GREMLIN Database
MRAZ - Transcriptional regulator MraZ
UniProt: P55343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (133)
Sequences: 2439 (1654)
Seq/√Len: 143.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_E117_K4.0231.00
98_K119_I3.4671.00
47_E50_Q2.9781.00
32_L40_L2.9761.00
104_V117_K2.8701.00
117_K121_E2.5691.00
16_M105_V2.4461.00
14_G94_L2.4291.00
42_G114_L2.4121.00
32_L89_I2.1311.00
42_G112_I2.1261.00
38_Q119_I2.0871.00
100_E116_S2.0441.00
7_Q104_V2.0171.00
70_R113_E1.8841.00
119_I122_Q1.8821.00
31_V45_M1.8671.00
3_M52_E1.8541.00
9_T102_E1.8191.00
118_V122_Q1.7581.00
91_S95_N1.7271.00
2_F112_I1.6401.00
116_S119_I1.5881.00
77_T90_A1.5701.00
37_D66_R1.5521.00
50_Q53_E1.4441.00
45_M49_K1.4391.00
16_M103_C1.4251.00
73_F109_S1.4221.00
59_P65_A1.4101.00
7_Q117_K1.3951.00
60_L69_T1.3901.00
3_M78_E1.3651.00
29_Q78_E1.3581.00
44_P47_E1.3491.00
47_E110_N1.3331.00
79_C87_V1.2981.00
22_F112_I1.2951.00
41_F111_R1.2901.00
99_L116_S1.2731.00
29_Q45_M1.2721.00
38_Q96_Y1.2681.00
56_K109_S1.2671.00
34_R75_G1.2551.00
43_Y51_I1.2501.00
2_F22_F1.2501.00
121_E125_E1.2471.00
3_M31_V1.2431.00
31_V76_A1.2361.00
74_S120_W1.2331.00
21_K78_E1.2321.00
49_K53_E1.2131.00
94_L99_L1.1821.00
130_S133_E1.1681.00
10_I99_L1.1681.00
5_E75_G1.1561.00
63_K67_A1.1540.99
118_V121_E1.1340.99
122_Q125_E1.1310.99
50_Q54_K1.1300.99
122_Q126_E1.1270.99
9_T101_K1.1140.99
43_Y48_W1.1100.99
32_L79_C1.1040.99
91_S94_L1.0990.99
41_F72_F1.0860.99
53_E57_A1.0810.99
6_Y22_F1.0690.99
79_C90_A1.0590.99
12_A83_K1.0300.99
52_E109_S1.0250.99
18_V87_V1.0130.99
46_H49_K1.0110.99
64_D67_A0.9650.98
17_I84_Q0.9620.98
29_Q80_E0.9400.98
77_T92_S0.9390.98
38_Q110_N0.9380.98
18_V105_V0.9350.98
105_V112_I0.9310.98
35_G41_F0.9150.97
126_E129_D0.9030.97
106_I120_W0.9030.97
10_I103_C0.9000.97
89_I114_L0.8850.97
53_E56_K0.8710.97
4_G33_T0.8700.96
5_E34_R0.8600.96
8_H105_V0.8560.96
32_L42_G0.8540.96
39_C113_E0.8460.96
11_D15_R0.8350.96
70_R108_V0.8310.95
98_K116_S0.8210.95
14_G99_L0.8190.95
8_H20_A0.8130.95
36_L68_F0.8080.95
58_L65_A0.7980.94
2_F44_P0.7950.94
31_V78_E0.7820.94
4_G76_A0.7780.94
12_A100_E0.7770.94
63_K132_A0.7770.94
56_K110_N0.7660.93
68_F131_F0.7570.93
49_K52_E0.7560.93
123_Y126_E0.7490.92
33_T76_A0.7490.92
39_C115_W0.7390.92
71_F124_T0.7360.92
45_M78_E0.7360.92
95_N98_K0.7350.92
2_F25_G0.7330.91
55_L69_T0.7270.91
41_F108_V0.7210.91
17_I23_R0.7200.91
101_K116_S0.7110.90
24_E27_G0.7040.90
68_F72_F0.7040.90
69_T127_Q0.6930.89
62_K65_A0.6910.89
8_H17_I0.6860.88
12_A88_N0.6850.88
50_Q57_A0.6790.88
21_K77_T0.6750.88
55_L58_L0.6750.88
5_E104_V0.6730.87
48_W70_R0.6710.87
27_G30_F0.6680.87
50_Q56_K0.6670.87
70_R115_W0.6650.87
51_I72_F0.6640.87
52_E55_L0.6580.86
67_A123_Y0.6580.86
50_Q110_N0.6550.86
16_M87_V0.6510.86
114_L121_E0.6490.86
35_G66_R0.6430.85
38_Q98_K0.6380.85
96_Y128_E0.6350.84
74_S106_I0.6290.84
23_R85_G0.6280.84
32_L87_V0.6270.84
34_R96_Y0.6260.83
100_E118_V0.6250.83
12_A101_K0.6230.83
30_F42_G0.6220.83
103_C117_K0.6210.83
28_E46_H0.6200.83
69_T111_R0.6190.83
26_L30_F0.6180.83
22_F105_V0.6150.82
95_N121_E0.6140.82
73_F108_V0.6090.82
81_L87_V0.6060.81
24_E84_Q0.6060.81
88_N94_L0.6060.81
56_K73_F0.6050.81
55_L73_F0.6040.81
5_E120_W0.5990.81
61_T68_F0.5970.81
48_W58_L0.5950.80
82_D86_R0.5940.80
48_W76_A0.5880.80
60_L65_A0.5850.79
125_E128_E0.5840.79
34_R72_F0.5840.79
40_L93_L0.5750.78
17_I20_A0.5750.78
42_G87_V0.5710.78
12_A80_E0.5700.77
119_I123_Y0.5660.77
23_R76_A0.5660.77
67_A126_E0.5640.77
34_R131_F0.5540.75
92_S95_N0.5530.75
130_S134_I0.5480.75
66_R69_T0.5390.73
76_A115_W0.5390.73
33_T48_W0.5360.73
47_E51_I0.5350.73
103_C109_S0.5330.73
52_E73_F0.5310.72
74_S94_L0.5300.72
31_V44_P0.5270.72
51_I60_L0.5220.71
55_L109_S0.5220.71
5_E92_S0.5210.71
21_K107_G0.5190.71
20_A117_K0.5190.71
72_F75_G0.5180.70
8_H40_L0.5150.70
33_T43_Y0.5130.70
18_V42_G0.5120.70
22_F75_G0.5090.69
3_M55_L0.5070.69
47_E54_K0.5070.69
75_G124_T0.5030.68
40_L134_I0.5030.68
51_I54_K0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n0eA 5 0.958 100 0.049 Contact Map
2glwA 1 0.6364 99.7 0.613 Contact Map
1yfbA 2 0.3287 92.5 0.879 Contact Map
2l66A 2 0.3287 89.4 0.888 Contact Map
2w1tA 2 0.4825 89.1 0.888 Contact Map
1mvfD 1 0.2937 58.6 0.915 Contact Map
2mrnA 2 0.3287 37.2 0.925 Contact Map
4k0mC 1 0.5944 15.6 0.938 Contact Map
3o27A 2 0.3706 15.3 0.938 Contact Map
1t4wA 1 0.4126 14.7 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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