GREMLIN Database
YITS - DegV domain-containing protein YitS
UniProt: P70945 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (272)
Sequences: 4507 (3631)
Seq/√Len: 220.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_T145_E3.2411.00
246_K250_E3.2391.00
81_P113_D3.0041.00
220_K252_A2.8671.00
15_R19_E2.6151.00
170_A180_A2.5241.00
90_G198_K2.4341.00
83_L143_I2.3771.00
239_K243_T2.3361.00
132_H135_D2.3351.00
141_N145_E2.3281.00
44_H47_Q2.2571.00
95_Y99_V2.2431.00
50_E54_N2.1801.00
72_F84_Y2.1651.00
66_Q70_N2.1611.00
115_R143_I2.1501.00
85_I119_S2.1251.00
73_L77_E2.0361.00
168_Y273_P2.0301.00
38_E67_T2.0251.00
203_E214_R2.0161.00
5_L137_C1.9901.00
33_G56_E1.9791.00
62_Q93_G1.9241.00
76_A112_F1.9151.00
14_P17_Y1.8371.00
151_K154_C1.8201.00
38_E42_T1.8041.00
243_T246_K1.7731.00
133_A150_V1.7471.00
147_E151_K1.7421.00
136_L149_S1.7341.00
170_A177_K1.7031.00
24_G75_Y1.6921.00
68_I98_A1.6921.00
238_N241_K1.6761.00
4_H24_G1.6681.00
136_L146_I1.6511.00
81_P143_I1.6501.00
24_G74_Q1.6361.00
69_K104_E1.6201.00
29_R67_T1.6151.00
35_K51_A1.6031.00
6_I71_V1.5961.00
214_R217_E1.5691.00
74_Q78_T1.5681.00
49_F268_G1.5671.00
149_S152_N1.5641.00
46_D50_E1.5631.00
115_R147_E1.5511.00
89_S118_D1.5501.00
69_K73_L1.5481.00
208_Q241_K1.5391.00
3_V137_C1.5271.00
148_T152_N1.5221.00
29_R36_E1.5211.00
31_S36_E1.5171.00
136_L141_N1.5041.00
6_I84_Y1.5031.00
16_S20_E1.4981.00
120_K154_C1.4791.00
135_D139_N1.4651.00
158_E222_R1.4601.00
73_L105_V1.4501.00
248_L251_E1.4451.00
134_A138_I1.4261.00
24_G71_V1.3921.00
242_A260_M1.3901.00
53_Q237_A1.3891.00
71_V74_Q1.3881.00
74_Q77_E1.3851.00
214_R218_L1.3821.00
47_Q50_E1.3771.00
31_S59_K1.3761.00
117_I151_K1.3681.00
141_N149_S1.3631.00
18_F25_F1.3531.00
117_I147_E1.3491.00
97_T101_I1.3461.00
68_I94_T1.3311.00
26_I71_V1.3281.00
28_L94_T1.3281.00
21_K138_I1.3271.00
152_N156_Q1.3121.00
117_I150_V1.3021.00
243_T247_H1.2921.00
244_D247_H1.2851.00
136_L139_N1.2761.00
10_A126_Y1.2741.00
46_D262_P1.2671.00
235_Y238_N1.2671.00
195_E200_V1.2621.00
12_D264_S1.2601.00
246_K260_M1.2521.00
81_P115_R1.2521.00
21_K134_A1.2471.00
132_H149_S1.2461.00
121_C125_G1.2441.00
235_Y260_M1.2431.00
32_L51_A1.2361.00
99_V102_A1.2271.00
7_A130_V1.2211.00
17_Y21_K1.2211.00
220_K253_F1.2181.00
72_F86_A1.2161.00
7_A126_Y1.2111.00
99_V103_N1.2101.00
217_E252_A1.2041.00
247_H251_E1.1981.00
132_H136_L1.1941.00
162_T211_L1.1931.00
233_I242_A1.1881.00
96_Q99_V1.1831.00
144_Q148_T1.1791.00
82_A112_F1.1781.00
4_H75_Y1.1741.00
7_A25_F1.1731.00
76_A105_V1.1591.00
141_N146_I1.1531.00
5_L130_V1.1421.00
23_I134_A1.1381.00
218_L221_E1.1351.00
53_Q273_P1.1251.00
67_T70_N1.1251.00
47_Q51_A1.1231.00
20_E138_I1.1221.00
247_H250_E1.1151.00
32_L58_P1.1061.00
193_Q202_L1.1041.00
6_I75_Y1.1031.00
93_G97_T1.1021.00
17_Y131_R1.0911.00
89_S95_Y1.0761.00
102_A114_L1.0651.00
71_V75_Y1.0611.00
145_E148_T1.0591.00
149_S153_F1.0471.00
