GREMLIN Database
YXEQ - Uncharacterized protein YxeQ
UniProt: P54956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (427)
Sequences: 2722 (1858)
Seq/√Len: 89.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_G176_L5.3581.00
172_T175_E4.1981.00
66_P116_A3.9051.00
297_R360_Q3.7891.00
12_E173_Q3.7271.00
296_E387_S3.7181.00
119_H122_R3.2151.00
400_K411_D3.1371.00
383_R393_E3.0681.00
30_K436_D3.0151.00
299_E362_V2.8931.00
281_V329_I2.7951.00
38_A416_L2.6911.00
301_I364_D2.6011.00
386_L392_C2.5991.00
296_E385_Y2.5881.00
299_E383_R2.5671.00
354_T358_R2.5661.00
31_K409_E2.5441.00
126_A168_A2.5221.00
17_S129_V2.5081.00
335_G342_H2.4461.00
297_R385_Y2.4261.00
301_I381_I2.3961.00
299_E360_Q2.3951.00
179_A217_A2.3911.00
282_R332_A2.3611.00
294_N387_S2.3561.00
27_H409_E2.3531.00
210_G214_V2.2861.00
21_H128_V2.2751.00
29_A128_V2.2741.00
25_A259_V2.2391.00
381_I395_R2.2251.00
169_E215_K2.2211.00
385_Y391_I2.2141.00
417_T426_R2.1791.00
270_F274_A2.1561.00
134_M160_A2.1531.00
34_L429_I2.1491.00
54_R219_S2.1211.00
299_E385_Y2.1161.00
145_H155_T2.0721.00
125_G167_Y2.0631.00
111_L123_L2.0091.00
24_D259_V2.0091.00
36_F87_A2.0071.00
33_L127_Y2.0011.00
111_L164_A1.9951.00
114_S165_V1.9811.00
291_S294_N1.9701.00
114_S211_L1.9671.00
337_G342_H1.9461.00
434_K437_I1.9311.00
408_S411_D1.9111.00
301_I383_R1.8951.00
22_S25_A1.8561.00
416_L420_V1.8441.00
417_T425_A1.8171.00
29_A124_L1.8151.00
287_E394_A1.8121.00
162_A179_A1.8011.00
386_L390_R1.7501.00
300_V329_I1.7321.00
15_R173_Q1.7281.00
163_C180_I1.7101.00
182_F198_M1.6791.00
301_I362_V1.6771.00
426_R430_T1.6641.00
413_I433_E1.6581.00
87_A105_A1.6411.00
114_S169_E1.6291.00
417_T429_I1.6211.00
58_D219_S1.5981.00
26_I30_K1.5881.00
169_E214_V1.5811.00
184_A227_A1.5701.00
122_R167_Y1.5631.00
41_F420_V1.5541.00
34_L432_V1.5541.00
283_Q394_A1.5421.00
327_Y356_M1.5421.00
383_R391_I1.5341.00
335_G350_N1.5321.00
334_H352_V1.5241.00
95_V264_W1.5241.00
122_R125_G1.5231.00
413_I429_I1.5051.00
335_G347_P1.5011.00
13_A256_W1.4981.00
76_P80_A1.4931.00
65_V79_S1.4851.00
278_A332_A1.4821.00
137_L159_I1.4811.00
381_I393_E1.4811.00
19_P121_E1.4691.00
279_D400_K1.4681.00
130_G164_A1.4671.00
21_H26_I1.4650.99
290_I386_L1.4530.99
13_A252_W1.4490.99
169_E218_Q1.4400.99
200_P322_R1.4370.99
280_A396_V1.4360.99
331_L342_H1.4330.99
67_V74_A1.4330.99
49_I86_I1.4330.99
26_I125_G1.4190.99
251_D254_A1.4190.99
40_S87_A1.4110.99
159_I180_I1.4060.99
430_T434_K1.3950.99
208_Q212_L1.3940.99
115_A123_L1.3790.99
298_I384_A1.3790.99
285_I336_H1.3720.99
162_A210_G1.3660.99
353_Q356_M1.3530.99
354_T357_G1.3500.99
413_I417_T1.3500.99
257_R260_Q1.3480.99
11_A15_R1.3360.99
267_I407_L1.3300.99
79_S83_N1.3270.99
