GREMLIN Database
YXER - Uncharacterized protein YxeR
UniProt: P54957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (356)
Sequences: 261 (178)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L255_F4.6601.00
82_N108_S3.8390.98
22_Y35_A3.5400.97
138_Y300_P3.3480.95
274_D299_T3.3220.95
19_A213_A3.3170.95
70_Y83_T3.1230.93
33_R36_D3.0890.93
14_F255_F3.0700.92
287_H319_S2.8790.90
115_M153_G2.8710.90
132_E296_K2.7890.88
99_A105_G2.7790.88
193_M196_L2.7540.87
287_H313_G2.7510.87
156_I160_C2.5430.83
41_M243_A2.5180.82
53_S215_V2.4740.81
260_F263_P2.4410.80
291_M306_N2.4410.80
92_Y327_M2.4270.80
305_I347_A2.3680.78
87_I324_V2.3400.77
135_D303_K2.2950.76
320_H335_M2.1580.71
249_A253_T2.1300.70
82_N109_W2.1220.69
313_G319_S2.0890.68
277_A302_G2.0850.68
280_G306_N2.0500.67
87_I114_T2.0170.65
92_Y328_K2.0150.65
35_A205_S1.9690.63
109_W114_T1.9370.62
63_I98_M1.9310.62
87_I110_V1.9120.61
19_A325_A1.8630.59
256_I317_L1.8600.59
336_I347_A1.8560.59
104_A163_F1.8490.58
266_A270_C1.8430.58
190_T252_M1.8310.57
163_F167_M1.8080.56
168_I252_M1.7820.55
155_L172_L1.7780.55
215_V219_T1.7740.55
75_A115_M1.7710.55
189_Y192_R1.7190.53
93_A208_A1.7090.52
182_I310_A1.6930.51
313_G316_V1.6890.51
169_G173_L1.6740.51
31_G251_P1.6560.50
14_F249_A1.6520.50
295_L307_V1.6430.49
165_I336_I1.6240.48
310_A315_F1.6120.48
84_I273_L1.6070.48
51_I84_I1.6050.47
114_T287_H1.6050.47
107_F316_V1.5980.47
143_I179_S1.5940.47
24_L28_W1.5810.46
69_F169_G1.5810.46
78_S263_P1.5800.46
92_Y221_T1.5790.46
26_N31_G1.5790.46
37_G243_A1.5770.46
29_G258_K1.5720.46
12_A216_S1.5700.46
264_L279_A1.5690.46
156_I341_A1.5600.45
145_I305_I1.5390.45
154_C327_M1.5320.44
249_A315_F1.5220.44
336_I340_L1.5130.43
217_V225_L1.5060.43
169_G184_F1.4920.42
246_L286_A1.4900.42
92_Y190_T1.4870.42
110_V209_I1.4750.42
172_L316_V1.4740.42
99_A331_M1.4680.41
43_P147_L1.4590.41
86_A320_H1.4380.40
72_A173_L1.4370.40
285_L336_I1.4320.40
3_V9_F1.4240.40
177_L344_V1.4190.39
7_V10_I1.4140.39
41_M322_G1.4010.39
216_S247_A1.3980.38
53_S219_T1.3930.38
155_L344_V1.3890.38
75_A226_I1.3860.38
141_K354_T1.3620.37
11_L15_L1.3600.37
301_R354_T1.3570.37
11_L245_A1.3570.37
38_F175_P1.3530.37
123_T284_S1.3520.37
23_C314_A1.3400.36
73_I150_V1.3340.36
137_P141_K1.3330.36
249_A286_A1.3320.36
97_E101_D1.3260.35
110_V324_V1.3080.35
252_M256_I1.2950.34
301_R349_A1.2920.34
109_W287_H1.2910.34
319_S332_A1.2910.34
287_H332_A1.2880.34
173_L327_M1.2720.33
176_S267_L1.2670.33
197_F315_F1.2640.33
276_T297_D1.2620.33
38_F282_V1.2610.33
294_S305_I1.2520.33
149_T346_A1.2500.32
95_A115_M1.2460.32
145_I353_M1.2440.32
9_F217_V1.2200.31
152_I345_T1.2120.31
82_N114_T1.2000.31
66_V177_L1.1980.30
33_R178_L1.1900.30
309_F314_A1.1870.30
111_F301_R1.1780.30
117_G339_K1.1730.30
79_S324_V1.1620.29
348_A352_W1.1610.29
149_T264_L1.1600.29
