GREMLIN Database
AMHX - Amidohydrolase AmhX
UniProt: P54983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 383 (347)
Sequences: 29109 (20535)
Seq/√Len: 1102.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_E118_R3.2371.00
177_T236_K2.9901.00
37_K41_E2.8161.00
177_T238_S2.8111.00
18_H35_F2.7721.00
61_G116_T2.5741.00
183_A191_G2.5471.00
37_K49_T2.5351.00
175_E238_S2.4481.00
197_I271_A2.4241.00
66_V116_T2.3431.00
255_I259_E2.3321.00
105_L364_A2.3301.00
300_E369_K2.3171.00
179_I236_K2.3071.00
296_E369_K2.2951.00
178_I201_L2.2931.00
179_I272_K2.2901.00
259_E263_E2.2891.00
300_E365_N2.2811.00
39_K42_D2.2461.00
175_E240_S2.1761.00
35_F39_K2.1611.00
59_E116_T2.1481.00
40_L58_G2.1411.00
66_V118_R2.1081.00
198_A223_L2.0971.00
198_A237_A2.0931.00
177_T274_E2.0621.00
224_Q238_S2.0561.00
43_L104_M2.0451.00
175_E276_H2.0191.00
198_A239_F1.9971.00
256_A260_R1.9851.00
222_K240_S1.9191.00
301_I365_N1.8821.00
179_I274_E1.8601.00
22_N35_F1.8531.00
200_F203_H1.8451.00
295_A299_T1.8321.00
30_Y34_S1.8221.00
68_A143_I1.8191.00
297_A369_K1.8171.00
11_T104_M1.8121.00
105_L109_Q1.7871.00
199_A202_V1.7771.00
294_M366_A1.7591.00
39_K43_L1.7521.00
38_Q42_D1.6831.00
132_L136_E1.6761.00
15_I39_K1.6671.00
201_L262_C1.6551.00
263_E267_A1.6411.00
199_A203_H1.6121.00
31_E34_S1.6031.00
192_K197_I1.6031.00
45_C60_I1.6001.00
35_F38_Q1.5891.00
12_I360_I1.5801.00
17_E21_A1.5681.00
34_S38_Q1.5641.00
293_I369_K1.5621.00
196_E206_G1.5491.00
104_M108_K1.5381.00
37_K56_V1.5341.00
200_F269_F1.5341.00
194_S237_A1.5301.00
181_E192_K1.5301.00
365_N368_L1.5181.00
34_S49_T1.5131.00
182_E235_G1.5131.00
12_I101_G1.5051.00
257_E260_R1.5011.00
250_A253_A1.4901.00
204_K261_A1.4751.00
252_E256_A1.4681.00
299_T305_E1.4681.00
18_H31_E1.4661.00
18_H21_A1.4621.00
65_P144_D1.4451.00
133_K136_E1.4451.00
133_K137_E1.4421.00
18_H22_N1.4421.00
33_T73_I1.4341.00
187_R190_L1.4311.00
68_A120_I1.4271.00
30_Y54_T1.4201.00
36_L73_I1.4181.00
14_D18_H1.4141.00
292_A295_A1.4141.00
41_E49_T1.4141.00
98_M359_G1.4111.00
177_T276_H1.3991.00
39_K104_M1.3991.00
38_Q41_E1.3981.00
365_N369_K1.3791.00
253_A257_E1.3791.00
68_A146_L1.3781.00
82_G85_R1.3751.00
10_Q14_D1.3721.00
204_K264_A1.3711.00
46_R61_G1.3671.00
323_A328_N1.3631.00
69_V367_V1.3621.00
298_I362_I1.3331.00
174_I241_L1.3301.00
60_I107_K1.3291.00
63_G114_K1.3181.00
62_S116_T1.3171.00
69_V99_A1.3131.00
266_A273_I1.3021.00
37_K47_T1.3011.00
358_T361_H1.2991.00
178_I198_A1.2891.00
172_Q251_M1.2861.00
176_G239_F1.2791.00
357_F361_H1.2721.00
301_I361_H1.2701.00
297_A365_N1.2661.00
21_A87_N1.2651.00
41_E47_T1.2491.00
354_N358_T1.2321.00
34_S37_K1.2281.00
14_D17_E1.2271.00
200_F268_A1.2271.00
256_A259_E1.2261.00
13_M17_E1.2241.00
214_I247_T1.2171.00
255_I277_K1.2161.00
