GREMLIN Database
GALE - UDP-glucose 4-epimerase
UniProt: P55180 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (293)
Sequences: 55433 (38517)
Seq/√Len: 2250.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G29_V3.3351.00
2_A26_E2.9571.00
241_G260_L2.8101.00
274_A318_E2.7891.00
19_E240_E2.7131.00
256_D304_K2.7001.00
258_Y308_E2.6351.00
66_D113_K2.6041.00
316_G319_E2.5691.00
98_H102_T2.3871.00
277_K318_E2.3661.00
76_A246_L2.2881.00
122_S242_H2.2241.00
30_L57_A2.2121.00
306_K312_E2.2081.00
92_I95_K2.2001.00
61_D64_A2.1811.00
6_T79_H2.1691.00
118_K170_S2.1451.00
180_F320_M2.1321.00
79_H121_F2.1071.00
19_E23_S2.1051.00
57_A64_A2.0801.00
240_E314_K2.0631.00
23_S247_E2.0251.00
78_I246_L2.0181.00
5_V17_C1.9571.00
19_E243_V1.9481.00
4_L74_I1.9251.00
303_A307_R1.9171.00
278_V322_A1.8811.00
240_E244_K1.8741.00
28_V53_T1.8741.00
269_L273_K1.8551.00
176_Y242_H1.8371.00
236_V323_D1.8251.00
274_A277_K1.7711.00
26_E53_T1.7711.00
28_V74_I1.7511.00
174_L245_A1.7281.00
159_L171_V1.7151.00
60_L98_H1.7031.00
267_S270_E1.7011.00
16_T239_A1.6971.00
16_T78_I1.6791.00
137_T140_F1.6771.00
263_G306_K1.6231.00
209_G212_E1.6061.00
33_L54_F1.6041.00
234_H323_D1.5921.00
205_Q209_G1.5851.00
28_V55_Y1.5851.00
128_Y259_N1.5571.00
270_E273_K1.5431.00
66_D110_A1.5331.00
123_S127_V1.5321.00
322_A326_R1.5291.00
16_T80_F1.5171.00
19_E22_N1.5151.00
305_A309_L1.4971.00
213_Q286_R1.4911.00
62_R109_E1.4891.00
12_I179_P1.4851.00
2_A28_V1.4831.00
75_E117_K1.4831.00
105_F109_E1.4691.00
148_Y152_K1.4621.00
79_H104_T1.4551.00
174_L242_H1.4371.00
274_A278_V1.4301.00
138_E304_K1.4261.00
78_I242_H1.4211.00
234_H320_M1.4201.00
23_S243_V1.4181.00
302_P306_K1.4171.00
105_F158_I1.4061.00
102_T105_F1.3991.00
18_V183_H1.3941.00
176_Y238_L1.3811.00
142_L153_L1.3661.00
243_V247_E1.3591.00
25_Y247_E1.3541.00
177_F300_A1.3451.00
97_Y154_M1.3421.00
235_V239_A1.3341.00
19_E239_A1.3341.00
100_N151_T1.3291.00
17_C29_V1.3271.00
66_D114_Y1.3231.00
319_E322_A1.3211.00
3_I25_Y1.3201.00
94_L98_H1.3201.00
118_K172_A1.3201.00
77_V111_M1.3171.00
153_L157_Q1.3091.00
231_D263_G1.3041.00
269_L287_F1.2911.00
104_T155_L1.2881.00
80_F122_S1.2851.00
107_L119_I1.2821.00
233_I238_L1.2781.00
64_A67_S1.2751.00
215_S286_R1.2661.00
244_K248_K1.2611.00
62_R106_I1.2601.00
206_V212_E1.2511.00
122_S176_Y1.2371.00
137_T301_D1.2311.00
157_Q160_R1.2231.00
108_C162_L1.2131.00
8_G17_C1.1971.00
109_E113_K1.1961.00
69_F77_V1.1951.00
302_P313_A1.1941.00
109_E112_E1.1931.00
319_E323_D1.1871.00
315_R323_D1.1841.00
67_S70_A1.1721.00
20_L243_V1.1661.00
256_D308_E1.1631.00
59_L103_G1.1451.00
175_R257_A1.1421.00
163_H171_V1.1361.00
241_G305_A1.1281.00
9_A31_D1.1271.00
21_L52_L1.1091.00
133_T137_T1.1031.00
229_V265_G1.1001.00
111_M119_I1.0961.00
213_Q284_P1.0871.00
69_F74_I1.0841.00
121_F155_L1.0771.00
266_Y317_L1.0751.00
227_T269_L1.0721.00
62_R66_D1.0711.00
240_E311_W1.0631.00
160_R257_A1.0621.00
160_R173_L1.0621.00
133_T140_F1.0581.00
18_V22_N1.0571.00
14_S183_H1.0571.00
70_A114_Y1.0561.00
175_R259_N1.0541.00
237_D262_T1.0541.00
15_H236_V1.0541.00
3_I20_L1.0511.00
80_F242_H1.0461.00
304_K308_E1.0411.00
