GREMLIN Database
YXEL - Uncharacterized N-acetyltransferase YxeL
UniProt: P54951 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (158)
Sequences: 135 (99)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A89_V3.3020.92
54_Y110_I3.2910.92
13_A41_L2.8670.84
8_A57_E2.7460.82
83_H152_H2.4910.75
65_T140_Y2.3920.71
47_N85_W2.3180.69
14_E93_T2.2580.67
22_R90_D2.2490.66
17_L21_L2.2140.65
48_I68_L2.2070.65
87_F99_G2.1610.63
6_R57_E2.0800.60
18_E22_R2.0380.58
78_P125_A1.9460.55
61_R92_D1.8270.50
58_E96_K1.7670.47
8_A55_V1.7540.47
83_H123_G1.7340.46
32_I159_K1.7270.46
24_Y36_A1.6800.44
73_G80_G1.6450.43
8_A140_Y1.6300.42
16_L62_I1.5770.40
15_Q104_Q1.5380.38
16_L55_V1.5170.38
13_A88_A1.4950.37
24_Y34_F1.4930.37
67_T151_G1.4720.36
123_G154_T1.4240.34
89_V123_G1.4210.34
71_P116_K1.4190.34
78_P152_H1.4180.34
9_V12_D1.4170.34
63_I93_T1.4120.34
25_E93_T1.4010.33
73_G77_G1.3870.33
57_E65_T1.3580.32
81_V119_F1.3480.31
61_R93_T1.3300.31
34_F152_H1.3190.30
77_G83_H1.3150.30
16_L53_C1.3120.30
62_I90_D1.3100.30
74_K102_L1.3080.30
8_A16_L1.2930.29
27_I134_M1.2810.29
8_A65_T1.2810.29
42_D59_D1.2770.29
84_I151_G1.2740.29
55_V62_I1.2740.29
4_R104_Q1.2730.29
7_L54_Y1.2730.29
27_I37_A1.2690.29
24_Y156_Y1.2530.28
102_L145_E1.2480.28
23_A88_A1.2470.28
125_A154_T1.2400.28
78_P83_H1.2370.28
24_Y64_A1.2320.27
34_F156_Y1.2270.27
40_D43_L1.2130.27
10_E49_R1.1930.26
21_L37_A1.1900.26
79_Y83_H1.1850.26
63_I98_I1.1640.25
118_P125_A1.1560.25
41_L45_L1.1500.25
36_A149_G1.1440.25
72_W116_K1.1340.24
57_E140_Y1.1280.24
58_E110_I1.1270.24
19_L69_R1.1170.24
12_D116_K1.1160.24
16_L111_L1.1130.24
70_M90_D1.1090.24
85_W140_Y1.1080.24
121_S143_S1.1060.24
17_L44_V1.0900.23
47_N140_Y1.0760.23
25_E29_K1.0590.22
16_L57_E1.0520.22
62_I111_L1.0480.22
85_W123_G1.0390.22
83_H154_T1.0380.22
76_P83_H1.0310.21
27_I30_L1.0190.21
136_E146_Q1.0090.21
51_N67_T1.0090.21
123_G143_S0.9970.21
19_L31_G0.9890.20
16_L65_T0.9860.20
72_W123_G0.9780.20
71_P123_G0.9770.20
84_I103_L0.9730.20
9_V29_K0.9620.20
64_A111_L0.9570.19
51_N110_I0.9530.19
125_A151_G0.9480.19
44_V110_I0.9410.19
71_P85_W0.9360.19
31_G123_G0.9360.19
54_Y68_L0.9290.19
8_A12_D0.9280.19
69_R76_P0.9230.19
30_L47_N0.9210.19
136_E142_R0.9130.18
71_P78_P0.9060.18
55_V140_Y0.8830.18
81_V105_W0.8780.18
17_L23_A0.8640.17
95_K138_K0.8620.17
79_Y121_S0.8540.17
78_P154_T0.8520.17
28_R43_L0.8520.17
65_T88_A0.8480.17
69_R85_W0.8460.17
57_E88_A0.8440.17
92_D100_T0.8410.17
47_N53_C0.8370.17
67_T158_K0.8370.17
77_G154_T0.8340.17
39_A103_L0.8300.16
158_K161_L0.8290.16
53_C65_T0.8210.16
17_L41_L0.8200.16
99_G119_F0.8180.16
27_I53_C0.8160.16
