GREMLIN Database
YXEB - Iron(3+)-hydroxamate-binding protein YxeB
UniProt: P54941 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (281)
Sequences: 13463 (10698)
Seq/√Len: 638.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_S161_K4.1171.00
247_A278_D4.0501.00
151_G160_A3.9311.00
144_E168_N3.8211.00
156_A159_Q3.3751.00
170_K306_D3.1801.00
152_D157_K3.1521.00
278_D282_H3.1101.00
44_K49_N3.0591.00
61_T65_A2.8731.00
159_Q162_S2.6661.00
42_T49_N2.6521.00
172_E176_K2.6451.00
148_S164_M2.6341.00
161_K165_A2.5631.00
165_A169_K2.5091.00
106_K109_E2.4851.00
214_Y219_L2.4771.00
242_V245_E2.3511.00
45_S50_V2.1921.00
60_V107_V2.1441.00
170_K302_S2.1041.00
168_N172_E2.0901.00
59_I154_A2.0531.00
187_T220_K2.0501.00
68_L154_A2.0371.00
269_E283_N2.0151.00
169_K173_A2.0101.00
58_R76_V1.9871.00
211_Q215_N1.9861.00
173_A177_K1.9511.00
249_D278_D1.9451.00
67_E147_V1.9151.00
73_A154_A1.8601.00
162_S166_D1.8541.00
125_K128_K1.8431.00
266_D270_N1.8351.00
42_T51_N1.8111.00
123_V127_K1.7771.00
40_M51_N1.7581.00
73_A156_A1.7571.00
142_N145_D1.7541.00
250_Y286_F1.7441.00
116_V150_F1.7421.00
250_Y284_R1.7351.00
277_L280_V1.7301.00
265_L269_E1.6961.00
158_D162_S1.6861.00
172_E175_K1.6681.00
278_D281_K1.6561.00
102_I107_V1.6011.00
145_D148_S1.5851.00
96_K106_K1.5851.00
276_N281_K1.5821.00
306_D310_D1.5411.00
77_G110_L1.5381.00
41_R152_D1.5371.00
60_V110_L1.5281.00
262_S266_D1.5121.00
124_D128_K1.4671.00
166_D170_K1.4611.00
108_M129_I1.4561.00
176_K179_A1.4341.00
240_Q271_S1.4321.00
274_W280_V1.4301.00
251_M279_A1.4291.00
145_D149_M1.4271.00
159_Q163_F1.4151.00
105_E241_E1.4151.00
266_D269_E1.4081.00
186_A250_Y1.4081.00
188_F219_L1.4001.00
120_E124_D1.3991.00
103_S106_K1.3871.00
174_A305_V1.3671.00
76_V110_L1.3601.00
174_A309_T1.3551.00
60_V77_G1.3411.00
144_E164_M1.3261.00
169_K172_E1.3071.00
45_S48_G1.3061.00
165_A168_N1.3021.00
61_T68_L1.2941.00
71_V156_A1.2911.00
117_V134_V1.2851.00
198_E237_Q1.2791.00
79_G82_S1.2781.00
157_K161_K1.2701.00
158_D161_K1.2691.00
133_V153_I1.2661.00
68_L73_A1.2481.00
307_I310_D1.2481.00
124_D127_K1.2421.00
14_L17_F1.2361.00
173_A176_K1.2291.00
170_K173_A1.2171.00
52_I55_H1.2141.00
263_K266_D1.1961.00
149_M152_D1.1941.00
187_T249_D1.1941.00
13_L16_M1.1901.00
148_S168_N1.1861.00
286_F311_M1.1861.00
57_K113_D1.1841.00
147_V160_A1.1791.00
163_F166_D1.1781.00
96_K99_G1.1751.00
58_R111_Q1.1711.00
189_G192_E1.1671.00
242_V246_Y1.1641.00
204_D215_N1.1611.00
166_D169_K1.1581.00
104_V125_K1.1501.00
86_P89_K1.1481.00
164_M168_N1.1271.00
133_V149_M1.1231.00
56_P113_D1.1181.00
45_S123_V1.1071.00
175_K216_A1.0951.00
177_K309_T1.0901.00
70_S163_F1.0861.00
59_I114_L1.0771.00
40_M54_A1.0751.00
222_P246_Y1.0661.00
114_L133_V1.0621.00
122_N125_K1.0581.00
69_L92_L1.0481.00
178_I181_V1.0431.00
223_E246_Y1.0401.00
190_I214_Y1.0341.00
115_I130_A1.0281.00
274_W277_L1.0211.00
90_S93_K1.0011.00
40_M55_H1.0011.00
220_K224_K0.9991.00
189_G201_V0.9961.00
186_A284_R0.9911.00
57_K74_N0.9901.00
189_G248_A0.9881.00
183_D186_A0.9871.00
