GREMLIN Database
YXEM - Probable amino-acid-binding protein YxeM
UniProt: P54952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (241)
Sequences: 23361 (17022)
Seq/√Len: 1096.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_G92_L3.8991.00
143_A183_V3.7151.00
34_V74_D3.6391.00
68_K239_E2.9541.00
151_A167_T2.4951.00
168_Y177_D2.4721.00
50_E55_T2.3891.00
86_E92_L2.3221.00
113_K238_D2.3201.00
101_V106_K2.3181.00
36_H74_D2.2861.00
170_T173_G2.2321.00
34_V72_K2.2251.00
101_V217_A2.1731.00
36_H76_K2.1411.00
151_A155_E2.1121.00
245_T248_K2.1091.00
103_D106_K2.1081.00
247_K251_E2.0811.00
64_A67_K2.0601.00
66_A73_L2.0451.00
88_Q108_T2.0431.00
109_Y219_P2.0101.00
141_T166_K2.0071.00
220_F230_R1.9721.00
230_R234_N1.9711.00
238_D242_K1.9671.00
110_N230_R1.9621.00
133_S136_D1.9511.00
68_K236_A1.9441.00
188_N193_L1.8801.00
174_T186_Y1.8551.00
220_F233_V1.8361.00
64_A245_T1.8191.00
113_K234_N1.8141.00
123_V193_L1.7401.00
227_D231_K1.7251.00
37_V62_M1.7231.00
141_T164_N1.7211.00
96_S218_F1.7011.00
86_E91_K1.6801.00
132_K136_D1.6801.00
177_D182_R1.6601.00
112_T234_N1.6361.00
64_A68_K1.6061.00
125_K181_G1.5901.00
146_L169_E1.5731.00
64_A240_L1.5571.00
221_A224_D1.5471.00
50_E53_K1.4991.00
78_L86_E1.4851.00
60_E252_K1.4831.00
231_K235_K1.4671.00
117_Y215_Q1.4571.00
127_D205_K1.4161.00
126_K203_P1.4141.00
68_K243_D1.4141.00
179_A203_P1.4141.00
83_L95_I1.4121.00
152_K156_S1.4051.00
48_Y55_T1.4021.00
223_D227_D1.3951.00
232_K235_K1.3771.00
84_M109_Y1.3701.00
110_N223_D1.3631.00
141_T184_D1.3551.00
37_V94_T1.3481.00
65_V236_A1.3451.00
63_E75_W1.3411.00
190_R194_I1.3331.00
59_V63_E1.3301.00
69_I236_A1.3221.00
177_D183_V1.3191.00
140_K184_D1.3001.00
99_V219_P1.2991.00
155_E167_T1.2981.00
121_Q190_R1.2931.00
58_D115_Y1.2561.00
49_K77_L1.2501.00
124_V185_A1.2441.00
236_A239_E1.2431.00
176_K180_Y1.2431.00
27_S31_D1.2291.00
126_K205_K1.2281.00
120_T150_H1.2261.00
169_E173_G1.2121.00
41_G77_L1.2081.00
178_V204_L1.2071.00
122_I185_A1.2011.00
239_E243_D1.1881.00
62_M96_S1.1861.00
144_A151_A1.1831.00
90_G221_A1.1781.00
143_A168_Y1.1661.00
85_G89_T1.1661.00
85_G88_Q1.1641.00
142_V185_A1.1641.00
236_A240_L1.1581.00
110_N227_D1.1551.00
104_E107_E1.1541.00
79_E82_G1.1531.00
26_S29_K1.1491.00
95_I99_V1.1481.00
153_N157_K1.1421.00
33_N71_M1.1311.00
241_R246_L1.1291.00
57_F249_L1.1171.00
78_L92_L1.1061.00
121_Q206_L1.0991.00
232_K236_A1.0921.00
124_V207_A1.0881.00
176_K179_A1.0871.00
168_Y174_T1.0611.00
57_F254_F1.0521.00
57_F250_S1.0501.00
178_V186_Y1.0421.00
60_E253_Y1.0391.00
63_E67_K1.0391.00
227_D230_R1.0381.00
71_M232_K1.0351.00
