YITS - BACSU - GREMLIN Contacts

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YITS - DegV domain-containing protein YitS

UniProt:	P70945	Sequences: MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIHADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIANEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHIFTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIELMKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTLAIFFLRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	283 (272)
Sequences:	4507 (3631)
Seq/√Len:	220.2

BACSU - YITS DEGV

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_T	145_E	3.241	1.00
246_K	250_E	3.239	1.00
81_P	113_D	3.004	1.00
220_K	252_A	2.867	1.00
15_R	19_E	2.615	1.00
170_A	180_A	2.524	1.00
90_G	198_K	2.434	1.00
83_L	143_I	2.377	1.00
239_K	243_T	2.336	1.00
132_H	135_D	2.335	1.00
141_N	145_E	2.328	1.00
44_H	47_Q	2.257	1.00
95_Y	99_V	2.243	1.00
50_E	54_N	2.180	1.00
72_F	84_Y	2.165	1.00
66_Q	70_N	2.161	1.00
115_R	143_I	2.150	1.00
85_I	119_S	2.125	1.00
73_L	77_E	2.036	1.00
168_Y	273_P	2.030	1.00
38_E	67_T	2.025	1.00
203_E	214_R	2.016	1.00
5_L	137_C	1.990	1.00
33_G	56_E	1.979	1.00
62_Q	93_G	1.924	1.00
76_A	112_F	1.915	1.00
14_P	17_Y	1.837	1.00
151_K	154_C	1.820	1.00
38_E	42_T	1.804	1.00
243_T	246_K	1.773	1.00
133_A	150_V	1.747	1.00
147_E	151_K	1.742	1.00
136_L	149_S	1.734	1.00
170_A	177_K	1.703	1.00
24_G	75_Y	1.692	1.00
68_I	98_A	1.692	1.00
238_N	241_K	1.676	1.00
4_H	24_G	1.668	1.00
136_L	146_I	1.651	1.00
81_P	143_I	1.650	1.00
24_G	74_Q	1.636	1.00
69_K	104_E	1.620	1.00
29_R	67_T	1.615	1.00
35_K	51_A	1.603	1.00
6_I	71_V	1.596	1.00
214_R	217_E	1.569	1.00
74_Q	78_T	1.568	1.00
49_F	268_G	1.567	1.00
149_S	152_N	1.564	1.00
46_D	50_E	1.563	1.00
115_R	147_E	1.551	1.00
89_S	118_D	1.550	1.00
69_K	73_L	1.548	1.00
208_Q	241_K	1.539	1.00
3_V	137_C	1.527	1.00
148_T	152_N	1.522	1.00
29_R	36_E	1.521	1.00
31_S	36_E	1.517	1.00
136_L	141_N	1.504	1.00
6_I	84_Y	1.503	1.00
16_S	20_E	1.498	1.00
120_K	154_C	1.479	1.00
135_D	139_N	1.465	1.00
158_E	222_R	1.460	1.00
73_L	105_V	1.450	1.00
248_L	251_E	1.445	1.00
134_A	138_I	1.426	1.00
24_G	71_V	1.392	1.00
242_A	260_M	1.390	1.00
53_Q	237_A	1.389	1.00
71_V	74_Q	1.388	1.00
74_Q	77_E	1.385	1.00
214_R	218_L	1.382	1.00
47_Q	50_E	1.377	1.00
31_S	59_K	1.376	1.00
117_I	151_K	1.368	1.00
141_N	149_S	1.363	1.00
18_F	25_F	1.353	1.00
117_I	147_E	1.349	1.00
97_T	101_I	1.346	1.00
68_I	94_T	1.331	1.00
26_I	71_V	1.328	1.00
28_L	94_T	1.328	1.00
21_K	138_I	1.327	1.00
152_N	156_Q	1.312	1.00
117_I	150_V	1.302	1.00
243_T	247_H	1.292	1.00
244_D	247_H	1.285	1.00
