GREMLIN Database
YXEK - Putative monooxygenase YxeK
UniProt: P54950 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (378)
Sequences: 4894 (2887)
Seq/√Len: 148.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_E372_Q6.6991.00
225_K251_S4.0961.00
193_K198_S3.9951.00
403_F407_V3.7281.00
151_Q195_E3.5351.00
371_E410_I3.5171.00
378_Q382_D3.5121.00
51_K420_E3.4041.00
278_D406_Q3.1581.00
410_I413_E3.1401.00
145_E148_L3.1221.00
376_K379_E3.0911.00
280_E369_T2.9711.00
50_G404_V2.9401.00
154_E230_K2.8831.00
251_S255_Q2.8541.00
148_L195_E2.8251.00
281_E285_A2.7781.00
280_E284_Q2.6551.00
226_A255_Q2.6261.00
46_T401_E2.4861.00
249_Y253_K2.4631.00
246_Q250_Q2.4621.00
256_A266_I2.4421.00
262_D265_K2.4201.00
161_K212_Q2.3871.00
51_K412_Q2.3801.00
136_L200_R2.3471.00
254_E258_E2.3081.00
288_K292_D2.2581.00
162_G190_L2.2441.00
412_Q419_K2.2171.00
41_K45_K2.2051.00
81_L93_L2.1581.00
316_P319_G2.1121.00
126_V215_I2.0971.00
278_D282_A2.0931.00
148_L151_Q2.0321.00
49_R405_D2.0291.00
225_K255_Q2.0271.00
226_A258_E2.0131.00
154_E231_T2.0091.00
226_A259_F1.9961.00
147_H223_D1.9951.00
378_Q416_V1.9781.00
30_P33_A1.9611.00
155_E194_G1.9521.00
38_D119_N1.9451.00
46_T49_R1.9241.00
277_A282_A1.9011.00
286_K402_V1.8841.00
115_D210_Q1.8841.00
102_S110_Q1.8811.00
148_L196_Y1.8761.00
230_K259_F1.8281.00
159_I199_V1.8101.00
375_D414_R1.7861.00
151_Q223_D1.7371.00
272_I377_M1.7311.00
85_A118_S1.7171.00
37_L83_A1.6851.00
41_K87_V1.6681.00
235_I252_I1.6651.00
151_Q196_Y1.6591.00
229_A255_Q1.6561.00
161_K231_T1.6551.00
132_E136_L1.6541.00
191_N200_R1.6231.00
94_T123_G1.6221.00
11_G54_M1.5701.00
42_E401_E1.5551.00
76_E79_T1.5541.00
369_T372_Q1.5421.00
159_I192_H1.5221.00
84_L93_L1.4961.00
193_K200_R1.4881.00
250_Q254_E1.4811.00
346_D356_Y1.4741.00
382_D416_V1.4671.00
191_N201_G1.4641.00
408_V412_Q1.4621.00
98_S129_S1.4481.00
45_K49_R1.4421.00
162_G192_H1.4401.00
51_K421_Y1.4361.00
155_E195_E1.4341.00
165_D212_Q1.4101.00
8_I381_V1.4031.00
38_D89_S1.3701.00
126_V157_V1.3681.00
159_I197_F1.3651.00
229_A259_F1.3651.00
158_E192_H1.3641.00
38_D41_K1.3621.00
287_Y291_Q1.3611.00
28_D398_E1.3601.00
249_Y384_K1.3591.00
279_T282_A1.3551.00
222_G255_Q1.3531.00
276_I370_P1.3431.00
285_A289_E1.3391.00
51_K417_F1.3391.00
94_T216_I1.3261.00
97_A107_I1.3231.00
378_Q414_R1.3181.00
42_E45_K1.3101.00
276_I373_L1.3051.00
401_E405_D1.3041.00
33_A36_N1.2921.00
158_E230_K1.2861.00