145_I347_A1.1570.29
24_L30_L1.1550.29
120_I314_A1.1540.29
192_R301_R1.1480.29
10_I191_D1.1440.28
49_I232_V1.1420.28
226_I232_V1.1410.28
54_L211_G1.1410.28
169_G305_I1.1340.28
81_A149_T1.1330.28
284_S346_A1.1310.28
176_S256_I1.1280.28
73_I317_L1.1280.28
224_V229_M1.1260.28
304_V314_A1.1200.28
30_L254_A1.1190.28
82_N91_G1.1190.28
14_F252_M1.1180.28
254_A258_K1.1140.27
301_R351_A1.0960.27
137_P143_I1.0960.27
207_V284_S1.0950.27
278_T313_G1.0850.26
264_L278_T1.0830.26
10_I63_I1.0780.26
110_V328_K1.0780.26
15_L288_H1.0750.26
6_A300_P1.0650.26
265_Q281_L1.0630.26
189_Y193_M1.0620.26
249_A283_T1.0600.25
14_F315_F1.0590.25
270_C277_A1.0530.25
155_L338_G1.0510.25
153_G171_N1.0390.25
80_F312_S1.0380.25
72_A342_G1.0370.25
93_A238_T1.0330.25
127_A292_L1.0310.25
320_H324_V1.0310.25
87_I292_L1.0310.25
173_L301_R1.0290.24
70_Y97_E1.0260.24
38_F216_S1.0210.24
179_S264_L1.0120.24
28_W259_T1.0050.24
57_V214_A0.9990.23
82_N332_A0.9970.23
214_A226_I0.9970.23
22_Y148_C0.9960.23
84_I191_D0.9960.23
205_S209_I0.9900.23
35_A109_W0.9830.23
181_V196_L0.9810.23
118_P315_F0.9810.23
165_I297_D0.9790.23
289_I321_L0.9790.23
120_I256_I0.9760.23
270_C305_I0.9750.23
14_F309_F0.9720.23
35_A238_T0.9700.23
194_I252_M0.9700.23
240_G246_L0.9700.23
22_Y209_I0.9690.23
61_I169_G0.9690.23
12_A220_M0.9640.22
185_G193_M0.9640.22
92_Y252_M0.9640.22
253_T283_T0.9630.22
27_R181_V0.9600.22
240_G286_A0.9590.22
17_W199_L0.9560.22
181_V231_N0.9560.22
177_L352_W0.9560.22
82_N319_S0.9530.22
83_T338_G0.9510.22
79_S319_S0.9500.22
35_A274_D0.9470.22
92_Y219_T0.9350.22
233_E237_Q0.9350.22
109_W175_P0.9340.21
137_P256_I0.9340.21
240_G249_A0.9260.21
100_K225_L0.9230.21
277_A351_A0.9220.21
121_V320_H0.9210.21
311_V340_L0.9200.21
316_V322_G0.9140.21
239_T305_I0.9060.21
288_H344_V0.9020.21
79_S320_H0.9010.20
206_M267_L0.9000.20
158_G211_G0.8980.20
78_S108_S0.8970.20
78_S189_Y0.8960.20
163_F342_G0.8890.20
246_L249_A0.8850.20
27_R269_K0.8840.20
123_T315_F0.8830.20
13_A20_A0.8820.20
40_A282_V0.8810.20
249_A309_F0.8790.20
145_I291_M0.8710.20
183_A304_V0.8700.20
75_A81_A0.8700.20
85_L306_N0.8640.19
266_A269_K0.8620.19
152_I342_G0.8610.19
283_T291_M0.8580.19
150_V325_A0.8570.19
48_M179_S0.8570.19
277_A301_R0.8510.19
129_G322_G0.8510.19
236_I240_G0.8460.19
25_G105_G0.8450.19
82_N324_V0.8430.19
204_V208_A0.8400.19
121_V347_A0.8400.19
234_T237_Q0.8380.19
305_I317_L0.8360.19
98_M164_D0.8350.19
189_Y301_R0.8350.19
314_A317_L0.8340.19
184_F195_Q0.8320.19
63_I67_A0.8310.19
280_G298_M0.8310.19
351_A355_P0.8300.19
286_A315_F0.8290.18
74_G334_A0.8250.18
104_A167_M0.8220.18
155_L247_A0.8190.18
67_A73_I0.8180.18
139_F179_S0.8170.18
73_I168_I0.8150.18
218_E250_F0.8140.18
324_V331_M0.8130.18
11_L280_G0.8100.18
202_K311_V0.8090.18
114_T324_V0.8050.18
113_G140_A0.8010.18
26_N165_I0.8000.18
203_A207_V0.7990.18
