YXEP - BACSU - GREMLIN Contacts

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YXEP - Uncharacterized hydrolase YxeP

UniProt:	P54955	Sequences: MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIEILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDFHTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNKPDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVSRNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIAAGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKIPGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (352)
Sequences:	29086 (20689)
Seq/√Len:	1102.7

ECOLI - ABGA ARGE YGEY DAPE PEPT ABGB ALLC PEPD
BACSU - YXEP YTNL YHAA DAPEL YODQ FAPD YQJE AMHX PEPT PEPVL ALLC YQJN
HALSA - Q9HS25
SULSO - CBPX2 CBPX1 Q97Y12 LYSK Q97ZB7 Q97V97 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_E	126_R	3.357	1.00
185_V	246_Q	3.123	1.00
35_R	39_E	2.916	1.00
185_V	248_E	2.904	1.00
16_D	33_K	2.857	1.00
191_G	199_S	2.622	1.00
60_K	124_T	2.600	1.00
183_E	248_E	2.575	1.00
94_T	355_T	2.570	1.00
205_A	281_A	2.484	1.00
67_V	124_T	2.430	1.00
186_I	209_I	2.409	1.00
187_K	246_Q	2.383	1.00
310_R	374_I	2.360	1.00
37_W	40_E	2.358	1.00
269_R	273_E	2.353	1.00
306_E	374_I	2.352	1.00
310_R	370_E	2.351	1.00
265_P	269_R	2.343	1.00
187_K	282_Q	2.327	1.00
183_E	250_E	2.279	1.00
113_L	369_A	2.271	1.00
33_K	37_W	2.209	1.00
35_R	47_D	2.207	1.00
67_V	126_R	2.192	1.00
235_Q	248_E	2.184	1.00
38_L	57_A	2.174	1.00
185_V	284_E	2.165	1.00
206_A	234_V	2.147	1.00
58_E	124_T	2.137	1.00
206_A	247_A	2.092	1.00
233_R	250_E	2.072	1.00
266_E	270_R	2.054	1.00
206_A	249_M	2.045	1.00
69_A	151_V	2.027	1.00
113_L	117_R	2.020	1.00
41_E	112_M	1.993	1.00
183_E	286_K	1.982	1.00
20_H	33_K	1.937	1.00
208_Q	211_S	1.928	1.00
207_G	210_I	1.873	1.00
305_S	309_A	1.865	1.00
187_K	284_E	1.863	1.00
28_V	32_K	1.852	1.00
37_W	41_E	1.823	1.00
84_N	91_V	1.818	1.00
9_R	112_M	1.808	1.00
273_E	277_A	1.781	1.00
140_R	144_E	1.776	1.00
209_I	272_A	1.769	1.00
304_A	371_L	1.728	1.00
36_R	40_E	1.684	1.00
207_G	211_S	1.675	1.00
33_K	36_R	1.659	1.00
13_M	37_W	1.648	1.00
29_E	32_K	1.641	1.00
200_I	205_A	1.639	1.00
189_K	200_I	1.637	1.00
43_I	59_I	1.636	1.00
15_R	19_E	1.622	1.00
32_K	36_R	1.617	1.00
202_P	247_A	1.605	1.00
10_L	365_S	1.601	1.00
267_H	270_R	1.577	1.00
204_A	214_Q	1.571	1.00
35_R	55_V	1.570	1.00
262_Q	266_E	1.569	1.00
260_A	263_A	1.567	1.00
112_M	116_Q	1.549	1.00
195_I	198_N	1.548	1.00
236_A	247_A	1.535	1.00
307_A	374_I	1.528	1.00
212_G	271_V	1.522	1.00
190_G	245_D	1.520	1.00
16_D	19_E	1.508	1.00
225_Q	257_Q	1.505	1.00
16_D	29_E	1.494	1.00
85_L	88_A	1.492	1.00
370_E	373_V	1.491	1.00
303_A	374_I	1.489	1.00
141_K	144_E	1.488	1.00