270_P386_C1.2851.00
154_E158_E1.2811.00
158_E231_T1.2791.00
55_L91_I1.2711.00
242_L379_E1.2661.00
406_Q410_I1.2611.00
42_E46_T1.2491.00
285_A288_K1.2481.00
402_V406_Q1.2461.00
37_L41_K1.2421.00
216_I234_V1.2331.00
276_I407_V1.2321.00
255_Q258_E1.2171.00
222_G251_S1.2101.00
51_K419_K1.2091.00
317_L320_P1.2041.00
226_A230_K1.1991.00
272_I366_F1.1951.00
322_P325_D1.1941.00
319_G322_P1.1941.00
321_L325_D1.1901.00
111_F122_A1.1901.00
192_H197_F1.1871.00
242_L246_Q1.1861.00
162_G166_S1.1781.00
46_T404_V1.1761.00
318_D351_R1.1641.00
112_A208_T1.1601.00
255_Q259_F1.1551.00
48_E90_K1.1461.00
241_H244_S1.1411.00
274_P403_F1.1401.00
57_L81_L1.1401.00
374_A410_I1.1381.00
283_A367_V1.1351.00
371_E375_D1.1330.99
284_Q288_K1.1330.99
112_A203_L1.1300.99
252_I266_I1.1260.99
286_K289_E1.1200.99
374_A407_V1.1170.99
256_A259_F1.1010.99
9_K53_D1.0950.99
44_A88_T1.0950.99
112_A205_V1.0870.99
81_L95_A1.0800.99
251_S254_E1.0790.99
284_Q372_Q1.0790.99
79_T113_S1.0780.99
129_S134_T1.0760.99
257_A262_D1.0760.99
158_E162_G1.0680.99
119_N209_P1.0610.99
333_K337_K1.0520.99
44_A91_I1.0510.99
289_E292_D1.0400.99
243_E246_Q1.0380.99
46_T50_G1.0360.99
45_K87_V1.0350.99
163_L190_L1.0230.99
237_T248_F1.0170.99
281_E284_Q1.0170.99
152_R197_F1.0150.99
47_A400_I1.0090.99
9_K267_A1.0060.99
220_S248_F1.0060.99
310_I315_Y1.0050.99
144_L152_R1.0000.99
351_R355_K0.9940.99
165_D207_R0.9870.99
250_Q384_K0.9860.99
276_I369_T0.9860.99
277_A286_K0.9860.99
348_M356_Y0.9850.99
370_P406_Q0.9800.99
372_Q375_D0.9780.99
9_K269_M0.9760.98
208_T212_Q0.9720.98
128_T153_A0.9700.98
199_V202_P0.9680.98
49_R404_V0.9670.98
278_D402_V0.9650.98
284_Q287_Y0.9630.98
10_L417_F0.9600.98
279_T283_A0.9590.98
220_S239_Q0.9570.98
366_F373_L0.9560.98
287_Y367_V0.9540.98
49_R89_S0.9480.98
375_D378_Q0.9480.98
85_A93_L0.9470.98
254_E257_A0.9450.98
34_S206_S0.9450.98
278_D370_P0.9420.98
418_R422_E0.9420.98
317_L351_R0.9320.98
399_G402_V0.9280.98
412_Q417_F0.9180.98
54_M94_T0.9160.98
410_I414_R0.9120.98
321_L324_L0.9120.98
244_S247_E0.9120.98
378_Q413_E0.9100.98
276_I406_Q0.9090.98
313_S316_P0.9090.98
159_I162_G0.9060.98
227_L231_T0.9010.97
320_P323_K0.9010.97
107_I156_F0.9000.97
288_K291_Q0.8990.97
249_Y268_I0.8980.97
271_G363_H0.8970.97
79_T82_S0.8930.97
319_G323_K0.8910.97
191_N202_P0.8890.97
189_E200_R0.8890.97
53_D418_R0.8890.97
36_N119_N0.8890.97
395_L398_E0.8860.97
318_D322_P0.8860.97
