AMHX - BACSU - GREMLIN Contacts

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AMHX - Amidohydrolase AmhX

UniProt:	P54983	Sequences: MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLGCRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGTLMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNGRCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTVKMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELHKEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTMLGLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	383 (347)
Sequences:	29109 (20535)
Seq/√Len:	1102.3

ECOLI - ABGA YGEY ARGE DAPE PEPT ABGB ALLC PEPD
BACSU - AMHX YODQ YHAA YTNL YXEP FAPD DAPEL YQJE PEPT ALLC PEPVL
HALSA - Q9HS25
SULSO - Q97Y12 CBPX1 CBPX2 LYSK Q97ZB7 Q97V97 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_E	118_R	3.237	1.00
177_T	236_K	2.990	1.00
37_K	41_E	2.816	1.00
177_T	238_S	2.811	1.00
18_H	35_F	2.772	1.00
61_G	116_T	2.574	1.00
183_A	191_G	2.547	1.00
37_K	49_T	2.535	1.00
175_E	238_S	2.448	1.00
197_I	271_A	2.424	1.00
66_V	116_T	2.343	1.00
255_I	259_E	2.332	1.00
105_L	364_A	2.330	1.00
300_E	369_K	2.317	1.00
179_I	236_K	2.307	1.00
296_E	369_K	2.295	1.00
178_I	201_L	2.293	1.00
179_I	272_K	2.290	1.00
259_E	263_E	2.289	1.00
300_E	365_N	2.281	1.00
39_K	42_D	2.246	1.00
175_E	240_S	2.176	1.00
35_F	39_K	2.161	1.00
59_E	116_T	2.148	1.00
40_L	58_G	2.141	1.00
66_V	118_R	2.108	1.00
198_A	223_L	2.097	1.00
198_A	237_A	2.093	1.00
177_T	274_E	2.062	1.00
224_Q	238_S	2.056	1.00
43_L	104_M	2.045	1.00
175_E	276_H	2.019	1.00
198_A	239_F	1.997	1.00
256_A	260_R	1.985	1.00
222_K	240_S	1.919	1.00
301_I	365_N	1.882	1.00
179_I	274_E	1.860	1.00
22_N	35_F	1.853	1.00
200_F	203_H	1.845	1.00
295_A	299_T	1.832	1.00
30_Y	34_S	1.822	1.00
68_A	143_I	1.819	1.00
297_A	369_K	1.817	1.00
11_T	104_M	1.812	1.00
105_L	109_Q	1.787	1.00
199_A	202_V	1.777	1.00
294_M	366_A	1.759	1.00
39_K	43_L	1.752	1.00
38_Q	42_D	1.683	1.00
132_L	136_E	1.676	1.00
15_I	39_K	1.667	1.00
201_L	262_C	1.655	1.00
263_E	267_A	1.641	1.00
199_A	203_H	1.612	1.00
31_E	34_S	1.603	1.00
192_K	197_I	1.603	1.00
45_C	60_I	1.600	1.00
35_F	38_Q	1.589	1.00
12_I	360_I	1.580	1.00
17_E	21_A	1.568	1.00
34_S	38_Q	1.564	1.00
293_I	369_K	1.562	1.00
196_E	206_G	1.549	1.00
104_M	108_K	1.538	1.00
37_K	56_V	1.534	1.00
200_F	269_F	1.534	1.00
194_S	237_A	1.530	1.00
181_E	192_K	1.530	1.00
365_N	368_L	1.518	1.00
34_S	49_T	1.513	1.00
182_E	235_G	1.513	1.00
12_I	101_G	1.505	1.00
257_E	260_R	1.501	1.00
250_A	253_A	1.490	1.00
204_K	261_A	1.475	1.00
252_E	256_A	1.468	1.00
299_T	305_E	1.468	1.00
18_H	31_E	1.466	1.00
18_H	21_A	1.462	1.00
65_P	144_D	1.445	1.00
