KIPI - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

KIPI - Kinase A inhibitor

UniProt:	P60495	Sequences: MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFPGFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIVEIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRIAAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRAGDIVKFVRISEKDYHAYKEESN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	240 (214)
Sequences:	2919 (2018)
Seq/√Len:	138.0

ECOLI - YBGJ
BACSU - KIPI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_T	226_R	4.716	1.00
103_E	225_V	4.349	1.00
117_E	127_P	3.867	1.00
133_I	159_R	3.365	1.00
165_K	196_Q	3.324	1.00
108_Y	134_H	3.262	1.00
132_D	136_N	3.146	1.00
138_E	221_I	3.029	1.00
171_S	190_S	2.864	1.00
100_R	220_D	2.704	1.00
142_Y	154_G	2.538	1.00
129_E	132_D	2.536	1.00
119_V	130_V	2.450	1.00
123_N	162_A	2.303	1.00
118_E	165_K	2.255	1.00
104_I	201_T	2.180	1.00
187_Y	193_G	2.153	1.00
141_V	216_L	2.129	1.00
128_E	132_D	2.063	1.00
126_S	129_E	1.969	1.00
138_E	223_K	1.945	1.00
103_E	223_K	1.904	1.00
43_F	46_F	1.842	1.00
207_R	210_E	1.794	1.00
105_P	203_L	1.774	1.00
133_I	160_I	1.765	1.00
107_C	112_F	1.749	1.00
205_L	216_L	1.749	1.00
11_G	14_A	1.719	1.00
117_E	121_K	1.709	1.00
150_F	185_G	1.613	1.00
133_I	157_S	1.608	1.00
19_F	34_A	1.607	1.00
109_G	113_G	1.593	1.00
101_I	138_E	1.588	1.00
134_H	184_T	1.560	1.00
178_G	187_Y	1.559	1.00
8_E	18_R	1.541	1.00
35_A	39_E	1.535	1.00
111_E	229_E	1.503	1.00
120_A	127_P	1.499	1.00
16_M	57_T	1.499	1.00
35_A	49_C	1.483	1.00
101_I	221_I	1.470	1.00
61_D	65_V	1.462	1.00
107_C	200_K	1.452	1.00
178_G	193_G	1.448	1.00
106_V	177_V	1.441	1.00
60_Y	67_K	1.431	1.00
17_I	34_A	1.410	1.00
153_L	222_V	1.386	1.00
37_Y	41_Q	1.382	1.00
123_N	130_V	1.372	1.00
50_I	59_F	1.370	1.00
204_A	207_R	1.369	1.00
14_A	57_T	1.355	1.00
118_E	121_K	1.353	1.00
202_P	227_I	1.336	1.00
212_P	217_R	1.324	1.00
178_G	196_Q	1.319	1.00
6_Q	18_R	1.313	1.00
120_A	123_N	1.305	1.00
178_G	185_G	1.302	1.00
161_A	182_L	1.291	1.00
186_V	205_L	1.275	1.00
42_P	46_F	1.268	1.00
107_C	202_P	1.257	1.00
10_L	57_T	1.254	1.00
37_Y	40_E	1.249	1.00
118_E	122_I	1.228	1.00
147_A	191_T	1.228	1.00
53_F	183_Q	1.218	1.00
173_P	176_S	1.214	1.00
81_K	85_E	1.192	1.00
129_E	133_I	1.192	1.00
141_V	151_P	1.184	1.00
61_D	64_E	1.184	1.00
156_M	161_A	1.179	1.00
131_I	135_T	1.176	0.99
139_Y	184_T	1.176	0.99
119_V	162_A	1.171	0.99
139_Y	156_M	1.160	0.99
112_F	229_E	1.155	0.99
123_N	160_I	1.146	0.99
165_K	169_R	1.146	0.99
105_P	225_V	1.136	0.99
179_I	198_I	1.126	0.99
116_L	120_A	1.123	0.99
10_L	16_M	1.116	0.99
52_A	55_S	1.114	0.99
46_F	58_V	1.109	0.99
137_G	157_S	1.094	0.99
110_G	229_E	1.092	0.99
120_A	126_S	1.083	0.99
34_A	56_L	1.079	0.99
118_E	196_Q	1.075	0.99
16_M	52_A	1.047	0.99