71_A92_H1.2131.00
94_S356_M1.2081.00
138_G141_D1.2041.00
260_R264_A1.2021.00
94_S351_F1.2001.00
262_C273_I1.1811.00
293_I297_A1.1811.00
145_Y370_T1.1781.00
83_T86_A1.1771.00
17_E353_R1.1721.00
24_E32_T1.1631.00
295_A310_P1.1551.00
296_E300_E1.1551.00
48_R59_E1.1531.00
15_I35_F1.1531.00
11_T14_D1.1451.00
203_H207_L1.1401.00
78_Q81_N1.1361.00
12_I97_T1.1341.00
80_V348_H1.1281.00
178_I197_I1.1271.00
208_I257_E1.1261.00
107_K110_P1.1091.00
247_T250_A1.1081.00
15_I101_G1.1051.00
64_S115_G1.1041.00
19_L32_T1.0961.00
216_H254_L1.0891.00
260_R263_E1.0881.00
22_N31_E1.0861.00
288_K292_A1.0801.00
109_Q364_A1.0801.00
192_K271_A1.0791.00
292_A296_E1.0781.00
297_A301_I1.0741.00
109_Q368_L1.0721.00
31_E35_F1.0631.00
26_S127_K1.0611.00
195_I223_L1.0571.00
88_H91_G1.0521.00
36_L96_M1.0521.00
153_P344_L1.0511.00
259_E275_L1.0431.00
253_A256_A1.0401.00
204_K207_L1.0401.00
261_A264_A1.0391.00
66_V144_D1.0371.00
261_A265_A1.0361.00
103_L119_F1.0361.00
174_I255_I1.0341.00
65_P115_G1.0261.00
204_K265_A1.0241.00
352_D355_A1.0201.00
94_S151_V1.0171.00
164_P292_A1.0161.00
18_H39_K1.0151.00
149_V363_L1.0141.00
43_L107_K1.0081.00
196_E202_V1.0041.00
60_I113_P1.0021.00
26_S29_E1.0011.00
45_C58_G1.0001.00
202_V239_F1.0001.00
257_E261_A0.9931.00
20_H89_S0.9911.00
33_T56_V0.9901.00
55_G123_P0.9831.00
11_T15_I0.9821.00
17_E86_A0.9811.00
297_A300_E0.9791.00
296_E299_T0.9791.00
102_T364_A0.9721.00
263_E266_A0.9691.00
209_H216_H0.9691.00
229_S232_I0.9671.00
105_L361_H0.9571.00
205_L258_T0.9491.00
198_A202_V0.9491.00
364_A368_L0.9451.00
132_L321_F0.9451.00
264_A267_A0.9441.00
220_M241_L0.9441.00
224_Q228_E0.9391.00
46_R59_E0.9371.00
40_L100_L0.9351.00
255_I279_H0.9341.00
200_F204_K0.9311.00
175_E230_S0.9301.00
73_I121_F0.9291.00
361_H365_N0.9281.00
27_W124_A0.9271.00
264_A268_A0.9261.00
200_F207_L0.9261.00
19_L35_F0.9251.00
78_Q82_G0.9221.00
147_Y370_T0.9201.00
12_I356_M0.9191.00
79_E82_G0.9181.00
33_T37_K0.9111.00
360_I364_A0.9101.00
145_Y290_A0.9091.00
297_A366_A0.9081.00
355_A358_T0.9071.00
230_S240_S0.9031.00
102_T363_L0.9031.00
299_T304_A0.9001.00
293_I296_E0.8941.00
67_V145_Y0.8931.00
21_A85_R0.8911.00
209_H257_E0.8901.00
196_E199_A0.8841.00
15_I97_T0.8801.00
179_I235_G0.8781.00
176_G201_L0.8771.00
101_G104_M0.8771.00
57_V118_R0.8761.00
11_T39_K0.8761.00
45_C103_L0.8731.00
71_A96_M0.8711.00
60_I103_L0.8691.00
176_G262_C0.8671.00
351_F356_M0.8651.00
335_G338_C0.8581.00
105_L360_I0.8571.00
195_I237_A0.8551.00
294_M329_L0.8541.00
252_E255_I0.8531.00
47_T58_G0.8481.00
103_L107_K0.8481.00
287_N290_A0.8461.00
99_A119_F0.8441.00
202_V220_M0.8431.00
223_L237_A0.8421.00
200_F206_G0.8401.00
101_G360_I0.8381.00
203_H206_G0.8371.00
32_T73_I0.8341.00
343_G346_H0.8331.00
15_I104_M0.8291.00
211_D214_I0.8291.00