175_K179_A0.9841.00
148_S152_D0.9821.00
171_A305_V0.9691.00
250_Y312_L0.9661.00
222_P225_I0.9591.00
280_V285_V0.9591.00
47_K127_K0.9561.00
272_S275_K0.9441.00
278_D284_R0.9431.00
219_L312_L0.9401.00
75_V95_V0.9371.00
11_L15_L0.9361.00
39_E54_A0.9341.00
252_F308_I0.9321.00
149_M153_I0.9321.00
188_F214_Y0.9311.00
52_I131_P0.9261.00
151_G164_M0.9251.00
171_A175_K0.9241.00
47_K134_V0.9231.00
135_I149_M0.9231.00
253_I287_I0.9171.00
212_A215_N0.9141.00
78_S95_V0.9141.00
59_I68_L0.9131.00
160_A164_M0.9061.00
305_V309_T0.9051.00
263_K267_K0.9031.00
170_K174_A0.9021.00
68_L75_V0.9001.00
223_E242_V0.8971.00
80_S97_D0.8961.00
167_F216_A0.8961.00
15_L18_V0.8931.00
269_E285_V0.8891.00
39_E155_G0.8821.00
150_F154_A0.8711.00
55_H156_A0.8701.00
52_I56_P0.8691.00
206_G211_Q0.8681.00
40_M53_P0.8671.00
68_L116_V0.8651.00
202_F206_G0.8581.00
225_I246_Y0.8551.00
54_A57_K0.8511.00
243_I277_L0.8441.00
67_E150_F0.8391.00
267_K270_N0.8391.00
69_L75_V0.8381.00
16_M19_S0.8351.00
45_S49_N0.8341.00
161_K164_M0.8341.00
112_P115_I0.8291.00
116_V153_I0.8281.00
289_D292_S0.8261.00
305_V310_D0.8241.00
89_K92_L0.8231.00
275_K280_V0.8211.00
56_P114_L0.8201.00
69_L91_K0.8181.00
244_P277_L0.8131.00
306_D309_T0.8131.00
55_H155_G0.8121.00
43_Y133_V0.8111.00
167_F171_A0.8101.00
66_G297_D0.8091.00
189_G193_N0.8081.00
78_S97_D0.8081.00
150_F153_I0.8041.00
71_V163_F0.8031.00
183_D220_K0.8021.00
74_N156_A0.8001.00
71_V154_A0.7971.00
289_D307_I0.7961.00
14_L18_V0.7941.00
115_I129_I0.7931.00
212_A216_A0.7921.00
41_R52_I0.7921.00
302_S306_D0.7911.00
39_E55_H0.7911.00
21_C24_T0.7881.00
162_S165_A0.7881.00
265_L287_I0.7861.00
114_L153_I0.7851.00
12_V16_M0.7801.00
264_T267_K0.7781.00
64_Y116_V0.7731.00
70_S147_V0.7711.00
86_P90_S0.7701.00
248_A251_M0.7681.00
190_I254_T0.7611.00
148_S151_G0.7501.00
177_K180_G0.7491.00
221_A225_I0.7441.00
77_G99_G0.7431.00
307_I311_M0.7421.00
71_V159_Q0.7411.00
201_V223_E0.7391.00
127_K132_T0.7381.00
252_F286_F0.7361.00
9_G13_L0.7341.00
71_V151_G0.7311.00
146_T149_M0.7281.00
19_S22_S0.7241.00
256_Y290_F0.7201.00
244_P276_N0.7181.00
147_V163_F0.7171.00
144_E148_S0.7121.00
202_F235_M0.7121.00
171_A216_A0.7101.00
191_Y251_M0.7091.00
186_A219_L0.7081.00
262_S265_L0.7061.00
163_F167_F0.7061.00
10_M14_L0.7051.00
178_I309_T0.7021.00
144_E171_A0.7011.00
271_S275_K0.7011.00
189_G243_I0.7011.00
191_Y194_T0.7011.00
98_V110_L0.6971.00
213_V305_V0.6961.00
61_T75_V0.6951.00
66_G299_I0.6941.00
11_L17_F0.6941.00
119_N136_P0.6881.00
92_L95_V0.6881.00
299_I302_S0.6821.00
253_I285_V0.6821.00
60_V112_P0.6821.00
10_M13_L0.6801.00
297_D300_S0.6801.00
190_I210_G0.6801.00
17_F20_A0.6771.00
309_T312_L0.6741.00
175_K217_L0.6731.00
107_V126_L0.6681.00
15_L19_S0.6681.00
304_Q308_I0.6671.00
11_L14_L0.6651.00
121_E124_D0.6631.00
304_Q307_I0.6581.00
238_L246_Y0.6551.00
72_G156_A0.6551.00
12_V15_L0.6551.00
91_K94_N0.6521.00
123_V134_V0.6511.00
188_F252_F0.6501.00
88_L92_L0.6501.00
174_A178_I0.6471.00
104_V122_N0.6461.00
298_P302_S0.6461.00
70_S299_I0.6441.00
170_K309_T0.6441.00