133_K	136_E	1.445	1.00
133_K	137_E	1.442	1.00
18_H	22_N	1.442	1.00
33_T	73_I	1.434	1.00
187_R	190_L	1.431	1.00
68_A	120_I	1.427	1.00
30_Y	54_T	1.420	1.00
36_L	73_I	1.418	1.00
14_D	18_H	1.414	1.00
292_A	295_A	1.414	1.00
41_E	49_T	1.414	1.00
98_M	359_G	1.411	1.00
177_T	276_H	1.399	1.00
39_K	104_M	1.399	1.00
38_Q	41_E	1.398	1.00
365_N	369_K	1.379	1.00
253_A	257_E	1.379	1.00
68_A	146_L	1.378	1.00
82_G	85_R	1.375	1.00
10_Q	14_D	1.372	1.00
204_K	264_A	1.371	1.00
46_R	61_G	1.367	1.00
323_A	328_N	1.363	1.00
69_V	367_V	1.362	1.00
298_I	362_I	1.333	1.00
174_I	241_L	1.330	1.00
60_I	107_K	1.329	1.00
63_G	114_K	1.318	1.00
62_S	116_T	1.317	1.00
69_V	99_A	1.313	1.00
266_A	273_I	1.302	1.00
37_K	47_T	1.301	1.00
358_T	361_H	1.299	1.00
178_I	198_A	1.289	1.00
172_Q	251_M	1.286	1.00
176_G	239_F	1.279	1.00
357_F	361_H	1.272	1.00
301_I	361_H	1.270	1.00
297_A	365_N	1.266	1.00
21_A	87_N	1.265	1.00
41_E	47_T	1.249	1.00
354_N	358_T	1.232	1.00
34_S	37_K	1.228	1.00
14_D	17_E	1.227	1.00
200_F	268_A	1.227	1.00
256_A	259_E	1.226	1.00
13_M	17_E	1.224	1.00
214_I	247_T	1.217	1.00
255_I	277_K	1.216	1.00
71_A	92_H	1.213	1.00
94_S	356_M	1.208	1.00
138_G	141_D	1.204	1.00
260_R	264_A	1.202	1.00
94_S	351_F	1.200	1.00
262_C	273_I	1.181	1.00
293_I	297_A	1.181	1.00
145_Y	370_T	1.178	1.00
83_T	86_A	1.177	1.00
17_E	353_R	1.172	1.00
24_E	32_T	1.163	1.00
295_A	310_P	1.155	1.00
296_E	300_E	1.155	1.00
48_R	59_E	1.153	1.00
15_I	35_F	1.153	1.00
11_T	14_D	1.145	1.00
203_H	207_L	1.140	1.00
78_Q	81_N	1.136	1.00
12_I	97_T	1.134	1.00
80_V	348_H	1.128	1.00
178_I	197_I	1.127	1.00
208_I	257_E	1.126	1.00
107_K	110_P	1.109	1.00
247_T	250_A	1.108	1.00
15_I	101_G	1.105	1.00
64_S	115_G	1.104	1.00
19_L	32_T	1.096	1.00
216_H	254_L	1.089	1.00
260_R	263_E	1.088	1.00
22_N	31_E	1.086	1.00
288_K	292_A	1.080	1.00
109_Q	364_A	1.080	1.00
192_K	271_A	1.079	1.00
292_A	296_E	1.078	1.00
297_A	301_I	1.074	1.00
109_Q	368_L	1.072	1.00
31_E	35_F	1.063	1.00
26_S	127_K	1.061	1.00
195_I	223_L	1.057	1.00
88_H	91_G	1.052	1.00
36_L	96_M	1.052	1.00
153_P	344_L	1.051	1.00
259_E	275_L	1.043	1.00
253_A	256_A	1.040	1.00
204_K	207_L	1.040	1.00
261_A	264_A	1.039	1.00
66_V	144_D	1.037	1.00
261_A	265_A	1.036	1.00
103_L	119_F	1.036	1.00
174_I	255_I	1.034	1.00
65_P	115_G	1.026	1.00
204_K	265_A	1.024	1.00
352_D	355_A	1.020	1.00
94_S	151_V	1.017	1.00
164_P	292_A	1.016	1.00
18_H	39_K	1.015	1.00
149_V	363_L	1.014	1.00
43_L	107_K	1.008	1.00
196_E	202_V	1.004	1.00
60_I	113_P	1.002	1.00
26_S	29_E	1.001	1.00
45_C	58_G	1.000	1.00
202_V	239_F	1.000	1.00
257_E	261_A	0.993	1.00
20_H	89_S	0.991	1.00
33_T	56_V	0.990	1.00
55_G	123_P	0.983	1.00
11_T	15_I	0.982	1.00
