PEPT - BACSU - GREMLIN Contacts

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PEPT - Peptidase T

UniProt:	P55179	Sequences: MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELKSIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGKDIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKHPEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKITIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEETKLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEIVNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNMVKAVNVIVEIAKQFEAQA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	410 (351)
Sequences:	29019 (20654)
Seq/√Len:	1102.4

ECOLI - PEPT DAPE YGEY ABGA ARGE PEPD ALLC ABGB
BACSU - PEPT YQJE YODQ FAPD YTNL YXEP DAPEL YHAA AMHX PEPVL ALLC YQJN
HALSA - Q9HS25
SULSO - Q97Y12 Q97ZB7 LYSK CBPX1 Q97V97 CBPX2 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_T	169_R	3.288	1.00
219_T	275_E	3.025	1.00
40_V	44_K	2.799	1.00
11_T	38_M	2.773	1.00
219_T	277_K	2.714	1.00
130_L	386_Y	2.656	1.00
225_V	234_M	2.561	1.00
64_P	167_T	2.555	1.00
240_I	310_Q	2.477	1.00
221_K	314_L	2.411	1.00
217_K	277_K	2.397	1.00
220_I	244_L	2.376	1.00
298_K	302_E	2.370	1.00
73_T	167_T	2.364	1.00
294_K	298_K	2.332	1.00
156_Y	400_V	2.326	1.00
221_K	312_R	2.322	1.00
42_E	45_S	2.302	1.00
340_Q	405_Q	2.284	1.00
344_N	401_E	2.247	1.00
221_K	275_E	2.211	1.00
46_I	155_D	2.188	1.00
219_T	314_L	2.188	1.00
344_N	405_Q	2.182	1.00
43_L	61_A	2.115	1.00
38_M	42_E	2.096	1.00
241_A	264_Y	2.091	1.00
217_K	279_H	2.088	1.00
265_H	277_K	2.074	1.00
295_E	299_R	2.054	1.00
73_T	169_R	2.043	1.00
62_T	167_T	2.025	1.00
241_A	276_T	1.998	1.00
217_K	316_D	1.990	1.00
156_Y	160_H	1.972	1.00
4_E	155_D	1.961	1.00
15_V	38_M	1.953	1.00
263_F	279_H	1.894	1.00
75_G	192_A	1.873	1.00
219_T	316_D	1.871	1.00
118_Q	384_F	1.864	1.00
241_A	278_L	1.863	1.00
243_K	246_S	1.861	1.00
339_K	343_E	1.849	1.00
242_M	245_N	1.843	1.00
345_L	401_E	1.831	1.00
119_F	127_G	1.827	1.00
183_H	187_V	1.745	1.00
42_E	46_I	1.737	1.00
338_A	402_I	1.713	1.00
41_D	45_S	1.705	1.00
8_R	42_E	1.669	1.00
302_E	306_N	1.664	1.00
120_P	123_S	1.663	1.00
34_T	37_N	1.644	1.00
37_N	41_D	1.639	1.00
244_L	301_V	1.637	1.00
155_D	159_K	1.626	1.00
242_M	246_S	1.621	1.00
67_T	70_D	1.613	1.00
235_I	240_I	1.607	1.00
5_I	396_V	1.576	1.00
401_E	404_K	1.570	1.00
291_Q	295_E	1.569	1.00
48_M	63_L	1.560	1.00
296_T	299_R	1.560	1.00
223_N	235_I	1.558	1.00
129_T	390_D	1.558	1.00
38_M	41_D	1.539	1.00
11_T	14_K	1.538	1.00
40_V	59_V	1.533	1.00
243_K	308_Y	1.522	1.00
7_E	11_T	1.521	1.00
36_G	80_V	1.510	1.00
343_E	348_E	1.499	1.00
10_T	14_K	1.498	1.00
237_S	276_T	1.495	1.00
11_T	34_T	1.491	1.00
