GREMLIN Database
IF3 - Translation initiation factor IF-3
UniProt: P55872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (163)
Sequences: 2526 (1460)
Seq/√Len: 114.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_F144_A4.0151.00
19_L30_K3.5091.00
106_N109_K2.9291.00
97_E101_N2.8211.00
108_I147_E2.7541.00
152_E167_A2.7501.00
143_E146_A2.6491.00
22_Q42_A2.5681.00
149_A166_L2.5531.00
108_I112_E2.2161.00
37_E41_R2.1981.00
21_G25_D2.1571.00
136_R139_D2.1491.00
34_E37_E2.1241.00
108_I148_V2.0931.00
48_L58_C2.0351.00
21_G42_A2.0251.00
31_S34_E2.0191.00
98_H101_N2.0171.00
107_A141_F1.9791.00
130_H133_I1.9681.00
135_Q139_D1.9451.00
14_A48_L1.9311.00
44_L60_I1.8781.00
36_L40_G1.8261.00
16_E54_K1.8181.00
107_A119_A1.7561.00
66_F70_Q1.7401.00
111_L149_A1.6671.00
38_I42_A1.6661.00
17_V58_C1.6651.00
38_I60_I1.6351.00
18_R26_Q1.6201.00
104_L144_A1.6151.00
104_L141_F1.5921.00
123_F134_G1.5891.00
37_E40_G1.5501.00
123_F162_M1.5251.00
14_A32_R1.5201.00
18_R29_I1.4721.00
139_D154_K1.4221.00
138_L164_L1.4051.00
142_S164_L1.3881.00
128_I131_K1.3801.00
102_T106_N1.3641.00
139_D142_S1.3571.00
47_V61_M1.3531.00
122_R161_S1.3471.00
67_R71_Q1.3301.00
107_A117_V1.3291.00
101_N104_L1.3141.00
10_E40_G1.3111.00
38_I41_R1.3001.00
151_V164_L1.2981.00
21_G27_L1.2880.99
150_T169_K1.2670.99
17_V32_R1.2670.99
100_F140_R1.2410.99
119_A141_F1.2400.99
140_R144_A1.2400.99
27_L30_K1.2400.99
109_K113_K1.2010.99
70_Q73_K1.1990.99
32_R58_C1.1990.99
90_R120_S1.1890.99
94_T127_A1.1840.99
121_I138_L1.1680.99
107_A145_C1.1650.99
139_D143_E1.1610.99
8_V63_Y1.1330.99
85_N115_D1.1090.98
48_L56_P1.1010.98
112_E148_V1.0990.98
89_V107_A1.0820.98
135_Q162_M1.0720.98
91_L119_A1.0660.98
20_I26_Q1.0660.98
100_F104_L1.0640.98
90_R122_R1.0600.98
121_I131_K1.0600.98
68_F72_K1.0420.98
105_R108_I1.0320.97
9_N45_D1.0290.97
22_Q44_L0.9870.97
153_T156_K0.9860.97
95_I137_V0.9820.97
139_D155_P0.9800.97
146_A169_K0.9400.96
153_T165_M0.9370.96
30_K38_I0.9300.95
9_N12_I0.9300.95
98_H102_T0.9290.95
48_L51_A0.9240.95
20_I28_G0.9090.95
142_S154_K0.9070.95
16_E31_S0.9070.95
26_Q29_I0.9020.95
116_K165_M0.8690.93
133_I136_R0.8680.93
67_R73_K0.8600.93
145_C149_A0.8570.93
92_S122_R0.8550.93
124_K127_A0.8530.93
17_V35_A0.8410.92
51_A55_P0.8370.92
111_L145_C0.8300.92
30_K34_E0.8300.92
34_E38_I0.8300.92
33_Q36_L0.8200.91
90_R100_F0.8190.91
32_R48_L0.8190.91
137_V140_R0.8040.90
77_A81_Q0.8040.90
33_Q37_E0.8020.90
67_R70_Q0.7980.90
49_V54_K0.7920.90
91_L121_I0.7810.89
146_A149_A0.7800.89
96_D114_G0.7780.89
39_A45_D0.7780.89
136_R140_R0.7750.89
72_K75_K0.7730.89
157_M161_S0.7700.88
109_K117_V0.7700.88
46_L58_C0.7690.88
138_L160_R0.7660.88
142_S151_V0.7610.88
117_V145_C0.7590.88
121_I137_V0.7580.88