166_G171_L1.3250.99
314_S357_G1.3210.99
431_A438_K1.3210.99
271_C323_F1.3140.99
182_F217_A1.3120.99
111_L165_V1.2990.99
114_S168_A1.2940.99
50_Q54_R1.2920.99
14_V176_L1.2840.99
316_K320_E1.2780.99
37_T432_V1.2780.99
319_E322_R1.2730.99
334_H355_T1.2700.99
66_P73_K1.2660.99
120_D435_A1.2620.98
106_V109_P1.2620.98
22_S256_W1.2570.98
33_L124_L1.2520.98
133_V163_C1.2470.98
76_P117_R1.2460.98
311_T326_E1.2380.98
26_I124_L1.2370.98
293_A387_S1.2340.98
111_L127_Y1.2310.98
205_L208_Q1.2280.98
95_V272_S1.2220.98
31_K412_I1.2190.98
280_A382_V1.2190.98
32_G265_F1.2170.98
56_I82_L1.2090.98
339_T342_H1.2030.98
278_A328_V1.2000.98
14_V163_C1.1990.98
40_S68_I1.1820.98
274_A328_V1.1820.98
7_T177_E1.1780.98
63_P73_K1.1750.98
122_R170_E1.1700.98
328_V343_F1.1630.97
123_L127_Y1.1550.97
11_A177_E1.1540.97
363_Y368_Q1.1440.97
12_E16_T1.1440.97
401_G406_E1.1370.97
15_R176_L1.1360.97
190_M237_L1.1340.97
281_V384_A1.1310.97
28_E31_K1.1270.97
165_V214_V1.1260.97
284_L384_A1.1260.97
428_I432_V1.1210.97
104_S131_V1.1130.97
171_L175_E1.1130.97
84_G202_H1.1120.97
171_L217_A1.1090.97
270_F343_F1.1060.96
216_L221_F1.1030.96
43_G86_I1.1030.96
96_H257_R1.0960.96
185_T202_H1.0950.96
17_S125_G1.0910.96
89_A200_P1.0890.96
171_L179_A1.0890.96
8_A174_E1.0880.96
68_I112_I1.0860.96
125_G129_V1.0850.96
422_Q426_R1.0850.96
88_H93_D1.0810.96
251_D255_P1.0800.96
8_A173_Q1.0780.96
110_A161_A1.0770.96
313_R326_E1.0750.96
161_A210_G1.0750.96
75_A78_Q1.0720.96
81_M204_G1.0720.96
65_V116_A1.0700.96
420_V425_A1.0670.96
151_H202_H1.0670.96
96_H99_V1.0660.96
34_L413_I1.0540.95
295_T384_A1.0500.95
294_N388_D1.0470.95
51_K197_E1.0450.95
171_L218_Q1.0410.95
185_T198_M1.0390.95
293_A351_G1.0390.95
110_A165_V1.0390.95
205_L209_A1.0340.95
67_V82_L1.0330.95
184_A190_M1.0330.95
268_Y279_D1.0310.95
60_G63_P1.0300.95
278_A338_L1.0270.95
52_L85_F1.0200.94
410_E413_I1.0050.94
414_E418_L1.0030.94
74_A82_L1.0010.94
163_C176_L1.0010.94
178_K217_A0.9920.94
267_I272_S0.9900.94
398_C404_G0.9880.94
304_P368_Q0.9830.93
91_D199_K0.9820.93
178_K222_G0.9740.93
81_M84_G0.9720.93
175_E178_K0.9710.93
51_K221_F0.9660.93
20_E125_G0.9640.93
8_A177_E0.9550.92
264_W272_S0.9550.92
281_V333_L0.9540.92
68_I83_N0.9520.92
159_I184_A0.9510.92
26_I121_E0.9460.92
364_D367_I0.9430.92
55_L219_S0.9400.92
366_A369_P0.9380.92
424_K427_R0.9310.91
38_A419_T0.9300.91
153_T189_G0.9290.91
289_T292_A0.9280.91
167_Y176_L0.9270.91
27_H31_K0.9200.91
49_I82_L0.9170.91
171_L214_V0.9150.91
13_A132_E0.9140.91
367_I395_R0.9110.90
278_A281_V0.9100.90
272_S275_H0.9080.90
26_I128_V0.9050.90
325_V361_R0.9040.90
409_E433_E0.9000.90
295_T333_L0.8970.90
80_A113_A0.8930.90
35_D415_K0.8880.89
158_A210_G0.8880.89
