ARGB - BACSU - GREMLIN Contacts

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ARGB - Acetylglutamate kinase

UniProt:	P68729	Sequences: MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPEITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGKDGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNADLAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNSALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (247)
Sequences:	3524 (2027)
Seq/√Len:	129.0

ECOLI - ARGB ARGA
BACSU - ARGB
SULSO - ARGB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_A	170_L	3.906	1.00
110_D	124_K	3.739	1.00
66_T	69_V	3.698	1.00
149_T	153_K	3.557	1.00
107_L	162_A	3.149	1.00
110_D	122_E	3.105	1.00
182_D	234_N	2.983	1.00
200_Q	224_S	2.953	1.00
67_K	119_E	2.922	1.00
4_T	34_K	2.664	1.00
3_K	173_D	2.626	1.00
143_I	166_V	2.571	1.00
196_P	220_L	2.544	1.00
186_K	189_Q	2.501	1.00
108_E	125_K	2.482	1.00
174_K	231_M	2.427	1.00
54_I	68_P	2.319	1.00
111_Y	116_T	2.313	1.00
173_D	228_S	2.236	1.00
107_L	126_V	2.220	1.00
89_L	142_V	2.135	1.00
50_K	55_K	2.101	1.00
201_M	205_Q	2.074	1.00
199_I	220_L	2.046	1.00
147_S	157_V	2.033	1.00
200_Q	204_K	2.019	1.00
48_M	52_L	2.007	1.00
5_I	33_W	2.001	1.00
109_A	147_S	1.976	1.00
49_L	56_T	1.932	1.00
168_G	225_D	1.906	1.00
195_T	198_E	1.878	1.00
203_I	217_N	1.808	1.00
52_L	72_V	1.754	1.00
198_E	201_M	1.753	1.00
133_A	137_N	1.739	1.00
111_Y	155_L	1.734	1.00
74_E	102_K	1.733	1.00
46_T	56_T	1.729	1.00
128_A	132_N	1.725	1.00
184_I	216_V	1.701	1.00
223_L	230_V	1.691	1.00
48_M	76_V	1.671	1.00
47_N	50_K	1.670	1.00
208_I	216_V	1.649	1.00
48_M	75_M	1.639	1.00
24_N	239_F	1.636	1.00
26_K	94_L	1.626	1.00
194_L	199_I	1.621	1.00
149_T	155_L	1.607	1.00
62_Q	161_L	1.559	1.00
94_L	140_I	1.556	1.00
107_L	166_V	1.523	1.00
108_E	127_D	1.514	1.00
63_R	156_N	1.488	1.00
219_A	230_V	1.478	1.00
70_L	73_A	1.473	1.00
73_A	146_L	1.407	1.00
182_D	185_M	1.386	1.00
131_V	166_V	1.366	1.00
4_T	132_N	1.357	1.00
109_A	155_L	1.350	1.00
185_M	190_R	1.343	1.00
216_V	220_L	1.341	1.00
78_S	100_S	1.332	1.00
52_L	75_M	1.329	1.00
200_Q	220_L	1.328	1.00
97_A	134_L	1.325	1.00
34_K	136_E	1.307	1.00
244_T	247_G	1.305	1.00
57_E	64_K	1.302	1.00
59_S	64_K	1.302	1.00
70_L	146_L	1.301	1.00
47_N	51_R	1.299	1.00
119_E	153_K	1.294	1.00
27_E	31_S	1.284	1.00
108_E	150_S	1.282	1.00
165_A	168_G	1.257	1.00
