GREMLIN Database
NATK - Sensor histidine kinase NatK
UniProt: P70954 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (249)
Sequences: 35409 (30337)
Seq/√Len: 1922.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_N258_G3.4081.00
253_E309_R3.3711.00
247_L313_K3.2421.00
300_D311_E3.0141.00
251_T309_R2.8911.00
289_Q293_K2.6711.00
264_L303_Y2.6121.00
251_T311_E2.5541.00
208_F295_A2.5461.00
196_S238_K2.4961.00
228_A255_S2.4701.00
240_E251_T2.3451.00
242_S249_V2.3071.00
196_S236_E2.2961.00
260_D263_V2.2911.00
236_E255_S2.2901.00
301_F310_L2.2371.00
249_V313_K2.2271.00
216_L292_V2.2171.00
249_V311_E2.2121.00
198_H240_E2.2091.00
242_S251_T2.1621.00
302_T311_E2.0921.00
238_K253_E2.0421.00
264_L301_F1.9951.00
268_Y299_L1.9601.00
292_V297_G1.9431.00
240_E253_E1.9321.00
302_T309_R1.9291.00
144_K164_S1.9161.00
266_T269_Q1.9141.00
298_R313_K1.9021.00
144_K163_Y1.8771.00
259_M267_I1.8561.00
222_E226_D1.8541.00
288_I299_L1.8191.00
303_Y308_F1.8101.00
149_K152_T1.7851.00
235_A255_S1.7821.00
194_S236_E1.7711.00
266_T273_R1.7621.00
263_V273_R1.7561.00
228_A235_A1.7421.00
198_H238_K1.7421.00
261_P264_L1.7361.00
263_V266_T1.7031.00
259_M308_F1.6901.00
135_D215_S1.6711.00
184_F218_G1.6541.00
292_V312_I1.6391.00
244_R249_V1.6271.00
144_K167_D1.6091.00
259_M263_V1.6011.00
208_F213_Q1.5981.00
300_D313_K1.5961.00
216_L288_I1.5931.00
148_P152_T1.5861.00
216_L291_L1.5611.00
293_K298_R1.5301.00
219_N288_I1.5251.00
160_A164_S1.5141.00
209_S212_D1.5061.00
179_G214_V1.4981.00
268_Y301_F1.4811.00
125_M129_V1.4371.00
101_Q106_A1.4271.00
123_N127_I1.4211.00
238_K255_S1.4141.00
127_I131_S1.3651.00
291_L295_A1.3601.00
183_D214_V1.3581.00
167_D170_L1.3561.00
146_A155_Y1.3541.00
228_A237_I1.3431.00
162_Q165_Q1.3311.00
297_G312_I1.3271.00
185_L189_R1.3091.00
260_D305_H1.3011.00
188_A225_L1.2981.00
217_V250_L1.2971.00
158_N162_Q1.2781.00
254_N307_I1.2761.00
213_Q295_A1.2661.00
303_Y306_P1.2531.00
98_R101_Q1.2501.00
199_M241_T1.2411.00
105_Q109_S1.2201.00
103_A106_A1.2181.00
269_Q273_R1.2101.00
144_K160_A1.2061.00
142_A146_A1.1991.00
102_S106_A1.1821.00
102_S105_Q1.1731.00
143_I163_Y1.1721.00
212_D291_L1.1721.00
254_N308_F1.1701.00
176_Y180_V1.1691.00
247_L298_R1.1671.00
212_D215_S1.1601.00
109_S112_I1.1541.00
109_S113_D1.1491.00
212_D294_G1.1381.00
149_K153_Q1.1351.00
152_T155_Y1.1351.00
258_G308_F1.1331.00
147_Q152_T1.1291.00
250_L312_I1.1241.00
297_G314_I1.1151.00
268_Y310_L1.1071.00
118_A122_A1.1031.00
267_I301_F1.0941.00
148_P151_D1.0821.00
113_D116_T1.0741.00
210_P214_V1.0711.00
292_V299_L1.0711.00
268_Y289_Q1.0441.00
159_W163_Y1.0331.00
179_G210_P1.0301.00
116_T119_E1.0261.00
108_L111_Q1.0231.00
115_L119_E1.0191.00
142_A145_S1.0121.00
128_D132_R1.0121.00
119_E122_A1.0081.00
143_I159_W1.0081.00
