GREMLIN Database
ECSB - Protein EcsB
UniProt: P55340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (395)
Sequences: 543 (459)
Seq/√Len: 23.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_T362_Q7.3171.00
251_R256_D4.9071.00
288_L358_A4.0521.00
256_D276_R3.5171.00
79_L105_Y3.3351.00
278_F354_L3.3131.00
67_F140_V2.7080.99
292_T320_T2.6540.99
331_F336_L2.5870.99
296_A365_L2.5800.99
263_P268_K2.5490.99
77_R105_Y2.5050.98
191_M195_L2.4860.98
277_A331_F2.4730.98
64_A68_S2.4240.98
216_F221_H2.3360.97
46_Y123_P2.2760.97
292_T362_Q2.2700.97
290_R323_Q2.2460.97
30_H40_A2.2150.96
259_L279_L2.2020.96
70_V117_L2.1720.96
8_W105_Y2.1440.96
25_Y31_L2.1090.95
72_T178_N2.0800.95
239_F323_Q2.0750.95
381_Y384_I2.0130.94
271_A353_S1.9550.93
313_T386_S1.9520.93
290_R341_P1.9330.92
115_I145_L1.8750.91
49_W355_L1.8710.91
25_Y37_F1.8610.91
27_L30_H1.8440.91
138_A176_A1.8320.90
65_V372_Y1.8210.90
89_L95_M1.8080.90
239_F341_P1.8050.90
209_S212_K1.7950.89
22_Y323_Q1.7910.89
146_L368_V1.7820.89
81_K336_L1.7580.88
111_L197_Y1.7480.88
15_H105_Y1.7470.88
29_D397_Y1.7290.87
349_K387_A1.6930.86
6_D10_S1.6890.86
43_A235_I1.6790.86
295_F366_M1.6770.86
308_I312_L1.6740.86
239_F290_R1.6650.85
26_M232_F1.6570.85
321_G359_L1.6380.84
385_G388_V1.6360.84
110_Q148_K1.6340.84
363_A390_I1.6310.84
274_F347_K1.6310.84
8_W15_H1.6180.84
104_V108_V1.5780.82
27_L41_G1.5700.82
30_H34_V1.5510.81
278_F358_A1.5420.80
22_Y25_Y1.5390.80
24_K234_R1.5310.80
222_I255_L1.5310.80
22_Y290_R1.5220.80
25_Y240_T1.5220.80
29_D40_A1.5150.79
323_Q341_P1.5140.79
39_L153_V1.5110.79
40_A77_R1.5060.79
26_M236_A1.5030.79
279_L380_L1.4950.78
179_T353_S1.4940.78
23_M159_T1.4850.78
145_L194_L1.4810.78
34_V37_F1.4810.78
319_I397_Y1.4800.78
98_Y323_Q1.4680.77
77_R225_E1.4650.77
92_E218_W1.4640.77
262_V271_A1.4610.77
191_M289_V1.4610.77
252_R290_R1.4600.77
238_L318_F1.4520.76
142_V191_M1.4510.76
267_R346_T1.4480.76
259_L276_R1.4430.76
33_I324_L1.4400.76
207_M360_S1.4250.75
25_Y34_V1.4150.74
383_L387_A1.4060.74
225_E273_M1.3960.73
285_L307_L1.3940.73
257_F279_L1.3770.72
78_T98_Y1.3750.72
82_E226_L1.3750.72
80_L99_L1.3680.72
48_K274_F1.3640.71
245_L255_L1.3590.71
289_V391_F1.3590.71
84_D280_R1.3490.71
125_Y137_Y1.3470.71
22_Y28_N1.3410.70
232_F362_Q1.3360.70
65_V392_V1.3350.70
265_E289_V1.3330.70
25_Y28_N1.3260.69
35_L285_L1.3260.69
69_L195_L1.3240.69
108_V142_V1.3220.69
22_Y242_V1.3210.69
22_Y239_F1.3180.69
30_H256_D1.3150.69
80_L222_I1.3090.68
30_H49_W1.3060.68
