GREMLIN Database
BDBA - SPBc2 prophage-derived disulfide bond formation protein A
UniProt: P68569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (108)
Sequences: 6539 (4214)
Seq/√Len: 405.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_E95_L3.4401.00
40_Q97_K2.6261.00
70_E124_A2.5471.00
123_S126_Q2.3041.00
34_I82_L2.2781.00
107_L117_R2.2651.00
58_C61_C2.1111.00
67_E124_A2.0101.00
98_Y109_Y1.9761.00
36_L93_E1.9371.00
49_K80_Q1.9281.00
74_K128_E1.9061.00
121_Y126_Q1.8951.00
85_E88_E1.8761.00
52_Y83_N1.8711.00
74_K124_A1.8641.00
36_L94_F1.8321.00
48_P108_Y1.8281.00
84_I94_F1.7371.00
67_E70_E1.7061.00
50_F68_L1.6631.00
30_F73_K1.6441.00
35_N38_Q1.6431.00
68_L81_A1.5751.00
71_V81_A1.5531.00
86_E103_T1.5341.00
49_K82_L1.5051.00
36_L91_N1.5051.00
30_F76_K1.4491.00
128_E132_D1.4391.00
38_Q42_E1.4381.00
50_F106_I1.4161.00
52_Y65_K1.3901.00
75_E132_D1.3871.00
42_E80_Q1.3821.00
71_V124_A1.3651.00
107_L114_E1.3451.00
56_T85_E1.3401.00
88_E91_N1.3211.00
40_Q44_D1.3161.00
47_K80_Q1.3121.00
32_N42_E1.2891.00
114_E117_R1.2831.00
42_E49_K1.2541.00
34_I42_E1.2451.00
75_E128_E1.2261.00
126_Q129_K1.1951.00
71_V128_E1.1831.00
64_I106_I1.1651.00
51_I109_Y1.1581.00
116_D134_N1.1521.00
64_I127_I1.1451.00
65_K69_N1.1351.00
33_D83_N1.0911.00
64_I67_E1.0271.00
108_Y130_F1.0121.00
39_Y43_V0.9901.00
35_N91_N0.9831.00
65_K83_N0.9751.00
39_Y53_V0.9611.00
92_T96_D0.9491.00
92_T95_L0.9461.00
118_L130_F0.9351.00
71_V127_I0.9221.00
54_Y83_N0.9181.00
56_T87_K0.9171.00
125_S129_K0.9091.00
69_N83_N0.8961.00
124_A128_E0.8901.00
53_V100_L0.8861.00
108_Y131_F0.8571.00
50_F81_A0.8551.00
52_Y60_P0.8431.00
118_L122_R0.8391.00
79_V131_F0.8381.00
71_V75_E0.8371.00
67_E71_V0.8291.00
54_Y85_E0.8101.00
53_V107_L0.8001.00
53_V98_Y0.7941.00
31_Y68_L0.7891.00
75_E81_A0.7861.00
48_P110_K0.7821.00
64_I68_L0.7821.00
29_P69_N0.7751.00
52_Y64_I0.7641.00
67_E123_S0.7461.00
32_N80_Q0.7441.00
101_N117_R0.7351.00
68_L131_F0.7271.00
60_P102_K0.7151.00
129_K132_D0.7131.00
60_P63_E0.7041.00
116_D130_F0.7021.00
91_N94_F0.6951.00
39_Y51_I0.6951.00
84_I91_N0.6891.00
50_F108_Y0.6790.99
25_G28_K0.6780.99
34_I51_I0.6760.99
46_K111_D0.6720.99
31_Y72_I0.6660.99
50_F127_I0.6570.99
32_N49_K0.6500.99
130_F134_N0.6490.99
86_E100_L0.6490.99
93_E97_K0.6470.99
43_V49_K0.6470.99
39_Y94_F0.6460.99
34_I38_Q0.6450.99
57_S62_Q0.6430.99
38_Q41_K0.6410.99
59_P63_E0.6380.99
39_Y98_Y0.6370.99
54_Y58_C0.6340.99
53_V109_Y0.6330.99
46_K49_K0.6300.99
63_E67_E0.6270.99
122_R126_Q0.6230.99
31_Y83_N0.6230.99
55_E58_C0.6210.99
108_Y134_N0.6120.99
42_E46_K0.6060.99
55_E66_P0.5950.99
48_P78_K0.5940.99
93_E96_D0.5890.99
84_I95_L0.5880.99
47_K78_K0.5870.99
72_I81_A0.5800.98
59_P62_Q0.5740.98
95_L98_Y0.5720.98
122_R130_F0.5650.98
59_P102_K0.5640.98
68_L127_I0.5630.98
109_Y114_E0.5620.98
120_G126_Q0.5600.98
57_S87_K0.5600.98
55_E87_K0.5590.98
100_L105_T0.5590.98
33_D88_E0.5580.98
50_F131_F0.5560.98
51_I82_L0.5520.98
94_F97_K0.5520.98
106_I127_I0.5490.98
53_V86_E0.5430.98
45_S48_P0.5410.98
124_A127_I0.5390.97
73_K76_K0.5390.97
61_C66_P0.5320.97
52_Y61_C0.5310.97
55_E61_C0.5300.97
29_P33_D0.5230.97
64_I122_R0.5220.97
99_N107_L0.5200.97
47_K111_D0.5200.97
34_I84_I0.5150.97
70_E74_K0.5140.97
75_E79_V0.5130.97
54_Y103_T0.5110.97
48_P111_D0.5020.96
118_L126_Q0.5020.96
118_L121_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.7591 99.8 0.267 Contact Map
3f8uA 2 0.781 99.8 0.267 Contact Map
2b5eA 1 0.854 99.8 0.274 Contact Map
4ekzA 1 0.9343 99.8 0.303 Contact Map
3ed3A 1 0.8467 99.8 0.308 Contact Map
3apoA 1 0.8686 99.8 0.309 Contact Map
1sjiA 2 0.8467 99.8 0.311 Contact Map
3us3A 2 0.8613 99.8 0.324 Contact Map
2pptA 2 0.9781 99.8 0.325 Contact Map
3t58A 1 0.8467 99.8 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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