17_E	86_A	0.981	1.00
297_A	300_E	0.979	1.00
296_E	299_T	0.979	1.00
102_T	364_A	0.972	1.00
263_E	266_A	0.969	1.00
209_H	216_H	0.969	1.00
229_S	232_I	0.967	1.00
105_L	361_H	0.957	1.00
205_L	258_T	0.949	1.00
198_A	202_V	0.949	1.00
364_A	368_L	0.945	1.00
132_L	321_F	0.945	1.00
264_A	267_A	0.944	1.00
220_M	241_L	0.944	1.00
224_Q	228_E	0.939	1.00
46_R	59_E	0.937	1.00
40_L	100_L	0.935	1.00
255_I	279_H	0.934	1.00
200_F	204_K	0.931	1.00
175_E	230_S	0.930	1.00
73_I	121_F	0.929	1.00
361_H	365_N	0.928	1.00
27_W	124_A	0.927	1.00
264_A	268_A	0.926	1.00
200_F	207_L	0.926	1.00
19_L	35_F	0.925	1.00
78_Q	82_G	0.922	1.00
147_Y	370_T	0.920	1.00
12_I	356_M	0.919	1.00
79_E	82_G	0.918	1.00
33_T	37_K	0.911	1.00
360_I	364_A	0.910	1.00
145_Y	290_A	0.909	1.00
297_A	366_A	0.908	1.00
355_A	358_T	0.907	1.00
230_S	240_S	0.903	1.00
102_T	363_L	0.903	1.00
299_T	304_A	0.900	1.00
293_I	296_E	0.894	1.00
67_V	145_Y	0.893	1.00
21_A	85_R	0.891	1.00
209_H	257_E	0.890	1.00
196_E	199_A	0.884	1.00
15_I	97_T	0.880	1.00
179_I	235_G	0.878	1.00
176_G	201_L	0.877	1.00
101_G	104_M	0.877	1.00
57_V	118_R	0.876	1.00
11_T	39_K	0.876	1.00
45_C	103_L	0.873	1.00
71_A	96_M	0.871	1.00
60_I	103_L	0.869	1.00
176_G	262_C	0.867	1.00
351_F	356_M	0.865	1.00
335_G	338_C	0.858	1.00
105_L	360_I	0.857	1.00
195_I	237_A	0.855	1.00
294_M	329_L	0.854	1.00
252_E	255_I	0.853	1.00
47_T	58_G	0.848	1.00
103_L	107_K	0.848	1.00
287_N	290_A	0.846	1.00
99_A	119_F	0.844	1.00
202_V	220_M	0.843	1.00
223_L	237_A	0.842	1.00
200_F	206_G	0.840	1.00
101_G	360_I	0.838	1.00
203_H	206_G	0.837	1.00
32_T	73_I	0.834	1.00
343_G	346_H	0.833	1.00
15_I	104_M	0.829	1.00
211_D	214_I	0.829	1.00
141_D	325_K	0.828	1.00
42_D	104_M	0.825	1.00
291_E	329_L	0.821	1.00
293_I	366_A	0.819	1.00
289_E	292_A	0.817	1.00
291_E	295_A	0.816	1.00
289_E	293_I	0.814	1.00
170_S	245_A	0.812	1.00
326_V	329_L	0.811	1.00
118_R	143_I	0.809	1.00
18_H	38_Q	0.807	1.00
102_T	360_I	0.807	1.00
138_G	142_D	0.805	1.00
148_G	330_K	0.804	1.00
248_N	252_E	0.802	1.00
64_S	116_T	0.797	1.00
98_M	360_I	0.797	1.00
39_K	100_L	0.797	1.00
210_I	216_H	0.794	1.00
172_Q	255_I	0.794	1.00
266_A	271_A	0.793	1.00
147_Y	366_A	0.792	1.00
281_L	284_A	0.789	1.00
175_E	278_E	0.788	1.00
202_V	223_L	0.787	1.00
331_T	362_I	0.786	1.00
69_V	102_T	0.785	1.00
33_T	49_T	0.782	1.00
24_E	93_D	0.780	1.00
45_C	107_K	0.774	1.00
43_L	100_L	0.773	1.00
98_M	102_T	0.771	1.00
15_I	18_H	0.770	1.00
265_A	268_A	0.767	1.00
109_Q	112_L	0.766	1.00
196_E	207_L	0.766	1.00
173_H	242_D	0.765	1.00
260_R	267_A	0.764	1.00
48_R	57_V	0.761	1.00
336_L	351_F	0.758	1.00
25_V	77_W	0.758	1.00
356_M	360_I	0.758	1.00
146_L	326_V	0.757	1.00
