GREMLIN Database
BDBB - SPBc2 prophage-derived disulfide bond formation protein B
UniProt: P68571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (128)
Sequences: 450 (343)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_A119_S3.6051.00
68_V130_G3.1591.00
26_F31_M3.1381.00
27_Y107_V2.9921.00
83_Y117_L2.9841.00
41_Y45_F2.9701.00
16_L125_L2.7081.00
110_L113_I2.6731.00
76_L124_A2.6341.00
73_S127_F2.6261.00
72_S127_F2.5530.99
27_Y118_M2.3970.99
24_S28_S2.3380.99
83_Y87_L2.1390.98
24_S47_Y2.0800.98
59_K66_F2.0110.97
12_L16_L1.8940.96
28_S47_Y1.7970.95
73_S77_I1.7340.94
34_K37_V1.6990.93
81_Y85_I1.6560.92
59_K67_Y1.6260.91
108_E112_F1.5970.90
76_L80_F1.5890.90
61_D67_Y1.5750.90
13_L53_L1.5430.89
51_I71_L1.5180.88
76_L120_S1.5060.88
65_I134_I1.4880.87
10_F56_G1.4800.87
56_G64_S1.4390.85
12_L129_I1.3700.82
19_F50_P1.3690.82
24_S27_Y1.3520.81
49_I70_F1.3510.81
10_F64_S1.3460.81
52_I64_S1.3400.81
13_L130_G1.3380.80
69_V127_F1.3160.79
84_I88_T1.3160.79
26_F30_I1.3140.79
12_L125_L1.2980.78
27_Y33_F1.2740.77
109_Y118_M1.2470.75
20_G23_A1.2380.75
14_F54_L1.1710.71
37_V41_Y1.1220.67
70_F130_G1.1150.67
83_Y86_Q1.1130.67
23_A115_L1.1120.67
20_G122_C1.1080.66
7_K60_K1.1040.66
17_S50_P1.0920.65
21_T44_I1.0730.64
76_L127_F1.0440.62
92_S95_C1.0260.60
53_L67_Y0.9990.58
13_L67_Y0.9950.58
80_F84_I0.9850.57
128_G131_L0.9780.57
113_I117_L0.9560.55
33_F47_Y0.9510.54
107_V118_M0.9450.54
52_I131_L0.9430.54
72_S76_L0.9350.53
86_Q114_T0.9300.53
49_I54_L0.9270.53
15_F121_V0.9220.52
107_V117_L0.9100.51
68_V134_I0.8990.50
121_V125_L0.8900.50
16_L129_I0.8900.50
79_A120_S0.8820.49
27_Y109_Y0.8780.49
38_L78_I0.8740.48
28_S114_T0.8730.48
65_I68_V0.8640.47
82_H119_S0.8480.46
21_T41_Y0.8460.46
81_Y98_G0.8390.45
109_Y112_F0.8380.45
16_L19_F0.8370.45
118_M121_V0.8240.44
20_G46_L0.8240.44
45_F74_I0.8210.44
45_F76_L0.8170.44
55_I66_F0.8110.43
23_A46_L0.8060.43
49_I68_V0.8020.43
21_T50_P0.7870.41
13_L49_I0.7820.41
80_F110_L0.7800.41
112_F117_L0.7710.40
11_L57_L0.7710.40
19_F121_V0.7680.40
53_L68_V0.7680.40
45_F78_I0.7680.40
27_Y106_E0.7620.39
70_F127_F0.7600.39
12_L132_K0.7550.39
120_S124_A0.7550.39
26_F94_V0.7470.38
105_I108_E0.7430.38
55_I70_F0.7430.38
28_S33_F0.7370.38
83_Y119_S0.7300.37
56_G67_Y0.7280.37
33_F114_T0.7270.37
108_E115_L0.7270.37
8_S96_E0.7230.37
8_S57_L0.7160.36
55_I64_S0.7130.36
27_Y114_T0.7110.36
57_L129_I0.7100.36
41_Y44_I0.7090.36
90_S94_V0.7090.36
24_S114_T0.7070.35
103_A130_G0.6930.34
62_L133_L0.6920.34
46_L123_F0.6910.34
24_S106_E0.6890.34
27_Y115_L0.6880.34
79_A82_H0.6860.34
25_L47_Y0.6830.34
77_I91_K0.6820.34
54_L57_L0.6820.34
66_F70_F0.6810.34
23_A27_Y0.6800.33
13_L61_D0.6780.33
86_Q106_E0.6670.33
47_Y106_E0.6670.33
51_I72_S0.6610.32
23_A107_V0.6570.32
79_A101_S0.6560.32
11_L65_I0.6540.32
27_Y108_E0.6390.31
94_V97_I0.6330.30
74_I78_I0.6250.30
37_V78_I0.6230.30
77_I131_L0.6160.29
15_F51_I0.6090.29
121_V124_A0.6050.28
94_V103_A0.6000.28
85_I97_I0.6000.28
101_S104_K0.6000.28
85_I94_V0.5970.28
66_F134_I0.5930.28
80_F122_C0.5920.28
80_F120_S0.5890.27
65_I85_I0.5890.27
31_M37_V0.5880.27
7_K134_I0.5860.27
87_L108_E0.5830.27
55_I74_I0.5790.27
105_I117_L0.5780.27
51_I60_K0.5750.26
70_F95_C0.5720.26
33_F106_E0.5700.26
85_I93_V0.5660.26
16_L68_V0.5650.26
74_I119_S0.5620.26
49_I53_L0.5600.26
35_P46_L0.5570.25
57_L62_L0.5560.25
40_W46_L0.5560.25
31_M105_I0.5530.25
67_Y130_G0.5510.25
11_L90_S0.5490.25
38_L53_L0.5450.25
61_D129_I0.5430.25
65_I130_G0.5420.24
84_I90_S0.5420.24
9_F125_L0.5410.24
55_I67_Y0.5400.24
13_L16_L0.5400.24
92_S97_I0.5380.24
52_I67_Y0.5370.24
29_E46_L0.5360.24
129_I132_K0.5360.24
14_F56_G0.5340.24
88_T93_V0.5280.24
21_T45_F0.5270.24
36_C43_R0.5220.23
14_F69_V0.5190.23
13_L65_I0.5170.23
51_I74_I0.5140.23
65_I70_F0.5140.23
53_L130_G0.5120.23
9_F129_I0.5110.23
28_S106_E0.5080.22
88_T94_V0.5070.22
49_I63_N0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi7B 1 0.75 100 0.578 Contact Map
4nv5A 1 0.527 88.2 0.922 Contact Map
2l0lA 1 0.1824 56.4 0.941 Contact Map
4xnvA 1 0.6149 21.4 0.953 Contact Map
4yayA 1 0.5068 21.1 0.953 Contact Map
2ks1B 1 0.2973 18.1 0.954 Contact Map
4p6vD 1 0.7973 14.6 0.956 Contact Map
4xt1A 1 0.5676 13.7 0.957 Contact Map
4ldeA 1 0.5878 12.4 0.958 Contact Map
2z73A 2 0.6216 12.2 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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