GREMLIN Database
CITM - Mg(2+)/citrate complex secondary transporter
UniProt: P55069 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (429)
Sequences: 658 (416)
Seq/√Len: 20.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_F267_V11.6571.00
278_R281_A5.5291.00
70_Y239_T4.5691.00
242_L260_A3.9381.00
228_R231_L3.9051.00
263_I267_V3.7781.00
5_L39_A3.6551.00
103_A143_I3.6381.00
50_M298_V3.5621.00
184_S422_I3.3181.00
271_N274_H3.2661.00
70_Y242_L3.2291.00
99_V143_I3.1260.99
36_A46_V3.0620.99
335_T348_Y3.0610.99
7_F312_M3.0040.99
103_A189_M2.8880.99
74_M239_T2.7540.99
15_A19_T2.7280.99
31_T34_V2.6800.98
6_G312_M2.6730.98
86_K89_S2.6280.98
228_R269_Y2.6240.98
41_F49_M2.5970.98
242_L256_L2.5520.98
183_A187_L2.5450.98
131_L137_P2.5010.97
404_H408_A2.4680.97
52_S305_G2.4230.97
61_A294_F2.3660.96
188_C415_A2.3160.96
83_M236_L2.2960.96
102_T130_Y2.2680.95
50_M255_V2.2500.95
98_I133_L2.2210.95
73_I261_F2.2200.95
87_I101_G2.1820.94
104_V190_V2.1700.94
345_N381_H2.1330.93
79_L236_L2.1150.93
74_M79_L2.1090.93
142_G408_A2.1030.93
417_I421_A2.0810.93
65_M290_G2.0750.92
29_V258_V2.0260.91
3_A315_S2.0230.91
387_V390_T2.0000.91
16_L31_T1.9790.90
100_V194_Y1.9460.90
77_T269_Y1.9240.89
99_V135_I1.8930.88
33_I259_I1.8840.88
344_P347_A1.8700.88
146_V412_A1.8640.88
119_Y389_S1.8170.86
200_E203_R1.8060.86
5_L35_F1.7770.85
47_G252_S1.7750.85
100_V190_V1.7660.85
64_I289_I1.7560.84
9_M35_F1.7320.83
67_A115_G1.7290.83
105_L126_M1.7110.83
226_W269_Y1.7030.82
307_K310_D1.6920.82
228_R278_R1.6800.81
162_R346_D1.6590.81
343_M381_H1.6590.81
226_W229_P1.6490.80
20_K403_D1.6450.80
3_A6_G1.6370.80
76_D282_H1.6350.80
65_M286_V1.6260.79
70_Y234_F1.6250.79
164_A171_P1.6230.79
136_R139_I1.6230.79
96_L201_R1.6230.79
152_N160_T1.6190.79
292_M388_P1.6110.79
170_D249_G1.5850.77
141_A397_V1.5580.76
244_G248_S1.5580.76
107_M186_M1.5410.75
163_A371_A1.5410.75
422_I426_I1.5340.75
2_L311_E1.5150.74
3_A312_M1.4970.73
340_T381_H1.4920.73
9_M355_I1.4900.73
340_T379_P1.4650.71
376_I420_T1.4570.71
399_V404_H1.4560.71
106_T122_T1.4460.70
411_W414_L1.4440.70
26_T265_L1.4370.70
76_D281_A1.4370.70
207_I210_K1.4250.69
403_D406_K1.4230.69
353_L370_I1.4190.69
340_T387_V1.4170.69
376_I423_A1.4030.68
312_M343_M1.3920.67
21_R319_M1.3820.67
178_M376_I1.3780.67
52_S55_Q1.3760.66
34_V244_G1.3630.66
4_I8_L1.3530.65
181_V426_I1.3470.65
229_P278_R1.3410.64
76_D278_R1.3310.64
150_I189_M1.3260.64
397_V404_H1.3250.63
234_F263_I1.3250.63
63_M242_L1.3220.63
54_I83_M1.3030.62
9_M341_F1.2970.62
401_I404_H1.2960.62
139_I407_F1.2880.61
340_T345_N1.2860.61
188_C192_V1.2840.61
231_L234_F1.2830.61
119_Y382_M1.2820.61
14_M345_N1.2790.61
187_L240_L1.2780.61
184_S320_I1.2630.60