65_K68_F0.7510.87
142_S146_A0.7410.86
157_M162_M0.7390.86
104_L108_I0.7390.86
14_A17_V0.7370.86
16_E29_I0.7340.86
49_V57_V0.7310.86
142_S166_L0.7230.85
128_I160_R0.7220.85
21_G28_G0.7190.85
95_I153_T0.7130.84
20_I24_G0.7120.84
21_G26_Q0.7110.84
86_L165_M0.7070.84
142_S149_A0.7040.83
101_N105_R0.7000.83
150_T167_A0.6960.83
35_A39_A0.6920.82
77_A85_N0.6920.82
92_S127_A0.6910.82
18_R55_P0.6760.81
136_R143_E0.6750.81
75_K79_K0.6730.81
128_I157_M0.6700.80
93_P123_F0.6660.80
116_K152_E0.6640.80
61_M95_I0.6640.80
88_E120_S0.6620.80
131_K157_M0.6620.80
119_A164_L0.6620.80
132_E136_R0.6570.79
26_Q61_M0.6560.79
74_E78_R0.6550.79
93_P120_S0.6520.79
152_E165_M0.6490.78
92_S124_K0.6480.78
32_R38_I0.6440.78
73_K76_E0.6430.78
96_D161_S0.6320.76
91_L137_V0.6270.76
69_E73_K0.6260.76
82_K158_D0.6250.76
129_T133_I0.6250.76
27_L38_I0.6230.75
22_Q60_I0.6220.75
17_V31_S0.6210.75
69_E74_E0.6160.75
71_Q82_K0.6140.74
135_Q157_M0.6140.74
69_E122_R0.6120.74
90_R93_P0.6110.74
155_P159_G0.6090.74
88_E118_K0.6080.74
63_Y68_F0.6050.73
71_Q150_T0.6050.73
145_C166_L0.5980.72
108_I146_A0.5910.71
98_H106_N0.5900.71
93_P103_K0.5860.71
95_I102_T0.5860.71
153_T166_L0.5820.70
57_V124_K0.5800.70
101_N144_A0.5790.70
76_E79_K0.5770.70
147_E169_K0.5750.69
64_G127_A0.5720.69
94_T106_N0.5700.69
102_T105_R0.5670.68
93_P121_I0.5650.68
43_N68_F0.5640.68
91_L100_F0.5640.68
32_R36_L0.5630.68
96_D106_N0.5630.68
18_R49_V0.5580.67
89_V110_F0.5570.67
49_V75_K0.5540.67
150_T170_N0.5540.67
15_R31_S0.5530.66
105_R113_K0.5520.66
91_L107_A0.5510.66
105_R109_K0.5510.66
121_I161_S0.5500.66
129_T132_E0.5470.66
35_A45_D0.5460.65
74_E82_K0.5460.65
51_A116_K0.5450.65
65_K125_G0.5450.65
90_R161_S0.5410.65
92_S100_F0.5400.65
26_Q49_V0.5390.64
87_K99_D0.5360.64
124_K155_P0.5360.64
103_K134_G0.5340.64
135_Q154_K0.5310.63
49_V94_T0.5290.63
73_K77_A0.5270.63
37_E43_N0.5270.63
105_R112_E0.5230.62
58_C95_I0.5180.61
96_D130_H0.5170.61
12_I17_V0.5170.61
89_V119_A0.5170.61
111_L148_V0.5160.61
91_L95_I0.5140.61
20_I59_R0.5120.61
45_D126_R0.5110.60
13_R16_E0.5100.60
43_N90_R0.5100.60
158_D162_M0.5080.60
67_R95_I0.5080.60
71_Q74_E0.5060.60
132_E165_M0.5050.60
94_T133_I0.5040.59
112_E147_E0.5030.59
29_I32_R0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ifeA 1 0.5202 100 0.478 Contact Map
1tigA 1 0.5087 99.9 0.493 Contact Map
1tifA 1 0.4393 99.9 0.507 Contact Map
2crqA 1 0.5838 99.9 0.515 Contact Map
1i96V 1 0.4971 99.9 0.516 Contact Map
2m71A 1 0.5318 99.9 0.518 Contact Map
1pbjA 2 0.2254 38.2 0.933 Contact Map
2rihA 2 0.2717 26.8 0.938 Contact Map
3gbyA 2 0.2486 23.1 0.94 Contact Map
3kpbA 2 0.2312 23.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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