227_A	264_V	1.485	1.00
302_N	305_S	1.481	1.00
31_T	74_I	1.478	1.00
141_K	145_A	1.478	1.00
28_V	53_T	1.475	1.00
12_N	16_D	1.471	1.00
16_D	20_H	1.470	1.00
212_G	274_G	1.456	1.00
263_A	267_H	1.454	1.00
69_A	128_I	1.451	1.00
331_Q	336_G	1.447	1.00
44_E	60_K	1.436	1.00
69_A	154_I	1.435	1.00
34_I	74_I	1.435	1.00
370_E	374_I	1.417	1.00
66_P	152_S	1.410	1.00
84_N	88_A	1.397	1.00
186_I	206_A	1.396	1.00
36_R	39_E	1.393	1.00
208_Q	279_Y	1.384	1.00
39_E	45_I	1.378	1.00
180_D	261_R	1.364	1.00
37_W	112_M	1.363	1.00
10_L	109_G	1.360	1.00
208_Q	278_G	1.355	1.00
220_N	267_H	1.353	1.00
63_E	122_K	1.349	1.00
35_R	45_I	1.341	1.00
59_I	115_N	1.340	1.00
106_S	364_A	1.333	1.00
185_V	286_K	1.326	1.00
182_F	251_G	1.324	1.00
363_V	366_Q	1.320	1.00
46_L	58_E	1.305	1.00
19_E	90_K	1.298	1.00
308_A	367_Y	1.278	1.00
70_I	372_A	1.277	1.00
11_I	15_R	1.275	1.00
266_E	269_R	1.268	1.00
270_R	274_G	1.260	1.00
184_I	249_M	1.256	1.00
32_K	35_R	1.238	1.00
359_E	363_V	1.238	1.00
12_N	15_R	1.234	1.00
311_L	370_E	1.231	1.00
62_R	122_K	1.210	1.00
265_P	287_W	1.209	1.00
362_T	366_Q	1.208	1.00
276_A	283_A	1.202	1.00
216_V	267_H	1.194	1.00
186_I	205_A	1.191	1.00
303_A	307_A	1.189	1.00
203_I	234_V	1.183	1.00
13_M	109_G	1.181	1.00
307_A	370_E	1.179	1.00
117_R	369_A	1.179	1.00
22_E	30_T	1.165	1.00
13_M	33_K	1.161	1.00
24_S	135_I	1.160	1.00
70_I	107_I	1.160	1.00
203_I	236_A	1.158	1.00
115_N	118_R	1.142	1.00
102_F	356_L	1.125	1.00
302_N	306_E	1.124	1.00
39_E	47_D	1.123	1.00
270_R	273_E	1.123	1.00
82_Q	353_A	1.122	1.00
231_I	251_G	1.111	1.00
298_G	302_N	1.109	1.00
16_D	37_W	1.109	1.00
20_H	29_E	1.109	1.00
257_Q	260_A	1.097	1.00
32_K	47_D	1.097	1.00
17_L	30_T	1.096	1.00
272_A	283_A	1.096	1.00
211_S	215_S	1.092	1.00
182_F	265_P	1.086	1.00
306_E	310_R	1.086	1.00
357_D	360_A	1.083	1.00
109_G	112_M	1.080	1.00
263_A	266_E	1.076	1.00
21_P	26_Q	1.072	1.00
9_R	12_N	1.067	1.00
66_P	123_G	1.066	1.00
271_V	274_G	1.065	1.00
18_H	97_A	1.062	1.00
157_M	368_F	1.057	1.00
18_H	100_H	1.055	1.00
305_S	318_A	1.051	1.00
10_L	105_A	1.051	1.00
117_R	373_V	1.047	1.00
19_E	88_A	1.046	1.00
200_I	281_A	1.045	1.00
212_G	215_S	1.039	1.00
15_R	358_E	1.039	1.00
80_Q	92_D	1.035	1.00
161_P	349_W	1.033	1.00
29_E	33_K	1.025	1.00
210_I	249_M	1.025	1.00
102_F	159_N	1.023	1.00
239_S	242_V	1.023	1.00
94_T	357_D	1.023	1.00
34_I	104_T	1.021	1.00
111_A	127_F	1.007	1.00
67_V	152_S	1.006	1.00
9_R	13_M	1.004	1.00
369_A	373_V	1.003	1.00
15_R	89_S	0.995	1.00
31_T	55_V	0.995	1.00
210_I	231_I	0.994	1.00
273_E	276_A	0.992	1.00
140_R	329_L	0.991	1.00
271_V	275_I	0.990	1.00
54_G	131_P	0.988	1.00
267_H	271_V	0.986	1.00
59_I	121_L	0.984	1.00
306_E	309_A	0.983	1.00
204_A	210_I	0.975	1.00
