GREMLIN Database
YITV - Putative esterase YitV
UniProt: P70948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (218)
Sequences: 47462 (34567)
Seq/√Len: 2341.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_G134_A4.6941.00
126_L135_G3.7081.00
230_I246_K3.1031.00
63_L91_E3.0131.00
33_I92_I2.7691.00
199_A233_E2.6561.00
53_K248_I2.3721.00
213_Y227_L2.3361.00
199_A231_G2.2911.00
210_R231_G2.2471.00
137_S140_G2.2301.00
206_Y231_G2.1381.00
213_Y229_F2.1141.00
123_L137_S2.1081.00
111_G251_F1.9841.00
112_L122_T1.9831.00
27_V56_R1.9811.00
49_L53_K1.9021.00
18_V56_R1.8791.00
30_V113_A1.8731.00
96_K132_I1.8541.00
29_L56_R1.8301.00
93_G97_N1.8231.00
93_G129_Y1.7991.00
29_L105_I1.7911.00
16_H56_R1.7871.00
193_L216_I1.7401.00
206_Y210_R1.7321.00
122_T135_G1.7321.00
106_D109_R1.7121.00
136_V247_T1.6671.00
135_G193_L1.6391.00
232_D246_K1.6381.00
197_H209_T1.6101.00
32_F113_A1.5951.00
115_T139_M1.5761.00
92_I125_A1.5521.00
194_L230_I1.5441.00
184_Q187_K1.5381.00
93_G128_A1.5381.00
19_K56_R1.5251.00
213_Y217_K1.5121.00
14_F58_V1.4871.00
124_G128_A1.4731.00
100_E131_W1.4671.00
93_G125_A1.4651.00
228_Q246_K1.4641.00
16_H58_V1.4311.00
210_R229_F1.4001.00
217_K227_L1.3851.00
47_A59_L1.3801.00
56_R105_I1.3771.00
216_I225_E1.3731.00
29_L99_F1.3731.00
197_H229_F1.3721.00
109_R133_K1.3621.00
98_H102_E1.3461.00
246_K249_E1.3351.00
173_M177_E1.3331.00
94_V97_N1.3321.00
33_I62_A1.3301.00
89_I124_G1.3251.00
30_V55_F1.3111.00
113_A136_V1.3091.00
29_L58_V1.3061.00
28_P109_R1.3041.00
115_T138_L1.2841.00
98_H101_K1.2821.00
28_P55_F1.2761.00
232_D235_A1.2731.00
17_I59_L1.2711.00
200_K234_N1.2651.00
60_P95_L1.2591.00
197_H206_Y1.2561.00
97_N131_W1.2551.00
188_L191_R1.2541.00
210_R214_D1.2411.00
172_L175_R1.2381.00
96_K110_I1.2361.00
97_N101_K1.2361.00
58_V99_F1.2271.00
113_A138_L1.2111.00
33_I60_P1.2031.00
35_G116_S1.2021.00
123_L212_F1.2011.00
119_G140_G1.1961.00
199_A234_N1.1871.00
85_V88_E1.1851.00
32_F57_A1.1851.00
38_S120_I1.1831.00
14_F95_L1.1791.00
33_I112_L1.1561.00
112_L125_A1.1551.00
169_V172_L1.1491.00
58_V95_L1.1481.00
124_G127_T1.1481.00
23_R27_V1.1391.00
199_A206_Y1.1391.00
90_E128_A1.1381.00
197_H231_G1.1301.00
196_W232_D1.1291.00
245_L249_E1.1081.00
136_V251_F1.1041.00
195_F213_Y1.1041.00
19_K27_V1.0991.00
243_A247_T1.0951.00
211_K215_T1.0931.00
211_K214_D1.0901.00
31_I95_L1.0871.00
44_L48_Y1.0841.00
49_L244_V1.0781.00
96_K100_E1.0781.00
137_S195_F1.0701.00
36_F117_M1.0541.00
31_I96_K1.0461.00
33_I122_T1.0451.00
24_H27_V1.0411.00
48_Y52_E1.0351.00
219_H225_E1.0301.00
51_A57_A1.0171.00
49_L52_E1.0151.00
49_L248_I1.0151.00
175_R178_L1.0081.00
152_I155_I1.0071.00
138_L247_T1.0031.00
195_F209_T0.9951.00
111_G133_K0.9871.00
180_D183_L0.9841.00
174_K177_E0.9811.00
103_G106_D0.9791.00
135_G191_R0.9731.00
192_P226_R0.9711.00
196_W230_I0.9681.00
13_P61_E0.9571.00
34_H62_A0.9441.00
173_M176_L0.9401.00
15_L40_K0.9311.00
166_E169_V0.9271.00
214_D218_S0.9241.00
139_M201_D0.9221.00
120_I124_G0.9121.00
127_T184_Q0.9111.00
207_A210_R0.9091.00
97_N129_Y0.9061.00
18_V104_L0.9051.00
174_K178_L0.9051.00
150_Q154_H0.9031.00
40_K67_E0.8971.00
147_L151_Q0.8971.00
120_I141_S0.8941.00
196_W243_A0.8931.00
32_F47_A0.8851.00
87_N90_E0.8841.00
14_F98_H0.8821.00
62_A117_M0.8671.00
92_I121_T0.8661.00
32_F43_N0.8571.00
112_L132_I0.8461.00
90_E94_V0.8431.00
139_M239_V0.8381.00
138_L243_A0.8371.00
46_I244_V0.8341.00
68_R87_N0.8271.00
151_Q155_I0.8261.00
168_K172_L0.8191.00
95_L98_H0.8171.00
11_G69_G0.8151.00
194_L228_Q0.8141.00
32_F59_L0.8121.00
10_S69_G0.8081.00
30_V111_G0.8071.00
17_I57_A0.8051.00
