GREMLIN Database
KIPI - Kinase A inhibitor
UniProt: P60495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (214)
Sequences: 2919 (2018)
Seq/√Len: 138.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_T226_R4.7161.00
103_E225_V4.3491.00
117_E127_P3.8671.00
133_I159_R3.3651.00
165_K196_Q3.3241.00
108_Y134_H3.2621.00
132_D136_N3.1461.00
138_E221_I3.0291.00
171_S190_S2.8641.00
100_R220_D2.7041.00
142_Y154_G2.5381.00
129_E132_D2.5361.00
119_V130_V2.4501.00
123_N162_A2.3031.00
118_E165_K2.2551.00
104_I201_T2.1801.00
187_Y193_G2.1531.00
141_V216_L2.1291.00
128_E132_D2.0631.00
126_S129_E1.9691.00
138_E223_K1.9451.00
103_E223_K1.9041.00
43_F46_F1.8421.00
207_R210_E1.7941.00
105_P203_L1.7741.00
133_I160_I1.7651.00
107_C112_F1.7491.00
205_L216_L1.7491.00
11_G14_A1.7191.00
117_E121_K1.7091.00
150_F185_G1.6131.00
133_I157_S1.6081.00
19_F34_A1.6071.00
109_G113_G1.5931.00
101_I138_E1.5881.00
134_H184_T1.5601.00
178_G187_Y1.5591.00
8_E18_R1.5411.00
35_A39_E1.5351.00
111_E229_E1.5031.00
120_A127_P1.4991.00
16_M57_T1.4991.00
35_A49_C1.4831.00
101_I221_I1.4701.00
61_D65_V1.4621.00
107_C200_K1.4521.00
178_G193_G1.4481.00
106_V177_V1.4411.00
60_Y67_K1.4311.00
17_I34_A1.4101.00
153_L222_V1.3861.00
37_Y41_Q1.3821.00
123_N130_V1.3721.00
50_I59_F1.3701.00
204_A207_R1.3691.00
14_A57_T1.3551.00
118_E121_K1.3531.00
202_P227_I1.3361.00
212_P217_R1.3241.00
178_G196_Q1.3191.00
6_Q18_R1.3131.00
120_A123_N1.3051.00
178_G185_G1.3021.00
161_A182_L1.2911.00
186_V205_L1.2751.00
42_P46_F1.2681.00
107_C202_P1.2571.00
10_L57_T1.2541.00
37_Y40_E1.2491.00
118_E122_I1.2281.00
147_A191_T1.2281.00
53_F183_Q1.2181.00
173_P176_S1.2141.00
81_K85_E1.1921.00
129_E133_I1.1921.00
141_V151_P1.1841.00
61_D64_E1.1841.00
156_M161_A1.1791.00
131_I135_T1.1760.99
139_Y184_T1.1760.99
119_V162_A1.1710.99
139_Y156_M1.1600.99
112_F229_E1.1550.99
123_N160_I1.1460.99
165_K169_R1.1460.99
105_P225_V1.1360.99
179_I198_I1.1260.99
116_L120_A1.1230.99
10_L16_M1.1160.99
52_A55_S1.1140.99
46_F58_V1.1090.99
137_G157_S1.0940.99
110_G229_E1.0920.99
120_A126_S1.0830.99
34_A56_L1.0790.99
118_E196_Q1.0750.99
16_M52_A1.0470.99
140_V221_I1.0400.99
125_L133_I1.0380.99
52_A143_M1.0310.99
128_E226_R1.0250.99
19_F31_V1.0250.99
133_I136_N1.0210.99
187_Y191_T1.0160.99
188_P197_L1.0150.98
106_V199_G1.0110.98
53_F142_Y1.0110.98
151_P216_L1.0100.98
113_G116_L1.0010.98
101_I223_K0.9960.98
176_S200_K0.9860.98
20_G27_V0.9790.98
134_H198_I0.9770.98
176_S197_L0.9640.98
99_R221_I0.9640.98
217_R220_D0.9610.98
203_L215_L0.9610.98
155_G185_G0.9590.98
77_F81_K0.9590.98
119_V123_N0.9580.98
162_A196_Q0.9570.98
108_Y135_T0.9510.98
116_L127_P0.9470.98
25_E140_V0.9470.98
36_A39_E0.9360.97
156_M180_A0.9310.97
178_G197_L0.9310.97
108_Y184_T0.9290.97
146_F187_Y0.9150.97
125_L130_V0.9150.97
154_G183_Q0.9140.97
156_M160_I0.9050.97
104_I186_V0.9040.97
136_N157_S0.9030.97
120_A129_E0.9000.97
104_I203_L0.8940.97
49_C58_V0.8930.97
102_V220_D0.8920.97
102_V105_P0.8830.96
44_P64_E0.8760.96
158_K182_L0.8690.96
35_A56_L0.8650.96
119_V198_I0.8640.96
8_E16_M0.8590.96
176_S190_S0.8560.96
60_Y63_Y0.8520.96
42_P45_G0.8500.96
146_F193_G0.8480.95
110_G113_G0.8460.95
173_P197_L0.8450.95
60_Y65_V0.8400.95
39_E49_C0.8380.95
153_L224_F0.8380.95
49_C56_L0.8360.95
143_M218_A0.8350.95
137_G155_G0.8330.95
116_L131_I0.8310.95
60_Y66_Y0.8310.95
187_Y197_L0.8240.95
28_N32_H0.8240.95
77_F83_D0.8220.95
108_Y131_I0.8190.95
105_P202_P0.8120.94
18_R54_T0.8110.94
38_I42_P0.8110.94
36_A40_E0.8070.94
45_G61_D0.8000.94