61_G	124_T	0.973	1.00
213_L	268_M	0.973	1.00
43_I	57_A	0.968	1.00
307_A	310_R	0.966	1.00
345_G	348_E	0.962	1.00
44_E	58_E	0.961	1.00
206_A	210_I	0.961	1.00
366_Q	370_E	0.961	1.00
68_I	153_A	0.957	1.00
74_I	129_F	0.953	1.00
153_A	300_F	0.952	1.00
212_G	275_I	0.950	1.00
274_G	278_G	0.945	1.00
365_S	369_A	0.945	1.00
17_L	33_K	0.945	1.00
184_I	272_A	0.941	1.00
183_E	240_W	0.939	1.00
234_V	247_A	0.935	1.00
269_R	285_F	0.933	1.00
31_T	35_R	0.933	1.00
208_Q	212_G	0.931	1.00
240_W	250_E	0.931	1.00
102_F	361_L	0.928	1.00
208_Q	215_S	0.926	1.00
265_P	289_P	0.919	1.00
10_L	361_L	0.915	1.00
274_G	277_A	0.907	1.00
113_L	366_Q	0.905	1.00
41_E	115_N	0.904	1.00
110_T	369_A	0.904	1.00
343_T	356_L	0.903	1.00
172_E	302_N	0.903	1.00
25_F	132_A	0.900	1.00
45_I	57_A	0.896	1.00
9_R	37_W	0.894	1.00
110_T	368_F	0.893	1.00
13_M	112_M	0.887	1.00
303_A	306_E	0.887	1.00
360_A	363_V	0.886	1.00
304_A	337_F	0.884	1.00
154_I	334_I	0.882	1.00
184_I	209_I	0.877	1.00
126_R	151_V	0.874	1.00
356_L	361_L	0.874	1.00
169_G	172_E	0.868	1.00
204_A	207_G	0.865	1.00
203_I	247_A	0.863	1.00
147_V	150_G	0.859	1.00
38_L	108_I	0.857	1.00
301_L	337_F	0.854	1.00
303_A	371_L	0.850	1.00
187_K	245_D	0.849	1.00
275_I	278_G	0.849	1.00
146_G	150_G	0.843	1.00
91_V	94_T	0.841	1.00
213_L	229_V	0.841	1.00
112_M	115_N	0.837	1.00
111_A	115_N	0.836	1.00
113_L	365_S	0.836	1.00
56_I	126_R	0.835	1.00
72_A	104_T	0.833	1.00
178_S	255_T	0.831	1.00
89_S	95_M	0.831	1.00
297_D	300_F	0.829	1.00
299_T	303_A	0.829	1.00
200_I	280_G	0.828	1.00
301_L	305_S	0.827	1.00
255_T	261_R	0.825	1.00
208_Q	214_Q	0.822	1.00
155_F	371_L	0.822	1.00
309_A	314_Q	0.822	1.00
262_Q	265_P	0.821	1.00
211_S	214_Q	0.820	1.00
72_A	102_F	0.818	1.00
361_L	365_S	0.815	1.00
210_I	234_V	0.813	1.00
43_I	111_A	0.813	1.00
30_T	74_I	0.811	1.00
183_E	288_F	0.806	1.00
180_D	265_P	0.805	1.00
299_T	302_N	0.803	1.00
270_R	277_A	0.799	1.00
107_I	127_F	0.796	1.00
309_A	313_Y	0.794	1.00
59_I	111_A	0.794	1.00
117_R	120_E	0.793	1.00
258_K	262_Q	0.790	1.00
16_D	36_R	0.787	1.00
156_G	338_F	0.781	1.00
204_A	215_S	0.780	1.00
41_E	108_I	0.780	1.00
221_I	224_L	0.772	1.00
113_L	116_Q	0.772	1.00
231_I	249_M	0.771	1.00
235_Q	238_T	0.770	1.00
327_F	336_G	0.767	1.00
79_I	87_F	0.765	1.00
74_I	104_T	0.761	1.00
40_E	112_M	0.758	1.00
123_G	152_S	0.757	1.00
304_A	339_V	0.754	1.00
93_G	359_E	0.753	1.00
261_R	265_P	0.749	1.00
359_E	362_T	0.748	1.00
37_W	108_I	0.748	1.00
186_I	249_M	0.747	1.00
259_E	263_A	0.746	1.00
218_S	221_I	0.745	1.00
290_Y	293_S	0.741	1.00
323_G	326_D	0.738	1.00
13_M	16_D	0.738	1.00
253_V	264_V	0.735	1.00
65_G	123_G	0.734	1.00
229_V	253_V	0.733	1.00
181_R	252_T	0.731	1.00
13_M	105_A	0.729	1.00
166_G	317_H	0.729	1.00
