GREMLIN Database
YCGA - Uncharacterized protein YcgA
UniProt: P55908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (432)
Sequences: 3071 (2140)
Seq/√Len: 103.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_T325_Q4.0291.00
456_L460_L3.9241.00
218_S461_I3.8231.00
24_V313_A3.3791.00
104_K322_T3.3621.00
312_A315_D3.2651.00
135_S212_Y3.0721.00
225_L229_K2.9351.00
452_V456_L2.8971.00
221_I225_L2.8881.00
464_V468_I2.8651.00
31_F35_I2.8161.00
381_H423_V2.6441.00
268_L272_V2.5931.00
402_A412_A2.5921.00
403_D409_R2.5651.00
92_I334_V2.5101.00
444_Y448_L2.4331.00
131_G223_I2.3791.00
233_S236_A2.3531.00
365_S368_A2.3051.00
128_C224_Y2.2861.00
282_Y287_L2.2381.00
28_M32_I2.2081.00
381_H420_E2.1951.00
227_T230_L2.1831.00
32_I36_A2.1631.00
74_F343_I2.1541.00
379_L383_L2.1461.00
224_Y228_R2.1191.00
377_S390_E2.1051.00
378_A423_V2.0881.00
460_L464_V2.0531.00
386_S389_G2.0521.00
114_N118_K2.0471.00
371_I463_L2.0241.00
367_I467_V1.9761.00
271_A275_L1.9661.00
467_V471_M1.9461.00
203_S410_Q1.9381.00
235_D240_G1.8721.00
213_I217_L1.8721.00
381_H390_E1.8701.00
420_E423_V1.8621.00
77_S80_D1.8411.00
104_K315_D1.8261.00
398_L412_A1.8261.00
371_I467_V1.8181.00
272_V276_S1.8121.00
420_E424_N1.8011.00
222_Y226_Y1.7641.00
40_V45_F1.7611.00
239_L242_D1.7561.00
75_F300_F1.7461.00
267_K271_A1.7441.00
36_A39_I1.7351.00
304_L308_I1.7331.00
377_S394_F1.7321.00
408_T411_V1.7301.00
129_I220_I1.7081.00
170_A450_F1.7021.00
282_Y286_K1.7011.00
390_E394_F1.6991.00
73_S77_S1.6981.00
42_A66_Q1.6891.00
80_D83_V1.6761.00
197_A399_A1.6741.00
36_A40_V1.6621.00
219_S458_W1.6561.00
211_I465_F1.6351.00
127_I161_L1.6291.00
209_V213_I1.6261.00
205_I209_V1.6251.00
100_A323_G1.6171.00
38_Y42_A1.6171.00
237_S240_G1.6101.00
274_G278_V1.5901.00
30_A343_I1.5641.00
75_F78_L1.5621.00
265_R310_G1.5601.00
387_G420_E1.5511.00
276_S301_I1.5441.00
223_I227_T1.5361.00
302_S306_G1.5341.00
78_L83_V1.5211.00
97_G320_F1.5151.00
47_R351_D1.5151.00
228_R231_K1.5061.00
324_C332_L1.5051.00
135_S216_L1.4841.00
304_L307_L1.4831.00
167_A231_K1.4781.00
224_Y227_T1.4751.00
70_R73_S1.4741.00
269_I309_G1.4661.00
222_Y225_L1.4621.00
189_P387_G1.4591.00
281_L285_L1.4581.00
373_M398_L1.4401.00
371_I375_I1.4381.00
101_I302_S1.4381.00
215_F219_S1.4291.00
210_V465_F1.4241.00
164_D167_A1.4161.00
216_L220_I1.4141.00
357_L361_L1.4121.00
71_L75_F1.3991.00
33_C344_L1.3911.00
319_T322_T1.3871.00
370_A411_V1.3811.00
305_A310_G1.3681.00
132_A171_V1.3660.99
129_I216_L1.3560.99
76_T80_D1.3540.99
193_S197_A1.3540.99
240_G243_W1.3520.99
200_P204_G1.3460.99
226_Y229_K1.3350.99
306_G316_I1.3310.99
222_Y229_K1.3270.99
45_F355_N1.3260.99
27_F31_F1.3230.99
263_T266_H1.3170.99
110_G254_K1.3140.99
207_L211_I1.3070.99
119_F130_V1.3040.99