125_Y221_H1.2990.68
286_G290_R1.2960.67
228_R326_P1.2940.67
99_L249_A1.2920.67
263_P272_Y1.2830.67
78_T89_L1.2800.66
79_L337_Q1.2730.66
200_M361_I1.2710.66
390_I394_L1.2700.66
30_H276_R1.2680.66
218_W290_R1.2640.65
148_K340_Y1.2620.65
151_N178_N1.2610.65
119_I122_M1.2400.64
389_L393_V1.2370.64
202_V381_Y1.2350.64
207_M367_S1.2270.63
243_P323_Q1.2250.63
257_F373_A1.2240.63
19_T25_Y1.2190.63
77_R287_I1.2130.62
239_F242_V1.2130.62
133_S361_I1.2110.62
25_Y58_P1.2060.62
363_A387_A1.2010.61
122_M126_F1.2010.61
198_V364_L1.2010.61
198_V385_G1.2000.61
317_I359_L1.1960.61
253_A256_D1.1940.61
268_K271_A1.1920.61
122_M303_S1.1880.61
17_K121_A1.1860.60
29_D34_V1.1820.60
173_I254_Y1.1810.60
156_W174_R1.1800.60
50_I283_D1.1760.60
142_V199_I1.1760.60
173_I293_I1.1740.60
122_M137_Y1.1650.59
89_L92_E1.1540.58
12_L105_Y1.1520.58
137_Y311_V1.1510.58
186_F207_M1.1500.58
25_Y29_D1.1460.58
27_L35_L1.1440.58
27_L40_A1.1440.58
40_A276_R1.1400.57
191_M198_V1.1400.57
8_W101_Q1.1370.57
23_M34_V1.1320.57
241_D323_Q1.1280.57
180_L184_F1.1260.56
114_L144_L1.1250.56
102_A349_K1.1210.56
92_E323_Q1.1200.56
287_I326_P1.1170.56
48_K315_F1.0990.55
108_V349_K1.0980.54
199_I263_P1.0960.54
94_K365_L1.0850.54
146_L388_V1.0820.53
325_L397_Y1.0800.53
239_F243_P1.0760.53
27_L228_R1.0750.53
192_Y195_L1.0710.53
195_L391_F1.0690.52
172_I223_E1.0690.52
232_F236_A1.0680.52
10_S289_V1.0670.52
239_F252_R1.0600.52
92_E270_F1.0570.52
19_T281_S1.0550.51
77_R228_R1.0500.51
29_D74_S1.0480.51
104_V133_S1.0470.51
391_F395_P1.0470.51
72_T151_N1.0460.51
53_I138_A1.0460.51
232_F350_S1.0390.50
388_V396_A1.0390.50
111_L145_L1.0320.50
242_V323_Q1.0310.50
192_Y197_Y1.0300.50
332_D347_K1.0290.50
176_A368_V1.0290.50
135_V385_G1.0290.50
333_H338_E1.0250.49
82_E85_L1.0250.49
252_R255_L1.0200.49
29_D238_L1.0200.49
251_R276_R1.0190.49
360_S387_A1.0170.49
232_F246_R1.0150.49
141_F191_M1.0130.49
77_R158_T1.0110.48
63_M125_Y1.0110.48
34_V38_F1.0090.48
70_V108_V1.0050.48
124_L281_S1.0030.48
164_R361_I0.9980.47
6_D176_A0.9900.47
61_W343_Q0.9870.47
40_A256_D0.9860.47
107_Y279_L0.9810.46
284_Y327_L0.9790.46
150_W236_A0.9790.46
22_Y241_D0.9720.46
28_N31_L0.9710.46
338_E389_L0.9680.45
92_E291_L0.9670.45
26_M31_L0.9670.45
21_T54_P0.9610.45
343_Q380_L0.9560.45
294_V394_L0.9470.44
18_E229_K0.9450.44
51_R95_M0.9450.44
86_V90_P0.9440.44
237_N241_D0.9420.44
89_L240_T0.9380.43
8_W102_A0.9370.43
78_T95_M0.9340.43
92_E290_R0.9290.43
29_D158_T0.9260.43
286_G316_A0.9230.42
