YXJM - BACSU - GREMLIN Contacts

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YXJM - Sensor histidine kinase YxjM

UniProt:	P55183	Sequences: MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFAVYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRLPSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAERNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHELTSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTALRGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAVISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSLPLMTTNKEQKDEQR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	406 (334)
Sequences:	28719 (25618)
Seq/√Len:	1401.8

ECOLI - UHPB TORS BARA RCSC RCSD NARX KDPD GLRK BAES ARCB ENVZ EVGS PHOQ CPXA NARQ CREC CUSS ZRAS RSTB ATOS QSEC YEDV DCUS DPIB BASS PHOR YPDA
BACSU - YXJM YFIJ YDFH YVFT DESK GLNK KINB COMP LIAS YCLK KINE YVRG YKOH CSSS BCES LYTS YYCG KINA YVCQ YRKQ YCBM YHCY RESE YXDK PHOR KIND DCTS CITS YBDK MALK KINC NATK
HALSA - Q9HQG5 Q9HQE9 Q9HQ16 Q9HQ15 Q9HRG1 Q9HR10 Q9HNM2 O51970 Q9HRE4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
341_H	391_S	3.863	1.00
347_T	387_K	3.668	1.00
225_L	246_V	3.608	1.00
345_T	389_E	3.239	1.00
345_T	387_K	3.177	1.00
377_T	389_E	3.060	1.00
366_K	370_E	3.032	1.00
229_P	247_L	2.940	1.00
229_P	244_Q	2.866	1.00
343_Y	391_S	2.839	1.00
222_I	250_A	2.779	1.00
318_A	388_I	2.709	1.00
365_M	376_L	2.608	1.00
322_I	331_A	2.608	1.00
334_V	345_T	2.571	1.00
343_Y	389_E	2.536	1.00
292_S	332_A	2.527	1.00
292_S	330_H	2.496	1.00
314_I	369_A	2.488	1.00
326_A	349_D	2.441	1.00
221_V	250_A	2.435	1.00
330_H	349_D	2.426	1.00
369_A	390_L	2.425	1.00
294_D	334_V	2.405	1.00
378_F	388_I	2.388	1.00
338_D	343_Y	2.339	1.00
294_D	332_A	2.335	1.00
228_L	243_I	2.287	1.00
369_A	374_G	2.280	1.00
233_K	240_E	2.237	1.00
381_V	384_S	2.201	1.00
379_S	387_K	2.186	1.00
375_S	391_S	2.150	1.00
271_V	306_N	2.123	1.00
180_L	183_A	2.104	1.00
348_D	352_F	2.098	1.00
226_Q	247_L	2.057	1.00
173_L	176_A	2.051	1.00
336_S	343_Y	2.043	1.00
329_S	349_D	2.013	1.00
222_I	251_R	1.997	1.00
332_A	347_T	1.947	1.00
337_N	394_L	1.920	1.00
306_N	372_A	1.896	1.00
344_V	390_L	1.826	1.00
379_S	389_E	1.809	1.00
290_H	330_H	1.801	1.00
221_V	246_V	1.775	1.00
334_V	347_T	1.769	1.00
314_I	390_L	1.750	1.00
380_A	386_L	1.742	1.00
270_M	305_P	1.736	1.00
336_S	345_T	1.734	1.00
315_L	344_V	1.723	1.00
314_I	368_R	1.722	1.00
235_S	238_D	1.722	1.00
314_I	365_M	1.717	1.00
348_D	385_G	1.716	1.00
235_S	239_S	1.704	1.00
236_K	239_S	1.698	1.00
173_L	177_H	1.676	1.00
247_L	251_R	1.675	1.00
180_L	184_H	1.673	1.00
278_G	312_Y	1.671	1.00
353_T	386_L	1.670	1.00