222_Y457_I1.3010.99
264_V308_I1.3000.99
44_E348_K1.2920.99
101_I320_F1.2920.99
225_L228_R1.2910.99
273_A277_L1.2890.99
217_L221_I1.2850.99
47_R355_N1.2760.99
236_A239_L1.2520.99
104_K319_T1.2510.99
226_Y230_L1.2420.99
269_I272_V1.2410.99
272_V283_G1.2390.99
422_V459_F1.2380.99
204_G208_R1.2380.99
40_V349_L1.2380.99
236_A240_G1.2220.99
264_V268_L1.2210.99
228_R232_K1.2200.99
374_Y463_L1.2180.99
230_L233_S1.2160.99
107_A266_H1.2160.99
305_A309_G1.2070.99
468_I471_M1.2070.99
108_I149_G1.2050.99
378_A459_F1.2040.99
80_D346_N1.2030.99
105_T309_G1.1960.99
192_L195_S1.1880.99
21_D317_A1.1840.99
204_G207_L1.1790.98
241_T244_F1.1760.98
443_P446_K1.1730.98
358_A404_L1.1710.98
270_L274_G1.1640.98
199_L203_S1.1620.98
166_V450_F1.1580.98
225_L232_K1.1540.98
390_E420_E1.1530.98
324_C328_V1.1480.98
169_A440_S1.1460.98
81_G339_S1.1440.98
302_S310_G1.1430.98
75_F79_Q1.1430.98
212_Y216_L1.1420.98
303_V307_L1.1400.98
171_V175_G1.1380.98
110_G266_H1.1370.98
262_F266_H1.1360.98
277_L281_L1.1350.98
34_A74_F1.1300.98
375_I459_F1.1220.98
23_Y336_M1.1200.98
34_A38_Y1.1200.98
138_G146_S1.1180.98
376_A390_E1.1140.98
121_T126_F1.1130.98
419_G423_V1.1120.98
128_C171_V1.1060.98
366_P405_M1.1040.98
78_L82_M1.1010.98
260_V264_V1.0980.98
166_V170_A1.0970.98
73_S76_T1.0930.98
69_V347_G1.0920.98
132_A220_I1.0910.98
114_N117_S1.0890.97
180_F387_G1.0870.97
92_I330_G1.0870.97
40_V43_G1.0860.97
292_S296_A1.0840.97
78_L81_G1.0840.97
431_G435_A1.0820.97
38_Y41_P1.0820.97
381_H424_N1.0820.97
28_M31_F1.0800.97
21_D24_V1.0790.97
222_Y230_L1.0780.97
114_N259_S1.0780.97
84_G338_R1.0780.97
301_I304_L1.0750.97
224_Y230_L1.0730.97
139_T184_I1.0700.97
178_A458_W1.0690.97
314_N318_K1.0580.97
223_I230_L1.0500.97
468_I472_I1.0470.97
266_H270_L1.0430.97
299_I302_S1.0430.97
75_F83_V1.0390.97
261_P265_R1.0360.97
252_A255_E1.0350.97
382_F423_V1.0320.97
120_R126_F1.0300.96
174_I451_M1.0290.96
158_A171_V1.0270.96
266_H269_I1.0210.96
191_G194_Q1.0190.96
172_I175_G1.0180.96
177_Y182_S1.0160.96
193_S395_I1.0120.96
82_M90_F1.0110.96
302_S309_G1.0110.96
278_V282_Y1.0000.96
262_F265_R0.9990.96
272_V275_L0.9970.96
208_R212_Y0.9970.96
306_G310_G0.9960.96
205_I212_Y0.9950.96
230_L234_K0.9940.96
370_A466_I0.9910.96
239_L243_W0.9900.96
100_A319_T0.9860.95
348_K351_D0.9830.95
374_Y459_F0.9810.95
235_D239_L0.9760.95
327_L330_G0.9740.95
147_V177_Y0.9730.95
30_A339_S0.9710.95
71_L77_S0.9680.95
451_M455_A0.9590.95
300_F304_L0.9590.95
67_S348_K0.9590.95
234_K237_S0.9580.95
155_L169_A0.9540.95
131_G154_G0.9530.95
375_I379_L0.9530.95
93_L327_L0.9510.94
426_V455_A0.9500.94
149_G152_P0.9480.94
359_S362_D0.9470.94
231_K234_K0.9450.94
261_P308_I0.9430.94
268_L271_A0.9410.94
374_Y462_G0.9410.94
147_V176_C0.9400.94
167_A228_R0.9400.94