148_S157_K0.6431.00
295_P300_S0.6421.00
105_E108_M0.6421.00
43_Y52_I0.6411.00
58_R113_D0.6401.00
72_G159_Q0.6381.00
104_V129_I0.6381.00
247_A251_M0.6371.00
46_P149_M0.6351.00
200_W237_Q0.6311.00
244_P248_A0.6301.00
20_A24_T0.6281.00
71_V147_V0.6271.00
143_V167_F0.6261.00
52_I114_L0.6261.00
64_Y150_F0.6251.00
264_T268_L0.6241.00
75_V78_S0.6241.00
96_K110_L0.6221.00
120_E123_V0.6161.00
250_Y254_T0.6161.00
88_L91_K0.6161.00
174_A177_K0.6141.00
18_V21_C0.6101.00
39_E53_P0.6091.00
308_I312_L0.6071.00
255_D287_I0.6061.00
191_Y271_S0.6061.00
21_C25_A0.6051.00
52_I153_I0.6001.00
154_A157_K0.6001.00
240_Q274_W0.5981.00
50_V133_V0.5961.00
251_M274_W0.5961.00
61_T64_Y0.5951.00
65_A78_S0.5941.00
239_S242_V0.5941.00
41_R54_A0.5911.00
10_M17_F0.5911.00
188_F191_Y0.5851.00
55_H113_D0.5851.00
274_W285_V0.5841.00
104_V107_V0.5821.00
296_Y304_Q0.5811.00
167_F170_K0.5791.00
304_Q310_D0.5781.00
71_V150_F0.5761.00
87_F90_S0.5751.00
167_F301_V0.5731.00
135_I139_T0.5721.00
166_D302_S0.5681.00
204_D224_K0.5671.00
131_P134_V0.5671.00
144_E167_F0.5661.00
105_E239_S0.5641.00
164_M167_F0.5641.00
12_V17_F0.5631.00
211_Q221_A0.5611.00
254_T288_N0.5601.00
56_P154_A0.5601.00
135_I150_F0.5601.00
292_S307_I0.5591.00
71_V160_A0.5591.00
192_E196_K0.5581.00
62_D118_M0.5571.00
95_V99_G0.5561.00
102_I122_N0.5561.00
231_K236_K0.5521.00
53_P131_P0.5501.00
60_V76_V0.5491.00
20_A23_G0.5481.00
214_Y217_L0.5461.00
176_K180_G0.5451.00
106_K110_L0.5441.00
188_F192_E0.5441.00
68_L150_F0.5441.00
37_K40_M0.5401.00
217_L305_V0.5401.00
238_L243_I0.5370.99
60_V115_I0.5360.99
93_K96_K0.5350.99
36_E39_E0.5340.99
147_V164_M0.5330.99
268_L271_S0.5320.99
115_I126_L0.5310.99
168_N171_A0.5300.99
173_A306_D0.5300.99
191_Y201_V0.5290.99
264_T269_E0.5290.99
271_S274_W0.5290.99
143_V147_V0.5290.99
50_V131_P0.5290.99
69_L95_V0.5290.99
223_E238_L0.5270.99
58_R110_L0.5260.99
189_G222_P0.5260.99
186_A249_D0.5250.99
47_K123_V0.5250.99
64_Y135_I0.5250.99
75_V79_G0.5240.99
221_A224_K0.5240.99
13_L17_F0.5220.99
244_P273_I0.5200.99
41_R55_H0.5200.99
87_F91_K0.5190.99
77_G98_V0.5190.99
108_M241_E0.5180.99
293_F304_Q0.5180.99
144_E216_A0.5170.99
174_A217_L0.5160.99
187_T222_P0.5160.99
171_A174_A0.5150.99
277_L281_K0.5150.99
56_P59_I0.5150.99
148_S160_A0.5140.99
47_K120_E0.5120.99
301_V304_Q0.5120.99
121_E125_K0.5110.99
67_E298_P0.5090.99
67_E70_S0.5070.99
115_I132_T0.5060.99
247_A277_L0.5040.99
217_L309_T0.5030.99
65_A82_S0.5020.99
137_Y146_T0.5020.99
206_G235_M0.5020.99
219_L250_Y0.5010.99
99_G102_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.8505 100 0.245 Contact Map
4mlzA 1 0.8411 100 0.267 Contact Map
4hn9A 1 0.866 100 0.293 Contact Map
4mo9A 1 0.8442 100 0.298 Contact Map
4ovkA 1 0.8474 100 0.3 Contact Map
3tlkA 1 0.8411 100 0.306 Contact Map
3lhsA 1 0.8567 100 0.309 Contact Map
4ljsA 1 0.8785 100 0.319 Contact Map
3tnyA 1 0.8287 100 0.322 Contact Map
4pagA 2 0.838 100 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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