GREMLIN Database
ECSC - Protein EcsC
UniProt: P55341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (221)
Sequences: 708 (588)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_F232_E6.7621.00
124_C218_G4.4741.00
125_L221_A3.9001.00
193_K196_Q3.4141.00
223_H226_H3.2151.00
100_V207_G3.1901.00
168_N171_T2.9861.00
85_K222_R2.9381.00
92_Q215_A2.7921.00
159_R163_F2.6451.00
96_A211_Y2.6211.00
134_F228_R2.5291.00
192_V196_Q2.3821.00
88_I218_G2.2761.00
141_E228_R2.2200.99
198_L201_V2.2150.99
128_L221_A2.1190.99
89_V93_K2.1170.99
202_G206_G2.0800.99
124_C128_L2.0660.99
141_E225_F2.0140.99
116_L119_S2.0020.99
49_T60_M1.9770.99
134_F229_I1.9750.99
84_A128_L1.9610.99
81_N132_Y1.8880.98
121_K217_L1.8030.98
159_R162_L1.7830.98
105_G109_L1.7800.97
15_K167_E1.7150.97
125_L145_L1.6720.96
196_Q202_G1.6710.96
135_D138_D1.6690.96
35_K39_R1.6540.96
101_G195_F1.6360.96
59_T64_N1.6220.96
38_E42_E1.5720.95
158_G162_L1.5720.95
103_G106_G1.5070.93
87_T131_I1.5060.93
63_S66_I1.4790.93
76_S116_L1.4780.93
208_I212_K1.4640.92
164_S168_N1.4510.92
12_L25_F1.4490.92
106_G206_G1.4300.92
40_I44_I1.4240.91
71_D80_K1.4080.91
163_F167_E1.4020.91
11_A17_H1.4020.91
122_M126_F1.3970.91
92_Q210_N1.3820.90
106_G196_Q1.3810.90
74_A84_A1.3230.88
145_L225_F1.3060.87
73_S77_L1.3020.87
104_A203_A1.2840.86
156_D201_V1.2830.86
132_Y226_H1.2740.86
148_V224_V1.2730.86
123_K127_T1.2710.86
95_A120_I1.2540.85
149_F203_A1.2490.85
49_T56_V1.2470.85
36_V39_R1.2390.84
81_N84_A1.2350.84
158_G163_F1.2330.84
37_N40_I1.2310.84
12_L15_K1.2290.84
104_A200_G1.2270.84
132_Y141_E1.2240.84
83_L120_I1.2190.83
51_S59_T1.2160.83
97_A101_G1.2150.83
34_T46_T1.1990.82
168_N172_E1.1960.82
112_A207_G1.1840.81
15_K227_L1.1780.81
58_A161_S1.1670.81
42_E179_R1.1610.80
59_T66_I1.1320.78
98_E120_I1.1300.78
56_V66_I1.1270.78
162_L165_V1.1040.77
148_V221_A1.0920.76
182_Q186_R1.0910.76
58_A61_A1.0900.76
40_I114_F1.0890.76
84_A131_I1.0890.76
159_R164_S1.0870.76
122_M200_G1.0790.75
52_V60_M1.0710.74
56_V60_M1.0670.74
76_S172_E1.0650.74
142_R187_D1.0610.74
142_R228_R1.0550.73
97_A104_A1.0520.73
77_L81_N1.0470.73
177_D190_D1.0350.72
107_I110_S1.0220.71
51_S60_M1.0150.70
94_V120_I1.0130.70
112_A156_D1.0050.70
132_Y222_R1.0030.69
22_D31_R0.9990.69
88_I92_Q0.9990.69
161_S167_E0.9990.69
128_L218_G0.9970.69
61_A67_T0.9930.69
44_I47_V0.9920.69
62_G65_I0.9890.68
176_I179_R0.9890.68