388_P426_I1.2610.60
382_M387_V1.2590.59
152_N159_A1.2570.59
48_D52_S1.2550.59
74_M264_A1.2450.59
345_N382_M1.2440.58
325_G363_Y1.2360.58
374_S393_L1.2250.57
353_L374_S1.2230.57
5_L283_S1.2130.56
348_Y374_S1.2120.56
91_V101_G1.2080.56
380_I387_V1.2060.56
237_L425_L1.2040.56
315_S371_A1.1870.55
114_D117_T1.1750.54
296_A347_A1.1680.54
310_D314_I1.1630.53
157_G160_T1.1610.53
164_A169_V1.1580.53
240_L421_A1.1560.53
136_R407_F1.1520.53
229_P269_Y1.1510.52
142_G407_F1.1480.52
413_V416_V1.1470.52
336_S348_Y1.1450.52
110_A148_M1.1440.52
329_P430_S1.1440.52
114_D292_M1.1420.52
77_T98_I1.1210.51
231_L267_V1.1180.50
145_G404_H1.1170.50
130_Y141_A1.1160.50
5_L50_M1.1150.50
34_V237_L1.1120.50
114_D124_S1.1090.50
132_L359_T1.1090.50
237_L241_S1.1030.49
79_L239_T1.1010.49
89_S108_L1.0950.49
343_M382_M1.0910.49
170_D327_L1.0910.49
116_S341_F1.0880.48
221_A274_H1.0880.48
88_L191_A1.0870.48
149_G419_M1.0830.48
141_A404_H1.0820.48
106_T147_G1.0800.48
178_M375_I1.0800.48
178_M350_Y1.0790.48
174_L371_A1.0770.48
387_V391_H1.0760.48
371_A374_S1.0720.47
239_T242_L1.0700.47
64_I292_M1.0690.47
345_N380_I1.0680.47
94_D201_R1.0620.47
24_V68_I1.0570.46
129_L243_I1.0530.46
119_Y148_M1.0400.45
61_A137_P1.0390.45
343_M379_P1.0370.45
83_M343_M1.0370.45
175_T182_I1.0370.45
151_M398_G1.0330.45
120_M124_S1.0260.44
163_A353_L1.0250.44
63_M152_N1.0200.44
165_S324_M1.0170.44
131_L134_G1.0140.44
383_L410_K1.0140.44
109_V114_D1.0140.44
394_V401_I1.0100.43
4_I187_L1.0100.43
333_A420_T1.0040.43
245_C250_K0.9990.43
21_R134_G0.9980.43
72_G106_T0.9970.43
188_C414_L0.9870.42
238_L264_A0.9850.42
142_G404_H0.9810.42
179_I183_A0.9800.41
22_L27_A0.9760.41
394_V399_V0.9740.41
382_M389_S0.9710.41
205_G208_E0.9710.41
187_L191_A0.9640.40
374_S379_P0.9580.40
116_S293_I0.9550.40
99_V139_I0.9530.40
37_L42_G0.9530.40
161_P391_H0.9530.40
340_T380_I0.9500.40
61_A390_T0.9460.39
116_S160_T0.9450.39
106_T144_A0.9410.39
379_P387_V0.9390.39
343_M380_I0.9370.39
97_K393_L0.9330.39
140_L280_A0.9320.38
183_A425_L0.9320.38
106_T226_W0.9270.38
13_F114_D0.9250.38
100_V104_V0.9240.38
14_M343_M0.9160.37
70_Y79_L0.9150.37
378_Q393_L0.9150.37
87_I134_G0.9140.37
341_F387_V0.9120.37
234_F238_L0.9100.37
352_V359_T0.9090.37
345_N391_H0.9080.37
141_A393_L0.9080.37
177_P372_R0.9030.37
159_A200_E0.9020.37
64_I293_I0.9000.37
407_F410_K0.9000.37
136_R199_A0.8970.36
132_L380_I0.8960.36
231_L423_A0.8890.36
273_E279_I0.8870.36
89_S247_V0.8870.36
17_I91_V0.8840.36
149_G404_H0.8840.36
75_I114_D0.8840.36
262_C303_L0.8840.36
9_M387_V0.8830.35
11_L15_A0.8820.35
121_I366_D0.8810.35
340_T378_Q0.8810.35
41_F45_E0.8780.35
315_S333_A0.8780.35
345_N387_V0.8730.35
190_V421_A0.8710.35
265_L302_I0.8690.35