75_G	171_A	1.482	1.00
39_L	80_V	1.479	1.00
336_N	339_K	1.472	1.00
149_E	395_A	1.461	1.00
224_N	274_E	1.461	1.00
67_T	165_H	1.457	1.00
184_K	187_V	1.440	1.00
230_A	233_K	1.439	1.00
40_V	52_A	1.432	1.00
292_N	296_T	1.429	1.00
41_D	44_K	1.422	1.00
49_Q	64_P	1.414	1.00
364_S	370_T	1.409	1.00
247_L	300_A	1.401	1.00
305_Q	313_I	1.392	1.00
289_N	292_N	1.392	1.00
294_K	317_M	1.391	1.00
339_K	351_I	1.381	1.00
42_E	155_D	1.366	1.00
247_L	303_E	1.359	1.00
11_T	15_V	1.352	1.00
266_L	276_T	1.334	1.00
220_I	241_A	1.331	1.00
184_K	188_K	1.331	1.00
145_A	387_I	1.326	1.00
243_K	307_E	1.324	1.00
216_A	280_Y	1.304	1.00
394_K	397_N	1.300	1.00
145_A	392_M	1.291	1.00
78_A	143_N	1.286	1.00
206_L	209_E	1.282	1.00
158_I	161_P	1.280	1.00
72_P	193_S	1.276	1.00
217_K	318_N	1.270	1.00
66_N	165_H	1.270	1.00
63_L	158_I	1.269	1.00
17_T	35_L	1.258	1.00
298_K	315_L	1.257	1.00
75_G	195_A	1.255	1.00
218_I	278_L	1.250	1.00
76_F	150_I	1.249	1.00
337_I	405_Q	1.247	1.00
8_R	152_T	1.245	1.00
401_E	405_Q	1.240	1.00
14_K	126_K	1.235	1.00
295_E	298_K	1.233	1.00
206_L	210_S	1.231	1.00
257_T	293_R	1.230	1.00
5_I	152_T	1.227	1.00
65_S	167_T	1.222	1.00
126_K	389_V	1.206	1.00
341_A	405_Q	1.199	1.00
207_E	210_S	1.199	1.00
76_F	403_A	1.198	1.00
235_I	310_Q	1.194	1.00
342_M	398_V	1.193	1.00
345_L	397_N	1.183	1.00
301_V	313_I	1.179	1.00
12_Y	35_L	1.174	1.00
37_N	40_V	1.172	1.00
390_D	394_K	1.167	1.00
393_V	397_N	1.165	1.00
299_R	303_E	1.164	1.00
7_E	10_T	1.163	1.00
160_H	400_V	1.163	1.00
238_A	264_Y	1.159	1.00
220_I	240_I	1.156	1.00
336_N	340_Q	1.145	1.00
6_I	10_T	1.143	1.00
337_I	341_A	1.143	1.00
238_A	266_L	1.141	1.00
50_D	53_I	1.140	1.00
8_R	38_M	1.139	1.00
8_R	155_D	1.138	1.00
19_S	178_I	1.137	1.00
13_V	133_T	1.130	1.00
341_A	401_E	1.123	1.00
117_D	120_P	1.117	1.00
340_Q	344_N	1.114	1.00
13_V	136_T	1.100	1.00
255_E	296_T	1.100	1.00
23_V	57_G	1.097	1.00
154_M	170_V	1.096	1.00
294_K	319_D	1.096	1.00
5_I	148_A	1.096	1.00
67_T	71_V	1.094	1.00
341_A	345_L	1.092	1.00
11_T	42_E	1.082	1.00
10_T	126_K	1.079	1.00
388_S	391_N	1.076	1.00
299_R	302_E	1.072	1.00
130_L	388_S	1.070	1.00
71_V	166_G	1.066	1.00
214_A	290_F	1.065	1.00
160_H	404_K	1.054	1.00
72_P	166_G	1.045	1.00
292_N	295_E	1.044	1.00
338_A	371_P	1.041	1.00
15_V	34_T	1.040	1.00
36_G	59_V	1.038	1.00
44_K	50_D	1.035	1.00
73_T	193_S	1.035	1.00
286_D	289_N	1.034	1.00
369_P	372_N	1.033	1.00
10_T	389_V	1.032	1.00
198_V	399_I	1.030	1.00
152_T	155_D	1.029	1.00
119_F	123_S	1.026	1.00
51_A	54_D	1.017	1.00
34_T	38_M	1.013	1.00
332_I	336_N	1.013	1.00
39_L	147_I	1.009	1.00
245_N	278_L	1.001	1.00
43_L	151_M	0.999	1.00
58_Y	174_P	0.998	1.00
205_E	209_E	0.996	1.00
4_E	7_E	0.994	1.00
200_G	204_G	0.988	1.00
129_T	388_S	0.985	1.00