269_P338_L0.8830.89
165_V210_G0.8770.89
85_F204_G0.8750.89
185_T190_M0.8700.88
289_T336_H0.8660.88
277_A329_I0.8660.88
14_V167_Y0.8640.88
61_G64_L0.8630.88
178_K223_G0.8590.88
163_C166_G0.8580.88
8_A225_R0.8570.88
113_A116_A0.8560.87
136_R251_D0.8530.87
197_E221_F0.8530.87
97_S272_S0.8520.87
280_A394_A0.8520.87
296_E358_R0.8510.87
162_A214_V0.8490.87
314_S353_Q0.8420.87
14_V166_G0.8410.87
148_K240_D0.8400.86
197_E222_G0.8390.86
17_S20_E0.8370.86
78_Q82_L0.8360.86
88_H202_H0.8350.86
253_G256_W0.8350.86
288_E392_C0.8340.86
285_I332_A0.8330.86
8_A12_E0.8310.86
265_F412_I0.8300.86
269_P342_H0.8290.86
65_V83_N0.8290.86
312_E320_E0.8280.86
417_T422_Q0.8240.85
333_L355_T0.8170.85
88_H322_R0.8160.85
429_I432_V0.8160.85
129_V167_Y0.8140.85
327_Y331_L0.8140.85
171_L176_L0.8100.84
330_A355_T0.8070.84
406_E409_E0.8020.84
43_G89_A0.8020.84
269_P419_T0.8020.84
14_V180_I0.8010.84
93_D199_K0.8000.84
224_S230_G0.7970.83
255_P260_Q0.7950.83
351_G354_T0.7930.83
107_I111_L0.7930.83
215_K219_S0.7920.83
175_E218_Q0.7920.83
146_Y153_T0.7910.83
23_V27_H0.7900.83
330_A359_I0.7890.83
110_A164_A0.7890.83
77_L215_K0.7880.83
331_L352_V0.7870.83
51_K54_R0.7840.82
83_N113_A0.7820.82
96_H138_G0.7800.82
88_H151_H0.7790.82
277_A325_V0.7790.82
91_D323_F0.7740.82
300_V359_I0.7740.82
209_A213_A0.7730.82
80_A110_A0.7700.81
249_L252_W0.7690.81
84_G204_G0.7680.81
304_P308_A0.7660.81
57_E72_K0.7650.81
7_T181_G0.7650.81
285_I333_L0.7630.81
401_G407_L0.7630.81
139_E257_R0.7630.81
53_L70_Q0.7620.81
18_Q167_Y0.7620.81
273_A303_P0.7620.81
52_L81_M0.7610.81
268_Y400_K0.7600.80
76_P113_A0.7590.80
199_K202_H0.7570.80
335_G351_G0.7560.80
347_P350_N0.7530.80
223_G322_R0.7510.80
173_Q177_E0.7510.80
335_G352_V0.7500.80
332_A338_L0.7500.80
198_M202_H0.7480.79
292_A334_H0.7460.79
83_N116_A0.7440.79
99_V138_G0.7410.79
400_K405_N0.7410.79
300_V382_V0.7400.79
107_I127_Y0.7400.79
195_G324_S0.7390.79
430_T433_E0.7370.78
277_A300_V0.7340.78
53_L82_L0.7330.78
64_L76_P0.7300.78
94_D104_S0.7290.78
298_I355_T0.7280.78
358_R387_S0.7270.77
231_E236_S0.7250.77
88_H189_G0.7220.77
77_L208_Q0.7210.77
313_R357_G0.7160.76
74_A78_Q0.7130.76
417_T421_P0.7100.76
16_T173_Q0.7100.76
29_A127_Y0.7090.76
38_A41_F0.7080.76
45_E50_Q0.7080.76
302_F361_R0.7060.75
318_G348_I0.7040.75
349_P353_Q0.7030.75
48_G89_A0.7010.75
42_A90_L0.7000.75
425_A428_I0.6980.75
386_L389_G0.6980.75
191_R194_F0.6970.74
27_H30_K0.6960.74
303_P306_G0.6950.74
188_A238_Y0.6950.74
17_S21_H0.6940.74
334_H351_G0.6930.74
138_G191_R0.6920.74
196_T200_P0.6910.74
272_S402_A0.6900.74
281_V285_I0.6890.74
88_H105_A0.6890.74
409_E413_I0.6870.73
27_H433_E0.6870.73
54_R57_E0.6860.73
426_R429_I0.6860.73
