GREMLIN Database
YXEH - Putative phosphatase YxeH
UniProt: P54947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (256)
Sequences: 10937 (8938)
Seq/√Len: 558.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_R261_H4.2121.00
16_D255_N3.4881.00
216_C230_A3.1001.00
253_S256_E2.8661.00
227_I233_G2.8101.00
21_T257_H2.7161.00
3_K213_E2.6701.00
23_E257_H2.5641.00
204_A214_V2.5371.00
15_N19_E2.4221.00
23_E264_H2.4011.00
7_I38_I2.3901.00
241_P245_E2.3811.00
228_E246_A2.3391.00
201_R229_W2.2971.00
42_T49_V2.2431.00
211_Q229_W2.1031.00
195_S225_T2.0011.00
83_S202_Q1.9591.00
221_G242_E1.8751.00
224_L243_V1.8721.00
22_E26_D1.8391.00
233_G248_N1.8251.00
30_A33_A1.8211.00
235_A247_A1.8051.00
28_L38_I1.7831.00
31_A36_V1.7681.00
224_L246_A1.7671.00
241_P244_L1.7461.00
25_R55_E1.7441.00
221_G240_I1.7441.00
252_R256_E1.7411.00
30_A264_H1.7211.00
210_E213_E1.7001.00
88_G91_D1.6981.00
4_L39_V1.6921.00
30_A34_E1.6921.00
75_N80_E1.6851.00
6_A200_V1.6521.00
201_R205_Q1.6431.00
232_C249_F1.6411.00
249_F266_L1.6251.00
232_C248_N1.6251.00
202_Q206_L1.6231.00
202_Q205_Q1.6221.00
234_V262_A1.6131.00
197_G229_W1.5651.00
198_N201_R1.5431.00
21_T24_V1.5341.00
85_L202_Q1.5281.00
243_V246_A1.5271.00
200_V226_M1.5221.00
9_M14_L1.5121.00
37_K207_L1.4861.00
7_I217_I1.4841.00
216_C226_M1.4661.00
100_L117_P1.4621.00
99_S155_F1.4571.00
249_F262_A1.4481.00
217_I259_V1.4451.00
212_A231_G1.4351.00
24_V257_H1.4311.00
166_I170_P1.4171.00
23_E261_H1.4131.00
26_D30_A1.3971.00
25_R29_H1.3801.00
94_S176_K1.3561.00
91_D176_K1.3281.00
235_A239_A1.3231.00
32_K59_I1.3191.00
217_I262_A1.3181.00
27_A260_A1.3161.00
6_A41_C1.3011.00
224_L228_E1.3001.00
227_I243_V1.2921.00
84_E149_L1.2911.00
211_Q214_V1.2891.00
237_A253_S1.2871.00
204_A211_Q1.2751.00
81_V84_E1.2681.00
140_K143_E1.2591.00
249_F265_E1.2581.00
91_D94_S1.2571.00
178_T225_T1.2541.00
89_Y93_T1.2531.00
262_A266_L1.2411.00
27_A264_H1.2361.00
242_E245_E1.2341.00
244_L250_Q1.2331.00
98_L102_L1.2311.00
85_L191_H1.2291.00
161_N164_R1.2271.00
91_D177_Y1.2001.00
102_L168_S1.1981.00
5_I263_I1.1941.00
84_E151_P1.1861.00
259_V263_I1.1711.00
29_H33_A1.1601.00
15_N255_N1.1601.00
4_L209_I1.1591.00
23_E27_A1.1531.00
214_V230_A1.1451.00
72_L81_V1.1441.00
215_M266_L1.1431.00
39_V64_Y1.1371.00
39_V203_L1.1311.00
64_Y207_L1.1301.00
5_I31_A1.1291.00
66_I199_A1.1201.00
216_C227_I1.1161.00
178_T193_E1.1131.00
163_S167_T1.1121.00
5_I36_V1.1041.00
251_T262_A1.0921.00
215_M232_C1.0911.00
260_A264_H1.0821.00
9_M52_Y1.0811.00
73_V202_Q1.0781.00
29_H32_K1.0751.00
4_L204_A1.0751.00
236_M258_G1.0681.00
211_Q231_G1.0651.00
238_N254_N1.0641.00
234_V251_T1.0631.00
152_K188_E1.0591.00
163_S181_R1.0561.00
240_I243_V1.0501.00
22_E25_R1.0461.00
157_D161_N1.0391.00
