GREMLIN Database
DBH2 - SPBc2 prophage-derived DNA-binding protein HU 2
UniProt: P68573 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (90)
Sequences: 4855 (2731)
Seq/√Len: 287.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R78_A3.3371.00
59_K68_E2.7321.00
35_A40_E2.6471.00
22_A26_E2.4561.00
54_E75_K2.3971.00
57_A70_D2.3701.00
61_R66_G2.2441.00
59_K70_D2.1311.00
8_A18_K2.0921.00
52_V75_K2.0451.00
60_G71_I2.0081.00
20_E23_P1.9831.00
83_K87_D1.9361.00
61_R68_E1.8521.00
10_V25_V1.7971.00
19_K23_P1.7631.00
54_E73_A1.6641.00
41_K49_T1.5811.00
36_L85_L1.5791.00
28_V32_I1.5741.00
51_E80_K1.5691.00
36_L52_V1.5691.00
55_R76_A1.5551.00
17_S20_E1.4131.00
33_S85_L1.4101.00
41_K51_E1.3881.00
9_K13_K1.3381.00
10_V28_V1.3361.00
45_P82_A1.3001.00
21_G24_S1.2681.00
6_L44_I1.2451.00
57_A73_A1.2111.00
74_T90_K1.1771.00
16_V21_G1.1671.00
9_K31_T1.1451.00
3_K26_E1.1231.00
13_K34_E1.0901.00
48_G79_F1.0741.00
16_V24_S1.0731.00
32_I42_V1.0691.00
13_K31_T1.0601.00
33_S88_A1.0561.00
43_S49_T1.0481.00
9_K12_E1.0161.00
30_D33_S1.0041.00
29_F44_I1.0011.00
31_T35_A0.9951.00
29_F47_F0.9861.00
34_E38_S0.9751.00
39_G75_K0.9601.00
14_Q21_G0.9481.00
37_K88_A0.9201.00
5_E8_A0.9051.00
27_K31_T0.9041.00
10_V14_Q0.8901.00
74_T86_K0.8861.00
51_E78_A0.8821.00
28_V31_T0.8711.00
8_A12_E0.8691.00
47_F50_F0.8641.00
25_V29_F0.8461.00
64_Q67_E0.8451.00
16_V20_E0.8241.00
62_N67_E0.8211.00
1_M5_E0.8201.00
47_F82_A0.8080.99
58_R76_A0.8060.99
77_P89_V0.7780.99
55_R74_T0.7770.99
2_N5_E0.7720.99
34_E37_K0.7690.99
84_A87_D0.7500.99
36_L77_P0.7480.99
49_T80_K0.7420.99
10_V24_S0.7390.99
60_G69_I0.7290.99
13_K30_D0.7270.99
43_S58_R0.7230.99
33_S37_K0.7150.99
24_S31_T0.7110.99
61_R64_Q0.7080.99
35_A38_S0.7050.99
77_P85_L0.7040.99
77_P86_K0.7000.99
62_N66_G0.6990.99
35_A42_V0.6890.98
13_K27_K0.6830.98
4_T8_A0.6800.98
30_D34_E0.6800.98
50_F79_F0.6800.98
11_A14_Q0.6690.98
23_P27_K0.6680.98
45_P84_A0.6680.98
55_R58_R0.6590.98
17_S21_G0.6560.98
7_I22_A0.6500.98
39_G54_E0.6480.98
15_G23_P0.6470.98
22_A41_K0.6430.97
60_G68_E0.6420.97
31_T34_E0.6370.97
26_E30_D0.6280.97
57_A72_P0.6180.97
38_S54_E0.6130.97
62_N65_T0.6100.97
53_R76_A0.6060.96
34_E54_E0.6010.96
29_F33_S0.5960.96
7_I25_V0.5870.96
10_V21_G0.5830.96
49_T82_A0.5740.95
27_K30_D0.5710.95
32_I50_F0.5660.95
59_K69_I0.5570.94
11_A18_K0.5570.94
19_K22_A0.5520.94
15_G20_E0.5380.93
15_G21_G0.5380.93
9_K38_S0.5380.93
14_Q27_K0.5360.93
43_S84_A0.5350.93
63_P86_K0.5260.92
46_G82_A0.5250.92
11_A21_G0.5240.92
20_E24_S0.5210.92
2_N45_P0.5200.92
3_K85_L0.5180.92
84_A88_A0.5130.91
32_I47_F0.5130.91
9_K35_A0.5100.91
10_V31_T0.5070.91
3_K14_Q0.5050.91
1_M40_E0.5020.91
6_L10_V0.5000.90
52_V85_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjuA 2 0.9783 100 0.158 Contact Map
4p3vA 2 0.7826 100 0.167 Contact Map
2iieA 1 1 100 0.167 Contact Map
1mulA 2 0.8261 100 0.17 Contact Map
1b8zA 2 0.7283 100 0.171 Contact Map
1p71A 2 1 100 0.173 Contact Map
1exeA 2 1 100 0.175 Contact Map
4pt4A 2 1 100 0.175 Contact Map
1owfB 1 1 100 0.178 Contact Map
1owfA 1 1 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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