271_A275_T1.0451.00
243_T260_M1.0431.00
177_K180_A1.0411.00
95_Y116_V1.0391.00
62_Q97_T1.0361.00
129_A154_C1.0351.00
115_R144_Q1.0341.00
85_I133_A1.0291.00
164_D189_K1.0251.00
86_A95_Y1.0211.00
57_T171_R1.0201.00
163_V169_L1.0171.00
187_N207_G1.0161.00
217_E220_K1.0131.00
128_L232_G1.0081.00
233_I246_K0.9941.00
3_V146_I0.9921.00
113_D144_Q0.9911.00
135_D230_T0.9881.00
69_K101_I0.9871.00
68_I101_I0.9841.00
230_T257_E0.9841.00
75_Y82_A0.9841.00
115_R151_K0.9831.00
98_A116_V0.9791.00
13_L127_G0.9781.00
26_I63_A0.9651.00
192_L199_L0.9621.00
213_K248_L0.9591.00
16_S19_E0.9581.00
216_I248_L0.9571.00
237_A273_P0.9561.00
69_K105_V0.9551.00
248_L252_A0.9511.00
244_D248_L0.9471.00
24_G78_T0.9471.00
4_H80_D0.9441.00
137_C146_I0.9431.00
134_A137_C0.9401.00
82_A114_L0.9361.00
46_D237_A0.9351.00
213_K217_E0.9291.00
21_K135_D0.9280.99
143_I147_E0.9270.99
21_K131_R0.9260.99
6_I82_A0.9190.99
3_V83_L0.9140.99
246_K258_I0.9140.99
102_A116_V0.9130.99
129_A150_V0.9060.99
179_S204_K0.8970.99
235_Y239_K0.8900.99
90_G120_K0.8850.99
76_A113_D0.8790.99
153_F156_Q0.8760.99
242_A246_K0.8700.99
121_C194_M0.8640.99
113_D143_I0.8620.99
49_F236_A0.8610.99
193_Q200_V0.8530.99
38_E41_V0.8520.99
58_P269_S0.8470.99
235_Y242_A0.8460.99
222_R280_F0.8450.99
212_F245_M0.8450.99
52_M168_Y0.8380.99
26_I68_I0.8350.99
93_G96_Q0.8320.99
132_H153_F0.8300.99
183_G190_P0.8290.99
28_L266_A0.8280.99
176_S179_S0.8260.99
234_S263_I0.8230.99
76_A111_D0.8230.99
65_P100_M0.8200.99
240_E243_T0.8180.99
240_E244_D0.8170.99
91_L122_A0.8160.99
31_S34_D0.8160.99
7_A11_T0.8160.99
4_H22_G0.8120.99
72_F98_A0.8100.99
195_E198_K0.8010.99
37_F43_I0.7990.98
100_M103_N0.7980.98
167_T171_R0.7950.98
210_K213_K0.7950.98
124_L232_G0.7900.98
166_L183_G0.7860.98
6_I72_F0.7840.98
10_A266_A0.7790.98
217_E221_E0.7780.98
131_R134_A0.7780.98
230_T259_I0.7780.98
33_G51_A0.7760.98
219_M278_I0.7720.98
83_L117_I0.7710.98
105_V112_F0.7650.98
70_N74_Q0.7640.98
165_D168_Y0.7620.98
172_G270_H0.7610.98
131_R135_D0.7560.98
124_L234_S0.7550.98
17_Y134_A0.7550.98
201_P204_K0.7540.98
125_G279_F0.7540.98
60_T269_S0.7530.98
234_S277_A0.7500.98
51_A54_N0.7480.98
9_S39_D0.7470.98
129_A153_F0.7460.98
263_I268_G0.7400.98
130_V134_A0.7400.98
143_I146_I0.7370.97
148_T151_K0.7370.97
235_Y262_P0.7330.97
68_I72_F0.7300.97
121_C159_H0.7280.97
191_L211_L0.7230.97
66_Q69_K0.7200.97
144_Q147_E0.7150.97
178_T181_F0.7150.97
105_V111_D0.7140.97
48_I268_G0.7130.97
219_M223_G0.7100.97
51_A56_E0.7080.97
91_L199_L0.7070.97
50_E53_Q0.7070.97
3_V81_P0.7060.97
87_F91_L0.7030.97
43_I48_I0.7000.97
5_L134_A0.7000.97
150_V154_C0.6970.96
210_K217_E0.6970.96
76_A79_G0.6960.96
241_K244_D0.6940.96
125_G157_L0.6930.96
12_D123_S0.6930.96
236_A275_T0.6920.96
170_A175_I0.6920.96
89_S120_K0.6810.96
152_N155_S0.6810.96
88_S91_L0.6760.96
70_N73_L0.6750.96
233_I260_M0.6740.96
29_R38_E0.6720.96
22_G138_I0.6690.96
218_L222_R0.6670.95
17_Y20_E0.6670.95