150_Q154_M1.0401.00
59_L81_A1.0391.00
156_E175_R1.0341.00
234_H315_R1.0311.00
19_E236_V1.0211.00
29_V52_L1.0191.00
139_D304_K1.0181.00
276_E282_E1.0151.00
121_F159_L1.0151.00
21_L51_D1.0141.00
111_M116_V1.0131.00
99_N103_G1.0121.00
11_Y181_G1.0091.00
4_L30_L1.0081.00
108_C119_I1.0011.00
180_F234_H1.0001.00
66_D70_A0.9991.00
234_H237_D0.9891.00
261_G300_A0.9861.00
110_A114_Y0.9691.00
136_I140_F0.9691.00
318_E322_A0.9651.00
170_S254_G0.9641.00
30_L65_V0.9611.00
160_R171_V0.9581.00
121_F173_L0.9541.00
63_E67_S0.9491.00
258_Y304_K0.9461.00
123_S156_E0.9451.00
265_G297_T0.9431.00
11_Y235_V0.9401.00
2_A74_I0.9371.00
288_A291_R0.9361.00
278_V321_C0.9351.00
63_E66_D0.9351.00
55_Y68_V0.9311.00
158_I161_D0.9291.00
278_V325_W0.9271.00
273_K276_E0.9251.00
3_I76_A0.9221.00
64_A68_V0.9181.00
244_K309_L0.9161.00
119_I159_L0.9131.00
241_G311_W0.9121.00
179_P238_L0.9081.00
199_L203_V0.9061.00
279_S325_W0.9041.00
112_E167_N0.9021.00
83_L99_N0.9011.00
253_T256_D0.8981.00
248_K252_S0.8941.00
28_V73_E0.8921.00
108_C158_I0.8881.00
65_V110_A0.8861.00
206_V209_G0.8861.00
227_T267_S0.8841.00
112_E169_W0.8811.00
6_T81_A0.8801.00
32_N58_D0.8771.00
108_C159_L0.8771.00
2_A25_Y0.8761.00
172_A245_A0.8761.00
179_P233_I0.8731.00
265_G299_F0.8731.00
21_L27_I0.8711.00
120_V174_L0.8701.00
30_L68_V0.8691.00
261_G302_P0.8671.00
102_T106_I0.8631.00
211_L214_L0.8581.00
88_E92_I0.8571.00
198_N201_P0.8571.00
323_D326_R0.8461.00
15_H235_V0.8461.00
16_T20_L0.8421.00
240_E315_R0.8391.00
174_L260_L0.8351.00
266_Y270_E0.8341.00
69_F114_Y0.8331.00
17_C27_I0.8251.00
160_R164_T0.8251.00
278_V318_E0.8201.00
2_A75_E0.8171.00
173_L257_A0.8171.00
226_G269_L0.8151.00
245_A305_A0.8131.00
245_A309_L0.8111.00
69_F111_M0.8051.00
30_L64_A0.8041.00
110_A113_K0.8031.00
33_L36_S0.7991.00
3_I78_I0.7991.00
260_L305_A0.7991.00
62_R113_K0.7981.00
69_F110_A0.7971.00
106_I109_E0.7971.00
244_K247_E0.7961.00
97_Y101_L0.7961.00
127_V156_E0.7941.00
109_E162_L0.7931.00
34_S56_E0.7911.00
273_K277_K0.7911.00
263_G302_P0.7881.00
229_V267_S0.7851.00
264_T316_G0.7831.00
276_E281_K0.7811.00
236_V315_R0.7761.00
103_G106_I0.7751.00
229_V297_T0.7651.00
25_Y75_E0.7641.00
125_A177_F0.7621.00
324_S327_W0.7611.00
205_Q208_V0.7601.00
182_A323_D0.7601.00
31_D54_F0.7581.00
161_D165_A0.7571.00
3_I246_L0.7551.00
6_T107_L0.7511.00
266_Y271_M0.7501.00
15_H19_E0.7471.00
97_Y102_T0.7441.00
15_H239_A0.7441.00
15_H18_V0.7431.00
144_A149_G0.7391.00
60_L99_N0.7371.00
20_L246_L0.7341.00
4_L57_A0.7341.00
97_Y151_T0.7331.00
33_L56_E0.7301.00
303_A306_K0.7271.00
154_M157_Q0.7261.00
304_K307_R0.7231.00
96_Y151_T0.7221.00
12_I238_L0.7211.00
177_F261_G0.7211.00
101_L154_M0.7161.00
117_K170_S0.7091.00
244_K310_G0.7091.00
244_K311_W0.7071.00
138_E305_A0.7071.00
271_M317_L0.7041.00
70_A73_E0.6991.00
202_Y205_Q0.6961.00
282_E285_Y0.6951.00
315_R319_E0.6951.00
16_T242_H0.6931.00
4_L77_V0.6931.00
274_A317_L0.6931.00
237_D314_K0.6931.00
106_I110_A0.6891.00
104_T159_L0.6871.00
95_K98_H0.6861.00
90_V147_P0.6851.00
61_D65_V0.6821.00
58_D61_D0.6791.00
79_H107_L0.6791.00
83_L100_N0.6781.00
104_T108_C0.6741.00
204_A208_V0.6741.00
