GREMLIN Database
YXEP - Uncharacterized hydrolase YxeP
UniProt: P54955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (352)
Sequences: 29086 (20689)
Seq/√Len: 1102.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E126_R3.3571.00
185_V246_Q3.1231.00
35_R39_E2.9161.00
185_V248_E2.9041.00
16_D33_K2.8571.00
191_G199_S2.6221.00
60_K124_T2.6001.00
183_E248_E2.5751.00
94_T355_T2.5701.00
205_A281_A2.4841.00
67_V124_T2.4301.00
186_I209_I2.4091.00
187_K246_Q2.3831.00
310_R374_I2.3601.00
37_W40_E2.3581.00
269_R273_E2.3531.00
306_E374_I2.3521.00
310_R370_E2.3511.00
265_P269_R2.3431.00
187_K282_Q2.3271.00
183_E250_E2.2791.00
113_L369_A2.2711.00
33_K37_W2.2091.00
35_R47_D2.2071.00
67_V126_R2.1921.00
235_Q248_E2.1841.00
38_L57_A2.1741.00
185_V284_E2.1651.00
206_A234_V2.1471.00
58_E124_T2.1371.00
206_A247_A2.0921.00
233_R250_E2.0721.00
266_E270_R2.0541.00
206_A249_M2.0451.00
69_A151_V2.0271.00
113_L117_R2.0201.00
41_E112_M1.9931.00
183_E286_K1.9821.00
20_H33_K1.9371.00
208_Q211_S1.9281.00
207_G210_I1.8731.00
305_S309_A1.8651.00
187_K284_E1.8631.00
28_V32_K1.8521.00
37_W41_E1.8231.00
84_N91_V1.8181.00
9_R112_M1.8081.00
273_E277_A1.7811.00
140_R144_E1.7761.00
209_I272_A1.7691.00
304_A371_L1.7281.00
36_R40_E1.6841.00
207_G211_S1.6751.00
33_K36_R1.6591.00
13_M37_W1.6481.00
29_E32_K1.6411.00
200_I205_A1.6391.00
189_K200_I1.6371.00
43_I59_I1.6361.00
15_R19_E1.6221.00
32_K36_R1.6171.00
202_P247_A1.6051.00
10_L365_S1.6011.00
267_H270_R1.5771.00
204_A214_Q1.5711.00
35_R55_V1.5701.00
262_Q266_E1.5691.00
260_A263_A1.5671.00
112_M116_Q1.5491.00
195_I198_N1.5481.00
236_A247_A1.5351.00
307_A374_I1.5281.00
212_G271_V1.5221.00
190_G245_D1.5201.00
16_D19_E1.5081.00
225_Q257_Q1.5051.00
16_D29_E1.4941.00
85_L88_A1.4921.00
370_E373_V1.4911.00
303_A374_I1.4891.00
141_K144_E1.4881.00
227_A264_V1.4851.00
302_N305_S1.4811.00
31_T74_I1.4781.00
141_K145_A1.4781.00
28_V53_T1.4751.00
12_N16_D1.4711.00
16_D20_H1.4701.00
212_G274_G1.4561.00
263_A267_H1.4541.00
69_A128_I1.4511.00
331_Q336_G1.4471.00
44_E60_K1.4361.00
69_A154_I1.4351.00
34_I74_I1.4351.00
370_E374_I1.4171.00
66_P152_S1.4101.00
84_N88_A1.3971.00
186_I206_A1.3961.00
36_R39_E1.3931.00
208_Q279_Y1.3841.00
39_E45_I1.3781.00
180_D261_R1.3641.00
37_W112_M1.3631.00
10_L109_G1.3601.00
208_Q278_G1.3551.00
220_N267_H1.3531.00
63_E122_K1.3491.00
35_R45_I1.3411.00
59_I115_N1.3401.00
106_S364_A1.3331.00
185_V286_K1.3261.00
182_F251_G1.3241.00
363_V366_Q1.3201.00
46_L58_E1.3051.00
19_E90_K1.2981.00
308_A367_Y1.2781.00
70_I372_A1.2771.00
11_I15_R1.2751.00
266_E269_R1.2681.00
270_R274_G1.2601.00
184_I249_M1.2561.00
32_K35_R1.2381.00
359_E363_V1.2381.00
12_N15_R1.2341.00
311_L370_E1.2311.00
62_R122_K1.2101.00
265_P287_W1.2091.00
362_T366_Q1.2081.00
276_A283_A1.2021.00
216_V267_H1.1941.00