300_A	303_E	0.979	1.00
216_A	294_K	0.977	1.00
300_A	304_L	0.974	1.00
63_L	164_K	0.972	1.00
48_M	61_A	0.970	1.00
340_Q	343_E	0.969	1.00
195_A	368_L	0.966	1.00
12_Y	38_M	0.965	1.00
10_T	124_G	0.960	1.00
51_A	62_T	0.959	1.00
239_K	245_N	0.955	1.00
200_G	203_L	0.955	1.00
40_V	50_D	0.952	1.00
343_E	347_I	0.948	1.00
397_N	401_E	0.948	1.00
247_L	304_L	0.947	1.00
269_I	272_D	0.945	1.00
120_P	124_G	0.945	1.00
368_L	371_P	0.944	1.00
239_K	249_P	0.937	1.00
150_I	170_V	0.935	1.00
241_A	245_N	0.933	1.00
80_V	172_F	0.928	1.00
183_H	362_Q	0.927	1.00
14_K	123_S	0.927	1.00
156_Y	397_N	0.926	1.00
153_A	400_V	0.925	1.00
40_V	53_I	0.924	1.00
387_I	392_M	0.923	1.00
243_K	247_L	0.919	1.00
36_G	40_V	0.918	1.00
80_V	147_I	0.917	1.00
270_Q	279_H	0.916	1.00
296_T	300_A	0.916	1.00
5_I	392_M	0.915	1.00
341_A	344_N	0.914	1.00
217_K	270_Q	0.911	1.00
303_E	307_E	0.904	1.00
400_V	404_K	0.900	1.00
391_N	394_K	0.892	1.00
119_F	125_Y	0.889	1.00
396_V	400_V	0.888	1.00
335_V	371_P	0.887	1.00
78_A	147_I	0.886	1.00
245_N	261_E	0.883	1.00
49_Q	62_T	0.878	1.00
119_F	124_G	0.877	1.00
4_E	8_R	0.876	1.00
153_A	399_I	0.875	1.00
20_D	175_D	0.874	1.00
261_E	280_Y	0.873	1.00
302_E	305_Q	0.872	1.00
156_Y	396_V	0.871	1.00
201_G	204_G	0.870	1.00
48_M	154_M	0.870	1.00
125_Y	128_H	0.870	1.00
337_I	340_Q	0.865	1.00
218_I	301_V	0.861	1.00
221_K	274_E	0.859	1.00
46_I	158_I	0.855	1.00
251_D	255_E	0.855	1.00
265_H	268_S	0.853	1.00
127_G	130_L	0.852	1.00
248_L	297_M	0.850	1.00
333_E	337_I	0.848	1.00
87_T	128_H	0.846	1.00
238_A	276_T	0.844	1.00
63_L	154_M	0.839	1.00
182_P	186_D	0.838	1.00
239_K	242_M	0.836	1.00
264_Y	276_T	0.835	1.00
337_I	402_I	0.832	1.00
333_E	336_N	0.832	1.00
35_L	80_V	0.830	1.00
42_E	151_M	0.829	1.00
303_E	306_N	0.828	1.00
218_I	244_L	0.827	1.00
169_R	192_A	0.826	1.00
154_M	158_I	0.825	1.00
342_M	345_L	0.825	1.00
284_D	290_F	0.822	1.00
335_V	339_K	0.821	1.00
17_T	144_K	0.819	1.00
44_K	52_A	0.816	1.00
23_V	34_T	0.816	1.00
76_F	153_A	0.815	1.00
211_F	214_A	0.814	1.00
288_E	292_N	0.812	1.00
4_E	152_T	0.811	1.00
251_D	296_T	0.811	1.00
215_A	281_I	0.808	1.00
11_T	41_D	0.803	1.00
317_M	320_Q	0.802	1.00
37_N	52_A	0.802	1.00
119_F	122_L	0.802	1.00
287_K	291_Q	0.799	1.00
14_K	124_G	0.792	1.00
331_V	334_I	0.792	1.00
194_F	334_I	0.790	1.00
304_L	307_E	0.785	1.00
245_N	264_Y	0.784	1.00
368_L	372_N	0.783	1.00
126_K	129_T	0.782	1.00
291_Q	294_K	0.778	1.00
118_Q	122_L	0.772	1.00
4_E	42_E	0.770	1.00
18_Q	21_E	0.768	1.00
118_Q	127_G	0.768	1.00
121_E	124_G	0.766	1.00
304_L	308_Y	0.766	1.00
8_R	11_T	0.765	1.00
50_D	61_A	0.764	1.00
247_L	250_A	0.764	1.00
149_E	399_I	0.762	1.00
194_F	199_D	0.755	1.00
127_G	132_T	0.755	1.00
9_F	131_I	0.754	1.00