275_A	278_G	1.637	1.00
326_A	329_S	1.636	1.00
229_P	240_E	1.627	1.00
326_A	331_A	1.565	1.00
369_A	376_L	1.563	1.00
368_R	372_A	1.525	1.00
370_E	375_S	1.516	1.00
177_H	180_L	1.514	1.00
224_Q	245_N	1.510	1.00
193_L	197_Y	1.509	1.00
177_H	181_Q	1.496	1.00
313_R	316_Q	1.490	1.00
150_R	153_R	1.481	1.00
187_L	190_A	1.471	1.00
320_T	324_R	1.444	1.00
342_L	394_L	1.434	1.00
176_A	180_L	1.429	1.00
231_I	239_S	1.427	1.00
183_A	186_E	1.405	1.00
254_L	258_R	1.396	1.00
225_L	250_A	1.367	1.00
318_A	346_I	1.366	1.00
228_L	239_S	1.362	1.00
200_L	204_T	1.361	1.00
304_P	307_V	1.357	1.00
200_L	203_R	1.353	1.00
377_T	391_S	1.351	1.00
224_Q	242_V	1.341	1.00
201_E	205_R	1.340	1.00
188_Q	191_S	1.330	1.00
380_A	383_P	1.315	1.00
225_L	247_L	1.311	1.00
182_K	186_E	1.306	1.00
268_E	305_P	1.305	1.00
289_L	293_L	1.280	1.00
327_D	351_Q	1.277	1.00
179_E	183_A	1.276	1.00
269_S	308_S	1.266	1.00
193_L	196_R	1.261	1.00
197_Y	201_E	1.255	1.00
222_I	247_L	1.248	1.00
146_F	150_R	1.239	1.00
176_A	181_Q	1.237	1.00
181_Q	185_A	1.235	1.00
347_T	381_V	1.228	1.00
333_A	346_I	1.218	1.00
184_H	188_Q	1.214	1.00
225_L	243_I	1.212	1.00
244_Q	248_S	1.211	1.00
295_T	335_I	1.207	1.00
307_V	310_T	1.203	1.00
240_E	244_Q	1.202	1.00
150_R	154_E	1.201	1.00
296_A	336_S	1.196	1.00
220_S	224_Q	1.177	1.00
268_E	271_V	1.168	1.00
378_F	386_L	1.166	1.00
222_I	254_L	1.165	1.00
169_M	173_L	1.154	1.00
311_I	392_L	1.153	1.00
199_V	203_R	1.149	1.00
306_N	311_I	1.134	1.00
191_S	194_S	1.132	1.00
318_A	365_M	1.132	1.00
354_G	382_Q	1.128	1.00
310_T	313_R	1.123	1.00
380_A	384_S	1.121	1.00
332_A	349_D	1.108	1.00
317_E	365_M	1.103	1.00
194_S	198_A	1.103	1.00
319_L	331_A	1.103	1.00
286_R	289_L	1.094	1.00
363_T	367_E	1.090	1.00
203_R	207_A	1.088	1.00
184_H	187_L	1.085	1.00
312_Y	316_Q	1.082	1.00
47_L	51_W	1.082	1.00
196_R	200_L	1.074	1.00
280_I	293_L	1.074	1.00
195_L	198_A	1.072	1.00
181_Q	184_H	1.065	1.00
369_A	392_L	1.056	1.00
250_A	254_L	1.056	1.00
222_I	226_Q	1.056	1.00
151_F	154_E	1.053	1.00
214_I	257_V	1.050	1.00
177_H	184_H	1.049	1.00
280_I	284_E	1.039	1.00
283_V	323_I	1.034	1.00
214_I	253_C	1.032	1.00
213_S	313_R	1.031	1.00
245_N	249_V	1.025	1.00
202_E	205_R	1.021	1.00
270_M	303_W	1.017	1.00
275_A	279_L	1.017	1.00
281_H	284_E	1.015	1.00
255_Q	259_S	1.012	1.00
277_R	281_H	1.011	1.00
310_T	368_R	1.008	1.00
149_M	152_R	1.007	1.00
185_A	189_E	1.006	1.00
311_I	342_L	1.003	1.00
225_L	229_P	1.001	1.00
338_D	391_S	1.000	1.00
176_A	179_E	0.998	1.00
374_G	392_L	0.998	1.00
241_K	244_Q	0.995	1.00
179_E	182_K	0.990	1.00
218_L	253_C	0.988	1.00
46_Y	50_I	0.981	1.00
271_V	275_A	0.979	1.00
223_V	227_S	0.976	1.00
195_L	199_V	0.972	1.00
322_I	326_A	0.970	1.00
