GREMLIN Database
PEPT - Peptidase T
UniProt: P55179 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (351)
Sequences: 29019 (20654)
Seq/√Len: 1102.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_T169_R3.2881.00
219_T275_E3.0251.00
40_V44_K2.7991.00
11_T38_M2.7731.00
219_T277_K2.7141.00
130_L386_Y2.6561.00
225_V234_M2.5611.00
64_P167_T2.5551.00
240_I310_Q2.4771.00
221_K314_L2.4111.00
217_K277_K2.3971.00
220_I244_L2.3761.00
298_K302_E2.3701.00
73_T167_T2.3641.00
294_K298_K2.3321.00
156_Y400_V2.3261.00
221_K312_R2.3221.00
42_E45_S2.3021.00
340_Q405_Q2.2841.00
344_N401_E2.2471.00
221_K275_E2.2111.00
46_I155_D2.1881.00
219_T314_L2.1881.00
344_N405_Q2.1821.00
43_L61_A2.1151.00
38_M42_E2.0961.00
241_A264_Y2.0911.00
217_K279_H2.0881.00
265_H277_K2.0741.00
295_E299_R2.0541.00
73_T169_R2.0431.00
62_T167_T2.0251.00
241_A276_T1.9981.00
217_K316_D1.9901.00
156_Y160_H1.9721.00
4_E155_D1.9611.00
15_V38_M1.9531.00
263_F279_H1.8941.00
75_G192_A1.8731.00
219_T316_D1.8711.00
118_Q384_F1.8641.00
241_A278_L1.8631.00
243_K246_S1.8611.00
339_K343_E1.8491.00
242_M245_N1.8431.00
345_L401_E1.8311.00
119_F127_G1.8271.00
183_H187_V1.7451.00
42_E46_I1.7371.00
338_A402_I1.7131.00
41_D45_S1.7051.00
8_R42_E1.6691.00
302_E306_N1.6641.00
120_P123_S1.6631.00
34_T37_N1.6441.00
37_N41_D1.6391.00
244_L301_V1.6371.00
155_D159_K1.6261.00
242_M246_S1.6211.00
67_T70_D1.6131.00
235_I240_I1.6071.00
5_I396_V1.5761.00
401_E404_K1.5701.00
291_Q295_E1.5691.00
48_M63_L1.5601.00
296_T299_R1.5601.00
223_N235_I1.5581.00
129_T390_D1.5581.00
38_M41_D1.5391.00
11_T14_K1.5381.00
40_V59_V1.5331.00
243_K308_Y1.5221.00
7_E11_T1.5211.00
36_G80_V1.5101.00
343_E348_E1.4991.00
10_T14_K1.4981.00
237_S276_T1.4951.00
11_T34_T1.4911.00
75_G171_A1.4821.00
39_L80_V1.4791.00
336_N339_K1.4721.00
149_E395_A1.4611.00
224_N274_E1.4611.00
67_T165_H1.4571.00
184_K187_V1.4401.00
230_A233_K1.4391.00
40_V52_A1.4321.00
292_N296_T1.4291.00
41_D44_K1.4221.00
49_Q64_P1.4141.00
364_S370_T1.4091.00
247_L300_A1.4011.00
305_Q313_I1.3921.00
289_N292_N1.3921.00
294_K317_M1.3911.00
339_K351_I1.3811.00
42_E155_D1.3661.00
247_L303_E1.3591.00
11_T15_V1.3521.00
266_L276_T1.3341.00
220_I241_A1.3311.00
184_K188_K1.3311.00
145_A387_I1.3261.00
243_K307_E1.3241.00
216_A280_Y1.3041.00
394_K397_N1.3001.00
145_A392_M1.2911.00
78_A143_N1.2861.00
206_L209_E1.2821.00
158_I161_P1.2801.00
72_P193_S1.2761.00
217_K318_N1.2701.00
66_N165_H1.2701.00
63_L158_I1.2691.00
17_T35_L1.2581.00
298_K315_L1.2571.00
75_G195_A1.2551.00
218_I278_L1.2501.00
76_F150_I1.2491.00
337_I405_Q1.2471.00
8_R152_T1.2451.00
401_E405_Q1.2401.00
14_K126_K1.2351.00
295_E298_K1.2331.00
206_L210_S1.2311.00
257_T293_R1.2301.00
5_I152_T1.2271.00
65_S167_T1.2221.00
126_K389_V1.2061.00
341_A405_Q1.1991.00
207_E210_S1.1991.00