186_I205_A1.1911.00
303_A307_A1.1891.00
203_I234_V1.1831.00
13_M109_G1.1811.00
307_A370_E1.1791.00
117_R369_A1.1791.00
22_E30_T1.1651.00
13_M33_K1.1611.00
24_S135_I1.1601.00
70_I107_I1.1601.00
203_I236_A1.1581.00
115_N118_R1.1421.00
102_F356_L1.1251.00
302_N306_E1.1241.00
39_E47_D1.1231.00
270_R273_E1.1231.00
82_Q353_A1.1221.00
231_I251_G1.1111.00
298_G302_N1.1091.00
16_D37_W1.1091.00
20_H29_E1.1091.00
257_Q260_A1.0971.00
32_K47_D1.0971.00
17_L30_T1.0961.00
272_A283_A1.0961.00
211_S215_S1.0921.00
182_F265_P1.0861.00
306_E310_R1.0861.00
357_D360_A1.0831.00
109_G112_M1.0801.00
263_A266_E1.0761.00
21_P26_Q1.0721.00
9_R12_N1.0671.00
66_P123_G1.0661.00
271_V274_G1.0651.00
18_H97_A1.0621.00
157_M368_F1.0571.00
18_H100_H1.0551.00
305_S318_A1.0511.00
10_L105_A1.0511.00
117_R373_V1.0471.00
19_E88_A1.0461.00
200_I281_A1.0451.00
212_G215_S1.0391.00
15_R358_E1.0391.00
80_Q92_D1.0351.00
161_P349_W1.0331.00
29_E33_K1.0251.00
210_I249_M1.0251.00
102_F159_N1.0231.00
239_S242_V1.0231.00
94_T357_D1.0231.00
34_I104_T1.0211.00
111_A127_F1.0071.00
67_V152_S1.0061.00
9_R13_M1.0041.00
369_A373_V1.0031.00
15_R89_S0.9951.00
31_T55_V0.9951.00
210_I231_I0.9941.00
273_E276_A0.9921.00
140_R329_L0.9911.00
271_V275_I0.9901.00
54_G131_P0.9881.00
267_H271_V0.9861.00
59_I121_L0.9841.00
306_E309_A0.9831.00
204_A210_I0.9751.00
61_G124_T0.9731.00
213_L268_M0.9731.00
43_I57_A0.9681.00
307_A310_R0.9661.00
345_G348_E0.9621.00
44_E58_E0.9611.00
206_A210_I0.9611.00
366_Q370_E0.9611.00
68_I153_A0.9571.00
74_I129_F0.9531.00
153_A300_F0.9521.00
212_G275_I0.9501.00
274_G278_G0.9451.00
365_S369_A0.9451.00
17_L33_K0.9451.00
184_I272_A0.9411.00
183_E240_W0.9391.00
234_V247_A0.9351.00
269_R285_F0.9331.00
31_T35_R0.9331.00
208_Q212_G0.9311.00
240_W250_E0.9311.00
102_F361_L0.9281.00
208_Q215_S0.9261.00
265_P289_P0.9191.00
10_L361_L0.9151.00
274_G277_A0.9071.00
113_L366_Q0.9051.00
41_E115_N0.9041.00
110_T369_A0.9041.00
343_T356_L0.9031.00
172_E302_N0.9031.00
25_F132_A0.9001.00
45_I57_A0.8961.00
9_R37_W0.8941.00
110_T368_F0.8931.00
13_M112_M0.8871.00
303_A306_E0.8871.00
360_A363_V0.8861.00
304_A337_F0.8841.00
154_I334_I0.8821.00
184_I209_I0.8771.00
126_R151_V0.8741.00
356_L361_L0.8741.00
169_G172_E0.8681.00
204_A207_G0.8651.00
203_I247_A0.8631.00
147_V150_G0.8591.00
38_L108_I0.8571.00
301_L337_F0.8541.00
303_A371_L0.8501.00
187_K245_D0.8491.00
275_I278_G0.8491.00
146_G150_G0.8431.00
91_V94_T0.8411.00
213_L229_V0.8411.00
112_M115_N0.8371.00
111_A115_N0.8361.00
113_L365_S0.8361.00
56_I126_R0.8351.00
72_A104_T0.8331.00
178_S255_T0.8311.00
89_S95_M0.8311.00
297_D300_F0.8291.00
299_T303_A0.8291.00
200_I280_G0.8281.00
301_L305_S0.8271.00
255_T261_R0.8251.00
208_Q214_Q0.8221.00
155_F371_L0.8221.00
309_A314_Q0.8221.00
262_Q265_P0.8211.00
211_S214_Q0.8201.00