141_D325_K0.8281.00
42_D104_M0.8251.00
291_E329_L0.8211.00
293_I366_A0.8191.00
289_E292_A0.8171.00
291_E295_A0.8161.00
289_E293_I0.8141.00
170_S245_A0.8121.00
326_V329_L0.8111.00
118_R143_I0.8091.00
18_H38_Q0.8071.00
102_T360_I0.8071.00
138_G142_D0.8051.00
148_G330_K0.8041.00
248_N252_E0.8021.00
64_S116_T0.7971.00
98_M360_I0.7971.00
39_K100_L0.7971.00
210_I216_H0.7941.00
172_Q255_I0.7941.00
266_A271_A0.7931.00
147_Y366_A0.7921.00
281_L284_A0.7891.00
175_E278_E0.7881.00
202_V223_L0.7871.00
331_T362_I0.7861.00
69_V102_T0.7851.00
33_T49_T0.7821.00
24_E93_D0.7801.00
45_C107_K0.7741.00
43_L100_L0.7731.00
98_M102_T0.7711.00
15_I18_H0.7701.00
265_A268_A0.7671.00
109_Q112_L0.7661.00
196_E207_L0.7661.00
173_H242_D0.7651.00
260_R267_A0.7641.00
48_R57_V0.7611.00
336_L351_F0.7581.00
25_V77_W0.7581.00
356_M360_I0.7581.00
146_L326_V0.7571.00
105_L108_K0.7561.00
245_A251_M0.7551.00
27_W127_K0.7551.00
164_P288_K0.7541.00
115_G144_D0.7531.00
321_F324_V0.7481.00
223_L227_G0.7441.00
73_I96_M0.7411.00
293_I370_T0.7401.00
277_K280_S0.7391.00
294_M331_T0.7371.00
36_L100_L0.7351.00
342_P348_H0.7281.00
338_C341_Q0.7271.00
220_M239_F0.7271.00
218_V221_T0.7261.00
63_G112_L0.7241.00
327_P330_K0.7231.00
36_L121_F0.7231.00
181_E346_H0.7231.00
243_L254_L0.7221.00
224_Q240_S0.7201.00
88_H92_H0.7191.00
192_K270_G0.7191.00
301_I304_A0.7181.00
178_I239_F0.7181.00
17_E20_H0.7161.00
321_F325_K0.7161.00
21_A86_A0.7141.00
319_F328_N0.7111.00
205_L218_V0.7101.00
326_V330_K0.7081.00
118_R142_D0.7071.00
174_I258_T0.7021.00
13_M353_R0.7021.00
33_T54_T0.7021.00
99_A149_V0.7001.00
15_I100_L0.6971.00
16_F97_T0.6941.00
13_M357_F0.6931.00
249_E253_A0.6911.00
222_K238_S0.6881.00
294_M362_I0.6851.00
354_N357_F0.6851.00
328_N331_T0.6821.00
139_V142_D0.6811.00
84_F87_N0.6801.00
343_G350_T0.6781.00
147_Y290_A0.6781.00
160_G164_P0.6771.00
173_H230_S0.6771.00
343_G348_H0.6751.00
298_I301_I0.6751.00
251_M255_I0.6751.00
19_L96_M0.6741.00
201_L239_F0.6661.00
129_G281_L0.6651.00
69_V147_Y0.6641.00
126_E345_H0.6611.00
67_V367_V0.6611.00
56_V121_F0.6601.00
342_P346_H0.6591.00
75_A84_F0.6541.00
252_E279_H0.6541.00
96_M121_F0.6541.00
25_V28_K0.6491.00
66_V115_G0.6481.00
168_H317_E0.6471.00
60_I119_F0.6471.00
45_C119_F0.6461.00
129_G133_K0.6451.00
30_Y49_T0.6451.00
353_R357_F0.6441.00
106_L111_E0.6431.00
197_I269_F0.6431.00
98_M363_L0.6401.00
361_H364_A0.6391.00
183_A233_I0.6381.00
178_I194_S0.6381.00
248_N324_V0.6371.00
160_G309_D0.6361.00
15_I19_L0.6341.00
89_S92_H0.6311.00
287_N292_A0.6301.00
47_T56_V0.6301.00
200_F265_A0.6291.00
194_S234_P0.6281.00
40_L45_C0.6281.00
297_A362_I0.6261.00
148_G319_F0.6261.00
104_M107_K0.6241.00
218_V243_L0.6241.00
176_G275_L0.6201.00
317_E330_K0.6191.00
31_E38_Q0.6171.00
