GREMLIN Database
YITU - Putative phosphatase YitU
UniProt: P70947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (254)
Sequences: 10981 (9096)
Seq/√Len: 570.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_A262_R4.4441.00
19_D256_E3.5511.00
217_A231_A3.1621.00
254_T257_E2.9981.00
228_L234_G2.9161.00
6_Y214_R2.8681.00
24_S258_D2.7801.00
205_S215_I2.6101.00
26_N258_D2.6081.00
26_N265_K2.5141.00
10_L41_V2.4371.00
18_K22_T2.4191.00
242_D246_Q2.4061.00
45_T52_S2.4041.00
229_E247_I2.3081.00
202_Q230_F2.2501.00
253_A257_E2.1111.00
212_R230_F2.0581.00
196_N226_E1.9691.00
25_E29_H1.9281.00
225_L244_V1.9151.00
5_P216_I1.8821.00
33_R36_D1.8611.00
225_L247_I1.8411.00
222_D243_A1.8401.00
236_A248_A1.8301.00
222_D241_I1.8241.00
84_Y203_K1.8221.00
33_R265_K1.8021.00
234_G249_N1.7821.00
7_L42_C1.7761.00
242_D245_K1.7521.00
31_I41_V1.7501.00
34_L39_H1.7441.00
28_L58_Q1.7411.00
211_P214_R1.7401.00
89_P92_V1.7181.00
9_A201_L1.7051.00
202_Q206_D1.6891.00
33_R37_D1.6821.00
235_V263_F1.6271.00
233_C249_N1.6171.00
203_K206_D1.6091.00
12_L17_L1.5901.00
203_K207_Y1.5841.00
244_V247_I1.5811.00
233_C250_R1.5641.00
199_V202_Q1.5481.00
24_S27_T1.5441.00
10_L218_F1.5361.00
198_A230_F1.5311.00
250_R267_Y1.5271.00
40_Y208_Y1.5221.00
75_H78_D1.5101.00
201_L227_M1.5021.00
5_P39_H1.4921.00
86_T203_K1.4871.00
29_H33_R1.4591.00
100_S154_I1.4571.00
218_F260_V1.4451.00
217_A227_M1.4381.00
5_P233_C1.4251.00
5_P214_R1.4231.00
27_T258_D1.4161.00
213_E232_G1.4071.00
35_K62_T1.3971.00
165_R169_S1.3931.00
101_E119_H1.3831.00
26_N262_R1.3771.00
28_L32_Q1.3741.00
236_A240_G1.3551.00
250_R263_F1.3361.00
218_F263_F1.3261.00
228_L244_V1.3231.00
85_H148_D1.3211.00
30_T261_A1.3051.00
205_S212_R1.2941.00
238_G254_T1.2941.00
92_V95_Q1.2871.00
225_L229_E1.2851.00
212_R215_I1.2741.00
9_A44_S1.2631.00
160_D163_A1.2481.00
243_A246_Q1.2401.00
75_H79_D1.2311.00
90_L94_K1.2291.00
99_I103_Y1.2101.00
86_T192_K1.2091.00
95_Q171_V1.1981.00
32_Q36_D1.1851.00
103_Y167_Y1.1821.00
30_T265_K1.1801.00
215_I231_A1.1781.00
8_I34_L1.1691.00
18_K256_E1.1671.00
217_A228_L1.1661.00
8_I264_L1.1651.00
66_V200_G1.1601.00
26_N30_T1.1591.00
216_I267_Y1.1551.00
245_K251_T1.1461.00
7_L210_V1.1451.00
260_V264_L1.1421.00
250_R266_E1.1281.00
85_H150_T1.1211.00
239_N255_N1.1201.00
42_C204_I1.1031.00
253_A259_G1.1031.00
252_T263_F1.1021.00
237_M259_G1.0981.00
7_L205_S1.0921.00
231_A234_G1.0921.00
151_S189_E1.0861.00
162_P166_S1.0831.00
9_A215_I1.0821.00
192_K195_M1.0781.00
212_R232_G1.0761.00
263_F267_Y1.0761.00
140_D143_E1.0691.00
72_F82_G1.0691.00
73_V203_K1.0681.00
8_I39_H1.0581.00
241_I244_V1.0561.00
25_E28_L1.0551.00
12_L55_Y1.0391.00
252_T259_G1.0341.00
238_G253_A1.0301.00
205_S230_F1.0291.00
