GREMLIN Database
MTBP - Phi-3T prophage-derived modification methylase Phi3TI
UniProt: P68585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (384)
Sequences: 2436 (2117)
Seq/√Len: 108.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
391_R397_D7.9611.00
146_V200_G4.8021.00
133_E136_L4.6431.00
427_E431_Q4.6021.00
22_N427_E4.1581.00
70_D144_K4.1201.00
74_S134_T3.8921.00
20_L430_F3.5391.00
394_A424_S3.5141.00
152_K194_E3.3351.00
11_S34_E3.1671.00
176_R203_E2.8861.00
422_T425_V2.8541.00
138_A146_V2.8471.00
184_S422_T2.7791.00
8_S17_E2.6961.00
387_L391_R2.5621.00
42_S416_Q2.4431.00
6_V29_L2.3081.00
347_R350_G2.3021.00
57_D60_K2.2721.00
432_E435_H2.2701.00
315_T318_T2.2611.00
395_F420_S2.1061.00
80_T128_G2.1051.00
9_L72_L2.1031.00
19_A23_I2.0901.00
384_L389_C2.0641.00
62_K65_N2.0141.00
350_G353_F1.9901.00
36_D415_K1.9831.00
5_R28_E1.9821.00
390_W417_A1.9811.00
348_Q351_R1.9781.00
387_L390_W1.9651.00
389_C414_Y1.9471.00
292_V295_V1.8981.00
320_G323_H1.8881.00
38_Y412_Q1.8691.00
154_L196_V1.8631.00
142_K202_R1.8611.00
409_S412_Q1.8271.00
349_N352_R1.8221.00
8_S11_S1.8031.00
312_L315_T1.7991.00
18_A47_H1.7971.00
346_K350_G1.7731.00
382_R388_E1.7521.00
7_M31_G1.7451.00
367_D370_G1.7251.00
183_N192_N1.7181.00
5_R30_I1.7041.00
69_F72_L1.6901.00
315_T319_M1.6501.00
314_P317_T1.6321.00
339_L342_E1.6311.00
79_P127_R1.6101.00
345_E349_N1.6061.00
252_E256_D1.5831.00
348_Q352_R1.5771.00
360_A392_L1.5611.00
345_E350_G1.5601.00
229_Q232_N1.5491.00
368_R371_V1.5481.00
80_T92_Y1.5451.00
318_T322_G1.5381.00
20_L71_L1.5381.00
327_K330_E1.5101.00
147_I429_I1.5011.00
317_T320_G1.4851.00
346_K349_N1.4781.00
387_L397_D1.4771.00
317_T321_G1.4751.00
15_A395_F1.4751.00
341_P346_K1.4481.00
343_R346_K1.4431.00
320_G324_R1.4381.00
321_G324_R1.4341.00
272_L275_Q1.4321.00
254_L257_F1.4281.00
342_E345_E1.4061.00
139_E173_I1.3911.00
201_I204_D1.3911.00
18_A396_D1.3911.00
368_R372_A1.3861.00
245_T256_D1.3831.00
212_V215_Q1.3791.00
318_T321_G1.3761.00
328_I331_K1.3681.00
56_G60_K1.3651.00
168_E172_N1.3631.00
350_G354_K1.3501.00
146_V170_M1.3461.00
155_I196_V1.3451.00
346_K351_R1.3441.00
137_L141_K1.3361.00
143_P175_Y1.3351.00
317_T324_R1.3260.99
314_P318_T1.3190.99
268_K274_E1.3000.99
154_L166_I1.2940.99
71_L430_F1.2870.99
237_N240_W1.2780.99
16_F75_G1.2770.99
293_G296_D1.2740.99
314_P322_G1.2430.99
131_F169_T1.2420.99
396_D399_D1.2360.99
346_K352_R1.2330.99
36_D39_A1.2320.99
147_I199_I1.2300.99