169_V173_M0.8021.00
215_T219_H0.7991.00
182_S185_P0.7961.00
195_F212_F0.7931.00
186_E215_T0.7891.00
168_K171_Q0.7881.00
148_F152_I0.7841.00
149_Q152_I0.7831.00
112_L135_G0.7801.00
29_L110_I0.7791.00
47_A57_A0.7721.00
23_R26_A0.7681.00
126_L191_R0.7651.00
86_L90_E0.7631.00
215_T218_S0.7611.00
136_V194_L0.7601.00
161_E166_E0.7571.00
47_A51_A0.7551.00
38_S42_H0.7551.00
100_E110_I0.7521.00
123_L142_P0.7461.00
43_N115_T0.7421.00
202_K236_D0.7411.00
213_Y219_H0.7391.00
124_G184_Q0.7381.00
182_S215_T0.7371.00
149_Q153_D0.7371.00
143_N211_K0.7371.00
60_P92_I0.7351.00
100_E107_G0.7341.00
55_F251_F0.7341.00
167_E170_Q0.7311.00
125_A129_Y0.7251.00
167_E172_L0.7231.00
111_G136_V0.7211.00
235_A239_V0.7201.00
138_L196_W0.7191.00
123_L140_G0.7191.00
134_A194_L0.7171.00
210_R213_Y0.7121.00
197_H204_V0.7031.00
139_M238_K0.7001.00
244_V247_T0.6981.00
220_Y227_L0.6911.00
89_I93_G0.6901.00
150_Q153_D0.6901.00
216_I227_L0.6891.00
139_M240_P0.6861.00
50_L113_A0.6851.00
220_Y225_E0.6791.00
17_I47_A0.6781.00
28_P111_G0.6751.00
171_Q174_K0.6731.00
135_G212_F0.6721.00
139_M198_G0.6721.00
43_N46_I0.6711.00
171_Q175_R0.6661.00
207_A211_K0.6631.00
167_E171_Q0.6611.00
168_K175_R0.6571.00
26_A106_D0.6561.00
177_E183_L0.6511.00
209_T213_Y0.6501.00
185_P188_L0.6491.00
26_A104_L0.6471.00
161_E167_E0.6431.00
71_E74_V0.6421.00
27_V54_G0.6411.00
34_H65_H0.6411.00
169_V176_L0.6401.00
115_T240_P0.6381.00
141_S144_Y0.6361.00
186_E189_Q0.6361.00
55_F111_G0.6351.00
30_V50_L0.6341.00
134_A250_W0.6321.00
31_I99_F0.6321.00
110_I132_I0.6291.00
13_P67_E0.6281.00
95_L99_F0.6251.00
97_N100_E0.6231.00
134_A251_F0.6191.00
208_P211_K0.6171.00
170_Q173_M0.6171.00
116_S237_H0.6141.00
27_V104_L0.6141.00
172_L176_L0.6131.00
119_G137_S0.6091.00
170_Q174_K0.6061.00
167_E176_L0.6041.00
217_K220_Y0.6041.00
89_I128_A0.6031.00
166_E170_Q0.6021.00
58_V103_G0.6001.00
17_I51_A0.5991.00
166_E171_Q0.5961.00
198_G239_V0.5921.00
151_Q154_H0.5911.00
62_A65_H0.5901.00
107_G110_I0.5891.00
213_Y220_Y0.5871.00
148_F153_D0.5841.00
123_L193_L0.5841.00
50_L247_T0.5811.00
142_P212_F0.5801.00
94_V98_H0.5781.00
149_Q154_H0.5761.00
88_E91_E0.5731.00
128_A184_Q0.5731.00
173_M178_L0.5711.00
134_A192_P0.5701.00
115_T238_K0.5671.00
100_E103_G0.5631.00
108_G133_K0.5631.00
106_D133_K0.5621.00
148_F151_Q0.5621.00
31_I58_V0.5611.00
244_V248_I0.5601.00
90_E93_G0.5601.00
15_L44_L0.5591.00
93_G131_W0.5571.00
122_T137_S0.5541.00
93_G96_K0.5511.00
140_G204_V0.5501.00
110_I133_K0.5461.00
38_S141_S0.5451.00
65_H68_R0.5351.00
209_T229_F0.5331.00
100_E133_K0.5311.00
40_K61_E0.5301.00
168_K173_M0.5301.00
96_K125_A0.5301.00
86_L128_A0.5291.00
161_E168_K0.5291.00
183_L186_E0.5281.00
117_M121_T0.5271.00
247_T251_F0.5231.00
232_D239_V0.5221.00
200_K236_D0.5201.00
48_Y51_A0.5191.00
195_F227_L0.5141.00
103_G107_G0.5131.00
167_E175_R0.5131.00
37_T65_H0.5131.00
88_E121_T0.5111.00
87_N91_E0.5101.00
228_Q231_G0.5091.00
147_L150_Q0.5081.00
71_E75_E0.5071.00
32_F115_T0.5061.00
245_L248_I0.5051.00
40_K59_L0.5031.00
182_S211_K0.5021.00
180_D184_Q0.5011.00
62_A121_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q1vA 2 0.9255 100 0.285 Contact Map
2z3zA 2 0.9216 100 0.285 Contact Map
1xfdA 2 0.9255 100 0.286 Contact Map
4hxfB 4 0.9451 100 0.294 Contact Map
3azoA 1 0.9569 100 0.299 Contact Map
4wjlA 2 0.9255 100 0.299 Contact Map
2ecfA 2 0.9255 100 0.3 Contact Map
4bp8A 1 0.9647 100 0.303 Contact Map
2xe4A 1 0.9647 100 0.309 Contact Map
1z68A 2 0.9333 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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