185_Y197_L0.9870.68
48_V52_V0.9820.68
134_F225_F0.9720.67
107_I166_I0.9700.67
59_T62_G0.9630.66
122_M196_Q0.9480.65
74_A83_L0.9270.63
72_T75_L0.9240.63
99_G210_N0.9220.63
182_Q190_D0.9210.63
56_V65_I0.9190.63
13_E107_I0.9190.63
117_L152_A0.9170.62
32_V35_K0.9160.62
108_F111_I0.9150.62
95_A187_D0.9100.62
99_G103_G0.9080.62
17_H28_F0.9050.61
23_S26_E0.9020.61
103_G115_P0.8960.61
50_E86_K0.8950.61
17_H21_K0.8930.60
107_I197_L0.8930.60
99_G206_G0.8880.60
71_D79_E0.8850.60
74_A171_T0.8820.59
57_E207_G0.8810.59
98_E144_F0.8760.59
152_A217_L0.8750.59
97_A209_A0.8740.59
81_N226_H0.8730.59
201_V204_A0.8720.59
164_S167_E0.8670.58
86_K89_V0.8650.58
120_I129_S0.8630.58
26_E29_S0.8620.58
95_A178_W0.8590.57
213_L231_K0.8560.57
91_Y120_I0.8560.57
70_K137_K0.8550.57
113_D193_K0.8550.57
41_P51_S0.8440.56
18_F21_K0.8380.55
70_K200_G0.8330.55
21_K200_G0.8300.55
88_I222_R0.8280.55
95_A100_V0.8270.54
227_L231_K0.8170.54
106_G115_P0.8120.53
92_Q213_L0.8070.53
132_Y229_I0.8060.53
75_L79_E0.8010.52
124_C214_L0.8000.52
157_D163_F0.8000.52
141_E144_F0.8000.52
45_H97_A0.7990.52
113_D132_Y0.7960.52
16_M25_F0.7910.51
128_L131_I0.7890.51
155_S205_V0.7800.50
190_D202_G0.7750.50
41_P45_H0.7740.50
42_E160_K0.7720.49
124_C195_F0.7670.49
33_Q40_I0.7660.49
73_S84_A0.7660.49
65_I180_V0.7650.49
152_A220_T0.7570.48
18_F26_E0.7560.48
114_F173_K0.7540.48
161_S164_S0.7460.47
78_S171_T0.7460.47
18_F25_F0.7450.47
106_G203_A0.7430.47
115_P122_M0.7420.47
102_T114_F0.7390.46
104_A107_I0.7330.46
77_L144_F0.7300.46
30_K49_T0.7250.45
62_G67_T0.7210.45
12_L16_M0.7160.44
15_K163_F0.7160.44
120_I223_H0.7150.44
158_G161_S0.7140.44
140_Q171_T0.7130.44
13_E135_D0.7110.44
102_T116_L0.7110.44
61_A64_N0.7090.44
46_T137_K0.7080.44
61_A68_Y0.7070.44
101_G149_F0.7070.44
17_H34_T0.7070.44
186_R190_D0.7050.43
85_K165_V0.7050.43
62_G198_L0.7010.43
147_L219_E0.7010.43
31_R35_K0.6990.43
37_N41_P0.6960.43
66_I180_V0.6960.43
148_V202_G0.6960.43
54_K180_V0.6920.42
106_G199_P0.6910.42
134_F141_E0.6910.42
121_K213_L0.6910.42
187_D210_N0.6900.42
84_A225_F0.6890.42
62_G178_W0.6890.42
12_L21_K0.6880.42
13_E16_M0.6870.42
36_V40_I0.6840.42
123_K207_G0.6830.41
21_K29_S0.6830.41
95_A214_L0.6820.41
175_S180_V0.6790.41
58_A66_I0.6780.41
142_R217_L0.6770.41
101_G124_C0.6730.41
159_R169_W0.6700.40
24_M29_S0.6680.40
59_T128_L0.6670.40
169_W173_K0.6670.40
203_A209_A0.6650.40
48_V79_E0.6640.40