19_S	22_S	0.753	1.00
209_E	353_P	0.753	1.00
149_E	396_V	0.753	1.00
392_M	396_V	0.752	1.00
197_T	372_N	0.750	1.00
46_I	151_M	0.750	1.00
18_Q	84_T	0.747	1.00
239_K	250_A	0.746	1.00
212_N	284_D	0.746	1.00
160_H	163_I	0.745	1.00
373_I	398_V	0.745	1.00
45_S	155_D	0.744	1.00
360_G	370_T	0.742	1.00
60_M	169_R	0.741	1.00
291_Q	319_D	0.739	1.00
299_R	306_N	0.738	1.00
66_N	163_I	0.737	1.00
8_R	148_A	0.736	1.00
214_A	294_K	0.733	1.00
223_N	382_G	0.732	1.00
240_I	308_Y	0.731	1.00
246_S	250_A	0.730	1.00
282_I	293_R	0.728	1.00
196_Y	402_I	0.727	1.00
117_D	121_E	0.723	1.00
153_A	396_V	0.722	1.00
248_L	259_G	0.718	1.00
48_M	158_I	0.718	1.00
124_G	131_I	0.715	1.00
390_D	393_V	0.712	1.00
23_V	37_N	0.712	1.00
261_E	278_L	0.712	1.00
195_A	199_D	0.712	1.00
36_G	57_G	0.712	1.00
298_K	317_M	0.712	1.00
220_I	278_L	0.711	1.00
358_T	372_N	0.706	1.00
20_D	178_I	0.703	1.00
338_A	398_V	0.701	1.00
322_Y	365_Y	0.700	1.00
218_I	315_L	0.697	1.00
156_Y	159_K	0.695	1.00
149_E	153_A	0.694	1.00
362_Q	365_Y	0.692	1.00
205_E	210_S	0.692	1.00
82_T	134_D	0.689	1.00
220_I	313_I	0.688	1.00
59_V	172_F	0.688	1.00
287_K	365_Y	0.684	1.00
74_I	403_A	0.682	1.00
362_Q	366_M	0.681	1.00
290_F	294_K	0.676	1.00
147_I	172_F	0.674	1.00
149_E	198_V	0.674	1.00
150_I	198_V	0.674	1.00
39_L	172_F	0.674	1.00
216_A	297_M	0.673	1.00
169_R	191_N	0.671	1.00
225_V	273_V	0.665	1.00
82_T	122_L	0.663	1.00
244_L	278_L	0.659	1.00
397_N	400_V	0.657	1.00
152_T	396_V	0.656	1.00
252_E	256_Y	0.653	1.00
290_F	322_Y	0.651	1.00
249_P	252_E	0.651	1.00
39_L	151_M	0.648	1.00
195_A	370_T	0.648	1.00
398_V	402_I	0.648	1.00
341_A	402_I	0.640	1.00
252_E	259_G	0.638	1.00
216_A	317_M	0.636	1.00
63_L	170_V	0.634	1.00
212_N	323_N	0.633	1.00
8_R	12_Y	0.630	1.00
39_L	59_V	0.629	1.00
8_R	151_M	0.629	1.00
305_Q	310_Q	0.627	1.00
54_D	57_G	0.625	1.00
205_E	352_S	0.625	1.00
251_D	254_P	0.622	1.00
334_I	337_I	0.622	1.00
263_F	277_K	0.621	1.00
265_H	279_H	0.621	1.00
78_A	150_I	0.619	1.00
341_A	398_V	0.616	1.00
259_G	282_I	0.616	1.00
220_I	237_S	0.616	1.00
10_T	131_I	0.616	1.00
40_V	51_A	0.614	1.00
6_I	126_K	0.613	1.00
73_T	166_G	0.607	1.00
12_Y	148_A	0.607	1.00
44_K	49_Q	0.607	1.00
34_T	41_D	0.606	1.00
258_E	262_G	0.606	1.00
376_G	387_I	0.605	1.00
305_Q	312_R	0.604	1.00
155_D	158_I	0.604	1.00
243_K	304_L	0.603	1.00
77_L	171_A	0.601	1.00
345_L	398_V	0.601	1.00
74_I	194_F	0.601	1.00
194_F	369_P	0.601	1.00
252_E	255_E	0.600	1.00
249_P	253_A	0.599	1.00
197_T	360_G	0.598	1.00
157_L	162_E	0.598	1.00
6_I	393_V	0.597	1.00
15_V	35_L	0.597	1.00
331_V	336_N	0.596	1.00
48_M	170_V	0.594	1.00
175_D	178_I	0.593	1.00
375_T	395_A	0.592	1.00
210_S	358_T	0.591	1.00
10_T	13_V	0.591	1.00
301_V	315_L	0.590	1.00