118_A121_H1.0011.00
146_A158_N0.9921.00
204_S248_Y0.9831.00
157_Q161_D0.9811.00
227_S257_P0.9811.00
216_L312_I0.9751.00
117_Q121_H0.9741.00
116_T120_Q0.9741.00
263_V275_T0.9671.00
187_K190_A0.9611.00
290_K294_G0.9591.00
290_K293_K0.9581.00
301_F308_F0.9331.00
91_F95_E0.9291.00
253_E304_R0.9131.00
142_A162_Q0.9121.00
115_L118_A0.9111.00
168_R211_A0.9051.00
178_A197_L0.9031.00
180_V214_V0.8951.00
244_R247_L0.8901.00
150_A153_Q0.8891.00
121_H124_Q0.8861.00
181_L197_L0.8851.00
176_Y208_F0.8851.00
101_Q105_Q0.8841.00
101_Q109_S0.8821.00
264_L268_Y0.8791.00
218_G222_E0.8781.00
214_V218_G0.8771.00
98_R102_S0.8741.00
112_I115_L0.8701.00
220_I312_I0.8681.00
154_A158_N0.8651.00
204_S243_L0.8631.00
178_A182_Y0.8611.00
193_V228_A0.8591.00
164_S167_D0.8591.00
217_V252_C0.8591.00
120_Q123_N0.8561.00
200_H203_L0.8511.00
177_V241_T0.8471.00
219_N222_E0.8411.00
220_I310_L0.8361.00
220_I288_I0.8341.00
254_N257_P0.8331.00
153_Q157_Q0.8331.00
106_A109_S0.8291.00
111_Q115_L0.8231.00
192_N234_K0.8211.00
259_M265_D0.8201.00
104_L108_L0.8171.00
187_K222_E0.8151.00
224_A237_I0.8151.00
112_I116_T0.8141.00
211_A214_V0.8141.00
200_H242_S0.8131.00
162_Q170_L0.8091.00
217_V221_L0.8091.00
186_E189_R0.8061.00
123_N126_L0.8051.00
220_I299_L0.8011.00
155_Y158_N0.8001.00
171_K175_A0.7991.00
226_D280_H0.7971.00
212_D295_A0.7931.00
181_L195_V0.7931.00
166_Y170_L0.7871.00
183_D218_G0.7811.00
162_Q166_Y0.7801.00
288_I292_V0.7791.00
180_V218_G0.7781.00
259_M264_L0.7741.00
201_T204_S0.7721.00
105_Q108_L0.7721.00
264_L310_L0.7721.00
129_V133_N0.7721.00
221_L239_L0.7681.00
261_P303_Y0.7631.00
131_S135_D0.7611.00
244_R313_K0.7611.00
193_V197_L0.7611.00
292_V314_I0.7611.00
158_N161_D0.7611.00
108_L112_I0.7601.00
181_L185_L0.7601.00
267_I310_L0.7551.00
99_I106_A0.7531.00
137_M167_D0.7521.00
229_A235_A0.7511.00
283_M287_I0.7391.00
113_D117_Q0.7371.00
215_S218_G0.7351.00
184_F222_E0.7341.00
59_G64_I0.7311.00
133_N139_H0.7271.00
289_Q298_R0.7231.00
138_K142_A0.7161.00
192_N233_E0.7161.00
259_M303_Y0.7151.00
166_Y169_F0.7141.00
157_Q160_A0.7121.00
182_Y186_E0.7111.00
163_Y167_D0.7091.00
226_D278_G0.7051.00
229_A233_E0.7031.00
156_I159_W0.7001.00
136_T166_Y0.6991.00
160_A163_Y0.6961.00
162_Q167_D0.6941.00
259_M301_F0.6921.00
182_Y185_L0.6921.00
259_M310_L0.6891.00
110_D114_K0.6851.00
138_K145_S0.6851.00
188_A195_V0.6821.00
152_T156_I0.6771.00
224_A252_C0.6751.00
251_T302_T0.6751.00
239_L252_C0.6721.00
102_S109_S0.6701.00
156_I160_A0.6701.00
176_Y181_L0.6671.00
215_S291_L0.6661.00
98_R106_A0.6651.00
101_Q104_L0.6641.00
127_I290_K0.6641.00
151_D155_Y0.6591.00
102_S108_L0.6591.00
179_G183_D0.6581.00
186_E190_A0.6581.00
200_H241_T0.6571.00
193_V225_L0.6571.00
200_H204_S0.6551.00
184_F187_K0.6511.00
165_Q214_V0.6501.00