187_L	191_S	0.970	1.00
237_E	240_E	0.970	1.00
183_A	187_L	0.969	1.00
48_A	52_I	0.962	1.00
176_A	184_H	0.962	1.00
297_G	337_N	0.958	1.00
198_A	201_E	0.956	1.00
220_S	249_V	0.954	1.00
197_Y	200_L	0.948	1.00
278_G	282_Q	0.942	1.00
319_L	323_I	0.935	1.00
319_L	333_A	0.934	1.00
279_L	282_Q	0.930	1.00
215_G	258_R	0.928	1.00
296_A	334_V	0.925	1.00
283_V	316_Q	0.925	1.00
228_L	246_V	0.918	1.00
302_S	337_N	0.908	1.00
376_L	388_I	0.906	1.00
149_M	153_R	0.897	1.00
178_K	181_Q	0.895	1.00
259_S	310_T	0.889	1.00
311_I	344_V	0.882	1.00
182_K	185_A	0.881	1.00
315_L	319_L	0.879	1.00
147_S	150_R	0.878	1.00
318_A	390_L	0.877	1.00
308_S	312_Y	0.875	1.00
86_A	90_L	0.875	1.00
176_A	183_A	0.873	1.00
97_Y	101_R	0.867	1.00
276_L	315_L	0.867	1.00
213_S	217_E	0.866	1.00
353_T	388_I	0.863	1.00
198_A	202_E	0.862	1.00
241_K	245_N	0.861	1.00
279_L	312_Y	0.860	1.00
244_Q	247_L	0.857	1.00
169_M	177_H	0.853	1.00
236_K	240_E	0.852	1.00
301_E	337_N	0.852	1.00
191_S	195_L	0.851	1.00
315_L	346_I	0.849	1.00
310_T	372_A	0.846	1.00
205_R	209_D	0.844	1.00
338_D	341_H	0.839	1.00
148_S	152_R	0.839	1.00
186_E	189_E	0.839	1.00
353_T	380_A	0.837	1.00
178_K	182_K	0.837	1.00
367_E	371_K	0.836	1.00
194_S	197_Y	0.836	1.00
279_L	283_V	0.832	1.00
213_S	256_E	0.826	1.00
298_L	301_E	0.826	1.00
307_V	372_A	0.824	1.00
277_R	280_I	0.818	1.00
50_I	54_P	0.816	1.00
242_V	245_N	0.815	1.00
216_H	220_S	0.812	1.00
51_W	54_P	0.811	1.00
227_S	242_V	0.811	1.00
186_E	190_A	0.809	1.00
174_E	178_K	0.806	1.00
362_L	365_M	0.806	1.00
376_L	390_L	0.803	1.00
360_F	364_G	0.801	1.00
311_I	372_A	0.797	1.00
341_H	375_S	0.793	1.00
352_F	386_L	0.792	1.00
248_S	252_E	0.790	1.00
302_S	342_L	0.787	1.00
224_Q	246_V	0.786	1.00
243_I	246_V	0.785	1.00
199_V	202_E	0.785	1.00
367_E	370_E	0.780	1.00
282_Q	312_Y	0.777	1.00
173_L	180_L	0.775	1.00
283_V	319_L	0.774	1.00
226_Q	229_P	0.772	1.00
38_L	41_F	0.772	1.00
96_I	100_F	0.770	1.00
380_A	385_G	0.770	1.00
229_P	243_I	0.769	1.00
210_I	260_V	0.768	1.00
206_I	210_I	0.763	1.00
49_F	52_I	0.759	1.00
249_V	252_E	0.758	1.00
340_S	394_L	0.757	1.00
277_R	295_T	0.756	1.00
279_L	316_Q	0.756	1.00
214_I	217_E	0.755	1.00
169_M	176_A	0.754	1.00
238_D	241_K	0.751	1.00
325_H	351_Q	0.748	1.00
348_D	386_L	0.747	1.00
280_I	283_V	0.747	1.00
270_M	273_L	0.745	1.00
287_S	323_I	0.744	1.00
145_L	148_S	0.744	1.00
285_E	288_G	0.741	1.00
139_M	143_Y	0.741	1.00
275_A	312_Y	0.740	1.00
272_G	275_A	0.740	1.00
276_L	335_I	0.737	1.00
148_S	151_F	0.734	1.00
275_A	280_I	0.732	1.00
315_L	333_A	0.732	1.00
233_K	236_K	0.730	1.00
175_H	179_E	0.729	1.00
145_L	153_R	0.727	1.00
280_I	291_V	0.725	1.00
249_V	253_C	0.724	1.00