205_G209_L0.8660.34
236_L323_Q0.8630.34
14_M381_H0.8630.34
81_D355_I0.8620.34
381_H387_V0.8620.34
100_V319_M0.8580.34
181_V428_A0.8490.33
383_L411_W0.8480.33
4_I52_S0.8460.33
319_M355_I0.8450.33
198_K202_K0.8430.33
259_I263_I0.8430.33
356_L370_I0.8380.33
34_V37_L0.8370.33
70_Y263_I0.8320.33
29_V365_V0.8290.32
241_S245_C0.8290.32
42_G73_I0.8270.32
106_T126_M0.8270.32
46_V398_G0.8240.32
337_G413_V0.8210.32
195_V199_A0.8200.32
325_G360_A0.8190.32
303_L397_V0.8180.32
143_I189_M0.8160.32
191_A195_V0.8140.31
61_A165_S0.8140.31
116_S152_N0.8130.31
72_G91_V0.8120.31
230_K334_L0.8110.31
341_F345_N0.8090.31
8_L35_F0.8060.31
6_G112_D0.8050.31
208_E211_Q0.8020.31
107_M147_G0.8010.31
169_V279_I0.8000.31
70_Y267_V0.7990.31
270_P306_T0.7980.31
206_V209_L0.7960.30
21_R59_P0.7960.30
84_V416_V0.7890.30
3_A9_M0.7850.30
173_E367_K0.7840.30
46_V357_S0.7830.30
329_P348_Y0.7810.30
8_L174_L0.7810.30
104_V425_L0.7810.30
110_A153_T0.7810.30
5_L9_M0.7780.30
119_Y404_H0.7770.29
187_L273_E0.7730.29
348_Y356_L0.7690.29
91_V344_P0.7680.29
138_I399_V0.7660.29
30_L100_V0.7630.29
340_T343_M0.7620.29
15_A31_T0.7590.28
187_L230_K0.7590.28
278_R283_S0.7580.28
119_Y380_I0.7580.28
110_A341_F0.7560.28
164_A174_L0.7550.28
402_D406_K0.7550.28
18_M100_V0.7540.28
251_V417_I0.7520.28
226_W231_L0.7510.28
64_I110_A0.7480.28
135_I146_V0.7470.28
153_T332_V0.7470.28
1_M260_A0.7470.28
19_T27_A0.7440.28
226_W230_K0.7440.28
282_H355_I0.7440.28
108_L287_L0.7430.28
144_A148_M0.7430.28
330_A429_I0.7430.28
176_G179_I0.7410.28
340_T344_P0.7410.28
73_I392_L0.7410.28
64_I392_L0.7410.28
99_V403_D0.7400.27
16_L196_L0.7380.27
285_N339_F0.7360.27
132_L424_L0.7320.27
143_I196_L0.7320.27
72_G281_A0.7310.27
70_Y139_I0.7290.27
5_L60_T0.7280.27
18_M323_Q0.7270.27
63_M129_L0.7260.27
94_D97_K0.7220.27
103_A107_M0.7200.26
14_M382_M0.7200.26
379_P401_I0.7190.26
68_I339_F0.7180.26
382_M390_T0.7180.26
185_G419_M0.7170.26
292_M405_Q0.7160.26
3_A129_L0.7160.26
251_V259_I0.7140.26
30_L262_C0.7140.26
340_T382_M0.7130.26
269_Y359_T0.7120.26
81_D227_K0.7110.26
31_T56_Q0.7110.26
14_M152_N0.7100.26
261_F265_L0.7090.26
75_I117_T0.7090.26
24_V258_V0.7080.26
23_S294_F0.7070.26
320_I331_I0.7060.26
165_S279_I0.7050.26
11_L99_V0.7050.26
60_T309_V0.7040.26
70_Y74_M0.7030.26
372_R428_A0.7020.26
163_A294_F0.6950.25
383_L405_Q0.6940.25
390_T408_A0.6930.25
62_V84_V0.6920.25
148_M349_F0.6920.25
184_S248_S0.6910.25
72_G283_S0.6890.25
413_V417_I0.6870.25
210_K425_L0.6840.25
262_C266_I0.6840.25
110_A345_N0.6830.25
23_S318_S0.6820.25
106_T404_H0.6820.25
18_M49_M0.6810.25
351_G378_Q0.6770.24
360_A370_I0.6770.24
278_R299_F0.6770.24
391_H401_I0.6760.24
95_P393_L0.6750.24
72_G196_L0.6740.24
269_Y278_R0.6740.24