105_L	108_K	0.756	1.00
245_A	251_M	0.755	1.00
27_W	127_K	0.755	1.00
164_P	288_K	0.754	1.00
115_G	144_D	0.753	1.00
321_F	324_V	0.748	1.00
223_L	227_G	0.744	1.00
73_I	96_M	0.741	1.00
293_I	370_T	0.740	1.00
277_K	280_S	0.739	1.00
294_M	331_T	0.737	1.00
36_L	100_L	0.735	1.00
342_P	348_H	0.728	1.00
338_C	341_Q	0.727	1.00
220_M	239_F	0.727	1.00
218_V	221_T	0.726	1.00
63_G	112_L	0.724	1.00
327_P	330_K	0.723	1.00
36_L	121_F	0.723	1.00
181_E	346_H	0.723	1.00
243_L	254_L	0.722	1.00
224_Q	240_S	0.720	1.00
88_H	92_H	0.719	1.00
192_K	270_G	0.719	1.00
301_I	304_A	0.718	1.00
178_I	239_F	0.718	1.00
17_E	20_H	0.716	1.00
321_F	325_K	0.716	1.00
21_A	86_A	0.714	1.00
319_F	328_N	0.711	1.00
205_L	218_V	0.710	1.00
326_V	330_K	0.708	1.00
118_R	142_D	0.707	1.00
174_I	258_T	0.702	1.00
13_M	353_R	0.702	1.00
33_T	54_T	0.702	1.00
99_A	149_V	0.700	1.00
15_I	100_L	0.697	1.00
16_F	97_T	0.694	1.00
13_M	357_F	0.693	1.00
249_E	253_A	0.691	1.00
222_K	238_S	0.688	1.00
294_M	362_I	0.685	1.00
354_N	357_F	0.685	1.00
328_N	331_T	0.682	1.00
139_V	142_D	0.681	1.00
84_F	87_N	0.680	1.00
343_G	350_T	0.678	1.00
147_Y	290_A	0.678	1.00
160_G	164_P	0.677	1.00
173_H	230_S	0.677	1.00
343_G	348_H	0.675	1.00
298_I	301_I	0.675	1.00
251_M	255_I	0.675	1.00
19_L	96_M	0.674	1.00
201_L	239_F	0.666	1.00
129_G	281_L	0.665	1.00
69_V	147_Y	0.664	1.00
126_E	345_H	0.661	1.00
67_V	367_V	0.661	1.00
56_V	121_F	0.660	1.00
342_P	346_H	0.659	1.00
75_A	84_F	0.654	1.00
252_E	279_H	0.654	1.00
96_M	121_F	0.654	1.00
25_V	28_K	0.649	1.00
66_V	115_G	0.648	1.00
168_H	317_E	0.647	1.00
60_I	119_F	0.647	1.00
45_C	119_F	0.646	1.00
129_G	133_K	0.645	1.00
30_Y	49_T	0.645	1.00
353_R	357_F	0.644	1.00
106_L	111_E	0.643	1.00
197_I	269_F	0.643	1.00
98_M	363_L	0.640	1.00
361_H	364_A	0.639	1.00
183_A	233_I	0.638	1.00
178_I	194_S	0.638	1.00
248_N	324_V	0.637	1.00
160_G	309_D	0.636	1.00
15_I	19_L	0.634	1.00
89_S	92_H	0.631	1.00
287_N	292_A	0.630	1.00
47_T	56_V	0.630	1.00
200_F	265_A	0.629	1.00
194_S	234_P	0.628	1.00
40_L	45_C	0.628	1.00
297_A	362_I	0.626	1.00
148_G	319_F	0.626	1.00
104_M	107_K	0.624	1.00
218_V	243_L	0.624	1.00
176_G	275_L	0.620	1.00
317_E	330_K	0.619	1.00
31_E	38_Q	0.617	1.00
327_P	331_T	0.616	1.00
62_S	110_P	0.616	1.00
44_G	47_T	0.612	1.00
131_A	135_I	0.612	1.00
196_E	200_F	0.612	1.00
70_R	120_I	0.611	1.00
36_L	56_V	0.610	1.00
159_N	306_R	0.607	1.00
98_M	149_V	0.605	1.00
362_I	366_A	0.605	1.00
82_G	348_H	0.605	1.00
193_N	234_P	0.604	1.00
165_S	312_V	0.602	1.00
197_I	265_A	0.602	1.00
140_L	326_V	0.600	1.00
206_G	269_F	0.599	1.00
248_N	282_P	0.598	1.00
11_T	101_G	0.598	1.00
124_A	127_K	0.598	1.00
22_N	32_T	0.595	1.00