189_K	351_H	0.727	1.00
70_I	110_T	0.727	1.00
307_A	371_L	0.727	1.00
25_F	135_I	0.726	1.00
31_T	53_T	0.726	1.00
155_F	300_F	0.725	1.00
43_I	115_N	0.725	1.00
191_G	243_I	0.725	1.00
106_S	365_S	0.724	1.00
26_Q	29_E	0.722	1.00
42_Q	45_I	0.718	1.00
182_F	268_M	0.717	1.00
221_I	227_A	0.717	1.00
339_V	343_T	0.712	1.00
221_I	225_Q	0.710	1.00
168_I	172_E	0.707	1.00
62_R	120_E	0.706	1.00
172_E	298_G	0.702	1.00
15_R	18_H	0.701	1.00
14_R	95_M	0.694	1.00
34_I	129_F	0.693	1.00
139_A	143_L	0.692	1.00
329_L	332_E	0.689	1.00
110_T	365_S	0.689	1.00
68_I	372_A	0.688	1.00
65_G	124_T	0.687	1.00
106_S	110_T	0.687	1.00
84_N	90_K	0.686	1.00
19_E	89_S	0.684	1.00
76_A	87_F	0.683	1.00
105_A	109_G	0.683	1.00
67_V	123_G	0.680	1.00
233_R	248_E	0.675	1.00
276_A	281_A	0.673	1.00
181_R	240_W	0.673	1.00
304_A	367_Y	0.671	1.00
222_S	225_Q	0.671	1.00
17_L	104_T	0.670	1.00
13_M	17_L	0.670	1.00
235_Q	250_E	0.669	1.00
22_E	103_H	0.666	1.00
329_L	333_K	0.665	1.00
209_I	249_M	0.659	1.00
358_E	362_T	0.657	1.00
55_V	129_F	0.657	1.00
23_L	78_P	0.656	1.00
208_Q	275_I	0.655	1.00
61_G	64_D	0.655	1.00
82_Q	352_P	0.655	1.00
126_R	150_G	0.653	1.00
83_T	88_A	0.651	1.00
156_G	327_F	0.650	1.00
137_A	141_K	0.648	1.00
341_M	344_N	0.648	1.00
109_G	365_S	0.647	1.00
182_F	285_F	0.646	1.00
38_L	43_I	0.644	1.00
154_I	330_Y	0.642	1.00
70_I	155_F	0.642	1.00
235_Q	246_Q	0.641	1.00
184_I	285_F	0.640	1.00
31_T	47_D	0.639	1.00
43_I	127_F	0.636	1.00
325_E	338_F	0.635	1.00
204_A	208_Q	0.632	1.00
186_I	202_P	0.631	1.00
258_K	292_P	0.630	1.00
71_R	128_I	0.630	1.00
262_Q	289_P	0.630	1.00
307_A	311_L	0.630	1.00
114_L	119_A	0.629	1.00
321_S	324_G	0.627	1.00
45_I	55_V	0.626	1.00
34_I	55_V	0.625	1.00
107_I	157_M	0.624	1.00
59_I	127_F	0.622	1.00
337_F	340_W	0.622	1.00
367_Y	371_L	0.620	1.00
258_K	332_E	0.620	1.00
11_I	362_T	0.620	1.00
132_A	135_I	0.619	1.00
297_D	302_N	0.617	1.00
96_H	355_T	0.616	1.00
46_L	56_I	0.614	1.00
109_G	113_L	0.613	1.00
63_E	124_T	0.613	1.00
366_Q	369_A	0.612	1.00
108_I	112_M	0.611	1.00
339_V	367_Y	0.611	1.00
128_I	142_V	0.610	1.00
11_I	358_E	0.610	1.00
23_L	87_F	0.609	1.00
275_I	279_Y	0.608	1.00
104_T	107_I	0.608	1.00
193_A	230_S	0.606	1.00
154_I	336_G	0.606	1.00
307_A	367_Y	0.606	1.00
23_L	94_T	0.605	1.00
23_L	26_Q	0.605	1.00
160_K	340_W	0.605	1.00
261_R	290_Y	0.605	1.00
209_I	271_V	0.603	1.00
144_E	333_K	0.603	1.00
9_R	109_G	0.603	1.00
168_I	171_K	0.601	1.00
27_E	31_T	0.601	1.00
193_A	232_T	0.601	1.00
24_S	136_A	0.601	1.00
342_G	345_G	0.599	1.00
29_E	36_R	0.597	1.00
52_K	141_K	0.596	1.00
204_A	211_S	0.596	1.00
276_A	282_Q	0.596	1.00
137_A	291_L	0.594	1.00
255_T	264_V	0.590	1.00
201_D	244_P	0.590	1.00
60_K	64_D	0.589	1.00