132_E256_W0.6840.73
300_V325_V0.6830.73
95_V378_R0.6810.73
435_A439_E0.6810.73
145_H156_L0.6800.73
33_L123_L0.6760.72
24_D27_H0.6760.72
103_P135_A0.6720.72
278_A282_R0.6690.71
329_I333_L0.6680.71
151_H185_T0.6670.71
88_H199_K0.6660.71
28_E32_G0.6660.71
338_L343_F0.6640.71
110_A211_L0.6640.71
423_E427_R0.6620.71
331_L335_G0.6610.70
90_L271_C0.6600.70
295_T298_I0.6580.70
296_E299_E0.6560.70
42_A340_V0.6560.70
65_V76_P0.6550.70
199_K415_K0.6550.70
36_F104_S0.6530.70
292_A386_L0.6520.69
88_H203_A0.6510.69
34_L433_E0.6510.69
290_I294_N0.6500.69
281_V382_V0.6500.69
39_A92_F0.6490.69
215_K218_Q0.6480.69
92_F419_T0.6470.69
81_M208_Q0.6460.69
94_D199_K0.6440.68
36_F40_S0.6440.68
131_V263_L0.6420.68
31_K433_E0.6410.68
181_G185_T0.6410.68
29_A258_I0.6410.68
400_K408_S0.6400.68
204_G207_A0.6400.68
59_E77_L0.6400.68
21_H125_G0.6400.68
163_C179_A0.6390.68
14_V133_V0.6380.68
104_S127_Y0.6380.68
170_E173_Q0.6380.68
281_V332_A0.6370.68
288_E390_R0.6360.68
95_V101_G0.6360.68
137_L249_L0.6360.68
33_L435_A0.6320.67
148_K239_G0.6310.67
295_T386_L0.6260.66
304_P363_Y0.6250.66
96_H135_A0.6250.66
285_I292_A0.6250.66
25_A28_E0.6230.66
92_F269_P0.6230.66
25_A258_I0.6220.66
141_I156_L0.6220.66
319_E323_F0.6200.66
66_P83_N0.6180.65
106_V134_M0.6170.65
136_R249_L0.6170.65
157_G189_G0.6160.65
121_E439_E0.6160.65
425_A429_I0.6150.65
7_T228_L0.6150.65
228_L235_F0.6150.65
356_M359_I0.6130.65
18_Q125_G0.6090.64
111_L159_I0.6080.64
111_L130_G0.6070.64
10_L133_V0.6060.64
145_H153_T0.6060.64
411_D414_E0.6060.64
96_H101_G0.6060.64
307_D361_R0.6050.64
345_S349_P0.6040.64
106_V153_T0.6040.64
60_G75_A0.6040.64
276_H380_T0.6030.63
272_S399_P0.6030.63
11_A176_L0.6020.63
199_K322_R0.6010.63
9_G12_E0.6010.63
88_H323_F0.6010.63
326_E356_M0.6010.63
36_F109_P0.6000.63
36_F39_A0.6000.63
114_S117_R0.6000.63
121_E125_G0.5990.63
288_E294_N0.5980.63
186_Q213_A0.5970.63
96_H186_Q0.5970.63
46_D49_I0.5960.63
6_L229_D0.5950.62
93_D189_G0.5940.62
52_L221_F0.5930.62
30_K124_L0.5930.62
427_R431_A0.5920.62
177_E225_R0.5920.62
52_L82_L0.5910.62
121_E426_R0.5890.62
321_G348_I0.5880.61
88_H157_G0.5880.61
153_T271_C0.5870.61
17_S128_V0.5870.61
277_A380_T0.5860.61
157_G206_A0.5860.61
273_A306_G0.5850.61
333_L386_L0.5840.61
150_W238_Y0.5830.61
152_N191_R0.5830.61
202_H322_R0.5810.61
120_D123_L0.5810.61
345_S348_I0.5810.61
310_L323_F0.5810.61
377_G398_C0.5780.60
117_R215_K0.5780.60
303_P375_P0.5770.60
32_G263_L0.5770.60
298_I359_I0.5760.60
132_E136_R0.5740.60
318_G345_S0.5740.60
106_V157_G0.5740.60
140_S248_L0.5730.60
151_H199_K0.5730.60
97_S271_C0.5720.59
194_F200_P0.5720.59
337_G414_E0.5720.59
318_G322_R0.5700.59
279_D283_Q0.5700.59
107_I164_A0.5700.59
