GREMLIN Database
ARGB - Acetylglutamate kinase
UniProt: P68729 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (247)
Sequences: 3524 (2027)
Seq/√Len: 129.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_A170_L3.9061.00
110_D124_K3.7391.00
66_T69_V3.6981.00
149_T153_K3.5571.00
107_L162_A3.1491.00
110_D122_E3.1051.00
182_D234_N2.9831.00
200_Q224_S2.9531.00
67_K119_E2.9221.00
4_T34_K2.6641.00
3_K173_D2.6261.00
143_I166_V2.5711.00
196_P220_L2.5441.00
186_K189_Q2.5011.00
108_E125_K2.4821.00
174_K231_M2.4271.00
54_I68_P2.3191.00
111_Y116_T2.3131.00
173_D228_S2.2361.00
107_L126_V2.2201.00
89_L142_V2.1351.00
50_K55_K2.1011.00
201_M205_Q2.0741.00
199_I220_L2.0461.00
147_S157_V2.0331.00
200_Q204_K2.0191.00
48_M52_L2.0071.00
5_I33_W2.0011.00
109_A147_S1.9761.00
49_L56_T1.9321.00
168_G225_D1.9061.00
195_T198_E1.8781.00
203_I217_N1.8081.00
52_L72_V1.7541.00
198_E201_M1.7531.00
133_A137_N1.7391.00
111_Y155_L1.7341.00
74_E102_K1.7331.00
46_T56_T1.7291.00
128_A132_N1.7251.00
184_I216_V1.7011.00
223_L230_V1.6911.00
48_M76_V1.6711.00
47_N50_K1.6701.00
208_I216_V1.6491.00
48_M75_M1.6391.00
24_N239_F1.6361.00
26_K94_L1.6261.00
194_L199_I1.6211.00
149_T155_L1.6071.00
62_Q161_L1.5591.00
94_L140_I1.5561.00
107_L166_V1.5231.00
108_E127_D1.5141.00
63_R156_N1.4881.00
219_A230_V1.4781.00
70_L73_A1.4731.00
73_A146_L1.4071.00
182_D185_M1.3861.00
131_V166_V1.3661.00
4_T132_N1.3571.00
109_A155_L1.3501.00
185_M190_R1.3431.00
216_V220_L1.3411.00
78_S100_S1.3321.00
52_L75_M1.3291.00
200_Q220_L1.3281.00
97_A134_L1.3251.00
34_K136_E1.3071.00
244_T247_G1.3051.00
57_E64_K1.3021.00
59_S64_K1.3021.00
70_L146_L1.3011.00
47_N51_R1.2991.00
119_E153_K1.2941.00
27_E31_S1.2841.00
108_E150_S1.2821.00
165_A168_G1.2571.00
57_E66_T1.2511.00
132_N136_E1.2441.00
146_L154_T1.2291.00
102_K154_T1.2231.00
131_V143_I1.2090.99
18_S84_F1.2040.99
82_N86_V1.2040.99
46_T58_F1.2000.99
166_V170_L1.1950.99
134_L139_I1.1870.99
177_F218_S1.1850.99
19_E91_K1.1850.99
12_S43_P1.1830.99
51_R71_E1.1720.99
184_I194_L1.1640.99
34_K135_M1.1560.99
130_M133_A1.1450.99
89_L94_L1.1400.99
78_S83_K1.1350.99
71_E80_S1.1290.99
113_D116_T1.1130.99
4_T36_A1.1030.99
200_Q217_N1.0920.99
44_E80_S1.0810.99
9_C18_S1.0720.99
23_Q92_H1.0710.99
54_I72_V1.0640.99
74_E154_T1.0610.99
82_N98_G1.0530.99
106_L130_M1.0470.98
49_L54_I1.0310.98
19_E88_E1.0310.98
22_Y37_I1.0290.98
175_L230_V1.0260.98
86_V98_G1.0230.98
70_L119_E1.0210.98
186_K191_L1.0180.98
212_M215_K1.0170.98
168_G223_L1.0130.98
95_R127_D1.0080.98
29_R34_K1.0050.98
174_K229_E1.0040.98
165_A221_S1.0000.98
60_G116_T0.9950.98
79_G98_G0.9940.98
107_L157_V0.9920.98
26_K92_H0.9890.98