16_D254_N1.0381.00
176_K192_S1.0311.00
32_K63_D1.0301.00
180_V190_L1.0191.00
234_V249_F1.0181.00
230_A233_G1.0171.00
220_N240_I1.0091.00
200_V230_A1.0061.00
251_T258_G1.0041.00
98_L101_E0.9981.00
6_A214_V0.9981.00
195_S198_N0.9971.00
204_A229_W0.9951.00
13_L24_V0.9941.00
59_I63_D0.9911.00
261_H265_E0.9911.00
215_M234_V0.9901.00
262_A265_E0.9871.00
73_V83_S0.9861.00
215_M262_A0.9841.00
93_T97_D0.9761.00
50_Q79_N0.9661.00
164_R168_S0.9591.00
239_A244_L0.9571.00
197_G225_T0.9541.00
191_H194_A0.9521.00
13_L28_L0.9521.00
237_A244_L0.9491.00
201_R211_Q0.9441.00
71_A194_A0.9421.00
221_G224_L0.9401.00
85_L193_E0.9371.00
4_L214_V0.9361.00
97_D101_E0.9301.00
46_I67_A0.9291.00
164_R167_T0.9271.00
204_A209_I0.9251.00
167_T170_P0.9241.00
29_H57_N0.9231.00
203_L207_L0.9211.00
7_I259_V0.9171.00
261_H264_H0.9121.00
86_S149_L0.9121.00
36_V215_M0.9101.00
67_A72_L0.9101.00
235_A243_V0.9091.00
26_D29_H0.9081.00
237_A252_R0.9061.00
190_L195_S0.9021.00
236_M251_T0.8991.00
252_R258_G0.8981.00
73_V199_A0.8971.00
42_T67_A0.8951.00
94_S97_D0.8941.00
24_V260_A0.8781.00
84_E111_S0.8741.00
157_D162_L0.8731.00
242_E246_A0.8701.00
204_A231_G0.8621.00
6_A39_V0.8621.00
31_A38_I0.8581.00
214_V231_G0.8561.00
158_K161_N0.8531.00
121_I125_T0.8501.00
82_V206_L0.8501.00
90_D94_S0.8411.00
98_L173_V0.8401.00
50_Q54_D0.8391.00
37_K64_Y0.8361.00
74_Q81_V0.8331.00
87_L191_H0.8301.00
7_I13_L0.8281.00
46_I74_Q0.8241.00
41_C66_I0.8241.00
74_Q79_N0.8221.00
231_G248_N0.8201.00
5_I215_M0.8161.00
179_M189_I0.8151.00
66_I203_L0.8131.00
237_A256_E0.8101.00
67_A74_Q0.8071.00
64_Y203_L0.8051.00
27_A30_A0.8051.00
64_Y75_N0.7991.00
214_V229_W0.7981.00
227_I246_A0.7971.00
24_V27_A0.7941.00
252_R265_E0.7901.00
9_M40_L0.7871.00
166_I181_R0.7871.00
175_E192_S0.7871.00
13_L20_V0.7821.00
216_C233_G0.7821.00
86_S151_P0.7821.00
102_L164_R0.7781.00
31_A263_I0.7711.00
97_D142_D0.7671.00
163_S166_I0.7661.00
23_E260_A0.7621.00
94_S98_L0.7611.00
45_P68_Y0.7571.00
15_N21_T0.7551.00
159_P163_S0.7531.00
101_E168_S0.7511.00
178_T195_S0.7471.00
126_V129_S0.7461.00
98_L168_S0.7431.00
236_M239_A0.7351.00
49_V67_A0.7341.00
94_S173_V0.7331.00
198_N202_Q0.7331.00
17_H255_N0.7321.00
36_V213_E0.7321.00
96_Y100_L0.7301.00
200_V216_C0.7251.00
122_S125_T0.7241.00
239_A243_V0.7151.00
80_E206_L0.7041.00
138_F141_I0.7041.00
168_S171_K0.7021.00
89_Y149_L0.6971.00
40_L49_V0.6961.00
136_L139_R0.6961.00
201_R204_A0.6941.00
15_N254_N0.6941.00
213_E231_G0.6881.00
71_A191_H0.6881.00
23_E26_D0.6881.00
219_D239_A0.6881.00
194_A198_N0.6821.00
93_T142_D0.6821.00
121_I124_F0.6811.00
249_F261_H0.6781.00
178_T192_S0.6781.00
110_D150_I0.6771.00
13_L254_N0.6741.00
227_I247_A0.6731.00
69_N188_E0.6691.00
152_K182_S0.6691.00
9_M49_V0.6681.00
125_T129_S0.6671.00