91_D104_S0.5690.59
91_D102_H0.5690.59
25_A256_W0.5670.59
342_H347_P0.5670.59
20_E167_Y0.5660.59
30_K432_V0.5660.59
24_D403_P0.5640.58
36_F265_F0.5640.58
431_A434_K0.5640.58
50_Q53_L0.5630.58
11_A173_Q0.5630.58
64_L117_R0.5610.58
359_I382_V0.5600.58
331_L338_L0.5590.58
294_N392_C0.5590.58
158_A187_S0.5590.58
91_D95_V0.5590.58
354_T359_I0.5570.57
377_G397_D0.5560.57
293_A427_R0.5560.57
273_A309_A0.5550.57
291_S386_L0.5540.57
367_I381_I0.5540.57
137_L228_L0.5530.57
93_D151_H0.5510.57
338_L342_H0.5510.57
94_D153_T0.5510.57
302_F306_G0.5500.56
103_P263_L0.5500.56
434_K438_K0.5500.56
159_I162_A0.5490.56
11_A163_C0.5480.56
248_L252_W0.5480.56
284_L288_E0.5480.56
189_G202_H0.5470.56
182_F213_A0.5470.56
47_K50_Q0.5460.56
39_A91_D0.5460.56
84_G109_P0.5460.56
159_I188_A0.5450.56
32_G127_Y0.5450.56
145_H151_H0.5440.56
88_H195_G0.5440.56
114_S215_K0.5420.55
186_Q201_L0.5420.55
279_D407_L0.5410.55
322_R343_F0.5410.55
416_L428_I0.5410.55
396_V405_N0.5410.55
325_V329_I0.5410.55
22_S259_V0.5400.55
121_E436_D0.5380.55
96_H100_R0.5380.55
155_T188_A0.5370.55
104_S269_P0.5370.55
132_E258_I0.5360.55
159_I183_A0.5360.55
271_C310_L0.5360.55
178_K225_R0.5360.55
81_M85_F0.5350.54
53_L57_E0.5340.54
88_H188_A0.5330.54
35_D199_K0.5320.54
44_R86_I0.5320.54
110_A114_S0.5300.54
128_V258_I0.5280.53
298_I329_I0.5280.53
152_N273_A0.5270.53
11_A162_A0.5260.53
49_I89_A0.5260.53
191_R271_C0.5260.53
273_A310_L0.5240.53
153_T157_G0.5240.53
271_C322_R0.5230.53
160_A164_A0.5230.53
17_S132_E0.5220.53
39_A43_G0.5210.52
91_D378_R0.5210.52
398_C402_A0.5200.52
61_G65_V0.5200.52
289_T294_N0.5200.52
283_Q287_E0.5180.52
151_H189_G0.5170.52
294_N390_R0.5170.52
129_V163_C0.5160.52
19_P22_S0.5160.52
360_Q385_Y0.5150.52
333_L336_H0.5150.52
146_Y155_T0.5150.52
388_D392_C0.5150.52
379_F395_R0.5130.51
337_G418_L0.5120.51
230_G233_G0.5110.51
15_R129_V0.5100.51
6_L228_L0.5100.51
151_H155_T0.5090.51
181_G225_R0.5080.51
355_T358_R0.5080.51
91_D191_R0.5060.50
88_H200_P0.5060.50
286_S357_G0.5050.50
327_Y347_P0.5050.50
137_L156_L0.5040.50
67_V133_V0.5040.50
88_H156_L0.5030.50
271_C402_A0.5030.50
82_L113_A0.5030.50
365_N369_P0.5020.50
209_A212_L0.5010.50
91_D273_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hp0A 2 0.9843 100 0.087 Contact Map
1szqA 2 0.9663 100 0.176 Contact Map
4rqoA 2 0.5708 96.2 0.944 Contact Map
1mkiA 3 0.1955 34.7 0.972 Contact Map
2jqtA 1 0.0831 29 0.973 Contact Map
3pgwB 1 0.1708 25 0.974 Contact Map
2pbyA 3 0.1775 19.4 0.975 Contact Map
4bqmA 3 0.2135 19.1 0.975 Contact Map
4lx3A 1 0.218 16.5 0.976 Contact Map
4asvA 2 0.1461 15.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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