183_G190_R0.9870.98
217_N221_S0.9870.98
68_P71_E0.9780.98
28_L33_W0.9770.98
84_F88_E0.9680.97
6_V172_A0.9640.97
201_M204_K0.9600.97
111_Y115_E0.9580.97
28_L246_Q0.9580.97
178_V233_V0.9550.97
196_P224_S0.9550.97
62_Q117_Y0.9520.97
211_G215_K0.9430.97
12_S15_R0.9310.97
26_K140_I0.9280.97
130_M139_I0.9240.97
46_T50_K0.9240.97
128_A169_A0.9230.97
56_T69_V0.9210.97
61_G214_P0.9080.96
17_L21_F0.9080.96
45_I73_A0.9070.96
123_I147_S0.9040.96
7_F25_L0.9030.96
29_R35_L0.9010.96
112_L122_E0.9000.96
4_T135_M0.8980.96
174_K244_T0.8950.96
164_S168_G0.8930.96
106_L143_I0.8840.96
36_A135_M0.8780.95
19_E92_H0.8780.95
193_V229_E0.8760.95
46_T49_L0.8730.95
67_K153_K0.8720.95
74_E84_F0.8680.95
109_A157_V0.8650.95
24_N28_L0.8650.95
9_C14_I0.8640.95
22_Y88_E0.8590.95
83_K100_S0.8570.95
18_S88_E0.8560.95
104_G139_I0.8540.95
48_M51_R0.8520.95
126_V166_V0.8500.95
65_T156_N0.8450.94
12_S44_E0.8260.94
202_L207_V0.8220.94
182_D237_G0.8220.94
33_W246_Q0.8210.94
186_K207_V0.8200.93
6_V166_V0.8160.93
85_F145_P0.8140.93
106_L131_V0.8120.93
164_S218_S0.8090.93
237_G243_Q0.8070.93
54_I66_T0.8060.93
90_A105_G0.7960.92
125_K150_S0.7960.92
182_D236_K0.7950.92
110_D150_S0.7950.92
86_V96_A0.7940.92
159_A215_K0.7880.92
83_K103_D0.7870.92
22_Y89_L0.7870.92
54_I69_V0.7820.92
160_D215_K0.7800.92
97_A139_I0.7790.92
108_E124_K0.7780.92
50_K53_N0.7770.92
23_Q26_K0.7740.91
105_G108_E0.7700.91
165_A169_A0.7700.91
184_I220_L0.7690.91
29_R94_L0.7660.91
118_G211_G0.7580.91
127_D130_M0.7570.90
72_V76_V0.7560.90
130_M134_L0.7560.90
200_Q203_I0.7550.90
194_L202_L0.7520.90
5_I176_M0.7500.90
44_E186_K0.7500.90
106_L127_D0.7450.90
147_S162_A0.7450.90
199_I216_V0.7450.90
82_N144_A0.7410.90
75_M103_D0.7330.89
33_W174_K0.7310.89
75_M101_G0.7300.89
218_S230_V0.7300.89
78_S146_L0.7250.88
8_K159_A0.7230.88
109_A123_I0.7210.88
10_G39_H0.7190.88
12_S180_D0.7190.88
75_M79_G0.7170.88
124_K150_S0.7150.88
7_F37_I0.7150.88
8_K160_D0.7140.88
241_A245_F0.7130.88
196_P223_L0.7100.87
158_N214_P0.7100.87
157_V162_A0.7030.87
70_L154_T0.7000.87
75_M80_S0.6960.86
158_N211_G0.6950.86
105_G148_M0.6930.86
120_V158_N0.6920.86
147_S155_L0.6920.86
112_L115_E0.6910.86
22_Y44_E0.6890.86
62_Q122_E0.6880.86
49_L69_V0.6870.86
5_I245_F0.6830.85
184_I191_L0.6810.85
45_I77_L0.6790.85
79_G103_D0.6780.85
179_T212_M0.6780.85
10_G211_G0.6770.85
80_S84_F0.6760.85
25_L35_L0.6700.84
10_G215_K0.6700.84
175_L222_A0.6690.84
168_G221_S0.6670.84
187_E205_Q0.6660.84
158_N215_K0.6630.84
221_S225_D0.6610.83
9_C13_V0.6600.83
239_F242_E0.6570.83
176_M241_A0.6560.83
191_L202_L0.6560.83
211_G214_P0.6540.83
69_V72_V0.6510.83
74_E78_S0.6500.82