59_G73_G0.6501.00
286_Y290_K0.6501.00
111_Q114_K0.6491.00
122_A125_M0.6491.00
191_S225_L0.6461.00
258_G307_I0.6451.00
243_L248_Y0.6451.00
267_I286_Y0.6451.00
300_D312_I0.6441.00
142_A158_N0.6431.00
94_C97_L0.6421.00
221_L237_I0.6391.00
187_K191_S0.6331.00
256_T308_F0.6311.00
184_F221_L0.6311.00
194_S197_L0.6301.00
101_Q108_L0.6291.00
229_A234_K0.6281.00
226_D276_K0.6281.00
180_V184_F0.6221.00
129_V132_R0.6201.00
135_D219_N0.6171.00
78_G82_M0.6151.00
193_V237_I0.6121.00
165_Q170_L0.6111.00
124_Q127_I0.6101.00
209_S295_A0.6061.00
106_A110_D0.6051.00
115_L122_A0.6041.00
183_D187_K0.6021.00
141_T145_S0.6001.00
135_D139_H0.6001.00
125_M135_D0.5991.00
249_V300_D0.5981.00
151_D154_A0.5931.00
260_D264_L0.5911.00
140_I170_L0.5881.00
154_A157_Q0.5851.00
68_Q71_S0.5851.00
229_A257_P0.5841.00
114_K118_A0.5831.00
136_T139_H0.5801.00
274_S278_G0.5791.00
108_L113_D0.5771.00
99_I103_A0.5761.00
177_V239_L0.5761.00
67_I71_S0.5761.00
274_S280_H0.5751.00
188_A193_V0.5741.00
114_K117_Q0.5731.00
70_M73_G0.5721.00
287_I291_L0.5721.00
216_L295_A0.5701.00
110_D113_D0.5681.00
126_L173_E0.5681.00
128_D135_D0.5661.00
220_I292_V0.5651.00
227_S278_G0.5651.00
146_A159_W0.5631.00
189_R192_N0.5611.00
299_L310_L0.5601.00
64_I67_I0.5591.00
146_A162_Q0.5591.00
176_Y213_Q0.5581.00
155_Y159_W0.5571.00
116_T122_A0.5541.00
181_L239_L0.5531.00
203_L241_T0.5521.00
141_T144_K0.5521.00
164_S168_R0.5491.00
241_T248_Y0.5481.00
243_L247_L0.5481.00
134_H138_K0.5461.00
292_V295_A0.5451.00
59_G74_V0.5451.00
297_G315_P0.5431.00
200_H240_E0.5421.00
184_F225_L0.5411.00
193_V235_A0.5401.00
99_I102_S0.5401.00
145_S163_Y0.5381.00
261_P304_R0.5371.00
267_I273_R0.5351.00
257_P278_G0.5331.00
92_A96_G0.5331.00
126_L130_R0.5261.00
228_A234_K0.5241.00
176_Y179_G0.5241.00
65_A68_Q0.5221.00
176_Y185_L0.5191.00
130_R133_N0.5191.00
147_Q151_D0.5191.00
122_A126_L0.5181.00
117_Q120_Q0.5171.00
142_A165_Q0.5161.00
228_A233_E0.5161.00
87_V91_F0.5151.00
304_R309_R0.5131.00
208_F297_G0.5111.00
269_Q289_Q0.5111.00
264_L302_T0.5111.00
253_E306_P0.5091.00
125_M128_D0.5081.00
98_R105_Q0.5071.00
135_D287_I0.5061.00
64_I68_Q0.5051.00
237_I252_C0.5031.00
212_D216_L0.5031.00
181_L184_F0.5021.00
161_D179_G0.5011.00
176_Y210_P0.5011.00
177_V180_V0.5011.00
212_D287_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.805 100 0.435 Contact Map
4q20A 2 0.6415 100 0.442 Contact Map
3d36A 2 0.6164 100 0.445 Contact Map
4gczA 2 0.9403 100 0.449 Contact Map
4bixA 2 0.6384 100 0.454 Contact Map
4ctiA 2 0.6698 100 0.455 Contact Map
3a0rA 2 0.8711 100 0.458 Contact Map
3jz3A 2 0.4214 100 0.46 Contact Map
4mpcA 2 0.7799 100 0.46 Contact Map
2c2aA 2 0.6541 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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