GREMLIN Database
53DR - Putative SPBc2 prophage-derived 5'(3')-deoxyribonucleotidase
UniProt: P68522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (168)
Sequences: 309 (234)
Seq/√Len: 18.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_R105_E6.7691.00
69_G73_V4.7581.00
7_I74_T4.2841.00
6_A126_A4.0621.00
59_D98_A3.7061.00
76_E168_E3.2960.99
22_A26_T3.0870.99
143_M159_I2.9090.99
148_D162_M2.8640.98
19_D63_N2.7340.98
62_R101_E2.6700.98
69_G165_E2.4500.96
73_V168_E2.3830.95
7_I88_T2.1420.92
87_T128_I2.0530.90
110_I115_V2.0320.89
6_A124_I2.0250.89
4_V84_Y1.7550.81
66_V107_F1.6870.78
14_A107_F1.6470.76
121_K131_D1.6370.76
13_L74_T1.6130.75
87_T117_L1.5790.73
125_K141_E1.5490.71
27_Y55_H1.5120.70
121_K132_D1.5120.70
18_S65_N1.4890.68
5_I77_L1.4760.68
130_I167_I1.4710.67
162_M166_E1.4620.67
103_L107_F1.4490.66
137_L158_F1.4470.66
148_D160_R1.4260.65
5_I8_D1.3890.63
148_D153_R1.3560.61
89_A118_C1.3410.60
27_Y54_R1.3350.60
12_V15_D1.3250.59
86_V136_N1.3210.59
11_Q39_C1.2990.57
81_Y85_V1.2950.57
9_M99_K1.2800.56
4_V82_E1.2660.55
37_I40_W1.2480.54
104_T115_V1.2370.54
15_D85_V1.1990.51
81_Y171_L1.1950.51
89_A95_S1.1870.51
108_P136_N1.1790.50
4_V126_A1.1720.50
61_F99_K1.1700.50
97_K101_E1.1670.49
16_L64_L1.1630.49
101_E105_E1.1590.49
19_D23_Y1.1530.48
102_W164_W1.1480.48
15_D18_S1.1410.48
86_V124_I1.1290.47
7_I130_I1.1220.47
14_A102_W1.1210.47
75_K79_K1.1180.46
100_L146_L1.1000.45
20_W23_Y1.0930.45
105_E124_I1.0920.45
27_Y57_D1.0740.44
103_L130_I1.0680.43
69_G163_N1.0640.43
86_V135_H1.0580.43
165_E169_R1.0360.41
114_N136_N1.0270.41
71_Q107_F1.0270.41
112_H136_N1.0120.40
54_R65_N1.0080.40
89_A119_G0.9990.39
25_N31_F0.9890.39
13_L139_S0.9820.38
95_S118_C0.9760.38
87_T171_L0.9750.38
56_L116_V0.9640.37
23_Y57_D0.9640.37
108_P137_L0.9620.37
11_Q19_D0.9590.37
128_I171_L0.9580.37
78_M114_N0.9540.37
145_I157_R0.9530.36
86_V129_M0.9410.36
84_Y123_I0.9400.36
99_K164_W0.9370.36
39_C151_H0.9290.35
90_T100_L0.9230.35
130_I147_F0.9230.35
90_T93_P0.9210.35
89_A93_P0.9170.34
92_H112_H0.9140.34
10_D121_K0.9140.34
42_I115_V0.9120.34
36_D75_K0.9120.34
159_I170_K0.9120.34
156_N163_N0.9080.34
40_W44_K0.8990.33
166_E169_R0.8970.33
44_K107_F0.8930.33
125_K169_R0.8900.33
87_T155_E0.8890.33
74_T107_F0.8810.32
20_W52_V0.8740.32
108_P111_P0.8710.32
4_V146_L0.8630.32
102_W140_F0.8590.31
8_D132_D0.8560.31
7_I81_Y0.8470.31
69_G168_E0.8430.30
65_N87_T0.8400.30
145_I170_K0.8320.30
120_N134_I0.8230.29
130_I164_W0.8220.29
21_V26_T0.8180.29
32_L39_C0.8120.29
40_W45_Y0.8080.29
128_I144_K0.8080.29
27_Y32_L0.8060.29
58_Y90_T0.8030.28
133_G136_N0.8030.28
31_F35_K0.7990.28
20_W43_K0.7970.28
61_F102_W0.7950.28
44_K163_N0.7920.28
32_L100_L0.7880.28
64_L99_K0.7870.28
93_P118_C0.7840.27
39_C148_D0.7820.27