76_A	98_C	0.588	1.00
300_F	337_F	0.588	1.00
305_S	317_H	0.587	1.00
82_Q	85_L	0.587	1.00
91_V	96_H	0.587	1.00
14_R	105_A	0.583	1.00
287_W	290_Y	0.583	1.00
23_L	79_I	0.581	1.00
205_A	279_Y	0.580	1.00
251_G	268_M	0.580	1.00
143_L	333_K	0.579	1.00
348_E	351_H	0.579	1.00
106_S	368_F	0.579	1.00
214_Q	279_Y	0.578	1.00
34_I	108_I	0.576	1.00
67_V	151_V	0.576	1.00
50_Q	54_G	0.573	1.00
213_L	231_I	0.573	1.00
362_T	365_S	0.572	1.00
184_I	283_A	0.572	1.00
20_H	91_V	0.571	1.00
106_S	157_M	0.571	1.00
237_G	246_Q	0.570	1.00
134_E	350_H	0.570	1.00
157_M	341_M	0.569	1.00
343_T	360_A	0.568	1.00
202_P	244_P	0.566	1.00
266_E	273_E	0.566	1.00
104_T	129_F	0.565	1.00
58_E	67_V	0.565	1.00
209_I	275_I	0.564	1.00
321_S	325_E	0.564	1.00
184_I	251_G	0.563	1.00
13_M	108_I	0.562	1.00
186_I	281_A	0.562	1.00
64_D	124_T	0.562	1.00
341_M	364_A	0.558	1.00
300_F	303_A	0.557	1.00
84_N	89_S	0.555	1.00
85_L	355_T	0.553	1.00
98_C	101_D	0.553	1.00
183_E	284_E	0.550	1.00
95_M	358_E	0.549	1.00
184_I	268_M	0.548	1.00
142_V	147_V	0.547	1.00
205_A	208_Q	0.547	1.00
54_G	142_V	0.547	1.00
20_H	30_T	0.546	1.00
62_R	124_T	0.546	1.00
15_R	95_M	0.546	1.00
197_N	222_S	0.545	1.00
83_T	87_F	0.543	1.00
128_I	330_Y	0.543	1.00
154_I	327_F	0.541	1.00
138_G	145_A	0.539	1.00
104_T	108_I	0.539	1.00
348_E	353_A	0.539	1.00
25_F	141_K	0.538	1.00
177_A	228_V	0.538	1.00
202_P	243_I	0.537	1.00
151_V	334_I	0.536	1.00
26_Q	94_T	0.536	1.00
349_W	354_F	0.536	1.00
160_K	349_W	0.535	1.00
340_W	343_T	0.532	1.00
89_S	100_H	0.531	1.00
95_M	100_H	0.531	1.00
205_A	275_I	0.529	1.00
157_M	364_A	0.529	1.00
186_I	272_A	0.528	1.00
41_E	116_Q	0.526	1.00
348_E	355_T	0.525	1.00
178_S	293_S	0.522	1.00
71_R	130_Q	0.521	1.00
66_P	153_A	0.520	1.00
39_E	44_E	0.519	1.00
209_I	213_L	0.518	1.00
17_L	105_A	0.517	1.00
167_T	317_H	0.516	1.00
95_M	98_C	0.513	1.00
119_A	373_V	0.513	1.00
97_A	100_H	0.513	1.00
259_E	262_Q	0.511	1.00
68_I	155_F	0.511	1.00
311_L	366_Q	0.510	1.00
207_G	214_Q	0.510	1.00
272_A	285_F	0.509	1.00
210_I	251_G	0.507	1.00
171_K	320_Q	0.507	1.00
9_R	40_E	0.505	1.00
341_M	367_Y	0.505	1.00
212_G	278_G	0.504	1.00
227_A	255_T	0.501	1.00
110_T	114_L	0.500	1.00
10_L	14_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ysjA	2	0.9447	100	0.223	Contact Map
4ewtA	4	0.9895	100	0.231	Contact Map
3io1A	4	0.9132	100	0.255	Contact Map
1xmbA	1	0.9395	100	0.266	Contact Map
3pfoA	2	0.9605	100	0.268	Contact Map
3rzaA	2	0.9316	100	0.292	Contact Map
3gb0A	2	0.9289	100	0.299	Contact Map
1cg2A	4	0.9579	100	0.303	Contact Map
3tx8A	2	0.9158	100	0.31	Contact Map
3ramA	4	0.9289	100	0.31	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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