ECSC - BACSU - GREMLIN Contacts

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ECSC - Protein EcsC

UniProt:	P55341	Sequences: MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKIHTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGTGAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRKSLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLGETARHVFHLRILKETAGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	236 (221)
Sequences:	708 (588)
Seq/√Len:	39.5

BACSU - ECSC YDBA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
134_F	232_E	6.762	1.00
124_C	218_G	4.474	1.00
125_L	221_A	3.900	1.00
193_K	196_Q	3.414	1.00
223_H	226_H	3.215	1.00
100_V	207_G	3.190	1.00
168_N	171_T	2.986	1.00
85_K	222_R	2.938	1.00
92_Q	215_A	2.792	1.00
159_R	163_F	2.645	1.00
96_A	211_Y	2.621	1.00
134_F	228_R	2.529	1.00
192_V	196_Q	2.382	1.00
88_I	218_G	2.276	1.00
141_E	228_R	2.220	0.99
198_L	201_V	2.215	0.99
128_L	221_A	2.119	0.99
89_V	93_K	2.117	0.99
202_G	206_G	2.080	0.99
124_C	128_L	2.066	0.99
141_E	225_F	2.014	0.99
116_L	119_S	2.002	0.99
49_T	60_M	1.977	0.99
134_F	229_I	1.975	0.99
84_A	128_L	1.961	0.99
81_N	132_Y	1.888	0.98
121_K	217_L	1.803	0.98
159_R	162_L	1.783	0.98
105_G	109_L	1.780	0.97
15_K	167_E	1.715	0.97
125_L	145_L	1.672	0.96
196_Q	202_G	1.671	0.96
135_D	138_D	1.669	0.96
35_K	39_R	1.654	0.96
101_G	195_F	1.636	0.96
59_T	64_N	1.622	0.96
38_E	42_E	1.572	0.95
158_G	162_L	1.572	0.95
103_G	106_G	1.507	0.93
87_T	131_I	1.506	0.93
63_S	66_I	1.479	0.93
76_S	116_L	1.478	0.93
208_I	212_K	1.464	0.92
164_S	168_N	1.451	0.92
12_L	25_F	1.449	0.92
106_G	206_G	1.430	0.92
40_I	44_I	1.424	0.91
71_D	80_K	1.408	0.91
163_F	167_E	1.402	0.91
11_A	17_H	1.402	0.91
122_M	126_F	1.397	0.91
92_Q	210_N	1.382	0.90
106_G	196_Q	1.381	0.90
74_A	84_A	1.323	0.88
145_L	225_F	1.306	0.87
73_S	77_L	1.302	0.87
104_A	203_A	1.284	0.86
156_D	201_V	1.283	0.86
132_Y	226_H	1.274	0.86
148_V	224_V	1.273	0.86
123_K	127_T	1.271	0.86
95_A	120_I	1.254	0.85
149_F	203_A	1.249	0.85
49_T	56_V	1.247	0.85
36_V	39_R	1.239	0.84
81_N	84_A	1.235	0.84
158_G	163_F	1.233	0.84
37_N	40_I	1.231	0.84
12_L	15_K	1.229	0.84
104_A	200_G	1.227	0.84
132_Y	141_E	1.224	0.84
83_L	120_I	1.219	0.83
51_S	59_T	1.216	0.83
97_A	101_G	1.215	0.83
34_T	46_T	1.199	0.82
168_N	172_E	1.196	0.82
112_A	207_G	1.184	0.81
15_K	227_L	1.178	0.81
58_A	161_S	1.167	0.81
42_E	179_R	1.161	0.80
59_T	66_I	1.132	0.78
98_E	120_I	1.130	0.78
56_V	66_I	1.127	0.78
162_L	165_V	1.104	0.77
148_V	221_A	1.092	0.76
182_Q	186_R	1.091	0.76
58_A	61_A	1.090	0.76
40_I	114_F	1.089	0.76
84_A	131_I	1.089	0.76
159_R	164_S	1.087	0.76
122_M	200_G	1.079	0.75
52_V	60_M	1.071	0.74
56_V	60_M	1.067	0.74
76_S	172_E	1.065	0.74
142_R	187_D	1.061	0.74
142_R	228_R	1.055	0.73
97_A	104_A	1.052	0.73
77_L	81_N	1.047	0.73
177_D	190_D	1.035	0.72
107_I	110_S	1.022	0.71
51_S	60_M	1.015	0.70