57_E	66_T	1.251	1.00
132_N	136_E	1.244	1.00
146_L	154_T	1.229	1.00
102_K	154_T	1.223	1.00
131_V	143_I	1.209	0.99
18_S	84_F	1.204	0.99
82_N	86_V	1.204	0.99
46_T	58_F	1.200	0.99
166_V	170_L	1.195	0.99
134_L	139_I	1.187	0.99
177_F	218_S	1.185	0.99
19_E	91_K	1.185	0.99
12_S	43_P	1.183	0.99
51_R	71_E	1.172	0.99
184_I	194_L	1.164	0.99
34_K	135_M	1.156	0.99
130_M	133_A	1.145	0.99
89_L	94_L	1.140	0.99
78_S	83_K	1.135	0.99
71_E	80_S	1.129	0.99
113_D	116_T	1.113	0.99
4_T	36_A	1.103	0.99
200_Q	217_N	1.092	0.99
44_E	80_S	1.081	0.99
9_C	18_S	1.072	0.99
23_Q	92_H	1.071	0.99
54_I	72_V	1.064	0.99
74_E	154_T	1.061	0.99
82_N	98_G	1.053	0.99
106_L	130_M	1.047	0.98
49_L	54_I	1.031	0.98
19_E	88_E	1.031	0.98
22_Y	37_I	1.029	0.98
175_L	230_V	1.026	0.98
86_V	98_G	1.023	0.98
70_L	119_E	1.021	0.98
186_K	191_L	1.018	0.98
212_M	215_K	1.017	0.98
168_G	223_L	1.013	0.98
95_R	127_D	1.008	0.98
29_R	34_K	1.005	0.98
174_K	229_E	1.004	0.98
165_A	221_S	1.000	0.98
60_G	116_T	0.995	0.98
79_G	98_G	0.994	0.98
107_L	157_V	0.992	0.98
26_K	92_H	0.989	0.98
183_G	190_R	0.987	0.98
217_N	221_S	0.987	0.98
68_P	71_E	0.978	0.98
28_L	33_W	0.977	0.98
84_F	88_E	0.968	0.97
6_V	172_A	0.964	0.97
201_M	204_K	0.960	0.97
111_Y	115_E	0.958	0.97
28_L	246_Q	0.958	0.97
178_V	233_V	0.955	0.97
196_P	224_S	0.955	0.97
62_Q	117_Y	0.952	0.97
211_G	215_K	0.943	0.97
12_S	15_R	0.931	0.97
26_K	140_I	0.928	0.97
130_M	139_I	0.924	0.97
46_T	50_K	0.924	0.97
128_A	169_A	0.923	0.97
56_T	69_V	0.921	0.97
61_G	214_P	0.908	0.96
17_L	21_F	0.908	0.96
45_I	73_A	0.907	0.96
123_I	147_S	0.904	0.96
7_F	25_L	0.903	0.96
29_R	35_L	0.901	0.96
112_L	122_E	0.900	0.96
4_T	135_M	0.898	0.96
174_K	244_T	0.895	0.96
164_S	168_G	0.893	0.96
106_L	143_I	0.884	0.96
36_A	135_M	0.878	0.95
19_E	92_H	0.878	0.95
193_V	229_E	0.876	0.95
46_T	49_L	0.873	0.95
67_K	153_K	0.872	0.95
74_E	84_F	0.868	0.95
109_A	157_V	0.865	0.95
24_N	28_L	0.865	0.95
9_C	14_I	0.864	0.95
22_Y	88_E	0.859	0.95
83_K	100_S	0.857	0.95
18_S	88_E	0.856	0.95
104_G	139_I	0.854	0.95
48_M	51_R	0.852	0.95
126_V	166_V	0.850	0.95
65_T	156_N	0.845	0.94
12_S	44_E	0.826	0.94
202_L	207_V	0.822	0.94
182_D	237_G	0.822	0.94
33_W	246_Q	0.821	0.94
186_K	207_V	0.820	0.93
6_V	166_V	0.816	0.93
85_F	145_P	0.814	0.93
106_L	131_V	0.812	0.93
164_S	218_S	0.809	0.93
237_G	243_Q	0.807	0.93
54_I	66_T	0.806	0.93
90_A	105_G	0.796	0.92
125_K	150_S	0.796	0.92
