GREMLIN Database
YXEI - Uncharacterized protein YxeI
UniProt: P54948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (290)
Sequences: 1245 (924)
Seq/√Len: 54.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_C121_K4.1341.00
77_C105_V3.5431.00
73_S113_Q3.4301.00
145_L155_I3.3861.00
243_D246_K3.1311.00
35_R72_E2.9741.00
221_D226_S2.9651.00
302_N305_H2.9251.00
70_I76_S2.9011.00
282_C285_T2.7621.00
116_E151_R2.7511.00
118_V145_L2.6841.00
158_R163_K2.6761.00
262_K274_Y2.6011.00
148_R286_G2.5941.00
119_K151_R2.4811.00
184_N187_Q2.4451.00
108_V145_L2.4411.00
33_Y66_F2.4171.00
113_Q117_D2.4101.00
151_R166_D2.3631.00
184_N229_V2.3611.00
3_T231_A2.3341.00
165_Y179_I2.2261.00
83_P224_P2.2251.00
252_F280_V2.1631.00
38_S49_Q2.1481.00
52_Y72_E2.1371.00
252_F298_I2.1351.00
84_G175_S2.1171.00
54_F110_S2.1141.00
184_N188_Y2.1081.00
116_E120_E2.1031.00
241_A246_K2.0721.00
119_K166_D2.0511.00
87_E159_A2.0361.00
77_C145_L2.0191.00
163_K179_I2.0091.00
10_A242_A1.9761.00
70_I281_M1.9721.00
28_T57_M1.9371.00
256_A259_T1.8710.99
76_S283_N1.8710.99
19_T259_T1.8520.99
69_G109_L1.8470.99
286_G304_F1.8390.99
4_S80_L1.8340.99
17_A255_L1.8200.99
17_A251_A1.8020.99
217_G221_D1.7700.99
75_L114_S1.7530.99
22_F140_P1.7200.99
180_W184_N1.7100.99
281_M288_Y1.7080.99
108_V122_I1.6940.99
287_N300_K1.6910.99
287_N302_N1.6840.99
168_Q178_F1.6230.98
9_T247_G1.5880.98
120_E123_R1.5820.98
82_F86_A1.5530.98
101_P127_I1.5400.98
38_S47_A1.5100.97
90_K129_E1.5020.97
104_F155_I1.4940.97
291_H296_R1.4880.97
32_L306_E1.4880.97
57_M288_Y1.4840.97
82_F158_R1.4740.97
98_H126_T1.4690.97
19_T278_T1.4630.97
14_H284_E1.4570.97
21_D259_T1.4330.96
167_N178_F1.4120.96
155_I162_L1.4030.96
180_W187_Q1.3670.95
153_L164_V1.3600.95
50_T110_S1.3550.95
238_L250_A1.3550.95
108_V118_V1.3520.95
35_R308_L1.3410.95
52_Y113_Q1.3400.95
115_L150_G1.3300.95
77_C108_V1.3220.94
186_Q225_P1.2950.94
157_P162_L1.2780.93
112_C145_L1.2750.93
160_D163_K1.2740.93
212_G217_G1.2610.93
251_A280_V1.2540.93
216_V221_D1.2510.93
30_V301_V1.2410.92
48_H110_S1.2390.92
185_L232_V1.2340.92
148_R284_E1.2320.92
215_T223_T1.2290.92
146_S152_N1.2260.92
51_Q111_V1.2220.92
115_L164_V1.2220.92
169_P185_L1.2200.92
211_Q224_P1.2110.91
278_T291_H1.2060.91
53_A308_L1.2040.91
29_E315_V1.2010.91
183_T186_Q1.1950.91
184_N225_P1.1900.91
256_A291_H1.1670.90
80_L172_M1.1660.90
244_E285_T1.1590.90
40_N47_A1.1520.89
36_R50_T1.1380.89
169_P235_K1.1250.88
122_I162_L1.1230.88
215_T221_D1.1150.88
188_Y229_V1.1110.87
101_P138_V1.1010.87
107_W112_C1.0930.87
231_A254_I1.0900.86
96_T126_T1.0890.86
15_V247_G1.0850.86
181_H184_N1.0750.86
158_R165_Y1.0730.86
122_I155_I1.0530.84
84_G186_Q1.0510.84
5_L231_A1.0510.84
32_L35_R1.0460.84
9_T13_K1.0430.84
21_D258_M1.0380.84
144_I172_M1.0330.83
173_T224_P1.0290.83
21_D80_L1.0200.82
89_E157_P1.0190.82
100_V138_V1.0170.82
35_R53_A1.0160.82
169_P182_V1.0150.82
244_E282_C1.0100.82
2_C18_R1.0060.82
35_R307_D1.0000.81
170_G235_K1.0000.81
82_F177_D0.9940.81
79_A141_L0.9940.81
255_L278_T0.9900.81
56_G66_F0.9850.80
122_I303_L0.9810.80
52_Y73_S0.9740.79
55_I301_V0.9740.79