15_A421_I1.2260.99
351_R371_V1.2260.99
157_S162_V1.2050.99
13_I420_S1.2040.99
268_K271_K1.1970.99
271_K274_E1.1950.99
8_S15_A1.1930.99
287_R291_M1.1930.99
301_D305_R1.1810.99
197_Y425_V1.1800.99
181_L194_E1.1750.99
272_L279_A1.1750.99
189_V422_T1.1740.99
10_F130_L1.1730.99
270_K274_E1.1680.99
327_K331_K1.1680.99
347_R351_R1.1590.99
302_A305_R1.1550.99
343_R349_N1.1550.99
236_F239_K1.1540.99
18_A21_R1.1490.98
298_K302_A1.1470.98
274_E277_G1.1460.98
202_R205_L1.1440.98
245_T248_K1.1350.98
387_L398_E1.1320.98
406_A416_Q1.1290.98
81_F156_N1.1220.98
11_S17_E1.1210.98
296_D299_G1.1110.98
361_F364_N1.1050.98
251_R254_L1.1030.98
326_P329_A1.1030.98
5_R70_D1.1030.98
68_Y141_K1.1010.98
291_M294_H1.0980.98
285_E289_P1.0980.98
355_E358_E1.0960.98
309_P312_L1.0950.98
13_I416_Q1.0860.98
19_A421_I1.0820.98
233_I236_F1.0810.98
71_L147_I1.0790.98
271_K276_L1.0760.98
229_Q235_S1.0760.98
286_V289_P1.0700.98
19_A430_F1.0690.98
88_D91_E1.0640.97
243_Q246_V1.0620.97
224_G228_L1.0500.97
343_R348_Q1.0480.97
250_L257_F1.0440.97
292_V296_D1.0430.97
318_T324_R1.0360.97
163_L179_L1.0350.97
135_A169_T1.0320.97
304_K307_Y1.0270.97
295_V298_K1.0270.97
264_L267_E1.0250.97
319_M322_G1.0240.97
318_T327_K1.0240.97
265_N268_K1.0210.97
312_L316_L1.0210.97
230_E233_I1.0190.97
253_I257_F1.0160.97
413_L417_A1.0160.97
319_M324_R1.0140.97
351_R354_K1.0130.97
144_K205_L1.0120.97
307_Y314_P1.0110.97
9_L33_S1.0070.97
187_F425_V1.0060.96
4_L25_V1.0040.96
184_S197_Y1.0030.96
299_G302_A1.0020.96
365_T368_R1.0000.96
183_N186_F0.9960.96
41_K44_C0.9950.96
390_W400_F0.9920.96
343_R350_G0.9910.96
76_F148_L0.9900.96
139_E169_T0.9870.96
311_G314_P0.9870.96
318_T323_H0.9810.96
291_M296_D0.9800.96
182_L197_Y0.9770.96
267_E270_K0.9740.96
353_F377_P0.9710.96
289_P294_H0.9690.96
390_W404_F0.9690.96
367_D371_V0.9680.96
250_L254_L0.9650.96
13_I42_S0.9650.96
270_K275_Q0.9590.95
289_P292_V0.9570.95
87_R153_G0.9550.95
72_L141_K0.9540.95
274_E279_A0.9420.95
294_H297_L0.9400.95
185_K192_N0.9380.95
289_P293_G0.9360.95
232_N236_F0.9360.95
252_E255_E0.9330.95
249_R253_I0.9290.95
250_L253_I0.9280.94
20_L73_T0.9260.94
245_T260_E0.9250.94
317_T322_G0.9240.94
412_Q415_K0.9220.94
394_A423_V0.9210.94
359_P362_T0.9170.94
245_T249_R0.9160.94
302_A306_V0.9140.94
236_F240_W0.9140.94
270_K279_A0.9100.94
372_A375_E0.9100.94
165_I169_T0.9070.94
258_V263_Y0.9070.94
223_K228_L0.9050.94
67_P141_K0.9050.94
253_I260_E0.9050.94
32_F46_I0.9040.94
276_L279_A0.9040.94