219_D236_M0.6661.00
249_F252_R0.6641.00
96_Y108_F0.6631.00
139_R142_D0.6611.00
49_V65_V0.6581.00
46_I50_Q0.6551.00
11_G236_M0.6531.00
72_L151_P0.6511.00
41_C226_M0.6511.00
232_C262_A0.6511.00
154_M188_E0.6491.00
233_G243_V0.6491.00
233_G247_A0.6491.00
93_T146_K0.6461.00
90_D93_T0.6451.00
224_L227_I0.6451.00
257_H260_A0.6421.00
92_L150_I0.6391.00
93_T145_P0.6351.00
139_R143_E0.6331.00
217_I251_T0.6311.00
217_I234_V0.6251.00
111_S149_L0.6231.00
81_V111_S0.6221.00
221_G243_V0.6221.00
142_D145_P0.6211.00
65_V76_T0.6201.00
197_G201_R0.6191.00
4_L203_L0.6181.00
225_T228_E0.6121.00
32_K57_N0.6091.00
68_Y151_P0.6081.00
9_M13_L0.6071.00
103_K161_N0.6061.00
251_T261_H0.6041.00
53_L65_V0.6041.00
141_I144_V0.6031.00
135_P139_R0.6031.00
127_Y130_Y0.6021.00
238_N244_L0.6021.00
58_L63_D0.6011.00
110_D148_I0.6011.00
162_L181_R0.6001.00
113_N136_L0.5991.00
100_L106_M0.5971.00
236_M254_N0.5931.00
100_L142_D0.5891.00
72_L111_S0.5881.00
167_T171_K0.5881.00
193_E198_N0.5871.00
183_A220_N0.5861.00
40_L53_L0.5851.00
92_L96_Y0.5841.00
235_A246_A0.5811.00
173_V176_K0.5811.00
5_I217_I0.5791.00
75_N82_V0.5781.00
14_L254_N0.5770.99
238_N253_S0.5770.99
257_H261_H0.5760.99
154_M186_F0.5760.99
127_Y131_V0.5750.99
20_V25_R0.5720.99
159_P184_P0.5710.99
260_A263_I0.5710.99
13_L40_L0.5710.99
27_A31_A0.5700.99
75_N206_L0.5680.99
108_F150_I0.5660.99
73_V203_L0.5610.99
24_V28_L0.5600.99
179_M187_Y0.5600.99
178_T190_L0.5580.99
209_I231_G0.5570.99
21_T260_A0.5560.99
125_T128_E0.5560.99
37_K63_D0.5540.99
51_R54_D0.5520.99
243_V247_A0.5520.99
73_V206_L0.5500.99
28_L263_I0.5480.99
118_N139_R0.5470.99
16_D253_S0.5470.99
234_V248_N0.5430.99
107_H154_M0.5430.99
252_R262_A0.5400.99
170_P179_M0.5390.99
104_T165_V0.5380.99
49_V52_Y0.5380.99
143_E146_K0.5350.99
31_A260_A0.5330.99
157_D165_V0.5300.99
217_I263_I0.5280.99
97_D100_L0.5270.99
209_I214_V0.5180.99
68_Y186_F0.5170.99
197_G214_V0.5150.99
240_I244_L0.5130.99
50_Q53_L0.5130.99
160_E164_R0.5120.99
159_P181_R0.5100.99
41_C69_N0.5100.99
76_T79_N0.5090.99
15_N257_H0.5070.99
98_L169_I0.5050.99
162_L187_Y0.5040.99
200_V204_A0.5040.99
96_Y106_M0.5040.99
142_D146_K0.5040.99
6_A204_A0.5030.99
45_P48_G0.5020.99
209_I213_E0.5020.99
68_Y109_F0.5010.99
3_K36_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9519 100 0.211 Contact Map
1rkqA 1 0.9963 100 0.213 Contact Map
2b30A 2 0.9926 100 0.219 Contact Map
1nrwA 1 0.963 100 0.224 Contact Map
3l7yA 1 0.9667 100 0.227 Contact Map
1nf2A 4 0.9778 100 0.235 Contact Map
3daoA 1 0.9667 100 0.24 Contact Map
2rbkA 1 0.963 100 0.241 Contact Map
3mpoA 1 0.9889 100 0.242 Contact Map
4qjbA 1 0.9741 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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