76_F403_A1.1981.00
235_I310_Q1.1941.00
342_M398_V1.1931.00
345_L397_N1.1831.00
301_V313_I1.1791.00
12_Y35_L1.1741.00
37_N40_V1.1721.00
390_D394_K1.1671.00
393_V397_N1.1651.00
299_R303_E1.1641.00
7_E10_T1.1631.00
160_H400_V1.1631.00
238_A264_Y1.1591.00
220_I240_I1.1561.00
336_N340_Q1.1451.00
6_I10_T1.1431.00
337_I341_A1.1431.00
238_A266_L1.1411.00
50_D53_I1.1401.00
8_R38_M1.1391.00
8_R155_D1.1381.00
19_S178_I1.1371.00
13_V133_T1.1301.00
341_A401_E1.1231.00
117_D120_P1.1171.00
340_Q344_N1.1141.00
13_V136_T1.1001.00
255_E296_T1.1001.00
23_V57_G1.0971.00
154_M170_V1.0961.00
294_K319_D1.0961.00
5_I148_A1.0961.00
67_T71_V1.0941.00
341_A345_L1.0921.00
11_T42_E1.0821.00
10_T126_K1.0791.00
388_S391_N1.0761.00
299_R302_E1.0721.00
130_L388_S1.0701.00
71_V166_G1.0661.00
214_A290_F1.0651.00
160_H404_K1.0541.00
72_P166_G1.0451.00
292_N295_E1.0441.00
338_A371_P1.0411.00
15_V34_T1.0401.00
36_G59_V1.0381.00
44_K50_D1.0351.00
73_T193_S1.0351.00
286_D289_N1.0341.00
369_P372_N1.0331.00
10_T389_V1.0321.00
198_V399_I1.0301.00
152_T155_D1.0291.00
119_F123_S1.0261.00
51_A54_D1.0171.00
34_T38_M1.0131.00
332_I336_N1.0131.00
39_L147_I1.0091.00
245_N278_L1.0011.00
43_L151_M0.9991.00
58_Y174_P0.9981.00
205_E209_E0.9961.00
4_E7_E0.9941.00
200_G204_G0.9881.00
129_T388_S0.9851.00
300_A303_E0.9791.00
216_A294_K0.9771.00
300_A304_L0.9741.00
63_L164_K0.9721.00
48_M61_A0.9701.00
340_Q343_E0.9691.00
195_A368_L0.9661.00
12_Y38_M0.9651.00
10_T124_G0.9601.00
51_A62_T0.9591.00
239_K245_N0.9551.00
200_G203_L0.9551.00
40_V50_D0.9521.00
343_E347_I0.9481.00
397_N401_E0.9481.00
247_L304_L0.9471.00
269_I272_D0.9451.00
120_P124_G0.9451.00
368_L371_P0.9441.00
239_K249_P0.9371.00
150_I170_V0.9351.00
241_A245_N0.9331.00
80_V172_F0.9281.00
183_H362_Q0.9271.00
14_K123_S0.9271.00
156_Y397_N0.9261.00
153_A400_V0.9251.00
40_V53_I0.9241.00
387_I392_M0.9231.00
243_K247_L0.9191.00
36_G40_V0.9181.00
80_V147_I0.9171.00
270_Q279_H0.9161.00
296_T300_A0.9161.00
5_I392_M0.9151.00
341_A344_N0.9141.00
217_K270_Q0.9111.00
303_E307_E0.9041.00
400_V404_K0.9001.00
391_N394_K0.8921.00
119_F125_Y0.8891.00
396_V400_V0.8881.00
335_V371_P0.8871.00
78_A147_I0.8861.00
245_N261_E0.8831.00
49_Q62_T0.8781.00
119_F124_G0.8771.00
4_E8_R0.8761.00
153_A399_I0.8751.00
20_D175_D0.8741.00
261_E280_Y0.8731.00
302_E305_Q0.8721.00
156_Y396_V0.8711.00
201_G204_G0.8701.00
48_M154_M0.8701.00
125_Y128_H0.8701.00
337_I340_Q0.8651.00
218_I301_V0.8611.00
221_K274_E0.8591.00
46_I158_I0.8551.00
251_D255_E0.8551.00
265_H268_S0.8531.00
127_G130_L0.8521.00
248_L297_M0.8501.00
333_E337_I0.8481.00
87_T128_H0.8461.00
238_A276_T0.8441.00
63_L154_M0.8391.00
182_P186_D0.8381.00
239_K242_M0.8361.00
264_Y276_T0.8351.00
337_I402_I0.8321.00
333_E336_N0.8321.00
35_L80_V0.8301.00
42_E151_M0.8291.00