370_G373_I0.9030.94
263_Y268_K0.8980.93
145_F433_L0.8980.93
267_E276_L0.8960.93
348_Q353_F0.8930.93
291_M295_V0.8930.93
225_K229_Q0.8900.93
7_M72_L0.8890.93
253_I258_V0.8880.93
93_K129_T0.8860.93
131_F154_L0.8850.93
47_H399_D0.8840.93
367_D372_A0.8830.93
340_T344_E0.8830.93
256_D259_D0.8800.93
212_V216_K0.8800.93
342_E346_K0.8800.93
246_V250_L0.8790.93
264_L270_K0.8740.93
197_Y422_T0.8730.92
230_E237_N0.8720.92
301_D307_Y0.8670.92
230_E234_K0.8660.92
171_N203_E0.8630.92
375_E378_K0.8610.92
10_F14_G0.8570.92
366_I370_G0.8570.92
10_F76_F0.8510.92
17_E43_Y0.8480.91
290_L293_G0.8470.91
340_T345_E0.8470.91
344_E347_R0.8470.91
261_K265_N0.8420.91
274_E278_T0.8420.91
189_V424_S0.8420.91
284_Q292_V0.8420.91
223_K229_Q0.8400.91
288_E291_M0.8380.91
72_L138_A0.8380.91
272_L277_G0.8370.91
287_R290_L0.8360.91
390_W413_L0.8350.91
342_E348_Q0.8340.91
303_I307_Y0.8340.91
21_R28_E0.8320.91
311_G321_G0.8290.90
405_A416_Q0.8290.90
338_V341_P0.8280.90
306_V309_P0.8280.90
214_G217_R0.8270.90
343_R347_R0.8270.90
307_Y317_T0.8260.90
350_G369_H0.8250.90
182_L187_F0.8250.90
263_Y269_T0.8240.90
268_K276_L0.8240.90
268_K275_Q0.8200.90
369_H373_I0.8190.90
299_G303_I0.8190.90
272_L276_L0.8140.90
249_R257_F0.8090.89
235_S238_F0.8090.89
163_L167_S0.8040.89
227_R232_N0.8030.89
342_E347_R0.8030.89
346_K353_F0.8010.89
298_K301_D0.8000.89
250_L255_E0.7980.89
247_T259_D0.7970.89
244_D252_E0.7950.89
18_A399_D0.7940.88
229_Q236_F0.7940.88
268_K273_V0.7920.88
320_G327_K0.7900.88
248_K257_F0.7880.88
384_L392_L0.7860.88
17_E21_R0.7850.88
131_F166_I0.7840.88
271_K278_T0.7830.88
266_E269_T0.7830.88
59_S133_E0.7820.88
315_T320_G0.7820.88
345_E348_Q0.7800.88
266_E270_K0.7780.87
323_H330_E0.7760.87
323_H328_I0.7740.87
315_T321_G0.7730.87
18_A22_N0.7730.87
234_K237_N0.7710.87
364_N369_H0.7700.87
6_V20_L0.7690.87
176_R204_D0.7640.86
248_K251_R0.7640.86
346_K354_K0.7630.86
21_R29_L0.7630.86
46_I399_D0.7590.86
301_D304_K0.7580.86
81_F130_L0.7550.86
275_Q279_A0.7540.86
189_V394_A0.7500.85
253_I256_D0.7500.85
313_S316_L0.7490.85
394_A422_T0.7440.85
319_M323_H0.7430.85
393_Q422_T0.7420.85
350_G361_F0.7420.85
302_A307_Y0.7400.85
344_E348_Q0.7380.85
362_T365_T0.7380.85
288_E292_V0.7370.84
366_I369_H0.7370.84
83_V153_G0.7360.84
76_F134_T0.7360.84
302_A308_S0.7350.84
406_A413_L0.7340.84
344_E350_G0.7330.84
249_R252_E0.7330.84
225_K228_L0.7310.84
289_P295_V0.7300.84
296_D300_H0.7290.84
34_E40_I0.7270.84
337_A340_T0.7260.84