94_V	120_I	1.013	0.70
112_A	156_D	1.005	0.70
132_Y	222_R	1.003	0.69
22_D	31_R	0.999	0.69
88_I	92_Q	0.999	0.69
161_S	167_E	0.999	0.69
128_L	218_G	0.997	0.69
61_A	67_T	0.993	0.69
44_I	47_V	0.992	0.69
62_G	65_I	0.989	0.68
176_I	179_R	0.989	0.68
185_Y	197_L	0.987	0.68
48_V	52_V	0.982	0.68
134_F	225_F	0.972	0.67
107_I	166_I	0.970	0.67
59_T	62_G	0.963	0.66
122_M	196_Q	0.948	0.65
74_A	83_L	0.927	0.63
72_T	75_L	0.924	0.63
99_G	210_N	0.922	0.63
182_Q	190_D	0.921	0.63
56_V	65_I	0.919	0.63
13_E	107_I	0.919	0.63
117_L	152_A	0.917	0.62
32_V	35_K	0.916	0.62
108_F	111_I	0.915	0.62
95_A	187_D	0.910	0.62
99_G	103_G	0.908	0.62
17_H	28_F	0.905	0.61
23_S	26_E	0.902	0.61
103_G	115_P	0.896	0.61
50_E	86_K	0.895	0.61
17_H	21_K	0.893	0.60
107_I	197_L	0.893	0.60
99_G	206_G	0.888	0.60
71_D	79_E	0.885	0.60
74_A	171_T	0.882	0.59
57_E	207_G	0.881	0.59
98_E	144_F	0.876	0.59
152_A	217_L	0.875	0.59
97_A	209_A	0.874	0.59
81_N	226_H	0.873	0.59
201_V	204_A	0.872	0.59
164_S	167_E	0.867	0.58
86_K	89_V	0.865	0.58
120_I	129_S	0.863	0.58
26_E	29_S	0.862	0.58
95_A	178_W	0.859	0.57
213_L	231_K	0.856	0.57
91_Y	120_I	0.856	0.57
70_K	137_K	0.855	0.57
113_D	193_K	0.855	0.57
41_P	51_S	0.844	0.56
18_F	21_K	0.838	0.55
70_K	200_G	0.833	0.55
21_K	200_G	0.830	0.55
88_I	222_R	0.828	0.55
95_A	100_V	0.827	0.54
227_L	231_K	0.817	0.54
106_G	115_P	0.812	0.53
92_Q	213_L	0.807	0.53
132_Y	229_I	0.806	0.53
75_L	79_E	0.801	0.52
124_C	214_L	0.800	0.52
157_D	163_F	0.800	0.52
141_E	144_F	0.800	0.52
45_H	97_A	0.799	0.52
113_D	132_Y	0.796	0.52
16_M	25_F	0.791	0.51
128_L	131_I	0.789	0.51
155_S	205_V	0.780	0.50
190_D	202_G	0.775	0.50
41_P	45_H	0.774	0.50
42_E	160_K	0.772	0.49
124_C	195_F	0.767	0.49
33_Q	40_I	0.766	0.49
73_S	84_A	0.766	0.49
65_I	180_V	0.765	0.49
152_A	220_T	0.757	0.48
18_F	26_E	0.756	0.48
114_F	173_K	0.754	0.48
161_S	164_S	0.746	0.47
78_S	171_T	0.746	0.47
18_F	25_F	0.745	0.47
106_G	203_A	0.743	0.47
115_P	122_M	0.742	0.47
102_T	114_F	0.739	0.46
104_A	107_I	0.733	0.46
77_L	144_F	0.730	0.46
30_K	49_T	0.725	0.45
62_G	67_T	0.721	0.45
12_L	16_M	0.716	0.44
15_K	163_F	0.716	0.44
120_I	223_H	0.715	0.44
158_G	161_S	0.714	0.44
140_Q	171_T	0.713	0.44
13_E	135_D	0.711	0.44
102_T	116_L	0.711	0.44
61_A	64_N	0.709	0.44
46_T	137_K	0.708	0.44
61_A	68_Y	0.707	0.44
101_G	149_F	0.707	0.44
17_H	34_T	0.707	0.44
186_R	190_D	0.705	0.43
85_K	165_V	0.705	0.43
62_G	198_L	0.701	0.43
147_L	219_E	0.701	0.43
31_R	35_K	0.699	0.43
37_N	41_P	0.696	0.43
66_I	180_V	0.696	0.43
148_V	202_G	0.696	0.43
54_K	180_V	0.692	0.42
106_G	199_P	0.691	0.42
134_F	141_E	0.691	0.42
121_K	213_L	0.691	0.42
187_D	210_N	0.690	0.42
84_A	225_F	0.689	0.42
62_G	178_W	0.689	0.42
12_L	21_K	0.688	0.42
13_E	16_M	0.687	0.42
36_V	40_I	0.684	0.42
123_K	207_G	0.683	0.41
21_K	29_S	0.683	0.41
95_A	214_L	0.682	0.41
175_S	180_V	0.679	0.41
58_A	66_I	0.678	0.41
142_R	217_L	0.677	0.41