146_F	154_E	0.722	1.00
374_G	393_P	0.718	1.00
175_H	178_K	0.712	1.00
289_L	326_A	0.708	1.00
364_G	368_R	0.707	1.00
131_T	135_N	0.706	1.00
132_I	136_I	0.705	1.00
328_A	349_D	0.704	1.00
221_V	225_L	0.704	1.00
190_A	196_R	0.704	1.00
96_I	101_R	0.702	1.00
131_T	134_S	0.702	1.00
374_G	390_L	0.700	1.00
282_Q	316_Q	0.698	1.00
41_F	44_A	0.697	1.00
335_I	344_V	0.697	1.00
353_T	378_F	0.697	1.00
310_T	371_K	0.697	1.00
141_G	145_L	0.695	1.00
296_A	335_I	0.693	1.00
205_R	367_E	0.693	1.00
98_A	101_R	0.692	1.00
215_G	254_L	0.690	1.00
239_S	242_V	0.686	1.00
238_D	242_V	0.685	1.00
68_G	71_L	0.685	1.00
93_F	96_I	0.684	1.00
74_D	78_A	0.683	1.00
190_A	194_S	0.679	1.00
310_T	314_I	0.678	1.00
335_I	342_L	0.672	1.00
258_R	262_H	0.669	1.00
95_M	99_A	0.669	1.00
196_R	199_V	0.668	1.00
274_T	277_R	0.663	1.00
52_I	56_V	0.663	1.00
225_L	228_L	0.662	1.00
298_L	337_N	0.661	1.00
212_D	317_E	0.659	1.00
59_T	62_S	0.659	1.00
212_D	216_H	0.658	1.00
333_A	344_V	0.657	1.00
381_V	387_K	0.655	1.00
122_L	125_Q	0.654	1.00
106_L	109_I	0.653	1.00
215_G	253_C	0.653	1.00
177_H	183_A	0.651	1.00
265_G	360_F	0.647	1.00
185_A	188_Q	0.647	1.00
217_E	253_C	0.640	1.00
45_V	49_F	0.640	1.00
294_D	336_S	0.636	1.00
169_M	174_E	0.636	1.00
377_T	390_L	0.634	1.00
213_S	317_E	0.633	1.00
365_M	369_A	0.633	1.00
269_S	273_L	0.631	1.00
224_Q	249_V	0.628	1.00
90_L	94_L	0.626	1.00
231_I	234_S	0.626	1.00
44_A	48_A	0.626	1.00
227_S	230_Y	0.623	1.00
50_I	53_I	0.621	1.00
246_V	250_A	0.621	1.00
204_T	267_S	0.621	1.00
256_E	259_S	0.621	1.00
253_C	257_V	0.620	1.00
145_L	152_R	0.620	1.00
108_L	111_T	0.619	1.00
331_A	335_I	0.617	1.00
289_L	323_I	0.616	1.00
180_L	187_L	0.616	1.00
143_Y	147_S	0.613	1.00
189_E	193_L	0.613	1.00
247_L	250_A	0.613	1.00
345_T	379_S	0.612	1.00
53_I	56_V	0.611	1.00
350_G	385_G	0.611	1.00
211_H	217_E	0.610	1.00
280_I	319_L	0.609	1.00
145_L	149_M	0.607	1.00
255_Q	309_E	0.606	1.00
100_F	103_P	0.605	1.00
60_A	64_S	0.605	1.00
226_Q	230_Y	0.604	1.00
141_G	154_E	0.602	1.00
277_R	293_L	0.602	1.00
278_G	281_H	0.600	1.00
261_V	265_G	0.600	1.00
65_I	69_L	0.596	1.00
142_L	145_L	0.595	1.00
269_S	272_G	0.594	1.00
271_V	308_S	0.594	1.00
218_L	257_V	0.594	1.00
268_E	306_N	0.592	1.00
279_L	319_L	0.591	1.00
245_N	248_S	0.591	1.00
274_T	278_G	0.591	1.00
237_E	241_K	0.591	1.00
272_G	302_S	0.591	1.00
51_W	55_Y	0.590	1.00
379_S	386_L	0.587	1.00
252_E	256_E	0.587	1.00
93_F	97_Y	0.583	1.00
249_V	261_V	0.582	1.00
219_T	223_V	0.580	1.00
272_G	303_W	0.580	1.00
212_D	215_G	0.579	1.00
42_V	46_Y	0.577	1.00
201_E	204_T	0.577	1.00
250_A	253_C	0.576	1.00
341_H	394_L	0.576	1.00
52_I	55_Y	0.574	1.00
220_S	245_N	0.574	1.00
226_Q	251_R	0.574	1.00