174_A204_A0.7960.94
141_V222_V0.7920.93
120_A130_V0.7820.93
62_M65_V0.7800.93
46_F49_C0.7800.93
181_G185_G0.7790.93
10_L14_A0.7710.93
79_S83_D0.7680.92
186_V224_F0.7670.92
119_V122_I0.7670.92
210_E215_L0.7630.92
123_N156_M0.7590.92
32_H35_A0.7560.92
138_E156_M0.7520.92
193_G197_L0.7490.91
38_I58_V0.7490.91
191_T197_L0.7490.91
77_F84_V0.7480.91
147_A189_I0.7430.91
122_I163_P0.7430.91
31_V51_P0.7430.91
134_H224_F0.7280.90
141_V220_D0.7230.90
181_G196_Q0.7220.90
108_Y224_F0.7180.90
165_K170_P0.7130.89
151_P205_L0.7090.89
122_I196_Q0.7060.89
120_A125_L0.7040.89
188_P191_T0.7030.89
109_G112_F0.7020.89
169_R197_L0.6960.88
144_L218_A0.6950.88
38_I41_Q0.6910.88
184_T198_I0.6840.87
131_I134_H0.6840.87
48_E59_F0.6830.87
157_S160_I0.6730.86
104_I216_L0.6720.86
139_Y160_I0.6710.86
142_Y183_Q0.6700.86
107_C227_I0.6640.86
131_I226_R0.6640.86
169_R178_G0.6600.85
139_Y150_F0.6570.85
107_C228_S0.6560.85
115_D169_R0.6510.85
216_L222_V0.6490.84
20_G30_I0.6460.84
169_R187_Y0.6400.84
178_G191_T0.6360.83
173_P190_S0.6350.83
38_I49_C0.6320.83
161_A180_A0.6310.83
164_R195_W0.6310.83
47_I61_D0.6300.83
31_V56_L0.6300.83
17_I38_I0.6280.82
115_D150_F0.6280.82
13_S59_F0.6220.82
158_K161_A0.6190.82
108_Y139_Y0.6160.81
79_S82_R0.6150.81
185_G188_P0.6140.81
7_I15_M0.6130.81
206_F214_T0.6130.81
109_G229_E0.6100.81
61_D66_Y0.6060.80
169_R193_G0.6040.80
86_E93_E0.6040.80
125_L129_E0.6040.80
21_E54_T0.6020.80
35_A51_P0.6020.80
92_A97_V0.6010.80
16_M55_S0.6000.80
189_I214_T0.5980.79
153_L185_G0.5970.79
14_A170_P0.5940.79
148_P152_F0.5930.79
30_I34_A0.5890.78
13_S47_I0.5890.78
45_G65_V0.5890.78
26_Q121_K0.5860.78
24_N27_V0.5860.78
20_G31_V0.5850.78
97_V100_R0.5820.77
33_A37_Y0.5810.77
53_F143_M0.5800.77
19_F30_I0.5800.77
8_E37_Y0.5800.77
77_F80_V0.5760.77
152_F175_G0.5760.77
134_H177_V0.5750.77
180_A191_T0.5740.76
150_F153_L0.5720.76
150_F188_P0.5720.76
151_P220_D0.5710.76
134_H139_Y0.5710.76
95_Y132_D0.5670.76
13_S62_M0.5650.75
154_G182_L0.5640.75
122_I162_A0.5620.75
81_K84_V0.5610.75
107_C229_E0.5610.75
19_F154_G0.5600.75
139_Y179_I0.5600.75
7_I81_K0.5590.75
16_M143_M0.5590.75
100_R212_P0.5570.74
82_R96_E0.5570.74
172_I189_I0.5550.74
127_P131_I0.5520.74
188_P193_G0.5510.74
106_V130_V0.5500.73
10_L13_S0.5470.73
7_I17_I0.5470.73
32_H36_A0.5470.73
9_Q67_K0.5470.73
18_R55_S0.5450.73
143_M188_P0.5450.73
132_D204_A0.5440.73
110_G127_P0.5430.72
141_V185_G0.5400.72
98_N229_E0.5360.72
151_P215_L0.5350.71
27_V31_V0.5320.71
178_G188_P0.5280.70
31_V38_I0.5270.70
54_T147_A0.5250.70
125_L159_R0.5250.70
47_I59_F0.5240.70
23_I142_Y0.5240.70
9_Q17_I0.5230.70
23_I28_N0.5190.69
12_D60_Y0.5190.69
14_A59_F0.5190.69
53_F152_F0.5180.69
86_E98_N0.5170.69
83_D86_E0.5160.69
136_N223_K0.5150.68
143_M191_T0.5120.68
44_P82_R0.5110.68
215_L224_F0.5110.68
15_M58_V0.5110.68
113_G197_L0.5090.68
44_P96_E0.5080.67
143_M189_I0.5070.67
29_G140_V0.5070.67
85_E94_D0.5050.67
100_R217_R0.5040.67
165_K171_S0.5030.67
160_I196_Q0.5020.67
40_E211_N0.5000.66
204_A209_Q0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2phcB 1 0.9 100 0.068 Contact Map
3mmlB 1 0.875 100 0.154 Contact Map
3va7A 1 0.9458 100 0.162 Contact Map
3oepA 1 0.8542 100 0.173 Contact Map
2zp2A 1 0.5208 100 0.286 Contact Map
2kwaA 1 0.3708 99.6 0.793 Contact Map
4q2lA 1 0.2583 36.2 0.957 Contact Map
3mmlA 2 0.8458 28.5 0.96 Contact Map
1b4aA 5 0.3167 21.3 0.962 Contact Map
3lapA 6 0.3208 19.6 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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