_K215_E1.2011.00
135_E139_S1.1931.00
43_A57_F1.1891.00
57_F123_P1.1721.00
167_K170_K1.1661.00
133_L153_L1.1651.00
169_A173_Q1.1591.00
129_I159_E1.1491.00
148_E178_T1.1451.00
36_N147_G1.1401.00
195_N199_K1.1381.00
151_V179_V1.1131.00
49_K56_K1.0991.00
62_K66_K1.0881.00
38_A140_F1.0851.00
134_N138_S1.0831.00
134_N168_T1.0821.00
69_S111_E1.0711.00
116_N120_T1.0681.00
104_Y114_F1.0561.00
39_V67_F1.0551.00
66_K69_S1.0461.00
154_L184_F1.0301.00
137_K168_T1.0301.00
186_Y189_G1.0271.00
133_L172_L1.0201.00
80_S135_E1.0181.00
190_Y193_Q1.0151.00
192_G195_N1.0141.00
134_N171_E1.0141.00
133_L197_I1.0081.00
196_A199_K1.0061.00
70_S219_T1.0061.00
48_A123_P1.0011.00
59_S62_K0.9991.00
39_V152_Y0.9991.00
66_K70_S0.9971.00
43_A83_G0.9961.00
151_V172_L0.9941.00
80_S139_S0.9781.00
165_P168_T0.9761.00
191_K205_Y0.9701.00
80_S136_A0.9591.00
37_V150_V0.9551.00
126_W160_T0.9531.00
71_L75_T0.9531.00
78_K139_S0.9501.00
183_G205_Y0.9471.00
133_L179_V0.9461.00
159_E193_Q0.9391.00
47_M56_K0.9381.00
181_V205_Y0.9371.00
67_F71_L0.9361.00
131_K134_N0.9291.00
60_A154_L0.9211.00
72_P75_T0.9201.00
56_K123_P0.9191.00
82_F129_I0.9151.00
183_G189_G0.9151.00
154_L218_F0.9121.00
78_K140_F0.9041.00
168_T172_L0.9011.00
34_P147_G0.8981.00
199_K204_E0.8951.00
166_I169_A0.8921.00
104_Y117_S0.8871.00
152_Y182_I0.8871.00
115_L119_N0.8871.00
38_A139_S0.8871.00
168_T171_E0.8861.00
138_S141_D0.8811.00
111_E115_L0.8781.00
213_D216_K0.8751.00
117_S120_T0.8641.00
167_K171_E0.8631.00
170_K200_V0.8591.00
40_L80_S0.8551.00
68_A115_L0.8531.00
183_G207_P0.8531.00
41_L121_I0.8521.00
80_S86_G0.8511.00
112_Q115_L0.8501.00
56_K59_S0.8421.00
179_V197_I0.8411.00
204_E220_Q0.8361.00
164_N167_K0.8301.00
113_S117_S0.8171.00
159_E165_P0.8151.00
128_P160_T0.8151.00
105_G108_S0.8041.00
36_N144_D0.8011.00
196_A200_V0.8011.00
35_A150_V0.8001.00
116_N119_N0.7981.00
128_P161_C0.7861.00
84_S126_W0.7861.00
47_M60_A0.7821.00
195_N205_Y0.7811.00
189_G207_P0.7721.00
103_V117_S0.7711.00
35_A75_T0.7701.00
118_L121_I0.7691.00
40_L132_A0.7681.00
102_N135_E0.7621.00
169_A172_L0.7601.00
171_E175_D0.7551.00
61_K65_S0.7551.00
104_Y109_F0.7541.00
106_F109_F0.7531.00
65_S69_S0.7531.00
178_T204_E0.7511.00
49_K55_S0.7461.00
151_V177_I0.7441.00
35_A148_E0.7431.00
45_G125_G0.7421.00
132_A136_A0.7421.00
43_A124_T0.7291.00
102_N139_S0.7281.00
39_V77_V0.7271.00
140_F149_K0.7241.00
33_A148_E0.7231.00
180_N204_E0.7191.00
107_Q110_N0.7151.00
130_A134_N0.7111.00
113_S116_N0.7071.00
70_S222_S0.7021.00
38_A106_F0.6991.00
79_M114_F0.6981.00
79_M104_Y0.6971.00
169_A200_V0.6941.00
68_A111_E0.6901.00
170_K173_Q0.6901.00
57_F60_A0.6891.00
169_A197_I0.6881.00
45_G123_P0.6831.00
140_F151_V0.6821.00
39_V60_A0.6811.00
36_N106_F0.6801.00
137_K177_I0.6791.00
58_N62_K0.6681.00
155_T181_V0.6651.00
206_F217_I0.6631.00
84_S128_P0.6571.00
60_A184_F0.6561.00
62_K65_S0.6561.00
59_S212_K0.6531.00
86_G132_A0.6481.00
114_F117_S0.6471.00
83_G128_P0.6461.00
59_S211_Q0.6431.00
173_Q199_K0.6401.00
130_A163_G0.6381.00
48_A56_K0.6271.00
45_G48_A0.6261.00
131_K135_E0.6251.00
159_E162_G0.6251.00
73_E111_E0.6231.00
80_S102_N0.6200.99
182_I217_I0.6180.99
150_V178_T0.6150.99
200_V204_E0.6150.99
37_V77_V0.6070.99
138_S142_Q0.6030.99
109_F114_F0.6010.99
60_A64_I0.5960.99
67_F222_S0.5940.99
217_I220_Q0.5930.99
214_V218_F0.5880.99
184_F211_Q0.5870.99
182_I208_A0.5850.99
81_V101_R0.5830.99
153_L181_V0.5790.99
109_F113_S0.5760.99
77_V114_F0.5750.99
46_S157_G0.5680.99
198_A205_Y0.5680.99
157_G194_L0.5680.99
208_A217_I0.5650.99
56_K185_D0.5620.99
47_M57_F0.5610.99
83_G124_T0.5590.99
165_P172_L0.5570.99
209_Y213_D0.5500.99
42_D157_G0.5490.99
216_K219_T0.5470.99
111_E114_F0.5460.99
47_M127_T0.5420.99
199_K203_G0.5420.99
42_D46_S0.5360.99
76_Q106_F0.5340.99
128_P159_E0.5340.99
180_N206_F0.5330.98
184_F214_V0.5290.98
217_I221_Q0.5290.98
136_A139_S0.5200.98
79_M121_I0.5180.98
40_L153_L0.5160.98
85_E131_K0.5150.98
139_S142_Q0.5120.98
45_G156_D0.5120.98
39_V154_L0.5110.98
126_W161_C0.5100.98
57_F121_I0.5090.98
61_K121_I0.5080.98
102_N140_F0.5070.98
216_K220_Q0.5050.98
178_T201_G0.5000.98
64_I79_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nehA 1 0.9163 100 0.35 Contact Map
4okrA 1 0.7357 100 0.362 Contact Map
4okuA 2 0.7533 100 0.366 Contact Map
1ijbA 1 0.8194 100 0.374 Contact Map
1mf7A 1 0.7841 100 0.38 Contact Map
4cn9A 1 0.793 100 0.386 Contact Map
4bj3A 1 0.7225 100 0.387 Contact Map
1pt6A 1 0.7621 100 0.387 Contact Map
4f1jA 1 0.7885 100 0.388 Contact Map
1n3yA 1 0.7753 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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