140_V	221_I	1.040	0.99
125_L	133_I	1.038	0.99
52_A	143_M	1.031	0.99
128_E	226_R	1.025	0.99
19_F	31_V	1.025	0.99
133_I	136_N	1.021	0.99
187_Y	191_T	1.016	0.99
188_P	197_L	1.015	0.98
106_V	199_G	1.011	0.98
53_F	142_Y	1.011	0.98
151_P	216_L	1.010	0.98
113_G	116_L	1.001	0.98
101_I	223_K	0.996	0.98
176_S	200_K	0.986	0.98
20_G	27_V	0.979	0.98
134_H	198_I	0.977	0.98
176_S	197_L	0.964	0.98
99_R	221_I	0.964	0.98
217_R	220_D	0.961	0.98
203_L	215_L	0.961	0.98
155_G	185_G	0.959	0.98
77_F	81_K	0.959	0.98
119_V	123_N	0.958	0.98
162_A	196_Q	0.957	0.98
108_Y	135_T	0.951	0.98
116_L	127_P	0.947	0.98
25_E	140_V	0.947	0.98
36_A	39_E	0.936	0.97
156_M	180_A	0.931	0.97
178_G	197_L	0.931	0.97
108_Y	184_T	0.929	0.97
146_F	187_Y	0.915	0.97
125_L	130_V	0.915	0.97
154_G	183_Q	0.914	0.97
156_M	160_I	0.905	0.97
104_I	186_V	0.904	0.97
136_N	157_S	0.903	0.97
120_A	129_E	0.900	0.97
104_I	203_L	0.894	0.97
49_C	58_V	0.893	0.97
102_V	220_D	0.892	0.97
102_V	105_P	0.883	0.96
44_P	64_E	0.876	0.96
158_K	182_L	0.869	0.96
35_A	56_L	0.865	0.96
119_V	198_I	0.864	0.96
8_E	16_M	0.859	0.96
176_S	190_S	0.856	0.96
60_Y	63_Y	0.852	0.96
42_P	45_G	0.850	0.96
146_F	193_G	0.848	0.95
110_G	113_G	0.846	0.95
173_P	197_L	0.845	0.95
60_Y	65_V	0.840	0.95
39_E	49_C	0.838	0.95
153_L	224_F	0.838	0.95
49_C	56_L	0.836	0.95
143_M	218_A	0.835	0.95
137_G	155_G	0.833	0.95
116_L	131_I	0.831	0.95
60_Y	66_Y	0.831	0.95
187_Y	197_L	0.824	0.95
28_N	32_H	0.824	0.95
77_F	83_D	0.822	0.95
108_Y	131_I	0.819	0.95
105_P	202_P	0.812	0.94
18_R	54_T	0.811	0.94
38_I	42_P	0.811	0.94
36_A	40_E	0.807	0.94
45_G	61_D	0.800	0.94
174_A	204_A	0.796	0.94
141_V	222_V	0.792	0.93
120_A	130_V	0.782	0.93
62_M	65_V	0.780	0.93
46_F	49_C	0.780	0.93
181_G	185_G	0.779	0.93
10_L	14_A	0.771	0.93
79_S	83_D	0.768	0.92
186_V	224_F	0.767	0.92
119_V	122_I	0.767	0.92
210_E	215_L	0.763	0.92
123_N	156_M	0.759	0.92
32_H	35_A	0.756	0.92
138_E	156_M	0.752	0.92
193_G	197_L	0.749	0.91
38_I	58_V	0.749	0.91
191_T	197_L	0.749	0.91
77_F	84_V	0.748	0.91
147_A	189_I	0.743	0.91
122_I	163_P	0.743	0.91
31_V	51_P	0.743	0.91
134_H	224_F	0.728	0.90
141_V	220_D	0.723	0.90
181_G	196_Q	0.722	0.90
108_Y	224_F	0.718	0.90
165_K	170_P	0.713	0.89
151_P	205_L	0.709	0.89
122_I	196_Q	0.706	0.89
120_A	125_L	0.704	0.89
188_P	191_T	0.703	0.89
109_G	112_F	0.702	0.89
169_R	197_L	0.696	0.88
144_L	218_A	0.695	0.88
38_I	41_Q	0.691	0.88
184_T	198_I	0.684	0.87
131_I	134_H	0.684	0.87
48_E	59_F	0.683	0.87
157_S	160_I	0.673	0.86
104_I	216_L	0.672	0.86
139_Y	160_I	0.671	0.86
142_Y	183_Q	0.670	0.86
107_C	227_I	0.664	0.86
131_I	226_R	0.664	0.86
169_R	178_G	0.660	0.85
139_Y	150_F	0.657	0.85
107_C	228_S	0.656	0.85
115_D	169_R	0.651	0.85
216_L	222_V	0.649	0.84
20_G	30_I	0.646	0.84
169_R	187_Y	0.640	0.84
178_G	191_T	0.636	0.83