72_A102_F0.8181.00
361_L365_S0.8151.00
210_I234_V0.8131.00
43_I111_A0.8131.00
30_T74_I0.8111.00
183_E288_F0.8061.00
180_D265_P0.8051.00
299_T302_N0.8031.00
270_R277_A0.7991.00
107_I127_F0.7961.00
309_A313_Y0.7941.00
59_I111_A0.7941.00
117_R120_E0.7931.00
258_K262_Q0.7901.00
16_D36_R0.7871.00
156_G338_F0.7811.00
204_A215_S0.7801.00
41_E108_I0.7801.00
221_I224_L0.7721.00
113_L116_Q0.7721.00
231_I249_M0.7711.00
235_Q238_T0.7701.00
327_F336_G0.7671.00
79_I87_F0.7651.00
74_I104_T0.7611.00
40_E112_M0.7581.00
123_G152_S0.7571.00
304_A339_V0.7541.00
93_G359_E0.7531.00
261_R265_P0.7491.00
359_E362_T0.7481.00
37_W108_I0.7481.00
186_I249_M0.7471.00
259_E263_A0.7461.00
218_S221_I0.7451.00
290_Y293_S0.7411.00
323_G326_D0.7381.00
13_M16_D0.7381.00
253_V264_V0.7351.00
65_G123_G0.7341.00
229_V253_V0.7331.00
181_R252_T0.7311.00
13_M105_A0.7291.00
166_G317_H0.7291.00
189_K351_H0.7271.00
70_I110_T0.7271.00
307_A371_L0.7271.00
25_F135_I0.7261.00
31_T53_T0.7261.00
155_F300_F0.7251.00
43_I115_N0.7251.00
191_G243_I0.7251.00
106_S365_S0.7241.00
26_Q29_E0.7221.00
42_Q45_I0.7181.00
182_F268_M0.7171.00
221_I227_A0.7171.00
339_V343_T0.7121.00
221_I225_Q0.7101.00
168_I172_E0.7071.00
62_R120_E0.7061.00
172_E298_G0.7021.00
15_R18_H0.7011.00
14_R95_M0.6941.00
34_I129_F0.6931.00
139_A143_L0.6921.00
329_L332_E0.6891.00
110_T365_S0.6891.00
68_I372_A0.6881.00
65_G124_T0.6871.00
106_S110_T0.6871.00
84_N90_K0.6861.00
19_E89_S0.6841.00
76_A87_F0.6831.00
105_A109_G0.6831.00
67_V123_G0.6801.00
233_R248_E0.6751.00
276_A281_A0.6731.00
181_R240_W0.6731.00
304_A367_Y0.6711.00
222_S225_Q0.6711.00
17_L104_T0.6701.00
13_M17_L0.6701.00
235_Q250_E0.6691.00
22_E103_H0.6661.00
329_L333_K0.6651.00
209_I249_M0.6591.00
358_E362_T0.6571.00
55_V129_F0.6571.00
23_L78_P0.6561.00
208_Q275_I0.6551.00
61_G64_D0.6551.00
82_Q352_P0.6551.00
126_R150_G0.6531.00
83_T88_A0.6511.00
156_G327_F0.6501.00
137_A141_K0.6481.00
341_M344_N0.6481.00
109_G365_S0.6471.00
182_F285_F0.6461.00
38_L43_I0.6441.00
154_I330_Y0.6421.00
70_I155_F0.6421.00
235_Q246_Q0.6411.00
184_I285_F0.6401.00
31_T47_D0.6391.00
43_I127_F0.6361.00
325_E338_F0.6351.00
204_A208_Q0.6321.00
186_I202_P0.6311.00
258_K292_P0.6301.00
71_R128_I0.6301.00
262_Q289_P0.6301.00
307_A311_L0.6301.00
114_L119_A0.6291.00
321_S324_G0.6271.00
45_I55_V0.6261.00
34_I55_V0.6251.00
107_I157_M0.6241.00
59_I127_F0.6221.00
337_F340_W0.6221.00
367_Y371_L0.6201.00
258_K332_E0.6201.00
11_I362_T0.6201.00
132_A135_I0.6191.00
297_D302_N0.6171.00
96_H355_T0.6161.00
46_L56_I0.6141.00
109_G113_L0.6131.00
63_E124_T0.6131.00
366_Q369_A0.6121.00
108_I112_M0.6111.00
339_V367_Y0.6111.00
128_I142_V0.6101.00
11_I358_E0.6101.00
23_L87_F0.6091.00
275_I279_Y0.6081.00
104_T107_I0.6081.00
193_A230_S0.6061.00
154_I336_G0.6061.00