320_P324_L0.8850.97
404_V408_V0.8840.97
132_E142_K0.8840.97
47_A52_L0.8740.97
103_E106_H0.8710.97
49_R401_E0.8700.97
408_V417_F0.8610.97
41_K86_Q0.8600.97
242_L385_A0.8560.97
239_Q245_A0.8560.97
311_D314_A0.8520.96
223_D227_L0.8520.96
52_L404_V0.8490.96
242_L384_K0.8490.96
60_S64_D0.8490.96
364_H376_K0.8450.96
247_E250_Q0.8430.96
44_A55_L0.8430.96
257_A265_K0.8420.96
318_D321_L0.8410.96
147_H333_K0.8400.96
340_Q344_E0.8400.96
267_A387_D0.8380.96
381_V416_V0.8350.96
137_N202_P0.8350.96
156_F160_V0.8320.96
315_Y324_L0.8240.96
51_K418_R0.8220.96
68_H295_I0.8210.96
252_I256_A0.8210.96
215_I232_A0.8190.96
274_P391_I0.8190.96
316_P320_P0.8170.95
145_E330_N0.8120.95
278_D405_D0.8080.95
25_R293_L0.8080.95
107_I111_F0.8050.95
116_H209_P0.8030.95
318_D324_L0.7990.95
101_Y143_H0.7980.95
114_L122_A0.7960.95
10_L408_V0.7960.95
105_F202_P0.7940.95
312_L316_P0.7940.95
157_V231_T0.7930.95
234_V269_M0.7910.95
207_R211_G0.7900.95
157_V227_L0.7900.95
225_K252_I0.7880.94
95_A122_A0.7850.94
100_T144_L0.7810.94
92_G123_G0.7790.94
47_A91_I0.7780.94
331_A334_S0.7780.94
76_E110_Q0.7760.94
160_V164_W0.7760.94
153_A227_L0.7760.94
366_F377_M0.7730.94
243_E379_E0.7730.94
10_L52_L0.7720.94
192_H195_E0.7720.94
61_L134_T0.7700.94
317_L322_P0.7690.94
10_L377_M0.7680.94
317_L321_L0.7670.94
256_A262_D0.7650.94
124_W160_V0.7640.94
220_S237_T0.7640.94
115_D120_G0.7630.94
8_I377_M0.7600.93
26_H289_E0.7600.93
126_V227_L0.7570.93
159_I194_G0.7550.93
237_T245_A0.7550.93
347_N350_I0.7530.93
38_D42_E0.7530.93
93_L118_S0.7520.93
317_L324_L0.7520.93
115_D212_Q0.7500.93
330_N334_S0.7470.93
154_E223_D0.7450.93
407_V410_I0.7400.92
19_H392_M0.7390.92
250_Q385_A0.7350.92
216_I388_G0.7320.92
159_I190_L0.7320.92
167_W207_R0.7320.92
12_V393_P0.7250.92
350_I353_L0.7240.92
238_A363_H0.7240.92
8_I417_F0.7220.92
106_H138_F0.7200.91
249_Y386_C0.7160.91
311_D315_Y0.7150.91
115_D208_T0.7120.91
377_M389_F0.7100.91
9_K418_R0.7090.91
352_E355_K0.7070.91
44_A84_L0.7060.91
78_F82_S0.7050.91
315_Y318_D0.7040.90
162_G167_W0.7030.90
50_G412_Q0.7020.90
312_L315_Y0.7000.90
193_K196_Y0.7000.90
245_A380_W0.6980.90
282_A285_A0.6980.90
319_G325_D0.6970.90
12_V15_A0.6960.90
378_Q381_V0.6940.90
246_Q384_K0.6920.90
332_V336_F0.6920.90
252_I268_I0.6900.90
137_N201_G0.6870.89
14_L55_L0.6860.89
228_A235_I0.6850.89
276_I402_V0.6840.89
42_E397_P0.6830.89
370_P407_V0.6830.89
32_D36_N0.6820.89
48_E421_Y0.6820.89
