GREMLIN Database
YXEN - Probable amino-acid permease protein YxeN
UniProt: P54953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (202)
Sequences: 28392 (17210)
Seq/√Len: 1210.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_C136_A3.6101.00
33_F100_S3.3331.00
21_P25_F3.2431.00
132_T135_Q2.9431.00
154_G211_Q2.9071.00
95_A167_A2.8981.00
188_K191_E2.7911.00
29_A96_I2.7211.00
134_F138_R2.5931.00
44_I56_S2.3311.00
127_L136_A2.3011.00
209_I213_L2.2001.00
66_V71_Q2.1901.00
122_Q144_Q2.1781.00
123_L136_A2.1281.00
179_G196_V2.0331.00
41_L108_A2.0091.00
135_Q139_R1.9651.00
42_A111_F1.9441.00
51_V55_L1.9251.00
123_L127_L1.8991.00
41_L104_A1.8821.00
51_V54_Q1.8381.00
75_I98_G1.7831.00
50_P54_Q1.7561.00
22_I25_F1.7551.00
31_M157_F1.7311.00
177_A181_M1.7261.00
25_F92_L1.7201.00
17_I21_P1.6771.00
39_L111_F1.6721.00
131_M135_Q1.6561.00
213_L216_R1.6501.00
114_A148_N1.6071.00
18_Q21_P1.5831.00
37_G104_A1.5771.00
180_K183_A1.5761.00
50_P53_H1.5711.00
205_I209_I1.5521.00
112_R116_N1.5401.00
178_Q181_M1.5161.00
133_K137_Y1.5081.00
127_L133_K1.4971.00
177_A180_K1.4881.00
126_C131_M1.4871.00
175_M178_Q1.4861.00
45_T57_K1.4821.00
132_T136_A1.4591.00
36_I40_I1.4501.00
135_Q138_R1.4441.00
179_G183_A1.4371.00
90_T93_T1.4331.00
107_L156_T1.4321.00
123_L141_I1.4321.00
27_A157_F1.4291.00
209_I212_D1.4201.00
201_W205_I1.4151.00
210_L213_L1.4051.00
15_T18_Q1.3881.00
38_G107_L1.3781.00
133_K136_A1.3531.00
46_K116_N1.3401.00
109_E112_R1.3231.00
179_G182_Y1.3211.00
33_F96_I1.3191.00
49_I54_Q1.3111.00
20_L203_L1.3071.00
22_I172_V1.2781.00
25_F29_A1.2711.00
117_S148_N1.2681.00
126_C140_I1.2501.00
120_D124_E1.2421.00
96_I100_S1.2351.00
107_L153_T1.2301.00
71_Q102_K1.2181.00
60_I108_A1.2171.00
183_A189_Y1.2161.00
114_A149_A1.1941.00
29_A100_S1.1911.00
111_F149_A1.1821.00
57_K112_R1.1791.00
131_M139_R1.1771.00
34_A103_N1.1551.00
213_L217_A1.1551.00
27_A161_L1.1531.00
174_E178_Q1.1491.00
186_N189_Y1.1421.00
55_L59_Y1.1381.00
92_L96_I1.1341.00
81_Q84_P1.1301.00
49_I52_L1.1221.00
93_T96_I1.1101.00
35_I153_T1.0831.00
40_I44_I1.0701.00
15_T178_Q1.0641.00
55_L58_L1.0611.00
180_K184_S1.0561.00
191_E194_L1.0531.00
27_A164_T1.0511.00
179_G192_T1.0201.00
26_M167_A1.0171.00
115_L141_I1.0141.00
212_D215_E1.0091.00
53_H57_K1.0081.00
181_M185_G1.0061.00
14_P18_Q1.0031.00
89_M93_T0.9961.00
110_I152_A0.9901.00
173_M177_A0.9891.00
18_Q22_I0.9861.00
54_Q58_L0.9791.00
63_F101_L0.9781.00
66_V102_K0.9741.00
206_I210_L0.9631.00
29_A33_F0.9601.00
193_Y197_A0.9511.00
110_I156_T0.9471.00
41_L56_S0.9441.00
185_G188_K0.9371.00
74_L78_G0.9331.00
120_D123_L0.9301.00
148_N152_A0.9281.00
30_A100_S0.9271.00
72_L167_A0.9241.00
194_L197_A0.9171.00
71_Q75_I0.9121.00
42_A115_L0.9111.00
107_L111_F0.9021.00
193_Y196_V0.9011.00
23_T161_L0.8991.00
115_L145_A0.8961.00
176_F180_K0.8951.00
30_A99_L0.8931.00
30_A160_L0.8931.00
43_L137_Y0.8841.00
49_I53_H0.8831.00
183_A193_Y0.8831.00
169_T173_M0.8821.00
44_I47_N0.8811.00
46_K123_L0.8801.00
174_E177_A0.8741.00
38_G111_F0.8621.00
195_A199_V0.8621.00
137_Y142_L0.8611.00
72_L98_G0.8571.00
32_I36_I0.8561.00
121_G124_E0.8531.00
197_A200_Y0.8501.00
212_D216_R0.8461.00
103_N156_T0.8431.00
137_Y141_I0.8421.00
31_M160_L0.8221.00
61_S205_I0.8181.00
204_T208_S0.8161.00
118_V145_A0.8161.00
159_G163_E0.8151.00
92_L172_V0.8131.00
190_F194_L0.7851.00