182_D	236_K	0.795	0.92
110_D	150_S	0.795	0.92
86_V	96_A	0.794	0.92
159_A	215_K	0.788	0.92
83_K	103_D	0.787	0.92
22_Y	89_L	0.787	0.92
54_I	69_V	0.782	0.92
160_D	215_K	0.780	0.92
97_A	139_I	0.779	0.92
108_E	124_K	0.778	0.92
50_K	53_N	0.777	0.92
23_Q	26_K	0.774	0.91
105_G	108_E	0.770	0.91
165_A	169_A	0.770	0.91
184_I	220_L	0.769	0.91
29_R	94_L	0.766	0.91
118_G	211_G	0.758	0.91
127_D	130_M	0.757	0.90
72_V	76_V	0.756	0.90
130_M	134_L	0.756	0.90
200_Q	203_I	0.755	0.90
194_L	202_L	0.752	0.90
5_I	176_M	0.750	0.90
44_E	186_K	0.750	0.90
106_L	127_D	0.745	0.90
147_S	162_A	0.745	0.90
199_I	216_V	0.745	0.90
82_N	144_A	0.741	0.90
75_M	103_D	0.733	0.89
33_W	174_K	0.731	0.89
75_M	101_G	0.730	0.89
218_S	230_V	0.730	0.89
78_S	146_L	0.725	0.88
8_K	159_A	0.723	0.88
109_A	123_I	0.721	0.88
10_G	39_H	0.719	0.88
12_S	180_D	0.719	0.88
75_M	79_G	0.717	0.88
124_K	150_S	0.715	0.88
7_F	37_I	0.715	0.88
8_K	160_D	0.714	0.88
241_A	245_F	0.713	0.88
196_P	223_L	0.710	0.87
158_N	214_P	0.710	0.87
157_V	162_A	0.703	0.87
70_L	154_T	0.700	0.87
75_M	80_S	0.696	0.86
158_N	211_G	0.695	0.86
105_G	148_M	0.693	0.86
120_V	158_N	0.692	0.86
147_S	155_L	0.692	0.86
112_L	115_E	0.691	0.86
22_Y	44_E	0.689	0.86
62_Q	122_E	0.688	0.86
49_L	69_V	0.687	0.86
5_I	245_F	0.683	0.85
184_I	191_L	0.681	0.85
45_I	77_L	0.679	0.85
79_G	103_D	0.678	0.85
179_T	212_M	0.678	0.85
10_G	211_G	0.677	0.85
80_S	84_F	0.676	0.85
25_L	35_L	0.670	0.84
10_G	215_K	0.670	0.84
175_L	222_A	0.669	0.84
168_G	221_S	0.667	0.84
187_E	205_Q	0.666	0.84
158_N	215_K	0.663	0.84
221_S	225_D	0.661	0.83
9_C	13_V	0.660	0.83
239_F	242_E	0.657	0.83
176_M	241_A	0.656	0.83
191_L	202_L	0.656	0.83
211_G	214_P	0.654	0.83
69_V	72_V	0.651	0.83
74_E	78_S	0.650	0.82
61_G	158_N	0.648	0.82
161_L	217_N	0.642	0.82
166_V	169_A	0.642	0.82
168_G	227_V	0.639	0.81
111_Y	114_P	0.636	0.81
85_F	189_Q	0.635	0.81
104_G	130_M	0.635	0.81
196_P	219_A	0.635	0.81
220_L	224_S	0.633	0.81
196_P	200_Q	0.633	0.81
221_S	224_S	0.632	0.81
42_G	61_G	0.629	0.80
101_G	142_V	0.626	0.80
27_E	246_Q	0.623	0.80
197_K	201_M	0.618	0.79
10_G	159_A	0.617	0.79
54_I	73_A	0.617	0.79
186_K	202_L	0.615	0.79
125_K	169_A	0.614	0.79
87_A	91_K	0.612	0.78
117_Y	120_V	0.610	0.78
52_L	68_P	0.607	0.78
8_K	215_K	0.607	0.78
29_R	147_S	0.605	0.78
107_L	147_S	0.601	0.77
133_A	138_G	0.600	0.77
114_P	117_Y	0.598	0.77
11_G	40_G	0.597	0.77