336_F339_V0.6810.89
15_A19_H0.6740.88
346_D352_E0.6740.88
276_I410_I0.6730.88
12_V47_A0.6730.88
166_S190_L0.6720.88
277_A402_V0.6710.88
247_E251_S0.6710.88
50_G405_D0.6700.88
355_K358_A0.6690.88
253_K264_E0.6680.88
246_Q253_K0.6680.88
343_A348_M0.6680.88
264_E385_A0.6650.88
212_Q233_E0.6650.88
348_M354_Y0.6620.88
282_A286_K0.6620.88
299_G354_Y0.6610.88
39_Y43_L0.6590.87
45_K89_S0.6560.87
53_D403_F0.6540.87
333_K336_F0.6500.87
335_R338_L0.6500.87
229_A251_S0.6480.86
11_G390_N0.6430.86
83_A117_L0.6430.86
155_E159_I0.6400.86
418_R421_Y0.6390.86
50_G408_V0.6390.86
87_V93_L0.6390.86
106_H110_Q0.6380.86
278_D285_A0.6380.86
214_V233_E0.6350.85
149_R219_G0.6310.85
331_A336_F0.6300.85
256_A261_R0.6300.85
79_T114_L0.6280.85
128_T149_R0.6270.85
222_G226_A0.6270.85
142_K152_R0.6270.85
139_S198_S0.6260.85
78_F110_Q0.6260.85
343_A347_N0.6250.84
17_T23_S0.6240.84
41_K84_L0.6240.84
83_A86_Q0.6230.84
75_F205_V0.6230.84
253_K256_A0.6230.84
79_T117_L0.6230.84
349_T352_E0.6220.84
274_P377_M0.6210.84
314_A319_G0.6210.84
54_M390_N0.6200.84
267_A388_G0.6190.84
33_A42_E0.6170.84
48_E89_S0.6170.84
229_A252_I0.6160.84
374_A411_L0.6150.83
222_G225_K0.6140.83
59_D77_P0.6130.83
351_R354_Y0.6120.83
285_A371_E0.6110.83
53_D92_G0.6100.83
102_S134_T0.6100.83
97_A111_F0.6090.83
114_L118_S0.6090.83
377_M391_I0.6080.83
287_Y365_I0.6080.83
166_S188_H0.6080.83
47_A55_L0.6070.83
354_Y357_V0.6070.83
285_A292_D0.6050.82
334_S337_K0.6040.82
240_N244_S0.6040.82
400_I404_V0.6040.82
246_Q249_Y0.6030.82
339_V344_E0.6020.82
412_Q421_Y0.6010.82
285_A413_E0.6000.82
102_S107_I0.5990.82
125_N218_A0.5990.82
398_E401_E0.5980.82
289_E293_L0.5970.82
54_M216_I0.5970.82
273_F394_P0.5960.82
135_A142_K0.5960.82
332_V335_R0.5940.81
316_P324_L0.5920.81
318_D325_D0.5920.81
16_G74_R0.5920.81
69_P72_L0.5910.81
157_V215_I0.5910.81
37_L117_L0.5910.81
275_I290_L0.5900.81
42_E49_R0.5900.81
35_M206_S0.5880.81
370_P402_V0.5880.81
111_F164_W0.5870.81
52_L391_I0.5840.80
323_K344_E0.5830.80
417_F421_Y0.5800.80
348_M353_L0.5800.80
379_E382_D0.5790.80
90_K421_Y0.5790.80
373_L407_V0.5770.79
315_Y319_G0.5760.79
315_Y321_L0.5740.79
217_Q224_G0.5730.79
82_S86_Q0.5720.79
78_F97_A0.5700.79
103_E139_S0.5690.79
366_F407_V0.5680.78
165_D211_G0.5670.78
330_N336_F0.5670.78
14_L40_F0.5670.78
320_P347_N0.5670.78
393_P399_G0.5640.78
370_P410_I0.5640.78
277_A369_T0.5630.78
12_V43_L0.5630.78
245_A386_C0.5610.78
