GREMLIN Database
NATR - Transcriptional regulatory protein NatR
UniProt: P70955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (195)
Sequences: 71477 (51481)
Seq/√Len: 3686.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L32_S3.9501.00
14_L34_D3.5551.00
18_E32_S3.4831.00
7_V39_A2.8251.00
40_Y68_L2.7941.00
37_K59_H2.5201.00
60_M68_L2.5171.00
33_T42_R2.4401.00
31_F48_I2.4281.00
36_A60_M2.4141.00
44_K72_H2.3371.00
35_S59_H2.2661.00
31_F42_R2.1391.00
18_E22_S2.0651.00
20_I106_A2.0541.00
3_K31_F2.0531.00
56_E84_H2.0531.00
80_F96_V2.0181.00
31_F46_G2.0021.00
66_A78_V1.9831.00
3_K29_I1.9561.00
24_M110_A1.9561.00
53_A65_L1.8971.00
42_R46_G1.8961.00
88_A108_R1.8951.00
80_F91_A1.8281.00
34_D38_E1.7971.00
5_G33_T1.7891.00
51_L76_V1.6881.00
61_S64_E1.6831.00
35_S38_E1.6701.00
98_D112_S1.6611.00
68_L72_H1.6541.00
36_A65_L1.6461.00
66_A80_F1.6161.00
60_M64_E1.6151.00
70_K97_H1.6141.00
37_K60_M1.5911.00
26_D114_D1.5551.00
84_H87_Y1.5161.00
97_H119_K1.5011.00
42_R45_N1.4941.00
64_E67_D1.4931.00
40_Y65_L1.4921.00
68_L71_S1.4451.00
43_V69_I1.4171.00
55_I63_Y1.3991.00
156_T160_T1.3961.00
128_R141_Q1.3771.00
67_D94_L1.3531.00
79_I116_Y1.3421.00
55_I80_F1.3381.00
8_D14_L1.3371.00
187_R190_I1.3301.00
21_V113_F1.3281.00
40_Y60_M1.3011.00
192_N195_Y1.3011.00
42_R48_I1.3001.00
5_G48_I1.3001.00
53_A66_A1.2961.00
168_Q190_I1.2961.00
110_A114_D1.2831.00
33_T39_A1.2791.00
7_V57_M1.2751.00
11_R34_D1.2721.00
41_R45_N1.2671.00
5_G39_A1.2511.00
9_D54_D1.2501.00
172_D176_D1.2431.00
5_G42_R1.2261.00
63_Y90_H1.2251.00
3_K46_G1.2251.00
137_M144_D1.2081.00
73_S76_V1.1981.00
37_K41_R1.1941.00
50_L113_F1.1781.00
38_E41_R1.1761.00
38_E42_R1.1621.00
24_M114_D1.1481.00
39_A65_L1.1461.00
133_Q156_T1.1431.00
67_D90_H1.1431.00
130_L139_V1.1411.00
40_Y44_K1.1381.00
97_H116_Y1.1031.00
63_Y91_A1.0981.00
157_I176_D1.0921.00
139_V144_D1.0651.00
77_D119_K1.0631.00
77_D97_H1.0481.00
5_G31_F1.0481.00
11_R15_E1.0481.00
6_L17_L1.0301.00
90_H94_L1.0291.00
93_D114_D1.0221.00
161_A164_V1.0171.00
108_R111_A1.0151.00
66_A94_L1.0071.00
90_H93_D0.9961.00
89_V93_D0.9931.00
191_I194_H0.9891.00
88_A101_M0.9871.00
85_G101_M0.9771.00
55_I61_S0.9741.00
162_E166_T0.9721.00
17_L81_V0.9721.00
39_A43_V0.9711.00
111_A115_R0.9651.00
98_D115_R0.9621.00
132_K135_S0.9611.00
51_L78_V0.9551.00
15_E32_S0.9521.00
12_V16_K0.9421.00
7_V33_T0.9351.00
7_V51_L0.9341.00
79_I112_S0.9341.00
169_T172_D0.9281.00
10_Y13_D0.9161.00
33_T38_E0.9101.00
52_L109_L0.9041.00
5_G43_V0.9011.00
157_I166_T0.8941.00
56_E83_G0.8901.00
51_L69_I0.8891.00
15_E18_E0.8881.00
57_M65_L0.8751.00
106_A110_A0.8741.00
50_L117_L0.8721.00
161_A166_T0.8711.00
63_Y94_L0.8691.00
64_E68_L0.8681.00
81_V104_Y0.8641.00
19_A23_R0.8611.00
26_D117_L0.8561.00
120_K123_T0.8551.00
194_H198_H0.8461.00
41_R44_K0.8411.00
157_I161_A0.8401.00
172_D175_G0.8381.00
53_A78_V0.8381.00
52_L81_V0.8341.00
17_L109_L0.8321.00
93_D111_A0.8311.00
43_V73_S0.8301.00
147_F151_T0.8291.00
87_Y90_H0.8241.00
16_K20_I0.8191.00
55_I87_Y0.8121.00
53_A80_F0.8101.00
116_Y119_K0.8081.00
131_I159_T0.8061.00
92_F112_S0.8061.00
108_R112_S0.8041.00
120_K124_S0.8031.00
104_Y109_L0.8031.00