136_L	139_N	1.276	1.00
10_A	126_Y	1.274	1.00
46_D	262_P	1.267	1.00
235_Y	238_N	1.267	1.00
195_E	200_V	1.262	1.00
12_D	264_S	1.260	1.00
246_K	260_M	1.252	1.00
81_P	115_R	1.252	1.00
21_K	134_A	1.247	1.00
132_H	149_S	1.246	1.00
121_C	125_G	1.244	1.00
235_Y	260_M	1.243	1.00
32_L	51_A	1.236	1.00
99_V	102_A	1.227	1.00
7_A	130_V	1.221	1.00
17_Y	21_K	1.221	1.00
220_K	253_F	1.218	1.00
72_F	86_A	1.216	1.00
7_A	126_Y	1.211	1.00
99_V	103_N	1.210	1.00
217_E	252_A	1.204	1.00
247_H	251_E	1.198	1.00
132_H	136_L	1.194	1.00
162_T	211_L	1.193	1.00
233_I	242_A	1.188	1.00
96_Q	99_V	1.183	1.00
144_Q	148_T	1.179	1.00
82_A	112_F	1.178	1.00
4_H	75_Y	1.174	1.00
7_A	25_F	1.173	1.00
76_A	105_V	1.159	1.00
141_N	146_I	1.153	1.00
5_L	130_V	1.142	1.00
23_I	134_A	1.138	1.00
218_L	221_E	1.135	1.00
53_Q	273_P	1.125	1.00
67_T	70_N	1.125	1.00
47_Q	51_A	1.123	1.00
20_E	138_I	1.122	1.00
247_H	250_E	1.115	1.00
32_L	58_P	1.106	1.00
193_Q	202_L	1.104	1.00
6_I	75_Y	1.103	1.00
93_G	97_T	1.102	1.00
17_Y	131_R	1.091	1.00
89_S	95_Y	1.076	1.00
102_A	114_L	1.065	1.00
71_V	75_Y	1.061	1.00
145_E	148_T	1.059	1.00
149_S	153_F	1.047	1.00
271_A	275_T	1.045	1.00
243_T	260_M	1.043	1.00
177_K	180_A	1.041	1.00
95_Y	116_V	1.039	1.00
62_Q	97_T	1.036	1.00
129_A	154_C	1.035	1.00
115_R	144_Q	1.034	1.00
85_I	133_A	1.029	1.00
164_D	189_K	1.025	1.00
86_A	95_Y	1.021	1.00
57_T	171_R	1.020	1.00
163_V	169_L	1.017	1.00
187_N	207_G	1.016	1.00
217_E	220_K	1.013	1.00
128_L	232_G	1.008	1.00
233_I	246_K	0.994	1.00
3_V	146_I	0.992	1.00
113_D	144_Q	0.991	1.00
135_D	230_T	0.988	1.00
69_K	101_I	0.987	1.00
68_I	101_I	0.984	1.00
230_T	257_E	0.984	1.00
75_Y	82_A	0.984	1.00
115_R	151_K	0.983	1.00
98_A	116_V	0.979	1.00
13_L	127_G	0.978	1.00
26_I	63_A	0.965	1.00
192_L	199_L	0.962	1.00
213_K	248_L	0.959	1.00
16_S	19_E	0.958	1.00
216_I	248_L	0.957	1.00
237_A	273_P	0.956	1.00
69_K	105_V	0.955	1.00
248_L	252_A	0.951	1.00
244_D	248_L	0.947	1.00
24_G	78_T	0.947	1.00
4_H	80_D	0.944	1.00
137_C	146_I	0.943	1.00
134_A	137_C	0.940	1.00
82_A	114_L	0.936	1.00
46_D	237_A	0.935	1.00
213_K	217_E	0.929	1.00
21_K	135_D	0.928	0.99
143_I	147_E	0.927	0.99
21_K	131_R	0.926	0.99
6_I	82_A	0.919	0.99
3_V	83_L	0.914	0.99
246_K	258_I	0.914	0.99
102_A	116_V	0.913	0.99
129_A	150_V	0.906	0.99
179_S	204_K	0.897	0.99
235_Y	239_K	0.890	0.99
90_G	120_K	0.885	0.99
76_A	113_D	0.879	0.99
153_F	156_Q	0.876	0.99
242_A	246_K	0.870	0.99
121_C	194_M	0.864	0.99
113_D	143_I	0.862	0.99
49_F	236_A	0.861	0.99
193_Q	200_V	0.853	0.99
38_E	41_V	0.852	0.99
58_P	269_S	0.847	0.99
235_Y	242_A	0.846	0.99
222_R	280_F	0.845	0.99