152_T	156_Y	0.589	1.00
132_T	386_Y	0.588	1.00
243_K	250_A	0.588	1.00
171_A	185_F	0.586	1.00
117_D	384_F	0.583	1.00
215_A	270_Q	0.583	1.00
6_I	389_V	0.582	1.00
323_N	329_E	0.582	1.00
56_N	184_K	0.581	1.00
143_N	146_G	0.581	1.00
12_Y	147_I	0.580	1.00
379_N	384_F	0.573	1.00
118_Q	121_E	0.572	1.00
239_K	246_S	0.571	1.00
235_I	312_R	0.569	1.00
235_I	309_G	0.568	1.00
77_L	173_T	0.567	1.00
18_Q	130_L	0.567	1.00
10_T	123_S	0.566	1.00
177_E	381_H	0.564	1.00
239_K	243_K	0.564	1.00
65_S	70_D	0.564	1.00
131_I	389_V	0.563	1.00
6_I	131_I	0.562	1.00
253_A	256_Y	0.559	1.00
332_I	369_P	0.558	1.00
15_V	127_G	0.557	1.00
389_V	393_V	0.557	1.00
244_L	300_A	0.556	1.00
124_G	127_G	0.555	1.00
196_Y	199_D	0.552	1.00
248_L	261_E	0.550	1.00
284_D	293_R	0.549	1.00
257_T	260_Y	0.548	1.00
123_S	134_D	0.546	1.00
9_F	389_V	0.545	1.00
20_D	180_R	0.545	1.00
301_V	305_Q	0.545	1.00
244_L	248_L	0.544	1.00
195_A	363_L	0.544	1.00
240_I	243_K	0.544	1.00
18_Q	122_L	0.543	1.00
297_M	315_L	0.543	1.00
67_T	167_T	0.542	1.00
86_F	133_T	0.541	1.00
171_A	195_A	0.540	1.00
339_K	350_K	0.540	1.00
321_Y	324_M	0.539	1.00
377_G	380_F	0.539	1.00
9_F	148_A	0.537	1.00
380_F	385_E	0.534	1.00
186_D	366_M	0.532	1.00
280_Y	297_M	0.529	1.00
246_S	249_P	0.526	1.00
295_E	302_E	0.526	1.00
126_K	131_I	0.525	1.00
47_G	50_D	0.525	1.00
12_Y	39_L	0.523	1.00
249_P	254_P	0.523	1.00
43_L	48_M	0.522	1.00
66_N	70_D	0.521	1.00
257_T	261_E	0.520	1.00
16_D	21_E	0.519	1.00
162_E	404_K	0.519	1.00
71_V	165_H	0.518	1.00
123_S	126_K	0.517	1.00
198_V	375_T	0.517	1.00
237_S	273_V	0.517	1.00
218_I	313_I	0.516	1.00
234_M	237_S	0.515	1.00
255_E	292_N	0.514	1.00
240_I	304_L	0.514	1.00
257_T	284_D	0.514	1.00
22_S	175_D	0.514	1.00
148_A	392_M	0.512	1.00
329_E	332_I	0.511	1.00
21_E	130_L	0.511	1.00
60_M	171_A	0.511	1.00
195_A	198_V	0.510	1.00
265_H	275_E	0.508	1.00
48_M	51_A	0.508	1.00
256_Y	289_N	0.507	1.00
393_V	396_V	0.506	1.00
372_N	376_G	0.505	1.00
321_Y	362_Q	0.505	1.00
153_A	157_L	0.505	1.00
133_T	136_T	0.505	1.00
58_Y	185_F	0.504	1.00
125_Y	132_T	0.504	1.00
5_I	9_F	0.502	1.00
249_P	308_Y	0.501	1.00
205_E	350_K	0.500	1.00
8_R	46_I	0.500	1.00
187_V	366_M	0.500	1.00
171_A	363_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pfoA	2	0.8854	100	0.288	Contact Map
3ifeA	2	0.9293	100	0.297	Contact Map
3rzaA	2	0.8707	100	0.303	Contact Map
3gb0A	2	0.878	100	0.305	Contact Map
1fnoA	2	0.9122	100	0.314	Contact Map
3iszA	2	0.8537	100	0.324	Contact Map
4pqaA	2	0.861	100	0.326	Contact Map
1cg2A	4	0.8805	100	0.327	Contact Map
4mmoA	2	0.8756	100	0.346	Contact Map
3mruA	1	0.8707	100	0.349	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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