45_A175_P0.7980.18
169_G210_I0.7980.18
86_A117_G0.7980.18
104_A161_A0.7970.18
30_L307_V0.7960.18
54_L57_V0.7930.18
55_A62_L0.7920.18
188_R267_L0.7920.18
130_I289_I0.7860.17
126_V323_F0.7800.17
23_C284_S0.7770.17
16_L213_A0.7750.17
140_A277_A0.7750.17
143_I197_F0.7740.17
178_L217_V0.7730.17
107_F154_C0.7700.17
72_A277_A0.7690.17
20_A213_A0.7680.17
215_V344_V0.7650.17
249_A292_L0.7600.17
58_L200_F0.7580.17
149_T152_I0.7570.17
35_A175_P0.7560.17
104_A325_A0.7560.17
199_L295_L0.7540.17
337_I341_A0.7540.17
4_N47_S0.7500.16
315_F319_S0.7480.16
200_F296_K0.7460.16
96_G105_G0.7460.16
278_T301_R0.7410.16
140_A304_V0.7390.16
176_S223_I0.7350.16
324_V335_M0.7340.16
5_D38_F0.7340.16
147_L216_S0.7320.16
29_G74_G0.7300.16
145_I349_A0.7300.16
75_A325_A0.7270.16
95_A185_G0.7260.16
197_F249_A0.7260.16
66_V277_A0.7250.16
275_E347_A0.7210.16
115_M338_G0.7200.16
177_L191_D0.7170.16
135_D315_F0.7130.16
128_L143_I0.7110.16
8_V295_L0.7090.15
261_K267_L0.7080.15
52_V245_A0.7070.15
38_F357_Q0.7070.15
19_A289_I0.7020.15
238_T336_I0.7010.15
118_P154_C0.6990.15
49_I54_L0.6990.15
99_A126_V0.6960.15
118_P310_A0.6950.15
178_L203_A0.6930.15
119_A340_L0.6900.15
133_K136_H0.6900.15
281_L347_A0.6860.15
86_A89_M0.6860.15
27_R237_Q0.6840.15
41_M305_I0.6840.15
141_K255_F0.6810.15
53_S229_M0.6810.15
98_M311_V0.6800.15
72_A344_V0.6790.15
19_A33_R0.6780.15
101_D104_A0.6770.15
280_G291_M0.6720.15
256_I260_F0.6710.15
59_A346_A0.6700.15
149_T312_S0.6690.15
101_D131_I0.6680.15
79_S84_I0.6680.15
112_L327_M0.6660.15
212_L247_A0.6660.15
19_A113_G0.6640.14
108_S294_S0.6640.14
97_E337_I0.6630.14
201_G204_V0.6630.14
53_S141_K0.6620.14
24_L51_I0.6600.14
116_M133_K0.6590.14
13_A69_F0.6590.14
57_V161_A0.6580.14
35_A322_G0.6580.14
102_P177_L0.6560.14
230_E234_T0.6500.14
17_W239_T0.6500.14
226_I284_S0.6500.14
10_I69_F0.6470.14
58_L240_G0.6460.14
273_L299_T0.6460.14
162_G220_M0.6450.14
85_L323_F0.6440.14
150_V342_G0.6430.14
224_V290_P0.6430.14
283_T315_F0.6410.14
127_A130_I0.6400.14
105_G234_T0.6380.14
85_L112_L0.6370.14
27_R234_T0.6360.14
70_Y113_G0.6360.14
47_S356_A0.6360.14
44_L318_G0.6350.14
265_Q351_A0.6330.14
118_P282_V0.6280.14
308_A350_A0.6280.14
121_V335_M0.6280.14
43_P271_L0.6270.14
21_D27_R0.6260.14
153_G238_T0.6250.14
49_I53_S0.6220.14
92_Y112_L0.6220.14
265_Q301_R0.6220.14
36_D185_G0.6220.14
232_V284_S0.6220.14
103_Q164_D0.6200.14
21_D302_G0.6200.14
245_A331_M0.6170.13
14_F283_T0.6160.13
118_P290_P0.6160.13
214_A338_G0.6140.13
27_R138_Y0.6140.13
184_F337_I0.6130.13
249_A314_A0.6120.13
52_V169_G0.6110.13
161_A167_M0.6100.13
16_L269_K0.6090.13
69_F344_V0.6090.13
206_M304_V0.6070.13
136_H239_T0.6060.13
165_I348_A0.6050.13
74_G251_P0.6050.13
17_W28_W0.6040.13
6_A10_I0.6030.13
89_M122_F0.6030.13
29_G264_L0.6020.13
104_A267_L0.6010.13
150_V178_L0.5990.13
65_I199_L0.5980.13