115_I119_I0.9230.42
314_V385_G0.9200.42
40_A251_R0.9200.42
90_P240_T0.9180.42
90_P323_Q0.9160.42
183_Y274_F0.9160.42
318_F366_M0.9140.42
53_I289_V0.9100.41
346_T349_K0.9100.41
376_L382_A0.9080.41
117_L384_I0.9080.41
151_N174_R0.9070.41
172_I372_Y0.9060.41
12_L79_L0.9050.41
22_Y98_Y0.9050.41
393_V396_A0.9040.41
234_R307_L0.9030.41
148_K243_P0.9020.41
68_S175_F0.9020.41
29_D37_F0.9010.41
98_Y341_P0.9010.41
93_A176_A0.9000.41
71_L243_P0.8980.41
331_F340_Y0.8980.41
156_W218_W0.8930.40
394_L400_T0.8910.40
116_A201_A0.8910.40
148_K347_K0.8910.40
6_D39_L0.8900.40
40_A228_R0.8890.40
29_D41_G0.8890.40
256_D287_I0.8890.40
69_L267_R0.8870.40
62_V393_V0.8860.40
7_I11_R0.8830.40
148_K286_G0.8820.40
218_W336_L0.8800.39
393_V397_Y0.8790.39
74_S287_I0.8790.39
142_V206_Y0.8780.39
290_R327_L0.8760.39
181_V195_L0.8740.39
83_A87_F0.8720.39
367_S376_L0.8710.39
258_L323_Q0.8690.39
37_F86_V0.8690.39
22_Y233_Y0.8650.38
29_D256_D0.8650.38
388_V393_V0.8610.38
146_L197_Y0.8580.38
181_V200_M0.8560.38
291_L316_A0.8510.38
65_V131_G0.8510.38
239_F251_R0.8480.37
13_Q141_F0.8480.37
28_N259_L0.8470.37
140_V248_Q0.8450.37
349_K385_G0.8450.37
29_D326_P0.8420.37
305_S308_I0.8420.37
190_Y308_I0.8410.37
358_A361_I0.8400.37
31_L328_F0.8350.36
79_L201_A0.8330.36
15_H225_E0.8320.36
102_A291_L0.8270.36
28_N323_Q0.8250.36
322_I397_Y0.8240.36
26_M75_Y0.8240.36
218_W221_H0.8240.36
42_A227_R0.8230.36
98_Y239_F0.8220.36
59_S128_V0.8210.36
306_P309_A0.8200.36
272_Y323_Q0.8190.35
50_I124_L0.8190.35
26_M283_D0.8150.35
28_N34_V0.8120.35
47_S51_R0.8120.35
319_I322_I0.8110.35
95_M365_L0.8110.35
296_A369_A0.8100.35
146_L319_I0.8070.35
254_Y374_A0.8060.35
23_M217_K0.8060.35
295_F316_A0.8040.34
202_V265_E0.8020.34
178_N185_V0.8010.34
385_G395_P0.8010.34
205_L289_V0.8000.34
142_V202_V0.7990.34
268_K353_S0.7970.34
110_Q151_N0.7960.34
142_V375_G0.7950.34
229_K247_K0.7940.34
198_V295_F0.7910.34
343_Q364_L0.7830.33
339_L347_K0.7810.33
168_R364_L0.7800.33
107_Y111_L0.7760.33
150_W195_L0.7740.33
264_F336_L0.7740.33
49_W132_A0.7710.32
142_V179_T0.7690.32
299_I366_M0.7680.32
7_I25_Y0.7680.32
197_Y201_A0.7680.32
242_V341_P0.7670.32
34_V219_E0.7660.32
362_Q397_Y0.7640.32
132_A136_S0.7610.32
59_S74_S0.7610.32
156_W277_A0.7600.32
258_L388_V0.7530.31
237_N291_L0.7520.31
31_L106_S0.7480.31
228_R238_L0.7460.31
201_A388_V0.7460.31
25_Y262_V0.7450.31
288_L362_Q0.7440.31
335_A338_E0.7420.31
356_K391_F0.7410.31
196_V387_A0.7410.31
74_S256_D0.7410.31
98_Y290_R0.7400.31
