GREMLIN Database
YXJM - Sensor histidine kinase YxjM
UniProt: P55183 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (334)
Sequences: 28719 (25618)
Seq/√Len: 1401.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
341_H391_S3.8631.00
347_T387_K3.6681.00
225_L246_V3.6081.00
345_T389_E3.2391.00
345_T387_K3.1771.00
377_T389_E3.0601.00
366_K370_E3.0321.00
229_P247_L2.9401.00
229_P244_Q2.8661.00
343_Y391_S2.8391.00
222_I250_A2.7791.00
318_A388_I2.7091.00
365_M376_L2.6081.00
322_I331_A2.6081.00
334_V345_T2.5711.00
343_Y389_E2.5361.00
292_S332_A2.5271.00
292_S330_H2.4961.00
314_I369_A2.4881.00
326_A349_D2.4411.00
221_V250_A2.4351.00
330_H349_D2.4261.00
369_A390_L2.4251.00
294_D334_V2.4051.00
378_F388_I2.3881.00
338_D343_Y2.3391.00
294_D332_A2.3351.00
228_L243_I2.2871.00
369_A374_G2.2801.00
233_K240_E2.2371.00
381_V384_S2.2011.00
379_S387_K2.1861.00
375_S391_S2.1501.00
271_V306_N2.1231.00
180_L183_A2.1041.00
348_D352_F2.0981.00
226_Q247_L2.0571.00
173_L176_A2.0511.00
336_S343_Y2.0431.00
329_S349_D2.0131.00
222_I251_R1.9971.00
332_A347_T1.9471.00
337_N394_L1.9201.00
306_N372_A1.8961.00
344_V390_L1.8261.00
379_S389_E1.8091.00
290_H330_H1.8011.00
221_V246_V1.7751.00
334_V347_T1.7691.00
314_I390_L1.7501.00
380_A386_L1.7421.00
270_M305_P1.7361.00
336_S345_T1.7341.00
315_L344_V1.7231.00
314_I368_R1.7221.00
235_S238_D1.7221.00
314_I365_M1.7171.00
348_D385_G1.7161.00
235_S239_S1.7041.00
236_K239_S1.6981.00
173_L177_H1.6761.00
247_L251_R1.6751.00
180_L184_H1.6731.00
278_G312_Y1.6711.00
353_T386_L1.6701.00
275_A278_G1.6371.00
326_A329_S1.6361.00
229_P240_E1.6271.00
326_A331_A1.5651.00
369_A376_L1.5631.00
368_R372_A1.5251.00
370_E375_S1.5161.00
177_H180_L1.5141.00
224_Q245_N1.5101.00
193_L197_Y1.5091.00
177_H181_Q1.4961.00
313_R316_Q1.4901.00
150_R153_R1.4811.00
187_L190_A1.4711.00
320_T324_R1.4441.00
342_L394_L1.4341.00
176_A180_L1.4291.00
231_I239_S1.4271.00
183_A186_E1.4051.00
254_L258_R1.3961.00
225_L250_A1.3671.00
318_A346_I1.3661.00
228_L239_S1.3621.00
200_L204_T1.3611.00
304_P307_V1.3571.00
200_L203_R1.3531.00
377_T391_S1.3511.00
224_Q242_V1.3411.00
201_E205_R1.3401.00
188_Q191_S1.3301.00
380_A383_P1.3151.00
225_L247_L1.3111.00
182_K186_E1.3061.00
268_E305_P1.3051.00
289_L293_L1.2801.00
327_D351_Q1.2771.00
179_E183_A1.2761.00
269_S308_S1.2661.00
193_L196_R1.2611.00
197_Y201_E1.2551.00
222_I247_L1.2481.00
146_F150_R1.2391.00
176_A181_Q1.2371.00
181_Q185_A1.2351.00
347_T381_V1.2281.00
333_A346_I1.2181.00
184_H188_Q1.2141.00
225_L243_I1.2121.00
244_Q248_S1.2111.00
295_T335_I1.2071.00
307_V310_T1.2031.00
240_E244_Q1.2021.00
150_R154_E1.2011.00
296_A336_S1.1961.00
220_S224_Q1.1771.00
268_E271_V1.1681.00
378_F386_L1.1661.00