303_E306_N0.8281.00
218_I244_L0.8271.00
169_R192_A0.8261.00
154_M158_I0.8251.00
342_M345_L0.8251.00
284_D290_F0.8221.00
335_V339_K0.8211.00
17_T144_K0.8191.00
44_K52_A0.8161.00
23_V34_T0.8161.00
76_F153_A0.8151.00
211_F214_A0.8141.00
288_E292_N0.8121.00
4_E152_T0.8111.00
251_D296_T0.8111.00
215_A281_I0.8081.00
11_T41_D0.8031.00
317_M320_Q0.8021.00
37_N52_A0.8021.00
119_F122_L0.8021.00
287_K291_Q0.7991.00
14_K124_G0.7921.00
331_V334_I0.7921.00
194_F334_I0.7901.00
304_L307_E0.7851.00
245_N264_Y0.7841.00
368_L372_N0.7831.00
126_K129_T0.7821.00
291_Q294_K0.7781.00
118_Q122_L0.7721.00
4_E42_E0.7701.00
18_Q21_E0.7681.00
118_Q127_G0.7681.00
121_E124_G0.7661.00
304_L308_Y0.7661.00
8_R11_T0.7651.00
50_D61_A0.7641.00
247_L250_A0.7641.00
149_E399_I0.7621.00
194_F199_D0.7551.00
127_G132_T0.7551.00
9_F131_I0.7541.00
19_S22_S0.7531.00
209_E353_P0.7531.00
149_E396_V0.7531.00
392_M396_V0.7521.00
197_T372_N0.7501.00
46_I151_M0.7501.00
18_Q84_T0.7471.00
239_K250_A0.7461.00
212_N284_D0.7461.00
160_H163_I0.7451.00
373_I398_V0.7451.00
45_S155_D0.7441.00
360_G370_T0.7421.00
60_M169_R0.7411.00
291_Q319_D0.7391.00
299_R306_N0.7381.00
66_N163_I0.7371.00
8_R148_A0.7361.00
214_A294_K0.7331.00
223_N382_G0.7321.00
240_I308_Y0.7311.00
246_S250_A0.7301.00
282_I293_R0.7281.00
196_Y402_I0.7271.00
117_D121_E0.7231.00
153_A396_V0.7221.00
248_L259_G0.7181.00
48_M158_I0.7181.00
124_G131_I0.7151.00
390_D393_V0.7121.00
23_V37_N0.7121.00
261_E278_L0.7121.00
195_A199_D0.7121.00
36_G57_G0.7121.00
298_K317_M0.7121.00
220_I278_L0.7111.00
358_T372_N0.7061.00
20_D178_I0.7031.00
338_A398_V0.7011.00
322_Y365_Y0.7001.00
218_I315_L0.6971.00
156_Y159_K0.6951.00
149_E153_A0.6941.00
362_Q365_Y0.6921.00
205_E210_S0.6921.00
82_T134_D0.6891.00
220_I313_I0.6881.00
59_V172_F0.6881.00
287_K365_Y0.6841.00
74_I403_A0.6821.00
362_Q366_M0.6811.00
290_F294_K0.6761.00
147_I172_F0.6741.00
149_E198_V0.6741.00
150_I198_V0.6741.00
39_L172_F0.6741.00
216_A297_M0.6731.00
169_R191_N0.6711.00
225_V273_V0.6651.00
82_T122_L0.6631.00
244_L278_L0.6591.00
397_N400_V0.6571.00
152_T396_V0.6561.00
252_E256_Y0.6531.00
290_F322_Y0.6511.00
249_P252_E0.6511.00
39_L151_M0.6481.00
195_A370_T0.6481.00
398_V402_I0.6481.00
341_A402_I0.6401.00
252_E259_G0.6381.00
216_A317_M0.6361.00
63_L170_V0.6341.00
212_N323_N0.6331.00
8_R12_Y0.6301.00
39_L59_V0.6291.00
8_R151_M0.6291.00
305_Q310_Q0.6271.00
54_D57_G0.6251.00
205_E352_S0.6251.00
251_D254_P0.6221.00
334_I337_I0.6221.00
263_F277_K0.6211.00
265_H279_H0.6211.00
78_A150_I0.6191.00
341_A398_V0.6161.00
259_G282_I0.6161.00
220_I237_S0.6161.00
10_T131_I0.6161.00
40_V51_A0.6141.00
6_I126_K0.6131.00
73_T166_G0.6071.00
12_Y148_A0.6071.00
44_K49_Q0.6071.00
34_T41_D0.6061.00
258_E262_G0.6061.00
376_G387_I0.6051.00
305_Q312_R0.6041.00