212_F	245_M	0.845	0.99
52_M	168_Y	0.838	0.99
26_I	68_I	0.835	0.99
93_G	96_Q	0.832	0.99
132_H	153_F	0.830	0.99
183_G	190_P	0.829	0.99
28_L	266_A	0.828	0.99
176_S	179_S	0.826	0.99
234_S	263_I	0.823	0.99
76_A	111_D	0.823	0.99
65_P	100_M	0.820	0.99
240_E	243_T	0.818	0.99
240_E	244_D	0.817	0.99
91_L	122_A	0.816	0.99
31_S	34_D	0.816	0.99
7_A	11_T	0.816	0.99
4_H	22_G	0.812	0.99
72_F	98_A	0.810	0.99
195_E	198_K	0.801	0.99
37_F	43_I	0.799	0.98
100_M	103_N	0.798	0.98
167_T	171_R	0.795	0.98
210_K	213_K	0.795	0.98
124_L	232_G	0.790	0.98
166_L	183_G	0.786	0.98
6_I	72_F	0.784	0.98
10_A	266_A	0.779	0.98
217_E	221_E	0.778	0.98
131_R	134_A	0.778	0.98
230_T	259_I	0.778	0.98
33_G	51_A	0.776	0.98
219_M	278_I	0.772	0.98
83_L	117_I	0.771	0.98
105_V	112_F	0.765	0.98
70_N	74_Q	0.764	0.98
165_D	168_Y	0.762	0.98
172_G	270_H	0.761	0.98
131_R	135_D	0.756	0.98
124_L	234_S	0.755	0.98
17_Y	134_A	0.755	0.98
201_P	204_K	0.754	0.98
125_G	279_F	0.754	0.98
60_T	269_S	0.753	0.98
234_S	277_A	0.750	0.98
51_A	54_N	0.748	0.98
9_S	39_D	0.747	0.98
129_A	153_F	0.746	0.98
263_I	268_G	0.740	0.98
130_V	134_A	0.740	0.98
143_I	146_I	0.737	0.97
148_T	151_K	0.737	0.97
235_Y	262_P	0.733	0.97
68_I	72_F	0.730	0.97
121_C	159_H	0.728	0.97
191_L	211_L	0.723	0.97
66_Q	69_K	0.720	0.97
144_Q	147_E	0.715	0.97
178_T	181_F	0.715	0.97
105_V	111_D	0.714	0.97
48_I	268_G	0.713	0.97
219_M	223_G	0.710	0.97
51_A	56_E	0.708	0.97
91_L	199_L	0.707	0.97
50_E	53_Q	0.707	0.97
3_V	81_P	0.706	0.97
87_F	91_L	0.703	0.97
43_I	48_I	0.700	0.97
5_L	134_A	0.700	0.97
150_V	154_C	0.697	0.96
210_K	217_E	0.697	0.96
76_A	79_G	0.696	0.96
241_K	244_D	0.694	0.96
125_G	157_L	0.693	0.96
12_D	123_S	0.693	0.96
236_A	275_T	0.692	0.96
170_A	175_I	0.692	0.96
89_S	120_K	0.681	0.96
152_N	155_S	0.681	0.96
88_S	91_L	0.676	0.96
70_N	73_L	0.675	0.96
233_I	260_M	0.674	0.96
29_R	38_E	0.672	0.96
22_G	138_I	0.669	0.96
218_L	222_R	0.667	0.95
17_Y	20_E	0.667	0.95
18_F	22_G	0.662	0.95
84_Y	98_A	0.660	0.95
100_M	104_E	0.660	0.95
234_S	279_F	0.658	0.95
160_I	202_L	0.656	0.95
168_Y	171_R	0.656	0.95
23_I	130_V	0.652	0.95
13_L	18_F	0.651	0.95
75_Y	80_D	0.651	0.95
161_F	277_A	0.650	0.95
27_P	41_V	0.649	0.95
119_S	126_Y	0.649	0.95
164_D	208_Q	0.646	0.95
133_A	137_C	0.644	0.95
160_I	218_L	0.642	0.94
99_V	116_V	0.639	0.94
216_I	252_A	0.637	0.94
245_M	276_L	0.637	0.94
81_P	112_F	0.637	0.94
219_M	280_F	0.636	0.94
85_I	150_V	0.636	0.94
122_A	126_Y	0.634	0.94
96_Q	100_M	0.633	0.94
76_A	82_A	0.633	0.94
48_I	265_S	0.633	0.94
30_V	265_S	0.632	0.94
32_L	35_K	0.628	0.94
12_D	39_D	0.627	0.94
241_K	276_L	0.627	0.94
97_T	100_M	0.627	0.94