173_P	190_S	0.635	0.83
38_I	49_C	0.632	0.83
161_A	180_A	0.631	0.83
164_R	195_W	0.631	0.83
47_I	61_D	0.630	0.83
31_V	56_L	0.630	0.83
17_I	38_I	0.628	0.82
115_D	150_F	0.628	0.82
13_S	59_F	0.622	0.82
158_K	161_A	0.619	0.82
108_Y	139_Y	0.616	0.81
79_S	82_R	0.615	0.81
185_G	188_P	0.614	0.81
7_I	15_M	0.613	0.81
206_F	214_T	0.613	0.81
109_G	229_E	0.610	0.81
61_D	66_Y	0.606	0.80
169_R	193_G	0.604	0.80
86_E	93_E	0.604	0.80
125_L	129_E	0.604	0.80
21_E	54_T	0.602	0.80
35_A	51_P	0.602	0.80
92_A	97_V	0.601	0.80
16_M	55_S	0.600	0.80
189_I	214_T	0.598	0.79
153_L	185_G	0.597	0.79
14_A	170_P	0.594	0.79
148_P	152_F	0.593	0.79
30_I	34_A	0.589	0.78
13_S	47_I	0.589	0.78
45_G	65_V	0.589	0.78
26_Q	121_K	0.586	0.78
24_N	27_V	0.586	0.78
20_G	31_V	0.585	0.78
97_V	100_R	0.582	0.77
33_A	37_Y	0.581	0.77
53_F	143_M	0.580	0.77
19_F	30_I	0.580	0.77
8_E	37_Y	0.580	0.77
77_F	80_V	0.576	0.77
152_F	175_G	0.576	0.77
134_H	177_V	0.575	0.77
180_A	191_T	0.574	0.76
150_F	153_L	0.572	0.76
150_F	188_P	0.572	0.76
151_P	220_D	0.571	0.76
134_H	139_Y	0.571	0.76
95_Y	132_D	0.567	0.76
13_S	62_M	0.565	0.75
154_G	182_L	0.564	0.75
122_I	162_A	0.562	0.75
81_K	84_V	0.561	0.75
107_C	229_E	0.561	0.75
19_F	154_G	0.560	0.75
139_Y	179_I	0.560	0.75
7_I	81_K	0.559	0.75
16_M	143_M	0.559	0.75
100_R	212_P	0.557	0.74
82_R	96_E	0.557	0.74
172_I	189_I	0.555	0.74
127_P	131_I	0.552	0.74
188_P	193_G	0.551	0.74
106_V	130_V	0.550	0.73
10_L	13_S	0.547	0.73
7_I	17_I	0.547	0.73
32_H	36_A	0.547	0.73
9_Q	67_K	0.547	0.73
18_R	55_S	0.545	0.73
143_M	188_P	0.545	0.73
132_D	204_A	0.544	0.73
110_G	127_P	0.543	0.72
141_V	185_G	0.540	0.72
98_N	229_E	0.536	0.72
151_P	215_L	0.535	0.71
27_V	31_V	0.532	0.71
178_G	188_P	0.528	0.70
31_V	38_I	0.527	0.70
54_T	147_A	0.525	0.70
125_L	159_R	0.525	0.70
47_I	59_F	0.524	0.70
23_I	142_Y	0.524	0.70
9_Q	17_I	0.523	0.70
23_I	28_N	0.519	0.69
12_D	60_Y	0.519	0.69
14_A	59_F	0.519	0.69
53_F	152_F	0.518	0.69
86_E	98_N	0.517	0.69
83_D	86_E	0.516	0.69
136_N	223_K	0.515	0.68
143_M	191_T	0.512	0.68
44_P	82_R	0.511	0.68
215_L	224_F	0.511	0.68
15_M	58_V	0.511	0.68
113_G	197_L	0.509	0.68
44_P	96_E	0.508	0.67
143_M	189_I	0.507	0.67
29_G	140_V	0.507	0.67
85_E	94_D	0.505	0.67
100_R	217_R	0.504	0.67
165_K	171_S	0.503	0.67
160_I	196_Q	0.502	0.67
40_E	211_N	0.500	0.66
204_A	209_Q	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2phcB	1	0.9	100	0.068	Contact Map
3mmlB	1	0.875	100	0.154	Contact Map
3va7A	1	0.9458	100	0.162	Contact Map
3oepA	1	0.8542	100	0.173	Contact Map
2zp2A	1	0.5208	100	0.286	Contact Map
2kwaA	1	0.3708	99.6	0.793	Contact Map
4q2lA	1	0.2583	36.2	0.957	Contact Map
3mmlA	2	0.8458	28.5	0.96	Contact Map
1b4aA	5	0.3167	21.3	0.962	Contact Map
3lapA	6	0.3208	19.6	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.008 seconds.