327_P331_T0.6161.00
62_S110_P0.6161.00
44_G47_T0.6121.00
131_A135_I0.6121.00
196_E200_F0.6121.00
70_R120_I0.6111.00
36_L56_V0.6101.00
159_N306_R0.6071.00
98_M149_V0.6051.00
362_I366_A0.6051.00
82_G348_H0.6051.00
193_N234_P0.6041.00
165_S312_V0.6021.00
197_I265_A0.6021.00
140_L326_V0.6001.00
206_G269_F0.5991.00
248_N282_P0.5981.00
11_T101_G0.5981.00
124_A127_K0.5981.00
22_N32_T0.5951.00
241_L258_T0.5951.00
57_V120_I0.5951.00
174_I275_L0.5931.00
92_H95_H0.5911.00
43_L108_K0.5881.00
81_N85_R0.5871.00
196_E203_H0.5871.00
301_I362_I0.5861.00
334_L359_G0.5861.00
197_I200_F0.5861.00
222_K228_E0.5851.00
120_I322_Y0.5851.00
149_V359_G0.5841.00
226_G236_K0.5831.00
295_A309_D0.5821.00
201_L261_A0.5801.00
290_A329_L0.5761.00
136_E325_K0.5761.00
245_A254_L0.5721.00
26_S128_G0.5701.00
146_L319_F0.5691.00
176_G273_I0.5691.00
19_L97_T0.5671.00
101_G105_L0.5661.00
120_I134_M0.5651.00
25_V84_F0.5651.00
214_I250_A0.5651.00
199_A206_G0.5641.00
55_G134_M0.5631.00
134_M139_V0.5631.00
189_H211_D0.5621.00
256_A263_E0.5621.00
170_S283_A0.5611.00
16_F353_R0.5611.00
102_T106_L0.5611.00
176_G241_L0.5591.00
266_A272_K0.5521.00
59_E66_V0.5511.00
146_L328_N0.5481.00
194_S233_I0.5471.00
49_T54_T0.5471.00
326_V331_T0.5461.00
201_L205_L0.5441.00
178_I271_A0.5441.00
124_A129_G0.5441.00
174_I277_K0.5431.00
299_T306_R0.5411.00
67_V370_T0.5361.00
303_G306_R0.5351.00
235_G347_P0.5331.00
218_V223_L0.5321.00
135_I325_K0.5321.00
146_L322_Y0.5301.00
226_G237_A0.5281.00
201_L265_A0.5271.00
334_L337_G0.5271.00
282_P285_T0.5261.00
357_F360_I0.5261.00
298_I306_R0.5261.00
111_E368_L0.5251.00
120_I146_L0.5231.00
193_N196_E0.5221.00
65_P145_Y0.5221.00
224_Q236_K0.5221.00
169_G314_T0.5221.00
210_I214_I0.5221.00
220_M223_L0.5201.00
210_I213_Q0.5191.00
41_E46_R0.5191.00
282_P286_Q0.5181.00
12_I16_F0.5181.00
304_A358_T0.5181.00
80_V347_P0.5171.00
290_A293_I0.5161.00
217_T221_T0.5151.00
262_C266_A0.5141.00
202_V241_L0.5131.00
71_A99_A0.5121.00
249_E252_E0.5121.00
15_I43_L0.5111.00
334_L338_C0.5111.00
13_M16_F0.5091.00
73_I123_P0.5071.00
30_Y33_T0.5071.00
279_H282_P0.5071.00
160_G163_A0.5051.00
195_I199_A0.5041.00
68_A118_R0.5031.00
195_I202_V0.5031.00
52_D133_K0.5021.00
178_I262_C0.5021.00
152_R344_L0.5001.00
70_R122_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ewtA 4 0.9582 100 0.273 Contact Map
3io1A 4 0.9086 100 0.274 Contact Map
3pfoA 2 0.9321 100 0.274 Contact Map
3ramA 4 0.9478 100 0.283 Contact Map
1xmbA 1 0.9243 100 0.284 Contact Map
1ysjA 2 0.9112 100 0.295 Contact Map
3rzaA 2 0.906 100 0.301 Contact Map
2zogA 2 0.9504 100 0.31 Contact Map
1cg2A 4 0.9347 100 0.31 Contact Map
2pokA 2 0.9399 100 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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