GREMLIN Database
YXKA - Uncharacterized protein YxkA
UniProt: P55185 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (141)
Sequences: 2538 (1756)
Seq/√Len: 147.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_D155_H5.5181.00
40_I47_L4.2131.00
51_F128_L3.0191.00
17_K118_T2.9471.00
14_K81_E2.9191.00
49_L130_V2.8921.00
98_F115_C2.6921.00
10_Y165_L2.5661.00
4_Y81_E2.2911.00
71_N138_N2.2441.00
6_E9_P2.1641.00
45_K135_A2.0811.00
127_T163_E2.0141.00
4_Y34_P1.9771.00
47_L74_A1.9641.00
129_T161_S1.9551.00
5_V164_L1.8491.00
48_A148_L1.8091.00
40_I77_G1.7971.00
133_L152_M1.7961.00
34_P78_E1.7811.00
11_L117_P1.7291.00
70_A94_G1.6661.00
30_F116_G1.6541.00
94_G148_L1.6181.00
36_H78_E1.6171.00
32_S79_L1.5601.00
71_N136_E1.5351.00
37_F79_L1.5141.00
129_T159_E1.4651.00
48_A152_M1.4611.00
72_I76_I1.4271.00
55_D125_A1.3751.00
82_H85_E1.3461.00
123_D167_R1.3391.00
70_A148_L1.3351.00
130_V160_T1.3241.00
148_L152_M1.2971.00
46_T71_N1.2951.00
11_L164_L1.2831.00
15_Y81_E1.2321.00
65_I145_L1.2281.00
151_E154_E1.1911.00
46_T136_E1.1871.00
152_M156_I1.1691.00
52_I63_S1.1681.00
41_P132_A1.1551.00
53_D66_H1.1521.00
131_Y152_M1.1501.00
70_A143_F1.1310.99
80_P83_A1.1250.99
144_Y147_E1.1230.99
114_Y117_P1.1220.99
48_A133_L1.1190.99
40_I44_A1.1160.99
17_K115_C1.0710.99
68_T148_L1.0680.99
95_Q99_A1.0650.99
10_Y167_R1.0570.99
5_V12_H1.0570.99
127_T161_S1.0560.99
62_F146_N1.0510.99
137_L152_M1.0510.99
47_L130_V1.0400.99
44_A157_L1.0380.99
14_K31_V1.0370.99
47_L77_G1.0290.99
64_W98_F1.0250.99
84_S93_Q1.0180.99
71_N137_L1.0080.99
41_P44_A1.0060.99
15_Y34_P1.0060.99
71_N92_I0.9930.99
68_T94_G0.9910.99
131_Y156_I0.9900.99
88_Q91_M0.9890.99
93_Q113_Q0.9670.98
100_S113_Q0.9660.98
66_H124_H0.9570.98
119_P124_H0.9560.98
40_I43_G0.9460.98
37_F47_L0.9450.98
66_H119_P0.9450.98
52_I65_I0.9430.98
31_V81_E0.9410.98
14_K20_D0.9160.98
7_A163_E0.9050.97
125_A163_E0.8990.97
13_D18_Y0.8910.97
43_G157_L0.8880.97
33_F128_L0.8850.97
67_W93_Q0.8820.97
16_S166_A0.8760.97
143_F148_L0.8690.97
53_D124_H0.8680.97
35_I162_I0.8610.97
52_I129_T0.8590.97
17_K98_F0.8580.97
43_G158_A0.8570.97
52_I60_C0.8510.96
10_Y123_D0.8480.96
17_K30_F0.8350.96
16_S19_A0.8270.96
8_N163_E0.8260.96
61_G149_Y0.8240.96
16_S20_D0.8200.96
44_A132_A0.8170.95
56_A60_C0.8060.95
38_D77_G0.8060.95
51_F114_Y0.8040.95
35_I128_L0.8040.95
44_A47_L0.7900.95
68_T145_L0.7840.94
32_S67_W0.7730.94