305_P	395_M	0.573	1.00
179_E	184_H	0.573	1.00
263_Q	267_S	0.572	1.00
50_I	56_V	0.571	1.00
139_M	152_R	0.570	1.00
215_G	261_V	0.570	1.00
173_L	184_H	0.570	1.00
231_I	242_V	0.569	1.00
243_I	247_L	0.568	1.00
211_H	317_E	0.565	1.00
296_A	301_E	0.565	1.00
263_Q	363_T	0.564	1.00
146_F	149_M	0.564	1.00
313_R	364_G	0.564	1.00
109_I	113_C	0.563	1.00
104_S	108_L	0.561	1.00
57_A	62_S	0.560	1.00
191_S	196_R	0.560	1.00
317_E	364_G	0.558	1.00
39_L	42_V	0.557	1.00
57_A	61_V	0.557	1.00
253_C	258_R	0.556	1.00
283_V	320_T	0.556	1.00
234_S	239_S	0.556	1.00
102_L	106_L	0.555	1.00
265_G	358_Y	0.555	1.00
40_A	43_F	0.554	1.00
142_L	146_F	0.554	1.00
216_H	261_V	0.552	1.00
239_S	243_I	0.551	1.00
273_L	344_V	0.550	1.00
47_L	50_I	0.550	1.00
110_F	114_L	0.550	1.00
219_T	222_I	0.550	1.00
313_R	368_R	0.548	1.00
93_F	98_A	0.548	1.00
317_E	324_R	0.547	1.00
257_V	260_V	0.545	1.00
224_Q	227_S	0.544	1.00
290_H	293_L	0.544	1.00
369_A	372_A	0.543	1.00
318_A	369_A	0.540	1.00
366_K	375_S	0.539	1.00
309_E	313_R	0.539	1.00
275_A	282_Q	0.539	1.00
260_V	264_M	0.538	1.00
331_A	346_I	0.536	1.00
65_I	68_G	0.536	1.00
316_Q	320_T	0.534	1.00
189_E	194_S	0.534	1.00
183_A	188_Q	0.534	1.00
89_F	93_F	0.533	1.00
207_A	211_H	0.532	1.00
98_A	103_P	0.531	1.00
40_A	44_A	0.530	1.00
103_P	107_S	0.529	1.00
136_I	140_L	0.528	1.00
227_S	231_I	0.527	1.00
213_S	216_H	0.527	1.00
138_I	142_L	0.526	1.00
90_L	101_R	0.526	1.00
91_I	99_A	0.526	1.00
95_M	98_A	0.524	1.00
253_C	256_E	0.523	1.00
209_D	325_H	0.523	1.00
206_I	209_D	0.523	1.00
64_S	68_G	0.520	1.00
276_L	333_A	0.520	1.00
44_A	47_L	0.519	1.00
65_I	76_F	0.517	1.00
106_L	110_F	0.517	1.00
351_Q	386_L	0.515	1.00
365_M	368_R	0.514	1.00
39_L	43_F	0.513	1.00
286_R	290_H	0.513	1.00
111_T	114_L	0.513	1.00
56_V	59_T	0.513	1.00
341_H	393_P	0.512	1.00
61_V	64_S	0.512	1.00
220_S	223_V	0.510	1.00
190_A	195_L	0.509	1.00
317_E	320_T	0.509	1.00
203_R	211_H	0.508	1.00
291_V	333_A	0.508	1.00
289_L	331_A	0.507	1.00
217_E	249_V	0.506	1.00
381_V	385_G	0.504	1.00
88_Y	92_V	0.504	1.00
203_R	216_H	0.504	1.00
57_A	60_A	0.504	1.00
138_I	152_R	0.503	1.00
93_F	101_R	0.503	1.00
211_H	261_V	0.502	1.00
320_T	325_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.6601	100	0.446	Contact Map
4bixA	2	0.5074	100	0.483	Contact Map
4r39A	1	0.4951	100	0.487	Contact Map
3ehhA	2	0.4778	100	0.488	Contact Map
4q20A	2	0.5025	100	0.489	Contact Map
2c2aA	2	0.5197	100	0.49	Contact Map
4ctiA	2	0.5296	100	0.49	Contact Map
3d36A	2	0.4852	100	0.504	Contact Map
3jz3A	2	0.3695	100	0.506	Contact Map
4e01A	3	0.6502	100	0.512	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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