49_G52_L0.6701.00
77_V119_I0.6661.00
77_V107_L0.6651.00
83_L96_Y0.6641.00
155_L159_L0.6621.00
157_Q161_D0.6601.00
218_G226_G0.6601.00
93_P150_Q0.6561.00
112_E162_L0.6561.00
76_A118_K0.6551.00
100_N148_Y0.6531.00
253_T308_E0.6521.00
65_V106_I0.6511.00
240_E243_V0.6491.00
278_V326_R0.6491.00
182_A234_H0.6481.00
127_V142_L0.6471.00
162_L167_N0.6451.00
124_S152_K0.6441.00
95_K99_N0.6441.00
82_G100_N0.6431.00
14_S18_V0.6431.00
174_L241_G0.6431.00
134_S140_F0.6421.00
315_R320_M0.6421.00
89_S96_Y0.6401.00
202_Y206_V0.6391.00
138_E259_N0.6381.00
38_A56_E0.6361.00
159_L173_L0.6351.00
248_K253_T0.6351.00
276_E283_V0.6351.00
2_A73_E0.6331.00
285_Y288_A0.6321.00
131_P136_I0.6291.00
124_S127_V0.6271.00
28_V68_V0.6241.00
171_V255_A0.6231.00
215_S288_A0.6221.00
83_L95_K0.6211.00
239_A243_V0.6181.00
178_N230_R0.6161.00
125_A300_A0.6161.00
23_S240_E0.6141.00
120_V246_L0.6101.00
207_A214_L0.6081.00
264_T318_E0.6081.00
146_N149_G0.6071.00
270_E274_A0.6061.00
26_E51_D0.6061.00
154_M158_I0.6051.00
68_V74_I0.6031.00
112_E165_A0.6021.00
25_Y76_A0.6011.00
132_E140_F0.6001.00
161_D164_T0.5991.00
237_D240_E0.5981.00
231_D262_T0.5941.00
80_F176_Y0.5881.00
274_A321_C0.5871.00
15_H183_H0.5871.00
112_E168_E0.5841.00
306_K313_A0.5821.00
314_K319_E0.5821.00
150_Q157_Q0.5801.00
97_Y150_Q0.5791.00
104_T121_F0.5751.00
126_T149_G0.5751.00
204_A325_W0.5721.00
4_L68_V0.5711.00
158_I162_L0.5681.00
33_L38_A0.5671.00
142_L157_Q0.5671.00
76_A120_V0.5661.00
211_L215_S0.5661.00
207_A276_E0.5641.00
182_A236_V0.5621.00
144_A153_L0.5601.00
76_A117_K0.5601.00
9_A33_L0.5591.00
4_L69_F0.5571.00
198_N202_Y0.5551.00
20_L78_I0.5541.00
228_G268_V0.5541.00
150_Q161_D0.5541.00
180_F262_T0.5511.00
151_T155_L0.5511.00
120_V245_A0.5501.00
135_P301_D0.5501.00
276_E279_S0.5491.00
16_T243_V0.5481.00
5_V29_V0.5481.00
201_P205_Q0.5451.00
18_V236_V0.5431.00
48_T52_L0.5401.00
204_A275_F0.5401.00
147_P151_T0.5371.00
200_M271_M0.5371.00
229_V299_F0.5321.00
23_S244_K0.5321.00
176_Y179_P0.5291.00
57_A68_V0.5291.00
211_L281_K0.5281.00
123_S175_R0.5261.00
238_L260_L0.5251.00
79_H119_I0.5251.00
127_V175_R0.5241.00
295_I298_C0.5231.00
55_Y64_A0.5211.00
137_T303_A0.5171.00
275_F325_W0.5161.00
258_Y305_A0.5161.00
78_I243_V0.5141.00
231_D265_G0.5141.00
286_R289_D0.5131.00
17_C21_L0.5101.00
65_V69_F0.5101.00
216_V287_F0.5091.00
148_Y151_T0.5091.00
207_A275_F0.5081.00
218_G225_D0.5081.00
286_R290_R0.5061.00
89_S147_P0.5061.00
163_H255_A0.5051.00
120_V242_H0.5041.00
5_V20_L0.5041.00
111_M114_Y0.5041.00
108_C112_E0.5031.00
29_V54_F0.5021.00
147_P150_Q0.5021.00
177_F231_D0.5011.00
275_F321_C0.5011.00
184_P198_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1udbA 2 0.9941 100 0.19 Contact Map
1sb8A 2 0.9322 100 0.203 Contact Map
3enkA 2 0.9912 100 0.204 Contact Map
2c20A 2 0.9676 100 0.205 Contact Map
3rufA 2 0.9263 100 0.207 Contact Map
1ek6A 2 0.9941 100 0.211 Contact Map
4lisA 2 0.9941 100 0.214 Contact Map
1oc2A 2 0.9292 100 0.219 Contact Map
1gy8A 2 0.9853 100 0.222 Contact Map
1r6dA 2 0.9263 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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