222_I254_L1.1651.00
169_M173_L1.1541.00
311_I392_L1.1531.00
199_V203_R1.1491.00
306_N311_I1.1341.00
191_S194_S1.1321.00
318_A365_M1.1321.00
354_G382_Q1.1281.00
310_T313_R1.1231.00
380_A384_S1.1211.00
332_A349_D1.1081.00
317_E365_M1.1031.00
194_S198_A1.1031.00
319_L331_A1.1031.00
286_R289_L1.0941.00
363_T367_E1.0901.00
203_R207_A1.0881.00
184_H187_L1.0851.00
312_Y316_Q1.0821.00
47_L51_W1.0821.00
196_R200_L1.0741.00
280_I293_L1.0741.00
195_L198_A1.0721.00
181_Q184_H1.0651.00
369_A392_L1.0561.00
250_A254_L1.0561.00
222_I226_Q1.0561.00
151_F154_E1.0531.00
214_I257_V1.0501.00
177_H184_H1.0491.00
280_I284_E1.0391.00
283_V323_I1.0341.00
214_I253_C1.0321.00
213_S313_R1.0311.00
245_N249_V1.0251.00
202_E205_R1.0211.00
270_M303_W1.0171.00
275_A279_L1.0171.00
281_H284_E1.0151.00
255_Q259_S1.0121.00
277_R281_H1.0111.00
310_T368_R1.0081.00
149_M152_R1.0071.00
185_A189_E1.0061.00
311_I342_L1.0031.00
225_L229_P1.0011.00
338_D391_S1.0001.00
176_A179_E0.9981.00
374_G392_L0.9981.00
241_K244_Q0.9951.00
179_E182_K0.9901.00
218_L253_C0.9881.00
46_Y50_I0.9811.00
271_V275_A0.9791.00
223_V227_S0.9761.00
195_L199_V0.9721.00
322_I326_A0.9701.00
187_L191_S0.9701.00
237_E240_E0.9701.00
183_A187_L0.9691.00
48_A52_I0.9621.00
176_A184_H0.9621.00
297_G337_N0.9581.00
198_A201_E0.9561.00
220_S249_V0.9541.00
197_Y200_L0.9481.00
278_G282_Q0.9421.00
319_L323_I0.9351.00
319_L333_A0.9341.00
279_L282_Q0.9301.00
215_G258_R0.9281.00
296_A334_V0.9251.00
283_V316_Q0.9251.00
228_L246_V0.9181.00
302_S337_N0.9081.00
376_L388_I0.9061.00
149_M153_R0.8971.00
178_K181_Q0.8951.00
259_S310_T0.8891.00
311_I344_V0.8821.00
182_K185_A0.8811.00
315_L319_L0.8791.00
147_S150_R0.8781.00
318_A390_L0.8771.00
308_S312_Y0.8751.00
86_A90_L0.8751.00
176_A183_A0.8731.00
97_Y101_R0.8671.00
276_L315_L0.8671.00
213_S217_E0.8661.00
353_T388_I0.8631.00
198_A202_E0.8621.00
241_K245_N0.8611.00
279_L312_Y0.8601.00
244_Q247_L0.8571.00
169_M177_H0.8531.00
236_K240_E0.8521.00
301_E337_N0.8521.00
191_S195_L0.8511.00
315_L346_I0.8491.00
310_T372_A0.8461.00
205_R209_D0.8441.00
338_D341_H0.8391.00
148_S152_R0.8391.00
186_E189_E0.8391.00
353_T380_A0.8371.00
178_K182_K0.8371.00
367_E371_K0.8361.00
194_S197_Y0.8361.00
279_L283_V0.8321.00
213_S256_E0.8261.00
298_L301_E0.8261.00
307_V372_A0.8241.00
277_R280_I0.8181.00
50_I54_P0.8161.00
242_V245_N0.8151.00
216_H220_S0.8121.00
51_W54_P0.8111.00
227_S242_V0.8111.00
186_E190_A0.8091.00
174_E178_K0.8061.00
362_L365_M0.8061.00
376_L390_L0.8031.00
360_F364_G0.8011.00
311_I372_A0.7971.00
341_H375_S0.7931.00
352_F386_L0.7921.00
248_S252_E0.7901.00
302_S342_L0.7871.00
224_Q246_V0.7861.00
243_I246_V0.7851.00
199_V202_E0.7851.00
367_E370_E0.7801.00