86_A288_Y0.9620.79
306_E314_K0.9600.78
238_L254_I0.9600.78
5_L235_K0.9570.78
218_L229_V0.9530.78
39_W54_F0.9500.78
29_E63_N0.9490.78
73_S286_G0.9490.78
212_G216_V0.9450.77
39_W50_T0.9430.77
30_V57_M0.9400.77
78_A144_I0.9320.76
51_Q117_D0.9300.76
253_Q256_A0.9260.76
224_P241_A0.9250.76
80_L288_Y0.9230.76
19_T260_I0.9180.75
99_I108_V0.9110.75
16_L281_M0.9110.75
32_L55_I0.9070.74
127_I138_V0.9050.74
92_I98_H0.9040.74
245_T285_T0.9030.74
233_Y264_A0.9020.74
100_V103_E0.8950.73
6_T235_K0.8940.73
119_K153_L0.8890.73
259_T278_T0.8880.73
32_L314_K0.8860.73
16_L283_N0.8860.73
107_W125_L0.8840.72
187_Q225_P0.8770.72
230_R261_P0.8750.72
46_R99_I0.8720.71
20_M67_A0.8700.71
104_F127_I0.8670.71
217_G226_S0.8660.71
28_T277_Y0.8640.71
248_V289_Y0.8580.70
153_L165_Y0.8550.70
87_E90_K0.8510.70
53_A72_E0.8490.69
81_Y138_V0.8450.69
261_P264_A0.8440.69
22_F81_Y0.8420.69
161_G305_H0.8420.69
121_K124_S0.8360.68
41_S48_H0.8350.68
115_L153_L0.8320.68
129_E138_V0.8250.67
234_L257_N0.8190.67
116_E149_T0.8190.67
260_I273_H0.8180.67
177_D180_W0.8160.66
10_A246_K0.8150.66
139_L276_Q0.8090.66
116_E159_A0.8030.65
212_G221_D0.8030.65
266_I269_E0.8010.65
220_G263_G0.7990.65
292_H295_N0.7980.65
75_L115_L0.7940.64
31_I58_G0.7930.64
21_D260_I0.7920.64
76_S281_M0.7890.64
118_V153_L0.7890.64
131_K138_V0.7880.64
4_S172_M0.7870.63
188_Y214_G0.7830.63
21_D78_A0.7820.63
104_F107_W0.7770.62
83_P88_Y0.7750.62
33_Y54_F0.7750.62
6_T170_G0.7740.62
310_C314_K0.7670.61
51_Q112_C0.7660.61
33_Y37_Y0.7630.61
211_Q273_H0.7620.61
28_T276_Q0.7600.61
158_R177_D0.7590.61
70_I283_N0.7580.61
39_W110_S0.7570.60
234_L264_A0.7550.60
26_L276_Q0.7540.60
220_G226_S0.7490.60
106_T110_S0.7490.60
251_A255_L0.7490.60
244_E248_V0.7480.60
172_M258_M0.7470.59
186_Q265_V0.7420.59
215_T233_Y0.7410.59
168_Q182_V0.7380.59
222_Y234_L0.7360.58
295_N298_I0.7350.58
159_A309_D0.7340.58
231_A234_L0.7320.58
219_P230_R0.7270.57
251_A254_I0.7250.57
187_Q212_G0.7240.57
212_G273_H0.7220.57
75_L112_C0.7190.57
10_A47_A0.7180.56
154_T178_F0.7170.56
112_C118_V0.7170.56
83_P139_L0.7140.56
111_V121_K0.7140.56
97_V124_S0.7100.56
180_W225_P0.7100.56
115_L151_R0.7090.55
175_S214_G0.7070.55
187_Q216_V0.7060.55
53_A309_D0.7040.55
240_P246_K0.7030.55
75_L118_V0.7020.55
35_R309_D0.7020.55
301_V306_E0.7000.55
81_Y136_D0.6960.54
16_L78_A0.6950.54
84_G224_P0.6930.54
57_M290_F0.6930.54
4_S144_I0.6920.54
282_C287_N0.6860.53
67_A81_Y0.6850.53
36_R49_Q0.6850.53
214_G220_G0.6820.53
22_F101_P0.6810.53
75_L121_K0.6790.52
54_F66_F0.6760.52
15_V277_Y0.6760.52
224_P282_C0.6740.52
241_A247_G0.6730.52
214_G219_P0.6710.51
222_Y265_V0.6660.51
54_F300_K0.6660.51
118_V121_K0.6630.51
17_A42_E0.6630.51
54_F106_T0.6630.51
142_H174_N0.6610.50
11_D244_E0.6580.50
242_A310_C0.6570.50
6_T14_H0.6570.50
256_A296_R0.6560.50
107_W111_V0.6550.50
99_I120_E0.6530.50
224_P285_T0.6520.49
13_K285_T0.6520.49
32_L53_A0.6520.49
295_N299_Q0.6510.49
256_A278_T0.6510.49
68_D288_Y0.6490.49
131_K136_D0.6480.49
154_T169_P0.6460.49
50_T311_L0.6460.49
20_M277_Y0.6440.49
30_V181_H0.6430.48
311_L314_K0.6420.48
67_A141_L0.6400.48