159_R167_E0.6630.40
192_V216_Q0.6610.40
37_N48_V0.6580.39
88_I211_Y0.6550.39
111_I122_M0.6510.39
81_N222_R0.6460.38
111_I140_Q0.6460.38
11_A26_E0.6450.38
92_Q211_Y0.6430.38
130_S136_V0.6400.38
217_L226_H0.6370.37
54_K57_E0.6350.37
95_A219_E0.6320.37
129_S145_L0.6300.37
69_K80_K0.6290.37
164_S200_G0.6280.37
147_L165_V0.6270.37
144_F228_R0.6240.36
178_W182_Q0.6220.36
15_K159_R0.6220.36
89_V204_A0.6210.36
126_F136_V0.6210.36
55_M208_I0.6190.36
178_W196_Q0.6180.36
101_G200_G0.6170.36
33_Q37_N0.6110.35
163_F166_I0.6100.35
33_Q185_Y0.6080.35
27_R169_W0.5980.34
114_F119_S0.5930.34
120_I214_L0.5920.34
183_Q217_L0.5900.34
23_S44_I0.5880.33
189_I194_L0.5870.33
16_M89_V0.5870.33
49_T52_V0.5870.33
91_Y114_F0.5840.33
160_K165_V0.5820.33
93_K211_Y0.5760.32
91_Y153_F0.5750.32
188_Y200_G0.5730.32
106_G202_G0.5720.32
50_E168_N0.5700.32
82_E180_V0.5700.32
53_K56_V0.5680.32
116_L145_L0.5680.32
27_R174_K0.5670.32
43_K205_V0.5660.32
144_F147_L0.5650.32
39_R50_E0.5640.31
91_Y127_T0.5630.31
36_V41_P0.5620.31
12_L168_N0.5620.31
71_D75_L0.5610.31
149_F211_Y0.5600.31
98_E214_L0.5600.31
141_E193_K0.5600.31
25_F30_K0.5560.31
84_A132_Y0.5530.31
85_K90_S0.5520.31
220_T224_V0.5490.30
82_E85_K0.5480.30
41_P52_V0.5470.30
154_S178_W0.5470.30
16_M28_F0.5470.30
35_K38_E0.5440.30
68_Y188_Y0.5430.30
178_W185_Y0.5420.30
46_T165_V0.5380.29
88_I128_L0.5380.29
47_V108_F0.5380.29
101_G214_L0.5370.29
117_L213_L0.5350.29
106_G146_L0.5330.29
83_L214_L0.5320.29
200_G204_A0.5310.29
31_R34_T0.5280.29
149_F182_Q0.5210.28
121_K203_A0.5170.28
146_L210_N0.5170.28
25_F28_F0.5170.28
137_K168_N0.5150.28
110_S115_P0.5140.28
53_K101_G0.5130.28
48_V180_V0.5110.27
137_K170_E0.5110.27
77_L193_K0.5100.27
77_L214_L0.5090.27
147_L198_L0.5070.27
54_K211_Y0.5050.27
14_W125_L0.5040.27
31_R148_V0.5040.27
18_F22_D0.5040.27
76_S80_K0.5040.27
169_W185_Y0.5010.27
73_S79_E0.5000.27
67_T84_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yycA 2 0.2415 7 0.961 Contact Map
4mdaA 1 0.2669 6.7 0.961 Contact Map
1rh5B 1 0.2373 6.1 0.962 Contact Map
2qneA 2 0.2627 5.8 0.962 Contact Map
2kmfA 1 0.2669 5.4 0.962 Contact Map
4wv4A 1 0.2754 4.7 0.964 Contact Map
3f2kA 1 0.2627 4.6 0.964 Contact Map
2r80A 2 0.2881 4 0.965 Contact Map
4b4yA 2 0.2754 3.9 0.965 Contact Map
3rimA 2 0.678 3.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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