379_F383_L0.7390.31
174_R221_H0.7390.31
213_R383_L0.7350.30
4_M91_L0.7310.30
11_R84_D0.7310.30
256_D259_L0.7300.30
26_M336_L0.7280.30
118_S137_Y0.7270.30
218_W270_F0.7270.30
31_L34_V0.7270.30
235_I291_L0.7260.30
57_F232_F0.7230.30
29_D228_R0.7210.29
74_S110_Q0.7190.29
179_T365_L0.7150.29
53_I245_L0.7150.29
183_Y246_R0.7140.29
138_A263_P0.7120.29
22_Y31_L0.7120.29
370_S374_A0.7110.29
295_F387_A0.7100.29
23_M283_D0.7100.29
82_E262_V0.7090.29
34_V228_R0.7090.29
71_L312_L0.7050.29
175_F179_T0.7040.28
75_Y156_W0.7030.28
293_I372_Y0.7020.28
233_Y323_Q0.7010.28
15_H230_Q0.6990.28
360_S396_A0.6990.28
139_A365_L0.6980.28
240_T290_R0.6960.28
248_Q387_A0.6950.28
396_A399_T0.6950.28
32_V226_L0.6930.28
15_H19_T0.6920.28
23_M331_F0.6910.28
133_S388_V0.6890.28
369_A395_P0.6880.28
252_R273_M0.6860.27
104_V115_I0.6850.27
8_W245_L0.6810.27
50_I323_Q0.6810.27
100_K142_V0.6780.27
232_F281_S0.6770.27
66_L360_S0.6760.27
26_M29_D0.6730.27
289_V301_Y0.6720.27
17_K293_I0.6720.27
326_P397_Y0.6700.27
14_E354_L0.6680.26
166_M173_I0.6680.26
17_K259_L0.6650.26
272_Y290_R0.6640.26
238_L256_D0.6630.26
11_R280_R0.6620.26
226_L365_L0.6620.26
63_M67_F0.6610.26
87_F238_L0.6610.26
176_A398_M0.6580.26
366_M386_S0.6560.26
177_A311_V0.6550.26
50_I366_M0.6550.26
69_L364_L0.6550.26
121_A387_A0.6550.26
195_L381_Y0.6540.26
251_R273_M0.6510.26
111_L368_V0.6500.26
154_M203_L0.6500.26
6_D364_L0.6490.25
182_L262_V0.6450.25
22_Y29_D0.6440.25
159_T217_K0.6430.25
221_H393_V0.6430.25
269_T342_V0.6410.25
18_E233_Y0.6390.25
267_R380_L0.6380.25
43_A47_S0.6360.25
222_I321_G0.6350.25
255_L294_V0.6330.25
49_W52_D0.6330.25
79_L238_L0.6330.25
8_W56_H0.6320.25
252_R323_Q0.6310.25
97_P275_T0.6310.25
144_L269_T0.6300.24
185_V193_A0.6280.24
186_F298_I0.6270.24
150_W288_L0.6270.24
24_K93_A0.6260.24
19_T34_V0.6250.24
113_P148_K0.6240.24
126_F324_L0.6230.24
184_F192_Y0.6210.24
118_S122_M0.6210.24
98_Y283_D0.6210.24
148_K274_F0.6160.24
28_N40_A0.6160.24
22_Y252_R0.6160.24
24_K316_A0.6160.24
63_M79_L0.6150.24
122_M234_R0.6150.24
367_S379_F0.6140.24
212_K349_K0.6120.24
117_L353_S0.6120.24
177_A385_G0.6100.23
278_F386_S0.6090.23
255_L293_I0.6070.23
275_T297_L0.6060.23
310_A398_M0.6060.23
116_A366_M0.6030.23
146_L296_A0.6020.23
270_F287_I0.6010.23
281_S330_H0.5960.23
283_D290_R0.5940.23
289_V294_V0.5940.23
28_N256_D0.5920.23
64_A236_A0.5910.23
46_Y241_D0.5900.22
146_L364_L0.5890.22
183_Y255_L0.5890.22
218_W323_Q0.5890.22
180_L196_V0.5890.22
222_I311_V0.5880.22
106_S152_Q0.5880.22