28_L340_T0.6720.24
293_I344_P0.6720.24
61_A408_A0.6720.24
81_D303_L0.6710.24
194_Y198_K0.6710.24
195_V223_E0.6710.24
70_Y180_P0.6710.24
191_A199_A0.6710.24
320_I325_G0.6680.24
344_P380_I0.6680.24
92_K202_K0.6670.24
293_I336_S0.6660.24
90_M101_G0.6650.24
92_K120_M0.6630.24
104_V421_A0.6630.24
165_S202_K0.6630.24
13_F332_V0.6620.24
1_M28_L0.6620.24
154_I284_S0.6610.24
423_A429_I0.6600.24
19_T28_L0.6580.23
18_M51_I0.6570.23
63_M387_V0.6560.23
11_L322_E0.6530.23
237_L342_L0.6530.23
10_M267_V0.6530.23
85_G250_K0.6510.23
333_A383_L0.6510.23
400_S403_D0.6490.23
199_A259_I0.6490.23
258_V303_L0.6480.23
14_M380_I0.6470.23
420_T429_I0.6470.23
4_I219_A0.6470.23
172_A249_G0.6470.23
68_I286_V0.6460.23
9_M343_M0.6460.23
298_V302_I0.6450.23
116_S396_L0.6450.23
375_I391_H0.6430.23
68_I82_P0.6410.23
69_L269_Y0.6400.23
14_M60_T0.6390.23
198_K294_F0.6380.23
24_V70_Y0.6360.22
317_V365_V0.6350.22
316_L421_A0.6350.22
30_L422_I0.6350.22
63_M391_H0.6330.22
1_M174_L0.6320.22
40_G45_E0.6310.22
12_V34_V0.6310.22
341_F344_P0.6290.22
274_H298_V0.6290.22
187_L237_L0.6250.22
92_K414_L0.6240.22
10_M255_V0.6230.22
341_F413_V0.6230.22
188_C418_V0.6230.22
141_A399_V0.6220.22
36_A41_F0.6220.22
72_G117_T0.6220.22
157_G420_T0.6210.22
382_M388_P0.6180.22
37_L40_G0.6140.21
67_A290_G0.6140.21
213_A302_I0.6130.21
237_L240_L0.6120.21
187_L313_A0.6110.21
103_A225_E0.6100.21
391_H416_V0.6090.21
92_K121_I0.6090.21
176_G194_Y0.6050.21
70_Y253_L0.6040.21
37_L48_D0.6030.21
24_V391_H0.6020.21
153_T375_I0.6020.21
348_Y353_L0.6010.21
89_S237_L0.6010.21
72_G122_T0.6010.21
148_M382_M0.6000.21
24_V272_L0.5990.21
183_A207_I0.5990.21
348_Y430_S0.5980.21
150_I415_A0.5970.21
69_L405_Q0.5960.21
12_V16_L0.5960.21
184_S250_K0.5940.21
274_H277_Q0.5930.21
199_A202_K0.5930.21
327_L331_I0.5930.21
104_V417_I0.5920.21
45_E324_M0.5910.20
232_W236_L0.5910.20
296_A377_G0.5900.20
312_M399_V0.5900.20
353_L392_L0.5890.20
90_M406_K0.5890.20
292_M344_P0.5870.20
240_L323_Q0.5860.20
12_V334_L0.5840.20
84_V331_I0.5830.20
328_I415_A0.5820.20
267_V277_Q0.5810.20
311_E315_S0.5800.20
32_P308_M0.5790.20
98_I319_M0.5790.20
95_P141_A0.5790.20
349_F402_D0.5780.20
324_M327_L0.5780.20
290_G299_F0.5770.20
96_L204_L0.5770.20
122_T417_I0.5760.20
161_P303_L0.5750.20
158_G200_E0.5750.20
41_F299_F0.5750.20
205_G320_I0.5740.20
317_V355_I0.5730.20
296_A387_V0.5730.20
253_L303_L0.5730.20
38_I425_L0.5730.20
167_L371_A0.5720.20
2_L406_K0.5720.20
94_D393_L0.5710.20
38_I209_L0.5710.20
61_A151_M0.5710.20
2_L6_G0.5710.20
292_M350_Y0.5700.20
165_S355_I0.5690.20
61_A242_L0.5680.20
33_I37_L0.5680.20
355_I418_V0.5680.20
62_V242_L0.5660.19
119_Y145_G0.5640.19
143_I150_I0.5610.19
218_P259_I0.5590.19