61_G158_N0.6480.82
161_L217_N0.6420.82
166_V169_A0.6420.82
168_G227_V0.6390.81
111_Y114_P0.6360.81
85_F189_Q0.6350.81
104_G130_M0.6350.81
196_P219_A0.6350.81
220_L224_S0.6330.81
196_P200_Q0.6330.81
221_S224_S0.6320.81
42_G61_G0.6290.80
101_G142_V0.6260.80
27_E246_Q0.6230.80
197_K201_M0.6180.79
10_G159_A0.6170.79
54_I73_A0.6170.79
186_K202_L0.6150.79
125_K169_A0.6140.79
87_A91_K0.6120.78
117_Y120_V0.6100.78
52_L68_P0.6070.78
8_K215_K0.6070.78
29_R147_S0.6050.78
107_L147_S0.6010.77
133_A138_G0.6000.77
114_P117_Y0.5980.77
11_G40_G0.5970.77
131_V135_M0.5960.77
126_V162_A0.5890.76
195_T199_I0.5860.75
163_A175_L0.5780.74
25_L37_I0.5770.74
21_F189_Q0.5760.74
61_G211_G0.5740.74
209_T216_V0.5730.74
186_K198_E0.5720.74
208_I212_M0.5720.74
195_T220_L0.5710.74
7_F201_M0.5710.74
31_S245_F0.5660.73
220_L223_L0.5630.73
100_S103_D0.5590.72
88_E136_E0.5580.72
222_A227_V0.5580.72
27_E244_T0.5570.72
62_Q118_G0.5570.72
44_E47_N0.5560.72
194_L208_I0.5550.71
21_F44_E0.5540.71
118_G158_N0.5520.71
42_G158_N0.5520.71
10_G160_D0.5510.71
9_C12_S0.5480.71
42_G160_D0.5450.70
31_S244_T0.5440.70
161_L165_A0.5420.70
168_G230_V0.5420.70
41_G212_M0.5420.70
184_I223_L0.5410.70
75_M83_K0.5390.69
10_G156_N0.5380.69
148_M151_D0.5380.69
88_E91_K0.5370.69
8_K211_G0.5370.69
60_G113_D0.5360.69
203_I216_V0.5360.69
161_L164_S0.5350.69
27_E247_G0.5340.69
61_G120_V0.5330.68
174_K246_Q0.5330.68
151_D155_L0.5330.68
90_A95_R0.5280.68
8_K39_H0.5280.68
15_R47_N0.5280.68
69_V76_V0.5270.68
60_G115_E0.5270.68
27_E242_E0.5270.68
45_I76_V0.5270.68
159_A211_G0.5260.67
16_E236_K0.5250.67
95_R139_I0.5240.67
43_P49_L0.5210.67
18_S85_F0.5210.67
64_K115_E0.5200.67
120_V211_G0.5180.66
209_T213_I0.5170.66
176_M231_M0.5170.66
98_G103_D0.5160.66
56_T66_T0.5160.66
173_D229_E0.5160.66
179_T232_I0.5130.66
181_V185_M0.5130.66
82_N103_D0.5120.65
17_L20_E0.5120.65
161_L218_S0.5110.65
42_G211_G0.5110.65
79_G87_A0.5080.65
52_L71_E0.5080.65
39_H144_A0.5070.65
129_S133_A0.5070.65
120_V214_P0.5060.64
11_G211_G0.5060.64
81_V85_F0.5060.64
36_A131_V0.5060.64
90_A96_A0.5050.64
128_A166_V0.5030.64
86_V142_V0.5030.64
4_T170_L0.5010.64
66_T71_E0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ap9A 3 0.9922 100 0.336 Contact Map
2bufA 3 1 100 0.337 Contact Map
2v5hA 3 1 100 0.338 Contact Map
3l86A 1 0.9457 100 0.346 Contact Map
2btyA 3 1 100 0.347 Contact Map
2rd5A 3 0.9884 100 0.349 Contact Map
1gs5A 2 0.9767 100 0.356 Contact Map
3wwnA 2 0.9419 100 0.367 Contact Map
3s6kA 3 0.9806 100 0.373 Contact Map
3s6gA 4 0.9806 100 0.377 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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