120_V274_F0.5870.22
42_A120_V0.5850.22
16_I199_I0.5840.22
51_R149_A0.5830.22
142_V292_T0.5830.22
6_D97_P0.5830.22
22_Y92_E0.5820.22
221_H336_L0.5810.22
139_A254_Y0.5800.22
236_A339_L0.5800.22
65_V194_L0.5800.22
262_V382_A0.5800.22
29_D322_I0.5770.22
12_L15_H0.5750.22
149_A343_Q0.5750.22
74_S148_K0.5730.22
234_R245_L0.5720.22
63_M214_K0.5710.22
26_M320_T0.5710.22
50_I243_P0.5700.22
65_V179_T0.5700.22
254_Y351_Y0.5700.22
31_L241_D0.5690.21
10_S268_K0.5690.21
28_N237_N0.5690.21
31_L320_T0.5680.21
271_A357_T0.5670.21
37_F228_R0.5670.21
116_A139_A0.5670.21
274_F328_F0.5660.21
96_E139_A0.5620.21
26_M331_F0.5620.21
153_V197_Y0.5610.21
381_Y385_G0.5600.21
28_N236_A0.5600.21
22_Y30_H0.5580.21
189_V196_V0.5570.21
118_S141_F0.5560.21
232_F320_T0.5560.21
150_W200_M0.5560.21
259_L272_Y0.5550.21
39_L105_Y0.5540.21
310_A396_A0.5530.21
150_W212_K0.5520.21
260_R279_L0.5510.21
22_Y341_P0.5500.21
56_H61_W0.5490.21
225_E271_A0.5490.21
140_V265_E0.5490.21
345_E384_I0.5480.21
76_V279_L0.5470.20
97_P384_I0.5430.20
69_L356_K0.5420.20
67_F220_S0.5420.20
126_F201_A0.5400.20
60_F308_I0.5390.20
27_L32_V0.5390.20
141_F266_Q0.5380.20
267_R392_V0.5370.20
230_Q275_T0.5370.20
239_F273_M0.5370.20
21_T77_R0.5350.20
100_K357_T0.5320.20
101_Q329_G0.5320.20
116_A249_A0.5310.20
122_M141_F0.5310.20
120_V267_R0.5300.20
197_Y279_L0.5290.20
395_P400_T0.5280.20
69_L289_V0.5280.20
38_F140_V0.5280.20
29_D276_R0.5270.20
176_A380_L0.5250.19
20_R36_I0.5200.19
299_I395_P0.5190.19
120_V306_P0.5190.19
127_A219_E0.5170.19
27_L52_D0.5170.19
284_Y340_Y0.5170.19
356_K395_P0.5170.19
293_I392_V0.5140.19
330_H338_E0.5120.19
19_T193_A0.5100.19
115_I139_A0.5100.19
381_Y392_V0.5100.19
29_D32_V0.5100.19
292_T365_L0.5090.19
175_F368_V0.5070.19
19_T236_A0.5070.19
144_L354_L0.5070.19
12_L29_D0.5060.19
302_V312_L0.5050.19
20_R24_K0.5050.19
258_L290_R0.5050.19
10_S41_G0.5050.19
195_L213_R0.5040.19
39_L365_L0.5030.19
159_T220_S0.5020.18
6_D377_T0.5010.18
209_S381_Y0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.4877 21.2 0.967 Contact Map
3mktA 1 0.5147 13.3 0.97 Contact Map
4tq3A 1 0.299 12.4 0.97 Contact Map
3l1lA 2 0.5147 11.1 0.971 Contact Map
4wl1A 3 0.0196 10.1 0.972 Contact Map
4humA 1 0.5074 9 0.972 Contact Map
2m20A 2 0.0907 7.7 0.973 Contact Map
4lz6A 1 0.4951 7.7 0.973 Contact Map
3tx3A 2 0.4804 7 0.974 Contact Map
3giaA 1 0.5172 6.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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