62_V80_F0.5580.19
114_D289_I0.5580.19
400_S406_K0.5570.19
60_T165_S0.5530.19
19_T222_V0.5530.19
77_T371_A0.5530.19
279_I292_M0.5520.19
33_I255_V0.5510.19
48_D406_K0.5510.19
300_T343_M0.5500.19
96_L143_I0.5500.19
160_T174_L0.5490.19
20_K400_S0.5490.19
272_L391_H0.5480.19
320_I365_V0.5480.19
116_S289_I0.5480.19
5_L38_I0.5470.19
234_F266_I0.5450.19
88_L129_L0.5450.19
84_V161_P0.5450.19
119_Y343_M0.5440.19
197_G203_R0.5440.19
290_G388_P0.5430.19
46_V252_S0.5430.19
15_A37_L0.5420.18
135_I398_G0.5420.18
102_T418_V0.5410.18
379_P416_V0.5410.18
228_R281_A0.5380.18
25_L123_T0.5380.18
390_T401_I0.5380.18
30_L330_A0.5380.18
258_V392_L0.5370.18
46_V130_Y0.5370.18
84_V407_F0.5370.18
144_A293_I0.5360.18
17_I51_I0.5350.18
178_M408_A0.5340.18
335_T422_I0.5340.18
183_A208_E0.5340.18
70_Y245_C0.5330.18
29_V54_I0.5320.18
106_T294_F0.5320.18
89_S187_L0.5310.18
12_V202_K0.5310.18
23_S168_G0.5310.18
240_L277_Q0.5310.18
164_A307_K0.5300.18
25_L291_S0.5290.18
296_A344_P0.5290.18
84_V144_A0.5290.18
70_Y204_L0.5270.18
15_A92_K0.5260.18
307_K327_L0.5260.18
286_V359_T0.5260.18
220_A224_D0.5250.18
129_L287_L0.5250.18
309_V399_V0.5240.18
289_I344_P0.5240.18
139_I269_Y0.5240.18
299_F391_H0.5230.18
95_P374_S0.5230.18
145_G393_L0.5230.18
164_A371_A0.5230.18
109_V256_L0.5220.18
366_D430_S0.5210.18
28_L349_F0.5210.18
7_F339_F0.5200.18
121_I195_V0.5200.18
172_A263_I0.5200.18
307_K355_I0.5190.18
24_V332_V0.5190.18
56_Q429_I0.5180.18
118_T146_V0.5180.18
179_I368_V0.5170.18
180_P239_T0.5170.18
1_M285_N0.5170.18
202_K406_K0.5160.17
13_F289_I0.5160.17
386_L390_T0.5150.17
341_F380_I0.5150.17
383_L390_T0.5150.17
124_S289_I0.5140.17
345_N379_P0.5140.17
293_I383_L0.5130.17
326_G329_P0.5130.17
167_L386_L0.5120.17
148_M345_N0.5110.17
117_T201_R0.5110.17
104_V277_Q0.5100.17
153_T396_L0.5100.17
60_T399_V0.5100.17
120_M407_F0.5100.17
7_F180_P0.5100.17
89_S100_V0.5090.17
142_G303_L0.5090.17
95_P381_H0.5080.17
99_V103_A0.5080.17
316_L334_L0.5080.17
261_F370_I0.5070.17
237_L421_A0.5070.17
240_L365_V0.5060.17
28_L105_L0.5060.17
24_V64_I0.5050.17
110_A114_D0.5040.17
149_G343_M0.5030.17
95_P345_N0.5020.17
94_D182_I0.5010.17
73_I287_L0.5010.17
26_T266_I0.5010.17
9_M340_T0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.9746 100 0.799 Contact Map
4f35D 2 0.9053 100 0.815 Contact Map
4r1iA 2 0.9861 100 0.815 Contact Map
2a65A 2 0.4619 87.7 0.97 Contact Map
4dx5A 3 0.3741 82.6 0.972 Contact Map
3zuxA 1 0.3811 64.5 0.976 Contact Map
3w9iA 3 0.3487 61 0.976 Contact Map
3aqpA 1 0.3441 49.3 0.978 Contact Map
4k0jA 3 0.3303 47.6 0.978 Contact Map
4c7rA 3 0.448 39.4 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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