223_I454_L0.9360.94
432_V439_A0.9360.94
220_I457_I0.9350.94
356_A360_L0.9330.94
23_Y329_Y0.9310.94
273_A276_S0.9280.94
390_E423_V0.9270.94
70_R74_F0.9260.94
101_I316_I0.9220.94
79_Q82_M0.9220.94
79_Q83_V0.9210.93
21_D329_Y0.9200.93
30_A74_F0.9190.93
269_I273_A0.9180.93
378_A381_H0.9160.93
241_T446_K0.9130.93
267_K273_A0.9100.93
137_L184_I0.9090.93
225_L230_L0.9080.93
330_G334_V0.9060.93
101_I299_I0.9030.93
337_A389_G0.8960.93
192_L196_I0.8940.92
355_N358_A0.8940.92
232_K235_D0.8940.92
165_A243_W0.8920.92
399_A409_R0.8910.92
194_Q199_L0.8910.92
264_V267_K0.8870.92
163_W168_G0.8840.92
306_G311_L0.8800.92
295_A299_I0.8770.92
101_I105_T0.8760.92
93_L96_G0.8760.92
77_S346_N0.8720.91
91_L94_F0.8680.91
180_F183_T0.8670.91
461_I465_F0.8650.91
202_F205_I0.8650.91
197_A409_R0.8650.91
387_G424_N0.8620.91
237_S241_T0.8580.91
34_A69_V0.8570.91
21_D314_N0.8560.91
216_L228_R0.8540.91
368_A467_V0.8520.91
390_E416_V0.8500.90
44_E47_R0.8500.90
355_N359_S0.8480.90
210_V213_I0.8460.90
178_A219_S0.8440.90
422_V455_A0.8440.90
223_I226_Y0.8430.90
303_V310_G0.8420.90
179_G182_S0.8420.90
201_L204_G0.8410.90
337_A386_S0.8400.90
37_S347_G0.8400.90
268_L300_F0.8400.90
25_L28_M0.8370.90
200_P203_S0.8370.90
206_G210_V0.8360.90
268_L304_L0.8360.90
119_F419_G0.8350.90
380_L384_I0.8330.90
30_A33_C0.8300.89
357_L360_L0.8300.89
144_V148_I0.8280.89
302_S311_L0.8280.89
89_I335_G0.8260.89
198_E399_A0.8250.89
188_S191_G0.8240.89
173_Y425_C0.8200.89
303_V309_G0.8200.89
70_R81_G0.8190.89
220_I224_Y0.8180.89
400_P403_D0.8170.89
224_Y231_K0.8110.88
212_Y227_T0.8110.88
415_A419_G0.8110.88
415_A466_I0.8080.88
421_G424_N0.8030.88
78_L339_S0.8010.88
267_K272_V0.8000.88
177_Y425_C0.7980.87
384_I393_V0.7960.87
207_L210_V0.7940.87
106_G110_G0.7930.87
417_M420_E0.7930.87
315_D319_T0.7900.87
351_D355_N0.7900.87
311_L319_T0.7890.87
418_L466_I0.7880.87
169_A442_I0.7880.87
75_F80_D0.7870.87
139_T212_Y0.7870.87
178_A215_F0.7850.87
238_V243_W0.7820.86
180_F189_P0.7810.86
242_D245_P0.7800.86
147_V172_I0.7790.86
74_F78_L0.7780.86
411_V466_I0.7740.86
267_K270_L0.7730.86
23_Y317_A0.7720.86
42_A48_V0.7700.86
128_C163_W0.7700.86
98_T102_L0.7680.85
240_G244_F0.7660.85
205_I208_R0.7660.85
305_A311_L0.7650.85
199_L204_G0.7620.85
24_V28_M0.7620.85
303_V471_M0.7610.85
241_T245_P0.7590.85
159_R165_A0.7560.84
111_L114_N0.7540.84
177_Y385_S0.7510.84
147_V425_C0.7480.84
358_A401_L0.7470.84
142_I189_P0.7440.84
34_A68_P0.7440.84
135_S369_G0.7440.84
257_D260_V0.7430.83
349_L361_L0.7430.83
203_S208_R0.7400.83
349_L352_T0.7380.83
148_I436_V0.7380.83
381_H419_G0.7370.83
422_V462_G0.7360.83
144_V432_V0.7340.83
385_S430_S0.7330.83
271_A276_S0.7330.83
212_Y215_F0.7310.82
211_I418_L0.7300.82
201_L205_I0.7290.82