138_Y281_L0.5970.13
17_W247_A0.5970.13
111_F238_T0.5960.13
183_A305_I0.5950.13
131_I262_K0.5950.13
250_F307_V0.5940.13
204_V355_P0.5930.13
137_P225_L0.5930.13
112_L215_V0.5930.13
140_A303_K0.5930.13
56_P246_L0.5920.13
25_G225_L0.5920.13
197_F283_T0.5910.13
49_I214_A0.5910.13
89_M117_G0.5910.13
20_A24_L0.5890.13
78_S116_M0.5870.13
11_L22_Y0.5870.13
312_S342_G0.5860.13
24_L233_E0.5860.13
49_I173_L0.5860.13
18_G37_G0.5860.13
17_W168_I0.5850.13
13_A155_L0.5850.13
41_M45_A0.5850.13
206_M333_A0.5840.13
32_E128_L0.5840.13
198_H207_V0.5820.13
139_F282_V0.5820.13
85_L229_M0.5820.13
322_G326_G0.5800.13
106_L163_F0.5790.13
27_R195_Q0.5780.13
118_P345_T0.5750.13
199_L296_K0.5750.13
197_F309_F0.5750.13
190_T272_H0.5710.13
24_L73_I0.5710.13
46_L147_L0.5700.13
148_C236_I0.5690.12
186_L242_I0.5670.12
15_L139_F0.5670.12
52_V244_I0.5670.12
210_I326_G0.5660.12
202_K296_K0.5650.12
147_L182_I0.5650.12
33_R195_Q0.5640.12
305_I351_A0.5640.12
144_L234_T0.5630.12
17_W191_D0.5620.12
124_I238_T0.5610.12
47_S295_L0.5600.12
111_F327_M0.5600.12
111_F175_P0.5590.12
128_L238_T0.5570.12
41_M112_L0.5570.12
11_L216_S0.5570.12
38_F51_I0.5550.12
16_L206_M0.5540.12
17_W330_E0.5540.12
16_L103_Q0.5530.12
7_V62_L0.5520.12
141_K239_T0.5510.12
286_A318_G0.5500.12
66_V271_L0.5490.12
43_P188_R0.5490.12
70_Y192_R0.5470.12
177_L189_Y0.5470.12
27_R105_G0.5470.12
349_A355_P0.5450.12
98_M334_A0.5420.12
246_L251_P0.5420.12
43_P336_I0.5420.12
136_H170_K0.5410.12
51_I216_S0.5410.12
11_L209_I0.5400.12
52_V320_H0.5380.12
49_I141_K0.5380.12
10_I184_F0.5370.12
124_I334_A0.5370.12
119_A156_I0.5360.12
161_A219_T0.5350.12
200_F209_I0.5350.12
159_L169_G0.5340.12
80_F124_I0.5340.12
95_A350_A0.5330.12
82_N120_I0.5320.12
35_A209_I0.5310.12
310_A314_A0.5290.12
87_I304_V0.5270.12
313_G345_T0.5270.12
231_N234_T0.5270.12
210_I262_K0.5260.12
22_Y41_M0.5260.12
221_T244_I0.5250.12
29_G321_L0.5250.12
66_V204_V0.5250.12
84_I200_F0.5240.12
38_F324_V0.5230.12
130_I283_T0.5220.12
93_A110_V0.5200.12
122_F256_I0.5190.12
196_L200_F0.5170.12
119_A311_V0.5170.12
145_I281_L0.5160.11
253_T315_F0.5160.11
291_M310_A0.5140.11
226_I278_T0.5140.11
60_A120_I0.5130.11
55_A64_P0.5120.11
305_I336_I0.5100.11
51_I212_L0.5060.11
164_D244_I0.5060.11
150_V182_I0.5060.11
94_L264_L0.5040.11
73_I295_L0.5030.11
262_K344_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7703 89.2 0.963 Contact Map
4x5mA 2 0.2541 61.8 0.971 Contact Map
2kluA 1 0.1162 54.6 0.973 Contact Map
4pd6A 3 0.5568 45.5 0.974 Contact Map
3v5uA 1 0.7297 35.5 0.976 Contact Map
2cfqA 1 0.9514 32.9 0.976 Contact Map
4n7wA 2 0.7892 20.1 0.978 Contact Map
4pypA 1 0.9 14.9 0.98 Contact Map
2kncB 1 0.127 12.8 0.98 Contact Map
2kncA 1 0.1297 12 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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