7_M30_I0.7260.84
248_K252_E0.7240.83
249_R259_D0.7230.83
157_S160_G0.7230.83
224_G227_R0.7190.83
245_T255_E0.7180.83
305_R308_S0.7160.83
9_L74_S0.7150.83
220_V227_R0.7150.83
268_K272_L0.7120.82
145_F201_I0.7110.82
312_L320_G0.7100.82
231_I234_K0.7090.82
28_E49_V0.7080.82
305_R314_P0.7070.82
346_K368_R0.7070.82
251_R257_F0.7050.82
143_P202_R0.7040.82
247_T252_E0.7030.82
325_E328_I0.7030.82
293_G300_H0.7030.82
81_F166_I0.7000.81
314_P320_G0.6930.81
246_V249_R0.6930.81
34_E43_Y0.6880.80
39_A419_N0.6870.80
80_T162_V0.6870.80
264_L272_L0.6850.80
421_I426_L0.6850.80
324_R330_E0.6850.80
297_L302_A0.6840.80
211_W214_G0.6830.80
267_E271_K0.6820.80
349_N353_F0.6820.80
243_Q253_I0.6820.80
267_E279_A0.6810.79
338_V342_E0.6800.79
292_V299_G0.6800.79
226_K229_Q0.6750.79
322_G325_E0.6750.79
290_L294_H0.6750.79
171_N177_I0.6710.78
13_I17_E0.6700.78
313_S318_T0.6680.78
307_Y315_T0.6630.78
38_Y409_S0.6610.77
232_N237_N0.6580.77
8_S43_Y0.6560.77
316_L321_G0.6560.77
286_V290_L0.6560.77
366_I371_V0.6550.77
270_K277_G0.6540.77
384_L414_Y0.6540.77
263_Y267_E0.6540.77
170_M200_G0.6530.77
302_A324_R0.6520.76
184_S425_V0.6520.76
220_V223_K0.6510.76
297_L300_H0.6500.76
400_F413_L0.6480.76
254_L261_K0.6480.76
265_N271_K0.6480.76
247_T256_D0.6480.76
337_A343_R0.6470.76
339_L350_G0.6470.76
90_M93_K0.6470.76
300_H306_V0.6470.76
264_L274_E0.6470.76
287_R296_D0.6450.76
11_S15_A0.6430.75
160_G164_R0.6400.75
252_E269_T0.6400.75
263_Y270_K0.6380.75
307_Y313_S0.6370.75
243_Q248_K0.6370.75
299_G304_K0.6330.74
14_G421_I0.6310.74
271_K279_A0.6310.74
394_A428_S0.6300.74
254_L258_V0.6300.74
316_L320_G0.6280.74
321_G326_P0.6270.74
309_P314_P0.6230.73
304_K319_M0.6230.73
219_D223_K0.6230.73
251_R258_V0.6220.73
53_L56_G0.6220.73
314_P321_G0.6220.73
286_V291_M0.6190.73
340_T343_R0.6190.73
225_K235_S0.6170.72
285_E288_E0.6160.72
20_L147_I0.6160.72
348_Q369_H0.6140.72
307_Y319_M0.6140.72
9_L14_G0.6130.72
232_N240_W0.6110.72
13_I399_D0.6100.72
243_Q256_D0.6100.72
341_P345_E0.6100.72
265_N270_K0.6090.71
244_D257_F0.6070.71
155_I181_L0.6070.71
316_L319_M0.6030.71
313_S317_T0.6020.71
321_G325_E0.6020.71
32_F43_Y0.6010.71
304_K311_G0.6000.70
337_A341_P0.5990.70
267_E272_L0.5980.70
308_S314_P0.5980.70
341_P344_E0.5970.70
247_T251_R0.5970.70
63_K136_L0.5950.70
316_L323_H0.5930.69
345_E351_R0.5910.69
342_E349_N0.5900.69
249_R256_D0.5850.68
338_V344_E0.5850.68
319_M328_I0.5850.68
324_R327_K0.5840.68
257_F266_E0.5820.68
55_V58_I0.5810.68