66_A96_V0.7991.00
153_R156_T0.7981.00
150_R153_R0.7961.00
60_M65_L0.7881.00
3_K48_I0.7871.00
89_V107_D0.7831.00
11_R14_L0.7761.00
65_L69_I0.7751.00
91_A96_V0.7731.00
6_L18_E0.7691.00
148_A151_T0.7681.00
15_E19_A0.7671.00
3_K49_D0.7541.00
43_V48_I0.7491.00
105_Y108_R0.7491.00
55_I84_H0.7471.00
43_V76_V0.7451.00
6_L14_L0.7441.00
128_R140_L0.7361.00
140_L201_A0.7331.00
8_D57_M0.7331.00
67_D71_S0.7321.00
107_D111_A0.7311.00
7_V65_L0.7301.00
18_E30_V0.7281.00
4_V50_L0.7251.00
36_A40_Y0.7241.00
164_V167_Y0.7231.00
153_R157_I0.7221.00
69_I78_V0.7221.00
43_V51_L0.7201.00
174_K179_E0.7091.00
167_Y172_D0.7041.00
143_K146_I0.7031.00
111_A114_D0.6971.00
69_I74_L0.6751.00
44_K73_S0.6741.00
52_L79_I0.6741.00
14_L18_E0.6741.00
82_T88_A0.6731.00
115_R118_K0.6711.00
88_A105_Y0.6701.00
188_S192_N0.6701.00
40_Y43_V0.6701.00
131_I152_G0.6681.00
191_I195_Y0.6671.00
168_Q172_D0.6661.00
112_S116_Y0.6551.00
44_K68_L0.6531.00
157_I160_T0.6501.00
121_T124_S0.6471.00
114_D117_L0.6441.00
136_E153_R0.6441.00
66_A70_K0.6421.00
55_I91_A0.6391.00
75_D123_T0.6361.00
137_M140_L0.6321.00
157_I173_I0.6291.00
6_L32_S0.6291.00
79_I98_D0.6281.00
93_D98_D0.6241.00
131_I138_H0.6211.00
151_T199_F0.6201.00
83_G103_P0.6191.00
129_I132_K0.6151.00
26_D110_A0.6151.00
104_Y108_R0.6141.00
5_G51_L0.6141.00
150_R158_V0.6131.00
52_L113_F0.6131.00
77_D116_Y0.6121.00
149_E153_R0.6121.00
33_T36_A0.6111.00
77_D123_T0.6081.00
70_K76_V0.6081.00
36_A59_H0.6071.00
140_L143_K0.6051.00
136_E152_G0.6001.00
13_D104_Y0.5981.00
180_K184_R0.5981.00
16_K19_A0.5971.00
4_V21_V0.5951.00
40_Y72_H0.5941.00
20_I110_A0.5941.00
4_V26_D0.5841.00
77_D120_K0.5831.00
80_F94_L0.5821.00
69_I76_V0.5801.00
85_G103_P0.5791.00
133_Q160_T0.5771.00
150_R178_P0.5771.00
139_V142_K0.5721.00
13_D16_K0.5711.00
164_V168_Q0.5691.00
152_G156_T0.5681.00
89_V92_F0.5681.00
113_F116_Y0.5671.00
143_K151_T0.5661.00
154_S158_V0.5621.00
145_I151_T0.5611.00
7_V53_A0.5601.00
43_V65_L0.5581.00
122_E125_L0.5561.00
138_H141_Q0.5551.00
114_D118_K0.5501.00
169_T186_H0.5461.00
10_Y83_G0.5441.00
174_K184_R0.5431.00
141_Q151_T0.5401.00
47_D73_S0.5401.00
22_S25_Q0.5361.00
70_K77_D0.5331.00
50_L116_Y0.5291.00
11_R32_S0.5261.00
141_Q144_D0.5251.00
26_D29_I0.5231.00
88_A92_F0.5221.00
7_V36_A0.5191.00
20_I24_M0.5191.00
38_E59_H0.5181.00
4_V52_L0.5171.00
144_D151_T0.5151.00
129_I140_L0.5131.00
17_L104_Y0.5121.00
112_S115_R0.5111.00
145_I149_E0.5101.00
35_S57_M0.5101.00
180_K183_L0.5091.00
138_H145_I0.5091.00
56_E87_Y0.5081.00
19_A22_S0.5071.00
185_S188_S0.5071.00
29_I46_G0.5061.00
75_D122_E0.5051.00
154_S157_I0.5041.00
47_D74_L0.5031.00
190_I194_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cbvA 2 0.9785 100 0.266 Contact Map
1kgsA 1 0.9142 100 0.39 Contact Map
3r0jA 2 0.9056 100 0.392 Contact Map
1ys7A 2 0.9313 100 0.399 Contact Map
4g97A 1 0.5494 100 0.402 Contact Map
3n0rA 1 0.515 100 0.403 Contact Map
1yioA 1 0.8155 100 0.404 Contact Map
4kfcA 2 0.9185 99.9 0.41 Contact Map
2oqrA 2 0.9227 99.9 0.412 Contact Map
3q9sA 1 0.8884 99.9 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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