16_L27_T1.0231.00
196_N199_V1.0221.00
7_L215_I1.0221.00
181_W191_I1.0201.00
163_A166_S1.0141.00
32_Q35_K1.0131.00
216_I233_C1.0131.00
235_V252_T1.0091.00
166_S169_S1.0061.00
73_V84_Y1.0031.00
19_D255_N1.0021.00
221_E241_I0.9981.00
35_K63_T0.9961.00
201_L231_A0.9931.00
123_E127_D0.9921.00
235_V250_R0.9891.00
216_I235_V0.9771.00
64_P208_Y0.9731.00
16_L31_I0.9681.00
240_G245_K0.9631.00
71_A195_M0.9621.00
261_A265_K0.9611.00
162_P182_A0.9601.00
191_I196_N0.9591.00
238_G245_K0.9591.00
262_R266_E0.9561.00
156_A160_D0.9541.00
49_Y67_N0.9501.00
216_I263_F0.9501.00
32_Q60_E0.9491.00
198_A226_E0.9411.00
98_D102_S0.9391.00
263_F266_E0.9341.00
10_L260_V0.9331.00
94_K98_D0.9321.00
205_S210_V0.9311.00
236_A244_V0.9301.00
163_A167_Y0.9271.00
204_I208_Y0.9231.00
237_M252_T0.9231.00
86_T194_G0.9211.00
202_Q212_R0.9121.00
205_S232_G0.9081.00
222_D225_L0.9071.00
29_H32_Q0.8971.00
34_L41_V0.8971.00
88_L192_K0.8921.00
9_A42_C0.8861.00
95_Q98_D0.8841.00
87_S148_D0.8801.00
99_I102_S0.8771.00
45_T67_N0.8751.00
67_N72_F0.8741.00
215_I232_G0.8681.00
238_G257_E0.8651.00
73_V200_G0.8651.00
27_T261_A0.8641.00
165_R182_A0.8621.00
262_R265_K0.8621.00
53_S57_Q0.8581.00
156_A161_V0.8521.00
157_K160_D0.8501.00
228_L247_I0.8481.00
34_L264_L0.8361.00
123_E126_I0.8321.00
91_D95_Q0.8311.00
49_Y74_H0.8301.00
66_V204_I0.8271.00
215_I230_F0.8271.00
44_S66_V0.8211.00
167_Y171_V0.8181.00
30_T33_R0.8181.00
27_T30_T0.8161.00
243_A247_I0.8151.00
8_I216_I0.8141.00
126_I130_N0.8121.00
95_Q99_I0.8081.00
232_G249_N0.8071.00
48_P68_F0.8051.00
137_T140_D0.8041.00
83_R207_Y0.7981.00
16_L23_I0.7931.00
18_K24_S0.7881.00
162_P165_R0.7871.00
228_L248_A0.7861.00
97_V101_E0.7801.00
217_A234_G0.7791.00
39_H216_I0.7791.00
10_L16_L0.7701.00
74_H82_G0.7691.00
85_H113_I0.7611.00
99_I167_Y0.7611.00
18_K255_N0.7591.00
240_G244_V0.7581.00
102_S167_Y0.7561.00
12_L43_I0.7551.00
26_N261_A0.7531.00
220_D240_G0.7441.00
201_L217_A0.7441.00
67_N74_H0.7421.00
214_R232_G0.7411.00
82_G85_H0.7401.00
20_D256_E0.7251.00
42_C64_P0.7251.00
253_A263_F0.7221.00
127_D130_N0.7191.00
87_S150_T0.7171.00
153_L189_E0.7141.00
220_D237_M0.7141.00
14_G237_M0.7131.00
16_L255_N0.7091.00
250_R262_R0.7081.00
72_F150_T0.7081.00
180_R190_I0.7081.00
237_M240_G0.7041.00
141_L144_N0.7041.00
112_V117_Y0.7001.00
234_G244_V0.7001.00
90_L148_D0.6981.00
199_V203_K0.6981.00
166_S170_D0.6941.00
43_I52_S0.6931.00
167_Y170_D0.6921.00
71_A192_K0.6891.00
91_D94_K0.6881.00
52_S67_N0.6861.00
69_N189_E0.6811.00
103_Y163_A0.6791.00
99_I171_V0.6771.00
98_D142_R0.6721.00
202_Q205_S0.6721.00
195_M199_V0.6721.00
226_E229_E0.6671.00
132_N135_N0.6641.00
252_T262_R0.6611.00
112_V115_D0.6611.00
218_F235_V0.6571.00
52_S65_I0.6571.00
26_N29_H0.6531.00