18_F22_G0.6620.95
84_Y98_A0.6600.95
100_M104_E0.6600.95
234_S279_F0.6580.95
160_I202_L0.6560.95
168_Y171_R0.6560.95
23_I130_V0.6520.95
13_L18_F0.6510.95
75_Y80_D0.6510.95
161_F277_A0.6500.95
27_P41_V0.6490.95
119_S126_Y0.6490.95
164_D208_Q0.6460.95
133_A137_C0.6440.95
160_I218_L0.6420.94
99_V116_V0.6390.94
216_I252_A0.6370.94
245_M276_L0.6370.94
81_P112_F0.6370.94
219_M280_F0.6360.94
85_I150_V0.6360.94
122_A126_Y0.6340.94
96_Q100_M0.6330.94
76_A82_A0.6330.94
48_I265_S0.6330.94
30_V265_S0.6320.94
32_L35_K0.6280.94
12_D39_D0.6270.94
241_K276_L0.6270.94
97_T100_M0.6270.94
191_L205_I0.6250.94
129_A157_L0.6210.93
5_L133_A0.6200.93
160_I222_R0.6190.93
10_A87_F0.6180.93
87_F122_A0.6170.93
122_A199_L0.6150.93
205_I210_K0.6150.93
164_D274_G0.6140.93
101_I105_V0.6130.93
122_A267_I0.6100.93
14_P127_G0.6100.93
164_D180_A0.6050.93
9_S28_L0.6030.92
216_I245_M0.6030.92
65_P101_I0.6030.92
72_F114_L0.6020.92
131_R259_I0.6020.92
208_Q211_L0.5940.92
88_S120_K0.5940.92
86_A116_V0.5930.92
205_I214_R0.5910.92
161_F275_T0.5900.92
220_K224_D0.5880.91
212_F248_L0.5860.91
161_F192_L0.5850.91
83_L147_E0.5850.91
120_K197_G0.5840.91
85_I126_Y0.5810.91
117_I154_C0.5760.91
98_A101_I0.5750.91
119_S129_A0.5750.91
64_S67_T0.5740.90
158_E193_Q0.5740.90
250_E257_E0.5730.90
179_S201_P0.5730.90
83_L133_A0.5730.90
236_A263_I0.5710.90
36_E42_T0.5710.90
212_F276_L0.5700.90
161_F199_L0.5680.90
72_F82_A0.5640.90
32_L57_T0.5600.89
13_L23_I0.5570.89
83_L115_R0.5560.89
123_S275_T0.5540.89
216_I220_K0.5540.89
167_T170_A0.5440.88
132_H230_T0.5400.88
250_E258_I0.5380.87
35_K42_T0.5380.87
89_S96_Q0.5380.87
211_L215_I0.5360.87
131_R230_T0.5360.87
188_I204_K0.5350.87
219_M253_F0.5330.87
76_A80_D0.5320.87
191_L203_E0.5290.87
202_L218_L0.5290.87
181_F201_P0.5290.87
228_N256_K0.5290.87
15_R40_A0.5270.86
75_Y78_T0.5270.86
203_E218_L0.5260.86
233_I258_I0.5240.86
101_I104_E0.5230.86
136_L150_V0.5220.86
85_I130_V0.5200.86
72_F102_A0.5200.86
186_L206_R0.5190.85
88_S194_M0.5180.85
249_I278_I0.5170.85
33_G55_G0.5160.85
146_I150_V0.5150.85
239_K260_M0.5150.85
250_E254_K0.5130.85
18_F40_A0.5130.85
14_P259_I0.5120.85
162_T208_Q0.5120.85
91_L194_M0.5110.85
18_F21_K0.5100.84
65_P97_T0.5080.84
232_G259_I0.5060.84
135_D138_I0.5060.84
177_K181_F0.5050.84
159_H279_F0.5050.84
15_R18_F0.5040.84
83_L137_C0.5040.84
219_M249_I0.5040.84
229_Q255_P0.5020.84
88_S197_G0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pzxA 1 1 100 -0.004 Contact Map
3pl5A 1 0.9576 100 0.005 Contact Map
3fysA 1 0.9859 100 0.012 Contact Map
3nyiA 1 0.9929 100 0.013 Contact Map
2dt8A 1 0.9823 100 0.022 Contact Map
3lupA 1 0.9823 100 0.025 Contact Map
3jr7A 1 0.9788 100 0.033 Contact Map
2g7zA 3 0.9611 100 0.037 Contact Map
3fdjA 1 0.9682 100 0.049 Contact Map
1mgpA 1 0.9435 100 0.055 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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