383_L427_N0.7280.82
211_I462_G0.7270.82
221_I457_I0.7260.82
25_L83_V0.7260.82
85_S338_R0.7250.82
350_L358_A0.7240.82
35_I39_I0.7230.82
136_I140_T0.7220.82
386_S424_N0.7200.81
433_L444_Y0.7190.81
381_H387_G0.7180.81
138_G147_V0.7180.81
78_L335_G0.7180.81
357_L401_L0.7170.81
182_S185_L0.7120.81
38_Y347_G0.7110.81
294_M297_T0.7110.81
267_K277_L0.7100.81
343_I347_G0.7090.80
430_S434_M0.7070.80
165_A168_G0.7050.80
370_A415_A0.7040.80
128_C220_I0.7040.80
68_P72_I0.7030.80
272_V304_L0.7030.80
31_F34_A0.7030.80
261_P266_H0.7010.80
229_K232_K0.7000.80
430_S433_L0.7000.80
24_V314_N0.6990.80
312_A316_I0.6950.79
66_Q69_V0.6930.79
282_Y285_L0.6920.79
38_Y68_P0.6910.79
204_G210_V0.6910.79
302_S305_A0.6900.79
211_I339_S0.6900.79
306_G309_G0.6890.79
372_G375_I0.6890.79
387_G390_E0.6880.78
420_E427_N0.6870.78
132_A216_L0.6870.78
135_S139_T0.6850.78
195_S198_E0.6850.78
170_A451_M0.6850.78
433_L437_L0.6840.78
158_A168_G0.6830.78
136_I175_G0.6800.78
163_W224_Y0.6780.77
69_V73_S0.6770.77
170_A175_G0.6770.77
290_S294_M0.6750.77
354_V357_L0.6750.77
73_S346_N0.6740.77
199_L410_Q0.6720.77
265_R269_I0.6720.77
32_I39_I0.6700.77
232_K236_A0.6700.77
316_I319_T0.6680.76
217_L220_I0.6670.76
265_R268_L0.6670.76
402_A409_R0.6660.76
373_M412_A0.6650.76
358_A361_L0.6650.76
302_S316_I0.6640.76
315_D318_K0.6640.76
212_Y230_L0.6640.76
257_D261_P0.6630.76
146_S188_S0.6630.76
412_A415_A0.6620.76
68_P71_L0.6590.75
364_F368_A0.6580.75
210_V217_L0.6570.75
78_L343_I0.6560.75
222_Y228_R0.6510.75
128_C132_A0.6510.75
23_Y387_G0.6470.74
171_V219_S0.6460.74
69_V74_F0.6430.74
92_I152_P0.6400.73
98_T302_S0.6400.73
174_I455_A0.6390.73
265_R309_G0.6390.73
414_E469_G0.6380.73
263_T267_K0.6380.73
357_L376_A0.6360.73
269_I301_I0.6360.73
227_T234_K0.6340.73
464_V467_V0.6340.73
370_A407_I0.6340.73
301_I309_G0.6320.72
177_Y430_S0.6310.72
178_A425_C0.6300.72
174_I458_W0.6290.72
214_C465_F0.6270.72
307_L310_G0.6270.72
411_V469_G0.6270.72
163_W417_M0.6260.72
457_I460_L0.6260.72
147_V432_V0.6210.71
155_L168_G0.6170.71
209_V212_Y0.6170.71
276_S279_G0.6150.70
354_V393_V0.6140.70
33_C349_L0.6140.70
188_S413_V0.6140.70
225_L231_K0.6110.70
164_D450_F0.6110.70
132_A136_I0.6100.70
110_G258_Q0.6100.70
367_I471_M0.6100.70
71_L79_Q0.6090.70
440_S447_W0.6090.70
268_L276_S0.6090.70
111_L270_L0.6080.69
279_G285_L0.6080.69
136_I139_T0.6080.69
426_V452_V0.6060.69
166_V238_V0.6060.69
262_F267_K0.6060.69
292_S297_T0.6020.69
278_V359_S0.6000.68
387_G430_S0.5990.68
276_S283_G0.5990.68
35_I456_L0.5970.68
116_I150_F0.5960.68
85_S88_I0.5930.68
102_L305_A0.5900.67
290_S293_Q0.5890.67
104_K326_S0.5860.67
296_A299_I0.5840.66
158_A223_I0.5830.66
73_S81_G0.5820.66
142_I145_N0.5810.66
31_F74_F0.5800.66
361_L364_F0.5790.66
39_I127_I0.5790.66