282_Q312_Y0.7771.00
173_L180_L0.7751.00
283_V319_L0.7741.00
226_Q229_P0.7721.00
38_L41_F0.7721.00
96_I100_F0.7701.00
380_A385_G0.7701.00
229_P243_I0.7691.00
210_I260_V0.7681.00
206_I210_I0.7631.00
49_F52_I0.7591.00
249_V252_E0.7581.00
340_S394_L0.7571.00
277_R295_T0.7561.00
279_L316_Q0.7561.00
214_I217_E0.7551.00
169_M176_A0.7541.00
238_D241_K0.7511.00
325_H351_Q0.7481.00
348_D386_L0.7471.00
280_I283_V0.7471.00
270_M273_L0.7451.00
287_S323_I0.7441.00
145_L148_S0.7441.00
285_E288_G0.7411.00
139_M143_Y0.7411.00
275_A312_Y0.7401.00
272_G275_A0.7401.00
276_L335_I0.7371.00
148_S151_F0.7341.00
275_A280_I0.7321.00
315_L333_A0.7321.00
233_K236_K0.7301.00
175_H179_E0.7291.00
145_L153_R0.7271.00
280_I291_V0.7251.00
249_V253_C0.7241.00
146_F154_E0.7221.00
374_G393_P0.7181.00
175_H178_K0.7121.00
289_L326_A0.7081.00
364_G368_R0.7071.00
131_T135_N0.7061.00
132_I136_I0.7051.00
328_A349_D0.7041.00
221_V225_L0.7041.00
190_A196_R0.7041.00
96_I101_R0.7021.00
131_T134_S0.7021.00
374_G390_L0.7001.00
282_Q316_Q0.6981.00
41_F44_A0.6971.00
335_I344_V0.6971.00
353_T378_F0.6971.00
310_T371_K0.6971.00
141_G145_L0.6951.00
296_A335_I0.6931.00
205_R367_E0.6931.00
98_A101_R0.6921.00
215_G254_L0.6901.00
239_S242_V0.6861.00
238_D242_V0.6851.00
68_G71_L0.6851.00
93_F96_I0.6841.00
74_D78_A0.6831.00
190_A194_S0.6791.00
310_T314_I0.6781.00
335_I342_L0.6721.00
258_R262_H0.6691.00
95_M99_A0.6691.00
196_R199_V0.6681.00
274_T277_R0.6631.00
52_I56_V0.6631.00
225_L228_L0.6621.00
298_L337_N0.6611.00
212_D317_E0.6591.00
59_T62_S0.6591.00
212_D216_H0.6581.00
333_A344_V0.6571.00
381_V387_K0.6551.00
122_L125_Q0.6541.00
106_L109_I0.6531.00
215_G253_C0.6531.00
177_H183_A0.6511.00
265_G360_F0.6471.00
185_A188_Q0.6471.00
217_E253_C0.6401.00
45_V49_F0.6401.00
294_D336_S0.6361.00
169_M174_E0.6361.00
377_T390_L0.6341.00
213_S317_E0.6331.00
365_M369_A0.6331.00
269_S273_L0.6311.00
224_Q249_V0.6281.00
90_L94_L0.6261.00
231_I234_S0.6261.00
44_A48_A0.6261.00
227_S230_Y0.6231.00
50_I53_I0.6211.00
246_V250_A0.6211.00
204_T267_S0.6211.00
256_E259_S0.6211.00
253_C257_V0.6201.00
145_L152_R0.6201.00
108_L111_T0.6191.00
331_A335_I0.6171.00
289_L323_I0.6161.00
180_L187_L0.6161.00
143_Y147_S0.6131.00
189_E193_L0.6131.00
247_L250_A0.6131.00
345_T379_S0.6121.00
53_I56_V0.6111.00
350_G385_G0.6111.00
211_H217_E0.6101.00
280_I319_L0.6091.00
145_L149_M0.6071.00
255_Q309_E0.6061.00
100_F103_P0.6051.00
60_A64_S0.6051.00
226_Q230_Y0.6041.00
141_G154_E0.6021.00
277_R293_L0.6021.00
278_G281_H0.6001.00
261_V265_G0.6001.00
65_I69_L0.5961.00
142_L145_L0.5951.00
269_S272_G0.5941.00
271_V308_S0.5941.00
218_L257_V0.5941.00
268_E306_N0.5921.00
279_L319_L0.5911.00
245_N248_S0.5911.00
274_T278_G0.5911.00