58_E98_I0.8100.16
40_D136_E0.8070.16
98_I111_L0.8050.16
104_Q114_T0.8030.16
74_K101_K0.7990.16
66_I103_L0.7970.16
96_K103_L0.7840.15
34_F148_L0.7800.15
68_L103_L0.7770.15
119_F160_Q0.7670.15
87_F107_E0.7670.15
10_E45_L0.7600.15
127_K137_R0.7600.15
23_A99_G0.7580.15
91_P122_L0.7580.15
14_E41_L0.7570.15
148_L154_T0.7540.15
36_A148_L0.7520.15
69_R72_W0.7510.15
66_I84_I0.7490.15
5_Y149_G0.7480.15
147_D152_H0.7440.15
86_W151_G0.7360.14
27_I101_K0.7340.14
46_K160_Q0.7260.14
7_L110_I0.7220.14
99_G151_G0.7210.14
11_R93_T0.7200.14
104_Q109_T0.7160.14
11_R101_K0.7120.14
123_G152_H0.7080.14
33_R154_T0.7040.14
77_G152_H0.7010.14
66_I117_V0.6950.14
8_A88_A0.6920.14
52_A70_M0.6880.14
30_L128_H0.6840.13
5_Y134_M0.6790.13
71_P125_A0.6780.13
14_E54_Y0.6730.13
109_T112_R0.6700.13
34_F146_Q0.6680.13
16_L140_Y0.6650.13
70_M125_A0.6620.13
71_P111_L0.6610.13
78_P148_L0.6580.13
19_L96_K0.6520.13
83_H127_K0.6500.13
114_T127_K0.6490.13
71_P77_G0.6460.13
13_A64_A0.6430.13
14_E45_L0.6410.13
39_A44_V0.6370.13
108_E145_E0.6360.13
7_L59_D0.6340.13
84_I125_A0.6260.12
35_A65_T0.6240.12
7_L102_L0.6230.12
36_A85_W0.6160.12
60_G97_G0.6090.12
33_R146_Q0.6060.12
32_I155_V0.6010.12
26_P151_G0.6010.12
109_T137_R0.5990.12
76_P141_V0.5990.12
78_P123_G0.5980.12
37_A43_L0.5970.12
30_L86_W0.5960.12
93_T113_D0.5930.12
36_A154_T0.5890.12
104_Q108_E0.5840.12
69_R118_P0.5810.12
93_T160_Q0.5760.12
66_I101_K0.5750.11
64_A123_G0.5740.11
69_R123_G0.5720.11
133_E136_E0.5700.11
77_G125_A0.5680.11
61_R90_D0.5670.11
32_I69_R0.5650.11
84_I111_L0.5650.11
83_H121_S0.5610.11
7_L114_T0.5600.11
44_V67_T0.5540.11
56_M143_S0.5520.11
52_A110_I0.5490.11
24_Y154_T0.5470.11
90_D109_T0.5440.11
121_S152_H0.5410.11
67_T148_L0.5410.11
14_E68_L0.5390.11
93_T141_V0.5380.11
111_L116_K0.5330.11
4_R59_D0.5310.11
32_I153_I0.5310.11
82_P118_P0.5300.11
42_D92_D0.5270.11
84_I150_K0.5270.11
32_I71_P0.5260.11
95_K98_I0.5260.11
34_F73_G0.5230.11
72_W78_P0.5180.11
23_A157_M0.5120.10
47_N65_T0.5080.10
105_W143_S0.5080.10
77_G123_G0.5050.10
14_E109_T0.5020.10
136_E141_V0.5010.10
18_E108_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pc1A 1 0.9333 99.8 0.747 Contact Map
2fiaA 1 0.9394 99.8 0.753 Contact Map
2oh1A 1 0.9455 99.7 0.757 Contact Map
3h4qA 1 0.8242 99.7 0.772 Contact Map
4zbgA 1 0.8303 99.7 0.772 Contact Map
1gheA 1 0.9333 99.7 0.774 Contact Map
3fixA 2 0.8909 99.7 0.776 Contact Map
3blnA 2 0.8545 99.7 0.776 Contact Map
3kkwA 1 0.9333 99.7 0.776 Contact Map
3efaA 2 0.8667 99.6 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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