287_L290_S0.5790.66
29_I32_I0.5790.66
370_A470_V0.5780.66
154_G158_A0.5780.66
271_A309_G0.5770.65
181_N193_S0.5740.65
321_I325_Q0.5740.65
324_C327_L0.5720.65
177_Y444_Y0.5690.64
66_Q71_L0.5690.64
33_C343_I0.5680.64
27_F30_A0.5680.64
334_V386_S0.5680.64
173_Y421_G0.5670.64
105_T320_F0.5670.64
222_Y227_T0.5650.64
32_I310_G0.5650.64
71_L78_L0.5640.64
105_T311_L0.5640.64
418_L462_G0.5640.64
267_K283_G0.5640.64
197_A403_D0.5640.64
96_G323_G0.5630.64
152_P156_I0.5620.63
23_Y27_F0.5610.63
132_A219_S0.5600.63
266_H272_V0.5590.63
342_V346_N0.5580.63
142_I188_S0.5570.63
264_V275_L0.5570.63
155_L439_A0.5560.63
108_I291_D0.5560.63
466_I469_G0.5550.62
416_V420_E0.5530.62
369_G402_A0.5530.62
167_A227_T0.5530.62
406_G419_G0.5530.62
163_W231_K0.5530.62
366_P407_I0.5530.62
442_I446_K0.5520.62
361_L372_G0.5520.62
427_N432_V0.5520.62
211_I216_L0.5510.62
249_M252_A0.5500.62
207_L216_L0.5490.62
360_L364_F0.5490.62
200_P205_I0.5480.62
257_D310_G0.5470.61
377_S381_H0.5470.61
422_V458_W0.5450.61
91_L95_T0.5420.61
180_F420_E0.5420.61
194_Q201_L0.5420.61
390_E398_L0.5410.61
250_G256_E0.5410.61
176_C432_V0.5410.61
24_V27_F0.5380.60
116_I159_R0.5380.60
147_V151_I0.5370.60
148_I432_V0.5370.60
22_A432_V0.5350.60
216_L219_S0.5350.60
373_M390_E0.5340.60
227_T232_K0.5330.59
122_K126_F0.5320.59
425_C433_L0.5320.59
269_I276_S0.5310.59
34_A67_S0.5300.59
75_F82_M0.5290.59
82_M89_I0.5290.59
198_E280_F0.5260.58
281_L284_A0.5250.58
117_S129_I0.5250.58
373_M377_S0.5250.58
77_S81_G0.5250.58
148_I151_I0.5240.58
133_L138_G0.5230.58
191_G201_L0.5220.58
111_L262_F0.5220.58
331_A335_G0.5210.58
82_M331_A0.5210.58
83_V89_I0.5210.58
41_P45_F0.5200.58
267_K280_F0.5200.58
270_L273_A0.5190.57
144_V147_V0.5190.57
167_A230_L0.5180.57
253_G256_E0.5170.57
190_L194_Q0.5170.57
358_A405_M0.5170.57
254_K261_P0.5160.57
399_A403_D0.5150.57
93_L177_Y0.5140.57
207_L469_G0.5140.57
191_G202_F0.5140.57
437_L442_I0.5130.57
110_G114_N0.5130.57
275_L308_I0.5130.57
33_C347_G0.5120.56
229_K236_A0.5120.56
218_S457_I0.5100.56
219_S226_Y0.5090.56
138_G180_F0.5080.56
304_L310_G0.5080.56
214_C461_I0.5070.56
170_A223_I0.5070.56
199_L208_R0.5060.56
145_N188_S0.5050.55
69_V72_I0.5020.55
241_T464_V0.5020.55
381_H421_G0.5020.55
163_W167_A0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.914 100 0.434 Contact Map
4r1iA 2 0.9644 100 0.442 Contact Map
4f35D 2 0.8574 100 0.747 Contact Map
4pd6A 3 0.696 73.6 0.96 Contact Map
3giaA 1 0.4403 73.5 0.96 Contact Map
4tphA 2 0.4235 56.9 0.964 Contact Map
3qnqA 2 0.4885 55.9 0.965 Contact Map
4ikvA 1 0.8323 52.1 0.965 Contact Map
4j05A 3 0.4193 51 0.966 Contact Map
4pypA 1 0.3941 46.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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