28_S32_D1.0291.00
37_V73_L1.0231.00
235_K239_E1.0181.00
62_M75_W1.0181.00
110_N222_K1.0091.00
178_V183_V1.0091.00
68_K245_T1.0001.00
145_V148_S1.0001.00
62_M73_L1.0001.00
49_K52_G1.0001.00
18_L21_C0.9951.00
102_T105_R0.9941.00
245_T249_L0.9921.00
94_T233_V0.9901.00
55_T60_E0.9881.00
61_V246_L0.9881.00
146_L167_T0.9861.00
53_K63_E0.9741.00
61_V240_L0.9701.00
60_E63_E0.9651.00
143_A174_T0.9651.00
228_K232_K0.9541.00
24_G228_K0.9511.00
173_G176_K0.9411.00
94_T220_F0.9371.00
54_L59_V0.9361.00
65_V233_V0.9351.00
195_A199_K0.9251.00
27_S30_E0.9251.00
84_M99_V0.9231.00
32_D36_H0.9191.00
152_K155_E0.9071.00
88_Q109_Y0.9041.00
240_L245_T0.8981.00
234_N238_D0.8941.00
111_F219_P0.8921.00
248_K251_E0.8891.00
82_G86_E0.8881.00
57_F246_L0.8851.00
251_E255_N0.8811.00
13_A16_A0.8701.00
153_N156_S0.8681.00
80_F83_L0.8651.00
234_N237_L0.8611.00
49_K54_L0.8601.00
112_T233_V0.8601.00
44_Y48_Y0.8581.00
135_D138_K0.8561.00
224_D227_D0.8531.00
246_L250_S0.8521.00
248_K252_K0.8481.00
113_K241_R0.8471.00
41_G54_L0.8451.00
118_A191_T0.8441.00
119_G190_R0.8411.00
158_D163_I0.8401.00
25_N28_S0.8361.00
172_E176_K0.8351.00
62_M218_F0.8351.00
103_D107_E0.8321.00
124_V205_K0.8281.00
166_K177_D0.8231.00
159_P163_I0.8211.00
35_L71_M0.8191.00
46_F116_A0.8141.00
95_I219_P0.8101.00
94_T218_F0.8021.00
122_I187_V0.7991.00
106_K222_K0.7961.00
17_V20_A0.7951.00
39_A75_W0.7951.00
29_K32_D0.7931.00
240_L243_D0.7921.00
100_A214_E0.7911.00
239_E242_K0.7901.00
69_I232_K0.7871.00
30_E33_N0.7851.00
171_Q188_N0.7801.00
14_L17_V0.7771.00
35_L94_T0.7711.00
48_Y253_Y0.7701.00
68_K240_L0.7691.00
39_A59_V0.7681.00
62_M94_T0.7661.00
65_V69_I0.7591.00
39_A97_N0.7581.00
24_G27_S0.7551.00
87_L95_I0.7541.00
64_A236_A0.7501.00
123_V204_L0.7501.00
19_S22_G0.7491.00
247_K250_S0.7471.00
137_L185_A0.7421.00
29_K33_N0.7371.00
36_H93_D0.7341.00
105_R111_F0.7301.00
87_L92_L0.7271.00
84_M88_Q0.7161.00
24_G28_S0.7131.00
235_K238_D0.7121.00
76_K91_K0.7121.00
175_L179_A0.7111.00
194_I206_L0.7101.00
63_E73_L0.7091.00
250_S254_F0.7091.00
125_K203_P0.7081.00
34_V71_M0.7071.00
240_L246_L0.7051.00
240_L244_G0.7051.00
143_A177_D0.7041.00
228_K231_K0.7041.00
118_A190_R0.7021.00
29_K71_M0.7021.00
40_T47_A0.6961.00
35_L66_A0.6961.00
38_G83_L0.6951.00
175_L204_L0.6911.00
87_L109_Y0.6901.00
121_Q208_G0.6881.00
100_A105_R0.6851.00
101_V114_P0.6841.00
119_G213_Y0.6821.00
37_V75_W0.6801.00
64_A249_L0.6781.00
168_Y183_V0.6741.00
26_S30_E0.6721.00
112_T220_F0.6721.00
78_L83_L0.6711.00
112_T218_F0.6701.00
218_F233_V0.6701.00
11_V14_L0.6681.00
194_I198_K0.6661.00
119_G212_V0.6611.00