101_G	124_C	0.673	0.41
159_R	169_W	0.670	0.40
24_M	29_S	0.668	0.40
59_T	128_L	0.667	0.40
169_W	173_K	0.667	0.40
203_A	209_A	0.665	0.40
48_V	79_E	0.664	0.40
159_R	167_E	0.663	0.40
192_V	216_Q	0.661	0.40
37_N	48_V	0.658	0.39
88_I	211_Y	0.655	0.39
111_I	122_M	0.651	0.39
81_N	222_R	0.646	0.38
111_I	140_Q	0.646	0.38
11_A	26_E	0.645	0.38
92_Q	211_Y	0.643	0.38
130_S	136_V	0.640	0.38
217_L	226_H	0.637	0.37
54_K	57_E	0.635	0.37
95_A	219_E	0.632	0.37
129_S	145_L	0.630	0.37
69_K	80_K	0.629	0.37
164_S	200_G	0.628	0.37
147_L	165_V	0.627	0.37
144_F	228_R	0.624	0.36
178_W	182_Q	0.622	0.36
15_K	159_R	0.622	0.36
89_V	204_A	0.621	0.36
126_F	136_V	0.621	0.36
55_M	208_I	0.619	0.36
178_W	196_Q	0.618	0.36
101_G	200_G	0.617	0.36
33_Q	37_N	0.611	0.35
163_F	166_I	0.610	0.35
33_Q	185_Y	0.608	0.35
27_R	169_W	0.598	0.34
114_F	119_S	0.593	0.34
120_I	214_L	0.592	0.34
183_Q	217_L	0.590	0.34
23_S	44_I	0.588	0.33
189_I	194_L	0.587	0.33
16_M	89_V	0.587	0.33
49_T	52_V	0.587	0.33
91_Y	114_F	0.584	0.33
160_K	165_V	0.582	0.33
93_K	211_Y	0.576	0.32
91_Y	153_F	0.575	0.32
188_Y	200_G	0.573	0.32
106_G	202_G	0.572	0.32
50_E	168_N	0.570	0.32
82_E	180_V	0.570	0.32
53_K	56_V	0.568	0.32
116_L	145_L	0.568	0.32
27_R	174_K	0.567	0.32
43_K	205_V	0.566	0.32
144_F	147_L	0.565	0.32
39_R	50_E	0.564	0.31
91_Y	127_T	0.563	0.31
36_V	41_P	0.562	0.31
12_L	168_N	0.562	0.31
71_D	75_L	0.561	0.31
149_F	211_Y	0.560	0.31
98_E	214_L	0.560	0.31
141_E	193_K	0.560	0.31
25_F	30_K	0.556	0.31
84_A	132_Y	0.553	0.31
85_K	90_S	0.552	0.31
220_T	224_V	0.549	0.30
82_E	85_K	0.548	0.30
41_P	52_V	0.547	0.30
154_S	178_W	0.547	0.30
16_M	28_F	0.547	0.30
35_K	38_E	0.544	0.30
68_Y	188_Y	0.543	0.30
178_W	185_Y	0.542	0.30
46_T	165_V	0.538	0.29
88_I	128_L	0.538	0.29
47_V	108_F	0.538	0.29
101_G	214_L	0.537	0.29
117_L	213_L	0.535	0.29
106_G	146_L	0.533	0.29
83_L	214_L	0.532	0.29
200_G	204_A	0.531	0.29
31_R	34_T	0.528	0.29
149_F	182_Q	0.521	0.28
121_K	203_A	0.517	0.28
146_L	210_N	0.517	0.28
25_F	28_F	0.517	0.28
137_K	168_N	0.515	0.28
110_S	115_P	0.514	0.28
53_K	101_G	0.513	0.28
48_V	180_V	0.511	0.27
137_K	170_E	0.511	0.27
77_L	193_K	0.510	0.27
77_L	214_L	0.509	0.27
147_L	198_L	0.507	0.27
54_K	211_Y	0.505	0.27
14_W	125_L	0.504	0.27
31_R	148_V	0.504	0.27
18_F	22_D	0.504	0.27
76_S	80_K	0.504	0.27
169_W	185_Y	0.501	0.27
73_S	79_E	0.500	0.27
67_T	84_A	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yycA	2	0.2415	7	0.961	Contact Map
4mdaA	1	0.2669	6.7	0.961	Contact Map
1rh5B	1	0.2373	6.1	0.962	Contact Map
2qneA	2	0.2627	5.8	0.962	Contact Map
2kmfA	1	0.2669	5.4	0.962	Contact Map
4wv4A	1	0.2754	4.7	0.964	Contact Map
3f2kA	1	0.2627	4.6	0.964	Contact Map
2r80A	2	0.2881	4	0.965	Contact Map
4b4yA	2	0.2754	3.9	0.965	Contact Map
3rimA	2	0.678	3.8	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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