86_E89_D0.7680.94
70_A92_I0.7600.93
134_D156_I0.7440.93
54_H127_T0.7410.92
112_H142_G0.7380.92
147_E151_E0.7220.91
84_S91_M0.7170.91
143_F147_E0.7130.91
64_W115_C0.7120.91
140_Q143_F0.7110.91
10_Y13_D0.7110.91
5_V9_P0.7100.91
11_L15_Y0.7050.90
121_D167_R0.7030.90
35_I49_L0.7000.90
56_A64_W0.6990.90
32_S83_A0.6990.90
62_F65_I0.6900.89
5_V162_I0.6900.89
67_W84_S0.6860.89
95_Q142_G0.6820.89
53_D119_P0.6820.89
69_A91_M0.6820.89
86_E91_M0.6780.89
139_L143_F0.6750.88
30_F98_F0.6740.88
50_T152_M0.6740.88
145_L149_Y0.6650.88
30_F115_C0.6610.87
31_V82_H0.6530.87
122_K167_R0.6500.87
71_N135_A0.6490.86
41_P47_L0.6410.86
69_A93_Q0.6380.85
139_L148_L0.6360.85
19_A115_C0.6360.85
96_N100_S0.6310.85
48_A94_G0.6230.84
17_K20_D0.6220.84
156_I159_E0.6210.84
49_L72_I0.6200.84
41_P158_A0.6170.84
4_Y15_Y0.6160.83
66_H116_G0.6120.83
13_D16_S0.6070.83
92_I95_Q0.6040.82
56_A63_S0.6040.82
12_H15_Y0.6030.82
39_D47_L0.5980.82
15_Y117_P0.5970.82
154_E157_L0.5920.81
69_A72_I0.5920.81
53_D56_A0.5910.81
147_E150_Q0.5890.81
92_I97_S0.5880.81
36_H77_G0.5840.80
18_Y166_A0.5770.79
37_F130_V0.5760.79
9_P165_L0.5720.79
37_F158_A0.5680.78
37_F70_A0.5630.78
20_D147_E0.5620.78
87_R91_M0.5590.77
100_S115_C0.5580.77
64_W150_Q0.5570.77
153_K159_E0.5550.77
123_D165_L0.5550.77
69_A84_S0.5540.77
15_Y31_V0.5530.76
5_V11_L0.5520.76
96_N115_C0.5520.76
120_P124_H0.5500.76
93_Q112_H0.5460.75
48_A131_Y0.5420.75
139_L142_G0.5420.75
54_H120_P0.5390.75
64_W120_P0.5350.74
64_W147_E0.5340.74
52_I145_L0.5340.74
46_T155_H0.5340.74
73_P77_G0.5330.74
39_D77_G0.5300.73
52_I127_T0.5260.73
129_T149_Y0.5240.73
66_H120_P0.5240.73
55_D124_H0.5230.72
52_I149_Y0.5200.72
31_V85_E0.5170.72
64_W97_S0.5170.72
57_I63_S0.5140.71
33_F37_F0.5100.71
84_S87_R0.5090.70
46_T135_A0.5090.70
84_S88_Q0.5080.70
10_Y16_S0.5070.70
12_H114_Y0.5050.70
133_L154_E0.5020.69
56_A120_P0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fjjA 2 0.8929 100 0.22 Contact Map
2evvA 2 0.9762 100 0.227 Contact Map
3n08A 2 0.8571 100 0.236 Contact Map
1fuxA 2 0.8988 100 0.245 Contact Map
4begA 4 0.8988 100 0.254 Contact Map
1wpxB 1 0.875 99.9 0.546 Contact Map
2jyzA 1 0.7679 99.9 0.569 Contact Map
2gzqA 1 0.8512 99.9 0.585 Contact Map
1vw41 1 0.8571 99.9 0.586 Contact Map
3axyA 1 0.756 99.9 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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