43_S98_Q0.6611.00
40_T80_F0.6581.00
16_A19_S0.6551.00
111_F217_A0.6551.00
61_V237_L0.6531.00
224_D229_L0.6521.00
173_G177_D0.6511.00
155_E165_I0.6491.00
65_V96_S0.6481.00
130_D205_K0.6481.00
154_L165_I0.6461.00
55_T253_Y0.6441.00
123_V175_L0.6421.00
121_Q193_L0.6401.00
59_V75_W0.6391.00
41_G47_A0.6391.00
90_G223_D0.6381.00
14_L18_L0.6331.00
82_G85_G0.6321.00
112_T237_L0.6311.00
80_F99_V0.6281.00
18_L22_G0.6281.00
131_I136_D0.6241.00
23_N28_S0.6221.00
25_N29_K0.6201.00
149_N214_E0.6191.00
101_V111_F0.6191.00
39_A54_L0.6181.00
10_V13_A0.6171.00
117_Y213_Y0.6141.00
45_P48_Y0.6121.00
141_T183_V0.6111.00
201_G204_L0.6051.00
10_V14_L0.6041.00
156_S159_P0.6031.00
16_A21_C0.6021.00
144_A167_T0.6011.00
66_A71_M0.6001.00
238_D241_R0.5981.00
231_K234_N0.5971.00
114_P117_Y0.5961.00
66_A69_I0.5941.00
43_S80_F0.5911.00
110_N224_D0.5911.00
76_K92_L0.5891.00
166_K183_V0.5891.00
99_V109_Y0.5881.00
88_Q221_A0.5871.00
193_L197_I0.5831.00
113_K237_L0.5821.00
65_V218_F0.5811.00
62_M66_A0.5761.00
244_G247_K0.5741.00
47_A97_N0.5731.00
87_L221_A0.5731.00
204_L207_A0.5711.00
224_D228_K0.5691.00
40_T97_N0.5671.00
130_D140_K0.5671.00
123_V197_I0.5641.00
43_S46_F0.5641.00
195_A198_K0.5631.00
179_A201_G0.5591.00
188_N192_V0.5561.00
244_G248_K0.5561.00
154_L187_V0.5521.00
26_S71_M0.5521.00
12_A15_L0.5501.00
30_E232_K0.5491.00
179_A204_L0.5491.00
120_T187_V0.5471.00
40_T145_V0.5461.00
193_L206_L0.5451.00
67_K245_T0.5431.00
38_G95_I0.5411.00
26_S32_D0.5381.00
23_N27_S0.5371.00
220_F224_D0.5331.00
122_I137_L0.5331.00
25_N221_A0.5311.00
80_F105_R0.5301.00
116_A216_V0.5301.00
126_K202_L0.5301.00
198_K255_N0.5301.00
58_D98_Q0.5281.00
197_I204_L0.5261.00
123_V206_L0.5251.00
112_T230_R0.5231.00
138_K160_D0.5221.00
66_A70_D0.5211.00
119_G210_P0.5211.00
240_L249_L0.5211.00
106_K110_N0.5211.00
69_I229_L0.5201.00
183_V186_Y0.5191.00
154_L158_D0.5181.00
28_S31_D0.5181.00
54_L77_L0.5171.00
33_N232_K0.5161.00
127_D181_G0.5161.00
145_V171_Q0.5131.00
11_V15_L0.5111.00
83_L99_V0.5101.00
38_G78_L0.5091.00
36_H90_G0.5061.00
177_D180_Y0.5051.00
76_K86_E0.5011.00
51_N55_T0.5011.00
174_T177_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xt8A 1 0.8598 100 0.282 Contact Map
4powA 1 0.8485 100 0.283 Contact Map
4ohnA 1 0.8939 100 0.285 Contact Map
3hv1A 2 0.9242 100 0.287 Contact Map
2ylnA 1 0.875 100 0.289 Contact Map
3kbrA 4 0.8523 100 0.29 Contact Map
1pb7A 1 0.9167 100 0.293 Contact Map
2vhaA 2 0.9205 100 0.294 Contact Map
3delB 1 0.8485 100 0.299 Contact Map
2yjpA 1 0.8826 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.008 seconds.