237_E241_K0.5911.00
272_G302_S0.5911.00
51_W55_Y0.5901.00
379_S386_L0.5871.00
252_E256_E0.5871.00
93_F97_Y0.5831.00
249_V261_V0.5821.00
219_T223_V0.5801.00
272_G303_W0.5801.00
212_D215_G0.5791.00
42_V46_Y0.5771.00
201_E204_T0.5771.00
250_A253_C0.5761.00
341_H394_L0.5761.00
52_I55_Y0.5741.00
220_S245_N0.5741.00
226_Q251_R0.5741.00
305_P395_M0.5731.00
179_E184_H0.5731.00
263_Q267_S0.5721.00
50_I56_V0.5711.00
139_M152_R0.5701.00
215_G261_V0.5701.00
173_L184_H0.5701.00
231_I242_V0.5691.00
243_I247_L0.5681.00
211_H317_E0.5651.00
296_A301_E0.5651.00
263_Q363_T0.5641.00
146_F149_M0.5641.00
313_R364_G0.5641.00
109_I113_C0.5631.00
104_S108_L0.5611.00
57_A62_S0.5601.00
191_S196_R0.5601.00
317_E364_G0.5581.00
39_L42_V0.5571.00
57_A61_V0.5571.00
253_C258_R0.5561.00
283_V320_T0.5561.00
234_S239_S0.5561.00
102_L106_L0.5551.00
265_G358_Y0.5551.00
40_A43_F0.5541.00
142_L146_F0.5541.00
216_H261_V0.5521.00
239_S243_I0.5511.00
273_L344_V0.5501.00
47_L50_I0.5501.00
110_F114_L0.5501.00
219_T222_I0.5501.00
313_R368_R0.5481.00
93_F98_A0.5481.00
317_E324_R0.5471.00
257_V260_V0.5451.00
224_Q227_S0.5441.00
290_H293_L0.5441.00
369_A372_A0.5431.00
318_A369_A0.5401.00
366_K375_S0.5391.00
309_E313_R0.5391.00
275_A282_Q0.5391.00
260_V264_M0.5381.00
331_A346_I0.5361.00
65_I68_G0.5361.00
316_Q320_T0.5341.00
189_E194_S0.5341.00
183_A188_Q0.5341.00
89_F93_F0.5331.00
207_A211_H0.5321.00
98_A103_P0.5311.00
40_A44_A0.5301.00
103_P107_S0.5291.00
136_I140_L0.5281.00
227_S231_I0.5271.00
213_S216_H0.5271.00
138_I142_L0.5261.00
90_L101_R0.5261.00
91_I99_A0.5261.00
95_M98_A0.5241.00
253_C256_E0.5231.00
209_D325_H0.5231.00
206_I209_D0.5231.00
64_S68_G0.5201.00
276_L333_A0.5201.00
44_A47_L0.5191.00
65_I76_F0.5171.00
106_L110_F0.5171.00
351_Q386_L0.5151.00
365_M368_R0.5141.00
39_L43_F0.5131.00
286_R290_H0.5131.00
111_T114_L0.5131.00
56_V59_T0.5131.00
341_H393_P0.5121.00
61_V64_S0.5121.00
220_S223_V0.5101.00
190_A195_L0.5091.00
317_E320_T0.5091.00
203_R211_H0.5081.00
291_V333_A0.5081.00
289_L331_A0.5071.00
217_E249_V0.5061.00
381_V385_G0.5041.00
88_Y92_V0.5041.00
203_R216_H0.5041.00
57_A60_A0.5041.00
138_I152_R0.5031.00
93_F101_R0.5031.00
211_H261_V0.5021.00
320_T325_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6601 100 0.446 Contact Map
4bixA 2 0.5074 100 0.483 Contact Map
4r39A 1 0.4951 100 0.487 Contact Map
3ehhA 2 0.4778 100 0.488 Contact Map
4q20A 2 0.5025 100 0.489 Contact Map
2c2aA 2 0.5197 100 0.49 Contact Map
4ctiA 2 0.5296 100 0.49 Contact Map
3d36A 2 0.4852 100 0.504 Contact Map
3jz3A 2 0.3695 100 0.506 Contact Map
4e01A 3 0.6502 100 0.512 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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