91_A94_A0.7831.00
176_F179_G0.7831.00
91_A171_G0.7781.00
28_I32_I0.7781.00
71_Q98_G0.7771.00
34_A107_L0.7761.00
68_T163_E0.7711.00
48_K51_V0.7671.00
46_K115_L0.7661.00
103_N160_L0.7601.00
44_I52_L0.7601.00
125_A128_S0.7541.00
69_L169_T0.7471.00
210_L214_F0.7441.00
208_S212_D0.7391.00
48_K53_H0.7371.00
161_L203_L0.7351.00
54_Q57_K0.7341.00
56_S108_A0.7341.00
72_L170_L0.7271.00
26_M30_A0.7271.00
118_V148_N0.7261.00
111_F115_L0.7251.00
58_L61_S0.7221.00
38_G108_A0.7211.00
27_A31_M0.7181.00
17_I20_L0.7161.00
194_L198_I0.7141.00
52_L55_L0.7101.00
37_G100_S0.7071.00
29_A32_I0.7071.00
63_F105_A0.7061.00
45_T48_K0.7051.00
174_E179_G0.7031.00
99_L160_L0.7021.00
45_T109_E0.6931.00
93_T97_I0.6921.00
41_L44_I0.6921.00
59_Y63_F0.6901.00
26_M92_L0.6891.00
68_T102_K0.6861.00
207_Y211_Q0.6861.00
196_V200_Y0.6831.00
165_S168_F0.6831.00
72_L166_L0.6751.00
192_T195_A0.6741.00
75_I94_A0.6611.00
49_I55_L0.6581.00
190_F197_A0.6581.00
20_L199_V0.6521.00
185_G189_Y0.6521.00
25_F93_T0.6521.00
205_I208_S0.6501.00
141_I144_Q0.6491.00
21_P24_L0.6481.00
33_F36_I0.6481.00
59_Y104_A0.6471.00
42_A46_K0.6411.00
29_A92_L0.6361.00
118_V144_Q0.6351.00
47_N133_K0.6311.00
102_K163_E0.6291.00
181_M184_S0.6291.00
99_L167_A0.6281.00
45_T108_A0.6221.00
152_A155_N0.6211.00
167_A172_V0.6191.00
118_V141_I0.6151.00
75_I78_G0.6121.00
91_A172_V0.6091.00
123_L133_K0.6061.00
14_P17_I0.6011.00
24_L28_I0.6001.00
73_F77_Y0.5971.00
202_V206_I0.5941.00
57_K61_S0.5921.00
175_M179_G0.5921.00
179_G185_G0.5901.00
74_L194_L0.5891.00
27_A30_A0.5851.00
61_S109_E0.5841.00
100_S104_A0.5841.00
47_N56_S0.5831.00
180_K185_G0.5831.00
62_F66_V0.5831.00
47_N123_L0.5821.00
36_I39_L0.5811.00
31_M153_T0.5801.00
19_A178_Q0.5801.00
176_F181_M0.5801.00
31_M35_I0.5771.00
206_I209_I0.5761.00
192_T196_V0.5761.00
90_T94_A0.5711.00
25_F28_I0.5681.00
39_L142_L0.5651.00
61_S201_W0.5631.00
165_S200_Y0.5601.00
121_G125_A0.5591.00
95_A172_V0.5581.00
26_M95_A0.5551.00
131_M136_A0.5541.00
76_Y94_A0.5541.00
182_Y185_G0.5521.00
182_Y192_T0.5521.00
43_L142_L0.5511.00
35_I111_F0.5501.00
63_F71_Q0.5491.00
173_M178_Q0.5491.00
47_N50_P0.5471.00
151_P215_E0.5451.00
183_A186_N0.5401.00
120_D127_L0.5381.00
157_F207_Y0.5371.00
203_L207_Y0.5371.00
214_F218_M0.5351.00
38_G42_A0.5351.00
22_I92_L0.5341.00
80_P89_M0.5331.00
31_M107_L0.5321.00
182_Y186_N0.5311.00
122_Q140_I0.5311.00
111_F145_A0.5291.00
95_A99_L0.5241.00
161_L207_Y0.5221.00
104_A108_A0.5201.00
184_S187_L0.5181.00
79_L89_M0.5171.00
166_L171_G0.5161.00
42_A108_A0.5151.00
59_Y105_A0.5141.00
48_K52_L0.5141.00
99_L164_T0.5141.00
156_T159_G0.5121.00
89_M94_A0.5111.00
198_I202_V0.5081.00
126_C129_V0.5081.00
201_W208_S0.5061.00
45_T53_H0.5061.00
45_T60_I0.5051.00
200_Y204_T0.5041.00
20_L175_M0.5031.00
190_F193_Y0.5021.00
211_Q214_F0.5021.00
167_A174_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9598 100 0.354 Contact Map
2onkC 2 0.9598 100 0.36 Contact Map
3d31C 2 0.942 100 0.381 Contact Map
3rlfF 1 0.933 100 0.382 Contact Map
4tquM 1 0.9732 100 0.391 Contact Map
3tuiA 2 0.933 100 0.416 Contact Map
3rlfG 1 0.9955 99.9 0.433 Contact Map
4tquN 1 0.9286 99.9 0.467 Contact Map
2l2tA 2 0.1875 14.8 0.939 Contact Map
4mt1A 3 0.7946 12.1 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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