44_S227_M0.6481.00
136_V139_G0.6461.00
158_E162_P0.6391.00
101_E107_N0.6361.00
239_N245_K0.6351.00
233_C263_F0.6341.00
161_V165_R0.6321.00
7_L204_I0.6301.00
64_P204_I0.6281.00
234_G248_A0.6251.00
12_L16_L0.6251.00
42_C63_T0.6211.00
93_V149_V0.6211.00
49_Y53_S0.6181.00
218_F252_T0.6181.00
250_R253_A0.6171.00
12_L52_S0.6161.00
65_I76_P0.6121.00
5_P40_Y0.6121.00
222_D244_V0.6121.00
236_A247_I0.6111.00
104_N160_D0.6101.00
64_P75_H0.6081.00
17_L255_N0.6071.00
93_V97_V0.6071.00
6_Y39_H0.6061.00
225_L228_L0.6051.00
16_L43_I0.6041.00
126_I129_F0.6031.00
43_I56_Y0.6021.00
258_D261_A0.5991.00
244_V248_A0.5991.00
56_Y65_I0.5981.00
73_V207_Y0.5951.00
198_A202_Q0.5941.00
108_V153_L0.5921.00
39_H214_R0.5921.00
194_G199_V0.5911.00
54_M57_Q0.5911.00
180_R188_I0.5901.00
253_A266_E0.5901.00
8_I218_F0.5851.00
24_S261_A0.5841.00
210_V232_G0.5801.00
139_G143_E0.5791.00
97_V109_L0.5781.00
105_V110_A0.5781.00
75_H83_R0.5761.00
184_P221_E0.5761.00
29_H265_K0.5741.00
261_A264_L0.5731.00
64_P76_P0.5731.00
131_M134_T0.5711.00
258_D262_R0.5711.00
158_E185_W0.5711.00
99_I168_L0.5700.99
23_I28_L0.5700.99
40_Y63_T0.5670.99
23_I47_R0.5670.99
151_S183_A0.5660.99
34_L261_A0.5650.99
100_S107_N0.5640.99
156_A164_I0.5630.99
247_I250_R0.5630.99
30_T34_L0.5620.99
237_M255_N0.5620.99
94_K145_L0.5620.99
112_V147_E0.5600.99
154_I190_I0.5580.99
10_L34_L0.5570.99
218_F264_L0.5550.99
90_L146_G0.5550.99
73_V204_I0.5520.99
136_V141_L0.5500.99
233_C267_Y0.5490.99
35_K60_E0.5470.99
235_V249_N0.5470.99
19_D254_T0.5440.99
44_S69_N0.5440.99
239_N254_T0.5390.99
68_F71_A0.5370.99
68_F189_E0.5370.99
169_S173_A0.5360.99
16_L260_V0.5350.99
7_L40_Y0.5350.99
31_I264_L0.5350.99
27_T31_I0.5350.99
93_V152_V0.5320.99
153_L187_V0.5320.99
113_I150_T0.5320.99
49_Y68_F0.5300.99
40_Y64_P0.5300.99
31_I35_K0.5280.99
18_K258_D0.5280.99
212_R231_A0.5270.99
105_V164_I0.5270.99
201_L205_S0.5260.99
9_A205_S0.5250.99
158_E182_A0.5250.99
68_F187_V0.5240.99
105_V154_I0.5230.99
122_D125_L0.5170.99
68_F150_T0.5160.99
154_I164_I0.5130.99
99_I172_H0.5120.99
198_A215_I0.5110.99
54_M58_Q0.5090.99
98_D101_E0.5090.99
35_K41_V0.5080.99
46_G223_N0.5080.99
43_I59_M0.5070.99
62_T77_Q0.5050.99
210_V215_I0.5050.99
11_D15_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9519 100 0.225 Contact Map
4qjbA 1 0.9815 100 0.231 Contact Map
1nrwA 1 0.9519 100 0.235 Contact Map
2b30A 2 0.9815 100 0.243 Contact Map
1rkqA 1 0.9815 100 0.246 Contact Map
3l7yA 1 0.9593 100 0.248 Contact Map
3daoA 1 0.9704 100 0.256 Contact Map
1nf2A 4 0.9667 100 0.259 Contact Map
4dw8A 1 0.963 100 0.262 Contact Map
3dnpA 2 0.963 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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