340_T351_R0.5800.68
129_T162_V0.5800.68
386_P410_N0.5790.68
286_V292_V0.5790.68
229_Q237_N0.5780.68
81_F157_S0.5780.68
326_P331_K0.5760.67
321_G327_K0.5750.67
294_H299_G0.5750.67
305_R317_T0.5740.67
266_E279_A0.5740.67
256_D261_K0.5710.67
275_Q278_T0.5700.66
306_V318_T0.5690.66
269_T273_V0.5680.66
229_Q234_K0.5670.66
309_P319_M0.5670.66
284_Q287_R0.5670.66
262_Y279_A0.5660.66
326_P330_E0.5660.66
386_P417_A0.5650.66
280_P284_Q0.5620.65
347_R353_F0.5620.65
261_K264_L0.5610.65
255_E259_D0.5590.65
304_K314_P0.5590.65
293_G297_L0.5590.65
231_I236_F0.5580.65
267_E274_E0.5580.65
270_K276_L0.5570.65
339_L347_R0.5570.65
287_R295_V0.5560.65
295_V299_G0.5550.64
288_E293_G0.5530.64
252_E260_E0.5530.64
369_H372_A0.5520.64
224_G229_Q0.5510.64
244_D249_R0.5500.64
395_F416_Q0.5490.64
239_K242_L0.5480.63
307_Y321_G0.5480.63
9_L16_F0.5470.63
300_H314_P0.5470.63
134_T146_V0.5460.63
287_R292_V0.5450.63
247_T254_L0.5430.63
45_A400_F0.5420.63
360_A364_N0.5400.62
16_F426_L0.5380.62
6_V73_T0.5380.62
272_L278_T0.5370.62
390_W420_S0.5370.62
322_G329_A0.5360.62
7_M69_F0.5350.62
347_R369_H0.5330.61
12_G15_A0.5330.61
314_P319_M0.5330.61
8_S33_S0.5320.61
8_S14_G0.5320.61
85_G89_G0.5310.61
163_L198_I0.5310.61
269_T274_E0.5300.61
300_H305_R0.5300.61
92_Y127_R0.5290.61
368_R373_I0.5270.60
9_L137_L0.5260.60
290_L295_V0.5250.60
76_F128_G0.5240.60
270_K273_V0.5230.60
57_D61_A0.5230.60
135_A173_I0.5230.60
368_R375_E0.5210.60
229_Q233_I0.5200.59
350_G364_N0.5200.59
347_R354_K0.5200.59
39_A416_Q0.5190.59
80_T129_T0.5170.59
232_N235_S0.5160.59
245_T250_L0.5150.59
262_Y269_T0.5140.59
352_R369_H0.5140.59
81_F128_G0.5130.58
167_S171_N0.5110.58
246_V253_I0.5110.58
252_E257_F0.5100.58
63_K137_L0.5080.58
238_F241_P0.5080.58
298_K303_I0.5070.58
45_A405_A0.5060.57
348_Q354_K0.5060.57
322_G330_E0.5050.57
84_A414_Y0.5040.57
309_P315_T0.5030.57
315_T322_G0.5020.57
258_V262_Y0.5010.57
41_K405_A0.5000.57
341_P347_R0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3swrA 1 0.8984 100 0.227 Contact Map
4ft4B 1 0.8736 100 0.242 Contact Map
4wxxA 1 0.9007 100 0.267 Contact Map
4dkjA 1 0.7178 100 0.304 Contact Map
3g7uA 1 0.754 100 0.309 Contact Map
2c7pA 1 0.7133 100 0.314 Contact Map
3ubtY 2 0.702 100 0.33 Contact Map
3qv2A 1 0.6975 100 0.333 Contact Map
1g55A 1 0.6907 100 0.342 Contact Map
4h0nA 1 0.7178 100 0.349 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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