73_S114_S0.6390.48
101_P140_P0.6390.48
188_Y220_G0.6330.47
59_R67_A0.6330.47
211_Q265_V0.6320.47
95_D114_S0.6300.47
243_D247_G0.6290.47
9_T15_V0.6280.47
219_P263_G0.6250.47
215_T218_L0.6240.46
41_S107_W0.6240.46
77_C104_F0.6240.46
135_L138_V0.6230.46
49_Q73_S0.6210.46
9_T243_D0.6180.46
104_F143_W0.6170.46
234_L261_P0.6170.46
214_G229_V0.6160.46
14_H283_N0.6160.46
240_P243_D0.6120.45
127_I158_R0.6110.45
178_F182_V0.6060.45
46_R277_Y0.6060.45
115_L147_D0.6060.45
155_I314_K0.6040.44
228_F232_V0.6040.44
90_K124_S0.6020.44
113_Q230_R0.6000.44
52_Y303_L0.6000.44
233_Y266_I0.5990.44
248_V298_I0.5990.44
37_Y248_V0.5960.43
253_Q259_T0.5940.43
117_D120_E0.5930.43
81_Y140_P0.5900.43
188_Y219_P0.5900.43
211_Q267_T0.5900.43
302_N306_E0.5880.43
33_Y39_W0.5870.43
33_Y58_G0.5860.42
242_A246_K0.5840.42
97_V115_L0.5820.42
277_Y281_M0.5790.42
113_Q240_P0.5760.41
117_D245_T0.5750.41
19_T235_K0.5740.41
125_L236_E0.5740.41
83_P140_P0.5720.41
223_T260_I0.5690.41
23_A276_Q0.5680.41
25_Q28_T0.5680.41
46_R155_I0.5680.41
309_D313_P0.5660.40
172_M254_I0.5660.40
140_P276_Q0.5660.40
100_V127_I0.5640.40
185_L188_Y0.5640.40
253_Q293_Y0.5630.40
213_L216_V0.5630.40
185_L212_G0.5630.40
176_P220_G0.5630.40
123_R164_V0.5600.40
215_T272_I0.5580.40
17_A280_V0.5580.40
122_I247_G0.5570.39
312_E315_V0.5550.39
217_G223_T0.5550.39
35_R73_S0.5540.39
89_E107_W0.5510.39
2_C5_L0.5500.39
79_A139_L0.5500.39
35_R254_I0.5500.39
58_G233_Y0.5500.39
17_A213_L0.5490.39
11_D284_E0.5490.39
105_V175_S0.5480.39
127_I148_R0.5480.39
154_T167_N0.5450.38
185_L229_V0.5440.38
215_T222_Y0.5430.38
229_V312_E0.5430.38
215_T264_A0.5420.38
121_K126_T0.5420.38
181_H229_V0.5420.38
96_T111_V0.5410.38
83_P175_S0.5400.38
15_V251_A0.5390.38
57_M281_M0.5370.37
219_P229_V0.5360.37
104_F157_P0.5350.37
229_V246_K0.5340.37
120_E242_A0.5330.37
125_L230_R0.5330.37
53_A70_I0.5310.37
234_L256_A0.5300.37
289_Y295_N0.5270.36
96_T124_S0.5260.36
20_M128_V0.5260.36
65_L81_Y0.5240.36
53_A310_C0.5220.36
182_V286_G0.5210.36
45_G125_L0.5200.36
37_Y58_G0.5180.36
64_I103_E0.5180.36
4_S16_L0.5170.35
76_S105_V0.5170.35
11_D76_S0.5160.35
97_V126_T0.5160.35
48_H114_S0.5150.35
116_E242_A0.5140.35
71_N147_D0.5140.35
80_L258_M0.5130.35
170_G178_F0.5120.35
19_T255_L0.5120.35
4_S78_A0.5120.35
115_L149_T0.5120.35
22_F273_H0.5110.35
49_Q245_T0.5100.35
22_F77_C0.5100.35
10_A240_P0.5100.35
25_Q67_A0.5090.35
231_A252_F0.5080.35
48_H54_F0.5080.35
6_T146_S0.5060.34
107_W118_V0.5050.34
90_K149_T0.5050.34
29_E164_V0.5050.34
215_T266_I0.5030.34
59_R136_D0.5020.34
112_C117_D0.5010.34
181_H261_P0.5010.34
83_P101_P0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oqcA 3 0.9665 100 0.209 Contact Map
2bjfA 3 0.997 100 0.23 Contact Map
2quyA 4 0.997 100 0.242 Contact Map
2hf0A 4 0.9573 100 0.259 Contact Map
3hbcA 4 0.8902 100 0.317 Contact Map
2x1dA 1 0.7409 100 0.595 Contact Map
3gvzA 1 0.7409 100 0.622 Contact Map
3rmhA 2 0.1585 9 0.973 Contact Map
4rf6A 1 0.3445 5.4 0.975 Contact Map
1vq2A 3 0.1829 4.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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