155_D158_I0.6041.00
243_K304_L0.6031.00
77_L171_A0.6011.00
345_L398_V0.6011.00
74_I194_F0.6011.00
194_F369_P0.6011.00
252_E255_E0.6001.00
249_P253_A0.5991.00
197_T360_G0.5981.00
157_L162_E0.5981.00
6_I393_V0.5971.00
15_V35_L0.5971.00
331_V336_N0.5961.00
48_M170_V0.5941.00
175_D178_I0.5931.00
375_T395_A0.5921.00
210_S358_T0.5911.00
10_T13_V0.5911.00
301_V315_L0.5901.00
152_T156_Y0.5891.00
132_T386_Y0.5881.00
243_K250_A0.5881.00
171_A185_F0.5861.00
117_D384_F0.5831.00
215_A270_Q0.5831.00
6_I389_V0.5821.00
323_N329_E0.5821.00
56_N184_K0.5811.00
143_N146_G0.5811.00
12_Y147_I0.5801.00
379_N384_F0.5731.00
118_Q121_E0.5721.00
239_K246_S0.5711.00
235_I312_R0.5691.00
235_I309_G0.5681.00
77_L173_T0.5671.00
18_Q130_L0.5671.00
10_T123_S0.5661.00
177_E381_H0.5641.00
239_K243_K0.5641.00
65_S70_D0.5641.00
131_I389_V0.5631.00
6_I131_I0.5621.00
253_A256_Y0.5591.00
332_I369_P0.5581.00
15_V127_G0.5571.00
389_V393_V0.5571.00
244_L300_A0.5561.00
124_G127_G0.5551.00
196_Y199_D0.5521.00
248_L261_E0.5501.00
284_D293_R0.5491.00
257_T260_Y0.5481.00
123_S134_D0.5461.00
9_F389_V0.5451.00
20_D180_R0.5451.00
301_V305_Q0.5451.00
244_L248_L0.5441.00
195_A363_L0.5441.00
240_I243_K0.5441.00
18_Q122_L0.5431.00
297_M315_L0.5431.00
67_T167_T0.5421.00
86_F133_T0.5411.00
171_A195_A0.5401.00
339_K350_K0.5401.00
321_Y324_M0.5391.00
377_G380_F0.5391.00
9_F148_A0.5371.00
380_F385_E0.5341.00
186_D366_M0.5321.00
280_Y297_M0.5291.00
246_S249_P0.5261.00
295_E302_E0.5261.00
126_K131_I0.5251.00
47_G50_D0.5251.00
12_Y39_L0.5231.00
249_P254_P0.5231.00
43_L48_M0.5221.00
66_N70_D0.5211.00
257_T261_E0.5201.00
16_D21_E0.5191.00
162_E404_K0.5191.00
71_V165_H0.5181.00
123_S126_K0.5171.00
198_V375_T0.5171.00
237_S273_V0.5171.00
218_I313_I0.5161.00
234_M237_S0.5151.00
255_E292_N0.5141.00
240_I304_L0.5141.00
257_T284_D0.5141.00
22_S175_D0.5141.00
148_A392_M0.5121.00
329_E332_I0.5111.00
21_E130_L0.5111.00
60_M171_A0.5111.00
195_A198_V0.5101.00
265_H275_E0.5081.00
48_M51_A0.5081.00
256_Y289_N0.5071.00
393_V396_V0.5061.00
372_N376_G0.5051.00
321_Y362_Q0.5051.00
153_A157_L0.5051.00
133_T136_T0.5051.00
58_Y185_F0.5041.00
125_Y132_T0.5041.00
5_I9_F0.5021.00
249_P308_Y0.5011.00
205_E350_K0.5001.00
8_R46_I0.5001.00
187_V366_M0.5001.00
171_A363_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfoA 2 0.8854 100 0.288 Contact Map
3ifeA 2 0.9293 100 0.297 Contact Map
3rzaA 2 0.8707 100 0.303 Contact Map
3gb0A 2 0.878 100 0.305 Contact Map
1fnoA 2 0.9122 100 0.314 Contact Map
3iszA 2 0.8537 100 0.324 Contact Map
4pqaA 2 0.861 100 0.326 Contact Map
1cg2A 4 0.8805 100 0.327 Contact Map
4mmoA 2 0.8756 100 0.346 Contact Map
3mruA 1 0.8707 100 0.349 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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