307_A367_Y0.6061.00
23_L94_T0.6051.00
23_L26_Q0.6051.00
160_K340_W0.6051.00
261_R290_Y0.6051.00
209_I271_V0.6031.00
144_E333_K0.6031.00
9_R109_G0.6031.00
168_I171_K0.6011.00
27_E31_T0.6011.00
193_A232_T0.6011.00
24_S136_A0.6011.00
342_G345_G0.5991.00
29_E36_R0.5971.00
52_K141_K0.5961.00
204_A211_S0.5961.00
276_A282_Q0.5961.00
137_A291_L0.5941.00
255_T264_V0.5901.00
201_D244_P0.5901.00
60_K64_D0.5891.00
76_A98_C0.5881.00
300_F337_F0.5881.00
305_S317_H0.5871.00
82_Q85_L0.5871.00
91_V96_H0.5871.00
14_R105_A0.5831.00
287_W290_Y0.5831.00
23_L79_I0.5811.00
205_A279_Y0.5801.00
251_G268_M0.5801.00
143_L333_K0.5791.00
348_E351_H0.5791.00
106_S368_F0.5791.00
214_Q279_Y0.5781.00
34_I108_I0.5761.00
67_V151_V0.5761.00
50_Q54_G0.5731.00
213_L231_I0.5731.00
362_T365_S0.5721.00
184_I283_A0.5721.00
20_H91_V0.5711.00
106_S157_M0.5711.00
237_G246_Q0.5701.00
134_E350_H0.5701.00
157_M341_M0.5691.00
343_T360_A0.5681.00
202_P244_P0.5661.00
266_E273_E0.5661.00
104_T129_F0.5651.00
58_E67_V0.5651.00
209_I275_I0.5641.00
321_S325_E0.5641.00
184_I251_G0.5631.00
13_M108_I0.5621.00
186_I281_A0.5621.00
64_D124_T0.5621.00
341_M364_A0.5581.00
300_F303_A0.5571.00
84_N89_S0.5551.00
85_L355_T0.5531.00
98_C101_D0.5531.00
183_E284_E0.5501.00
95_M358_E0.5491.00
184_I268_M0.5481.00
142_V147_V0.5471.00
205_A208_Q0.5471.00
54_G142_V0.5471.00
20_H30_T0.5461.00
62_R124_T0.5461.00
15_R95_M0.5461.00
197_N222_S0.5451.00
83_T87_F0.5431.00
128_I330_Y0.5431.00
154_I327_F0.5411.00
138_G145_A0.5391.00
104_T108_I0.5391.00
348_E353_A0.5391.00
25_F141_K0.5381.00
177_A228_V0.5381.00
202_P243_I0.5371.00
151_V334_I0.5361.00
26_Q94_T0.5361.00
349_W354_F0.5361.00
160_K349_W0.5351.00
340_W343_T0.5321.00
89_S100_H0.5311.00
95_M100_H0.5311.00
205_A275_I0.5291.00
157_M364_A0.5291.00
186_I272_A0.5281.00
41_E116_Q0.5261.00
348_E355_T0.5251.00
178_S293_S0.5221.00
71_R130_Q0.5211.00
66_P153_A0.5201.00
39_E44_E0.5191.00
209_I213_L0.5181.00
17_L105_A0.5171.00
167_T317_H0.5161.00
95_M98_C0.5131.00
119_A373_V0.5131.00
97_A100_H0.5131.00
259_E262_Q0.5111.00
68_I155_F0.5111.00
311_L366_Q0.5101.00
207_G214_Q0.5101.00
272_A285_F0.5091.00
210_I251_G0.5071.00
171_K320_Q0.5071.00
9_R40_E0.5051.00
341_M367_Y0.5051.00
212_G278_G0.5041.00
227_A255_T0.5011.00
110_T114_L0.5001.00
10_L14_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ysjA 2 0.9447 100 0.223 Contact Map
4ewtA 4 0.9895 100 0.231 Contact Map
3io1A 4 0.9132 100 0.255 Contact Map
1xmbA 1 0.9395 100 0.266 Contact Map
3pfoA 2 0.9605 100 0.268 Contact Map
3rzaA 2 0.9316 100 0.292 Contact Map
3gb0A 2 0.9289 100 0.299 Contact Map
1cg2A 4 0.9579 100 0.303 Contact Map
3tx8A 2 0.9158 100 0.31 Contact Map
3ramA 4 0.9289 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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