46_T397_P0.5610.78
315_Y320_P0.5610.78
153_A217_Q0.5610.78
125_N149_R0.5600.77
115_D211_G0.5590.77
125_N150_Y0.5580.77
69_P74_R0.5550.77
101_Y135_A0.5550.77
105_F163_L0.5540.77
51_K90_K0.5540.77
372_Q376_K0.5520.76
354_Y358_A0.5520.76
314_A317_L0.5520.76
161_K233_E0.5520.76
13_F19_H0.5520.76
46_T405_D0.5510.76
366_F376_K0.5510.76
239_Q248_F0.5490.76
80_L117_L0.5490.76
316_P321_L0.5490.76
225_K248_F0.5470.76
111_F124_W0.5470.76
363_H392_M0.5460.76
245_A270_P0.5460.76
320_P325_D0.5460.76
378_Q410_I0.5450.76
137_N199_V0.5440.75
81_L122_A0.5430.75
97_A124_W0.5420.75
312_L321_L0.5420.75
325_D333_K0.5420.75
81_L84_L0.5410.75
157_V160_V0.5410.75
320_P352_E0.5410.75
253_K268_I0.5410.75
411_L415_G0.5400.75
335_R339_V0.5390.75
304_Q310_I0.5370.74
223_D226_A0.5350.74
414_R417_F0.5350.74
111_F114_L0.5340.74
343_A346_D0.5340.74
189_E201_G0.5330.74
26_H293_L0.5320.74
348_M352_E0.5320.74
217_Q232_A0.5310.74
216_I269_M0.5280.73
163_L202_P0.5280.73
290_L395_L0.5260.73
253_K387_D0.5260.73
60_S130_S0.5250.73
318_D323_K0.5250.73
85_A114_L0.5240.73
369_T406_Q0.5240.73
246_Q385_A0.5230.73
84_L87_V0.5230.73
317_L323_K0.5220.72
238_A338_L0.5200.72
335_R362_G0.5200.72
259_F266_I0.5200.72
12_V400_I0.5180.72
271_G392_M0.5180.72
95_A111_F0.5180.72
284_Q367_V0.5160.72
398_E402_V0.5160.72
21_V302_I0.5150.71
118_S210_Q0.5140.71
376_K380_W0.5140.71
302_I307_L0.5140.71
92_G214_V0.5140.71
291_Q355_K0.5130.71
56_F236_F0.5130.71
391_I403_F0.5130.71
101_Y138_F0.5130.71
37_L86_Q0.5120.71
272_I391_I0.5110.71
147_H151_Q0.5110.71
50_G400_I0.5100.71
307_L310_I0.5100.71
68_H71_V0.5080.70
155_E192_H0.5080.70
127_V150_Y0.5060.70
167_W188_H0.5060.70
316_P351_R0.5060.70
159_I163_L0.5050.70
102_S106_H0.5050.70
237_T270_P0.5040.70
234_V267_A0.5040.70
277_A399_G0.5040.70
286_K399_G0.5040.70
253_K384_K0.5030.70
150_Y221_S0.5020.69
163_L204_N0.5010.69
37_L87_V0.5010.69
19_H361_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tvlA 2 0.8844 100 0.16 Contact Map
3sdoA 2 0.9887 100 0.18 Contact Map
3b9oA 2 0.932 100 0.229 Contact Map
3raoA 2 0.7914 100 0.396 Contact Map
1nqkA 4 0.771 100 0.401 Contact Map
2wgkA 2 0.7755 100 0.407 Contact Map
1lucA 1 0.7188 100 0.416 Contact Map
2i7gA 2 0.7506 100 0.422 Contact Map
3c8nA 2 0.7506 100 0.428 Contact Map
1ezwA 3 0.7528 100 0.435 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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