191_L	205_I	0.625	0.94
129_A	157_L	0.621	0.93
5_L	133_A	0.620	0.93
160_I	222_R	0.619	0.93
10_A	87_F	0.618	0.93
87_F	122_A	0.617	0.93
122_A	199_L	0.615	0.93
205_I	210_K	0.615	0.93
164_D	274_G	0.614	0.93
101_I	105_V	0.613	0.93
122_A	267_I	0.610	0.93
14_P	127_G	0.610	0.93
164_D	180_A	0.605	0.93
9_S	28_L	0.603	0.92
216_I	245_M	0.603	0.92
65_P	101_I	0.603	0.92
72_F	114_L	0.602	0.92
131_R	259_I	0.602	0.92
208_Q	211_L	0.594	0.92
88_S	120_K	0.594	0.92
86_A	116_V	0.593	0.92
205_I	214_R	0.591	0.92
161_F	275_T	0.590	0.92
220_K	224_D	0.588	0.91
212_F	248_L	0.586	0.91
161_F	192_L	0.585	0.91
83_L	147_E	0.585	0.91
120_K	197_G	0.584	0.91
85_I	126_Y	0.581	0.91
117_I	154_C	0.576	0.91
98_A	101_I	0.575	0.91
119_S	129_A	0.575	0.91
64_S	67_T	0.574	0.90
158_E	193_Q	0.574	0.90
250_E	257_E	0.573	0.90
179_S	201_P	0.573	0.90
83_L	133_A	0.573	0.90
236_A	263_I	0.571	0.90
36_E	42_T	0.571	0.90
212_F	276_L	0.570	0.90
161_F	199_L	0.568	0.90
72_F	82_A	0.564	0.90
32_L	57_T	0.560	0.89
13_L	23_I	0.557	0.89
83_L	115_R	0.556	0.89
123_S	275_T	0.554	0.89
216_I	220_K	0.554	0.89
167_T	170_A	0.544	0.88
132_H	230_T	0.540	0.88
250_E	258_I	0.538	0.87
35_K	42_T	0.538	0.87
89_S	96_Q	0.538	0.87
211_L	215_I	0.536	0.87
131_R	230_T	0.536	0.87
188_I	204_K	0.535	0.87
219_M	253_F	0.533	0.87
76_A	80_D	0.532	0.87
191_L	203_E	0.529	0.87
202_L	218_L	0.529	0.87
181_F	201_P	0.529	0.87
228_N	256_K	0.529	0.87
15_R	40_A	0.527	0.86
75_Y	78_T	0.527	0.86
203_E	218_L	0.526	0.86
233_I	258_I	0.524	0.86
101_I	104_E	0.523	0.86
136_L	150_V	0.522	0.86
85_I	130_V	0.520	0.86
72_F	102_A	0.520	0.86
186_L	206_R	0.519	0.85
88_S	194_M	0.518	0.85
249_I	278_I	0.517	0.85
33_G	55_G	0.516	0.85
146_I	150_V	0.515	0.85
239_K	260_M	0.515	0.85
250_E	254_K	0.513	0.85
18_F	40_A	0.513	0.85
14_P	259_I	0.512	0.85
162_T	208_Q	0.512	0.85
91_L	194_M	0.511	0.85
18_F	21_K	0.510	0.84
65_P	97_T	0.508	0.84
232_G	259_I	0.506	0.84
135_D	138_I	0.506	0.84
177_K	181_F	0.505	0.84
159_H	279_F	0.505	0.84
15_R	18_F	0.504	0.84
83_L	137_C	0.504	0.84
219_M	249_I	0.504	0.84
229_Q	255_P	0.502	0.84
88_S	197_G	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pzxA	1	1	100	-0.004	Contact Map
3pl5A	1	0.9576	100	0.005	Contact Map
3fysA	1	0.9859	100	0.012	Contact Map
3nyiA	1	0.9929	100	0.013	Contact Map
2dt8A	1	0.9823	100	0.022	Contact Map
3lupA	1	0.9823	100	0.025	Contact Map
3jr7A	1	0.9788	100	0.033	Contact Map
2g7zA	3	0.9611	100	0.037	Contact Map
3fdjA	1	0.9682	100	0.049	Contact Map
1mgpA	1	0.9435	100	0.055	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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