131_V	135_M	0.596	0.77
126_V	162_A	0.589	0.76
195_T	199_I	0.586	0.75
163_A	175_L	0.578	0.74
25_L	37_I	0.577	0.74
21_F	189_Q	0.576	0.74
61_G	211_G	0.574	0.74
209_T	216_V	0.573	0.74
186_K	198_E	0.572	0.74
208_I	212_M	0.572	0.74
195_T	220_L	0.571	0.74
7_F	201_M	0.571	0.74
31_S	245_F	0.566	0.73
220_L	223_L	0.563	0.73
100_S	103_D	0.559	0.72
88_E	136_E	0.558	0.72
222_A	227_V	0.558	0.72
27_E	244_T	0.557	0.72
62_Q	118_G	0.557	0.72
44_E	47_N	0.556	0.72
194_L	208_I	0.555	0.71
21_F	44_E	0.554	0.71
118_G	158_N	0.552	0.71
42_G	158_N	0.552	0.71
10_G	160_D	0.551	0.71
9_C	12_S	0.548	0.71
42_G	160_D	0.545	0.70
31_S	244_T	0.544	0.70
161_L	165_A	0.542	0.70
168_G	230_V	0.542	0.70
41_G	212_M	0.542	0.70
184_I	223_L	0.541	0.70
75_M	83_K	0.539	0.69
10_G	156_N	0.538	0.69
148_M	151_D	0.538	0.69
88_E	91_K	0.537	0.69
8_K	211_G	0.537	0.69
60_G	113_D	0.536	0.69
203_I	216_V	0.536	0.69
161_L	164_S	0.535	0.69
27_E	247_G	0.534	0.69
61_G	120_V	0.533	0.68
174_K	246_Q	0.533	0.68
151_D	155_L	0.533	0.68
90_A	95_R	0.528	0.68
8_K	39_H	0.528	0.68
15_R	47_N	0.528	0.68
69_V	76_V	0.527	0.68
60_G	115_E	0.527	0.68
27_E	242_E	0.527	0.68
45_I	76_V	0.527	0.68
159_A	211_G	0.526	0.67
16_E	236_K	0.525	0.67
95_R	139_I	0.524	0.67
43_P	49_L	0.521	0.67
18_S	85_F	0.521	0.67
64_K	115_E	0.520	0.67
120_V	211_G	0.518	0.66
209_T	213_I	0.517	0.66
176_M	231_M	0.517	0.66
98_G	103_D	0.516	0.66
56_T	66_T	0.516	0.66
173_D	229_E	0.516	0.66
179_T	232_I	0.513	0.66
181_V	185_M	0.513	0.66
82_N	103_D	0.512	0.65
17_L	20_E	0.512	0.65
161_L	218_S	0.511	0.65
42_G	211_G	0.511	0.65
79_G	87_A	0.508	0.65
52_L	71_E	0.508	0.65
39_H	144_A	0.507	0.65
129_S	133_A	0.507	0.65
120_V	214_P	0.506	0.64
11_G	211_G	0.506	0.64
81_V	85_F	0.506	0.64
36_A	131_V	0.506	0.64
90_A	96_A	0.505	0.64
128_A	166_V	0.503	0.64
86_V	142_V	0.503	0.64
4_T	170_L	0.501	0.64
66_T	71_E	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ap9A	3	0.9922	100	0.336	Contact Map
2bufA	3	1	100	0.337	Contact Map
2v5hA	3	1	100	0.338	Contact Map
3l86A	1	0.9457	100	0.346	Contact Map
2btyA	3	1	100	0.347	Contact Map
2rd5A	3	0.9884	100	0.349	Contact Map
1gs5A	2	0.9767	100	0.356	Contact Map
3wwnA	2	0.9419	100	0.367	Contact Map
3s6kA	3	0.9806	100	0.373	Contact Map
3s6gA	4	0.9806	100	0.377	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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