241_L	258_T	0.595	1.00
57_V	120_I	0.595	1.00
174_I	275_L	0.593	1.00
92_H	95_H	0.591	1.00
43_L	108_K	0.588	1.00
81_N	85_R	0.587	1.00
196_E	203_H	0.587	1.00
301_I	362_I	0.586	1.00
334_L	359_G	0.586	1.00
197_I	200_F	0.586	1.00
222_K	228_E	0.585	1.00
120_I	322_Y	0.585	1.00
149_V	359_G	0.584	1.00
226_G	236_K	0.583	1.00
295_A	309_D	0.582	1.00
201_L	261_A	0.580	1.00
290_A	329_L	0.576	1.00
136_E	325_K	0.576	1.00
245_A	254_L	0.572	1.00
26_S	128_G	0.570	1.00
146_L	319_F	0.569	1.00
176_G	273_I	0.569	1.00
19_L	97_T	0.567	1.00
101_G	105_L	0.566	1.00
120_I	134_M	0.565	1.00
25_V	84_F	0.565	1.00
214_I	250_A	0.565	1.00
199_A	206_G	0.564	1.00
55_G	134_M	0.563	1.00
134_M	139_V	0.563	1.00
189_H	211_D	0.562	1.00
256_A	263_E	0.562	1.00
170_S	283_A	0.561	1.00
16_F	353_R	0.561	1.00
102_T	106_L	0.561	1.00
176_G	241_L	0.559	1.00
266_A	272_K	0.552	1.00
59_E	66_V	0.551	1.00
146_L	328_N	0.548	1.00
194_S	233_I	0.547	1.00
49_T	54_T	0.547	1.00
326_V	331_T	0.546	1.00
201_L	205_L	0.544	1.00
178_I	271_A	0.544	1.00
124_A	129_G	0.544	1.00
174_I	277_K	0.543	1.00
299_T	306_R	0.541	1.00
67_V	370_T	0.536	1.00
303_G	306_R	0.535	1.00
235_G	347_P	0.533	1.00
218_V	223_L	0.532	1.00
135_I	325_K	0.532	1.00
146_L	322_Y	0.530	1.00
226_G	237_A	0.528	1.00
201_L	265_A	0.527	1.00
334_L	337_G	0.527	1.00
282_P	285_T	0.526	1.00
357_F	360_I	0.526	1.00
298_I	306_R	0.526	1.00
111_E	368_L	0.525	1.00
120_I	146_L	0.523	1.00
193_N	196_E	0.522	1.00
65_P	145_Y	0.522	1.00
224_Q	236_K	0.522	1.00
169_G	314_T	0.522	1.00
210_I	214_I	0.522	1.00
220_M	223_L	0.520	1.00
210_I	213_Q	0.519	1.00
41_E	46_R	0.519	1.00
282_P	286_Q	0.518	1.00
12_I	16_F	0.518	1.00
304_A	358_T	0.518	1.00
80_V	347_P	0.517	1.00
290_A	293_I	0.516	1.00
217_T	221_T	0.515	1.00
262_C	266_A	0.514	1.00
202_V	241_L	0.513	1.00
71_A	99_A	0.512	1.00
249_E	252_E	0.512	1.00
15_I	43_L	0.511	1.00
334_L	338_C	0.511	1.00
13_M	16_F	0.509	1.00
73_I	123_P	0.507	1.00
30_Y	33_T	0.507	1.00
279_H	282_P	0.507	1.00
160_G	163_A	0.505	1.00
195_I	199_A	0.504	1.00
68_A	118_R	0.503	1.00
195_I	202_V	0.503	1.00
52_D	133_K	0.502	1.00
178_I	262_C	0.502	1.00
152_R	344_L	0.500	1.00
70_R	122_Q	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ewtA	4	0.9582	100	0.273	Contact Map
3io1A	4	0.9086	100	0.274	Contact Map
3pfoA	2	0.9321	100	0.274	Contact Map
3ramA	4	0.9478	100	0.283	Contact Map
1xmbA	1	0.9243	100	0.284	Contact Map
1ysjA	2	0.9112	100	0.295	Contact Map
3rzaA	2	0.906	100	0.301	Contact Map
2zogA	2	0.9504	100	0.31	Contact Map
1cg2A	4	0.9347	100	0.31	Contact Map
2pokA	2	0.9399	100	0.316	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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