GREMLIN Database
YITW - MIP18 family protein YitW
UniProt: P70949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (95)
Sequences: 1963 (1110)
Seq/√Len: 113.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D27_N5.2301.00
33_D45_T3.2791.00
91_M95_A3.0611.00
41_L75_D3.0171.00
45_T81_V2.7611.00
43_H77_E2.7281.00
45_T79_H2.5671.00
64_K68_A2.3451.00
10_M26_V2.2661.00
87_T90_K2.2061.00
36_M42_T2.1961.00
44_I67_L2.1171.00
41_L74_K1.9961.00
92_S95_A1.7911.00
43_H79_H1.7031.00
15_Q66_A1.6401.00
17_V22_G1.5991.00
25_I31_V1.5691.00
8_N72_E1.5241.00
6_K10_M1.5201.00
41_L77_E1.5051.00
37_D41_L1.4841.00
14_E27_N1.4131.00
40_G74_K1.3731.00
16_V66_A1.3701.00
61_D64_K1.3171.00
42_T67_L1.2530.99
68_A76_T1.2490.99
12_A16_V1.2380.99
8_N11_G1.2330.99
14_E24_D1.2060.99
67_L70_L1.1910.99
46_M63_V1.1650.99
9_I67_L1.1460.99
97_I100_G1.1270.99
62_E66_A1.1070.98
32_Y84_P1.1050.98
14_E94_Y1.0720.98
48_L55_L1.0640.98
59_I62_E1.0330.97
32_Y47_T1.0310.97
61_D65_K1.0280.97
60_V80_I1.0240.97
42_T73_V1.0060.97
60_V64_K1.0020.97
81_V84_P0.9950.97
93_R97_I0.9920.97
37_D43_H0.9430.96
23_V95_A0.9360.95
33_D43_H0.9190.95
47_T84_P0.9140.95
7_E11_G0.9130.95
12_A69_D0.9110.95
13_L63_V0.9090.95
32_Y90_K0.8880.94
58_I62_E0.8810.94
9_I36_M0.8720.93
31_V63_V0.8440.92
11_G14_E0.8170.91
46_M78_V0.8020.90
68_A75_D0.8010.90
56_A100_G0.7890.89
63_V78_V0.7870.89
88_R96_K0.7840.89
57_P62_E0.7760.89
23_V99_L0.7750.89
91_M99_L0.7660.88
17_V21_L0.7640.88
58_I61_D0.7580.87
55_L58_I0.7580.87
79_H83_N0.7510.87
48_L82_W0.7410.86
22_G55_L0.7400.86
8_N36_M0.7260.85
26_V56_A0.7220.85
66_A69_D0.7210.85
62_E65_K0.7120.84
23_V92_S0.7010.83
13_L25_I0.6940.82
8_N71_P0.6940.82
94_Y98_A0.6910.82
73_V76_T0.6850.82
25_I59_I0.6780.81
23_V91_M0.6750.81
30_L48_L0.6750.81
12_A66_A0.6700.80
67_L76_T0.6680.80
34_V50_S0.6550.79
9_I34_V0.6540.79
27_N94_Y0.6520.78
40_G73_V0.6520.78
36_M40_G0.6450.78
58_I82_W0.6380.77
95_A100_G0.6360.77
48_L60_V0.6340.76
16_V52_G0.6330.76
89_D99_L0.6320.76
35_D43_H0.6270.76
51_M93_R0.6250.75
44_I76_T0.6230.75
22_G50_S0.6190.75
32_Y46_M0.6190.75
39_D74_K0.6180.75
64_K77_E0.6120.74
50_S56_A0.6110.74
40_G72_E0.6100.74
10_M34_V0.6100.74
26_V60_V0.6090.74
17_V50_S0.6070.73
59_I88_R0.6050.73
50_S54_P0.5980.72
6_K33_D0.5930.72
12_A70_L0.5900.71
34_V54_P0.5860.71
35_D41_L0.5800.70
91_M100_G0.5740.69
56_A78_V0.5690.68
20_E49_T0.5690.68
9_I44_I0.5680.68
12_A15_Q0.5670.68
44_I63_V0.5600.67
48_L52_G0.5600.67
50_S62_E0.5570.67
94_Y97_I0.5530.66
49_T88_R0.5530.66
52_G61_D0.5530.66
30_L55_L0.5520.66
50_S55_L0.5510.66
21_L24_D0.5500.66
35_D45_T0.5500.66
49_T52_G0.5360.64
88_R97_I0.5260.62
35_D74_K0.5200.62
51_M82_W0.5180.61
38_E77_E0.5180.61
26_V52_G0.5170.61
22_G26_V0.5040.59
15_Q93_R0.5040.59
47_T81_V0.5040.59
40_G70_L0.5020.59
28_L80_I0.5010.59
69_D79_H0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnoA 1 1 100 0.276 Contact Map
1uwdA 1 0.9902 100 0.292 Contact Map
3cq1A 2 0.9706 100 0.3 Contact Map
3ux2A 2 0.9314 100 0.328 Contact Map
2m5oA 1 0.7941 91.3 0.867 Contact Map
1vehA 1 0.7941 90.2 0.87 Contact Map
1xhjA 1 0.8137 78.2 0.889 Contact Map
2z51A 2 0.9314 74.8 0.893 Contact Map
2ew9A 1 0.5784 50.9 0.908 Contact Map
4f2dA 5 0.9412 50.3 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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