75_K82_E0.7820.27
42_I64_L0.7730.27
11_Q133_G0.7720.27
89_A142_G0.7670.27
75_K107_F0.7650.27
25_N33_K0.7630.26
13_L85_V0.7610.26
147_F163_N0.7530.26
93_P103_L0.7510.26
94_D97_K0.7470.26
55_H70_S0.7450.26
43_K46_T0.7450.26
13_L23_Y0.7400.25
14_A140_F0.7400.25
7_I85_V0.7370.25
29_D34_E0.7370.25
57_D134_I0.7290.25
86_V126_A0.7210.24
7_I101_E0.7210.24
14_A61_F0.7200.24
116_V126_A0.7130.24
113_S120_N0.7030.24
124_I134_I0.6990.24
124_I133_G0.6980.23
92_H136_N0.6960.23
20_W56_L0.6960.23
23_Y26_T0.6940.23
143_M166_E0.6880.23
95_S102_W0.6880.23
44_K162_M0.6850.23
27_Y150_P0.6780.23
96_L100_L0.6750.22
145_I161_V0.6750.22
74_T83_V0.6690.22
91_N112_H0.6690.22
102_W106_Y0.6630.22
25_N48_T0.6620.22
43_K145_I0.6600.22
16_L112_H0.6590.22
64_L164_W0.6570.22
28_D124_I0.6560.22
6_A86_V0.6560.22
50_N54_R0.6470.21
27_Y51_N0.6470.21
83_V165_E0.6420.21
64_L85_V0.6410.21
89_A108_P0.6410.21
91_N135_H0.6400.21
13_L40_W0.6400.21
29_D84_Y0.6360.21
16_L60_L0.6340.21
21_V33_K0.6290.21
66_V165_E0.6280.21
13_L143_M0.6280.21
127_D131_D0.6280.21
35_K38_L0.6260.20
6_A89_A0.6210.20
59_D101_E0.6190.20
93_P98_A0.6160.20
84_Y101_E0.6150.20
11_Q47_N0.6140.20
31_F69_G0.6140.20
58_Y123_I0.6110.20
24_I120_N0.6100.20
11_Q98_A0.6100.20
51_N124_I0.6090.20
73_V164_W0.6080.20
120_N138_E0.6060.20
70_S107_F0.6030.20
117_L122_N0.5950.19
134_I137_L0.5920.19
18_S34_E0.5900.19
118_C142_G0.5900.19
145_I153_R0.5880.19
112_H151_H0.5810.19
81_Y150_P0.5790.19
163_N166_E0.5790.19
81_Y128_I0.5790.19
96_L136_N0.5700.18
89_A99_K0.5700.18
62_R98_A0.5680.18
10_D131_D0.5650.18
20_W40_W0.5650.18
56_L69_G0.5650.18
17_L126_A0.5640.18
26_T57_D0.5620.18
9_M15_D0.5610.18
116_V119_G0.5600.18
24_I28_D0.5590.18
29_D72_R0.5560.18
116_V166_E0.5530.18
128_I149_A0.5530.18
21_V36_D0.5510.18
39_C67_I0.5480.17
42_I96_L0.5390.17
60_L92_H0.5370.17
108_P142_G0.5340.17
55_H155_E0.5320.17
161_V169_R0.5300.17
28_D50_N0.5290.17
14_A74_T0.5290.17
29_D70_S0.5280.17
86_V133_G0.5260.17
5_I81_Y0.5250.17
34_E83_V0.5230.17
18_S22_A0.5220.17
96_L117_L0.5220.17
83_V166_E0.5170.16
70_S139_S0.5170.16
14_A95_S0.5130.16
135_H171_L0.5100.16
11_Q42_I0.5100.16
96_L133_G0.5090.16
89_A102_W0.5080.16
12_V147_F0.5060.16
121_K127_D0.5040.16
99_K102_W0.5040.16
154_N169_R0.5020.16
162_M169_R0.5020.16
74_T109_F0.5020.16
118_C140_F0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bwvA 2 0.9593 99.9 0.638 Contact Map
4mumA 2 0.9767 99.9 0.67 Contact Map
4l57A 2 0.9884 99.8 0.673 Contact Map
2b82A 4 0.9128 99 0.814 Contact Map
3sd7A 1 0.9535 98.6 0.834 Contact Map
2ah5A 1 0.9651 98.5 0.84 Contact Map
2obbA 2 0.5988 98.5 0.842 Contact Map
3kzxA 1 0.9244 98.5 0.842 Contact Map
4ezeA 1 0.9477 98.5 0.844 Contact Map
2go7A 2 0.9767 98.4 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.