GREMLIN Database
YXEA - Uncharacterized protein YxeA
UniProt: P54940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 115 (108)
Sequences: 316 (244)
Seq/√Len: 23.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_M110_V4.1561.00
62_G88_V3.2761.00
106_M111_Q2.7720.99
42_V62_G2.6460.99
29_D92_G2.5900.99
64_N68_K2.3980.98
60_L74_F2.3130.97
37_Q91_K2.2370.97
85_Y101_V2.1370.96
55_G77_G2.0300.94
48_G79_E1.9510.93
40_V70_E1.8680.91
87_K99_E1.8140.90
61_D69_K1.7640.89
47_D82_K1.7370.88
38_Q64_N1.7360.88
39_D87_K1.7340.88
72_V95_V1.6710.86
81_R84_A1.6040.84
57_E88_V1.5920.83
60_L95_V1.5590.82
88_V95_V1.5330.81
59_T71_E1.5190.80
62_G90_A1.4790.78
44_I74_F1.4620.77
42_V99_E1.4440.76
59_T73_T1.4060.74
37_Q89_K1.4020.74
40_V72_V1.3910.74
44_I84_A1.3740.73
3_K6_A1.3590.72
36_H96_E1.3390.71
68_K73_T1.2850.67
81_R100_E1.2820.67
44_I60_L1.2790.67
48_G93_K1.2620.66
29_D96_E1.2490.65
89_K96_E1.2100.63
6_A20_L1.2020.62
43_Q60_L1.1980.62
19_G87_K1.1830.61
27_V37_Q1.1790.61
12_A113_K1.1750.60
30_R92_G1.1700.60
72_V90_A1.1290.57
42_V98_W1.0980.55
40_V90_A1.0900.55
42_V88_V1.0880.54
59_T82_K1.0760.54
48_G84_A1.0670.53
55_G75_F1.0670.53
50_H85_Y1.0610.52
74_F98_W1.0570.52
37_Q96_E1.0340.51
52_S71_E1.0330.51
53_P64_N1.0290.50
50_H98_W1.0170.49
39_D89_K1.0170.49
44_I48_G1.0010.48
76_A81_R1.0010.48
8_L45_D0.9980.48
5_M108_D0.9810.47
43_Q83_N0.9520.45
101_V114_L0.9380.44
42_V60_L0.9330.44
52_S72_V0.9270.43
40_V94_Y0.9140.42
7_I110_V0.9130.42
11_L112_S0.9080.42
57_E73_T0.9030.41
74_F80_L0.8720.39
31_F94_Y0.8690.39
47_D79_E0.8630.39
18_C88_V0.8630.39
94_Y98_W0.8510.38
29_D90_A0.8440.38
28_T64_N0.8410.37
61_D66_S0.8240.36
85_Y106_M0.8230.36
79_E82_K0.8150.36
13_A88_V0.8030.35
7_I10_V0.8020.35
18_C21_L0.8010.35
61_D98_W0.7930.34
29_D94_Y0.7910.34
36_H94_Y0.7900.34
54_G104_E0.7670.33
42_V110_V0.7630.32
72_V88_V0.7550.32
18_C69_K0.7530.32
49_R88_V0.7530.32
58_Y74_F0.7420.31
13_A57_E0.7360.31
27_V99_E0.7290.30
60_L106_M0.7260.30
11_L109_S0.7100.29
6_A114_L0.7070.29
3_K14_A0.6920.28
10_V24_H0.6900.28
69_K73_T0.6900.28
43_Q102_K0.6760.27
45_D108_D0.6740.27
57_E75_F0.6700.27
6_A14_A0.6690.27
9_A13_A0.6560.26
23_F29_D0.6550.26
20_L101_V0.6550.26
9_A64_N0.6490.26
84_A96_E0.6430.25
12_A63_Y0.6320.25
91_K98_W0.6320.25
84_A100_E0.6310.25
25_N28_T0.6300.25
7_I37_Q0.6290.25
3_K48_G0.6260.25
21_L25_N0.6210.24
8_L14_A0.6150.24
95_V103_F0.6150.24
36_H84_A0.6130.24
9_A85_Y0.6130.24
84_A101_V0.6130.24
45_D98_W0.6110.24
4_A10_V0.6080.24
22_F59_T0.6080.24
5_M104_E0.6060.24
68_K112_S0.6030.23
7_I111_Q0.6010.23
102_K105_D0.6000.23
45_D48_G0.5960.23
38_Q56_T0.5940.23
44_I81_R0.5940.23
103_F111_Q0.5870.23
29_D93_K0.5870.23
75_F83_N0.5850.22
47_D62_G0.5800.22
37_Q97_T0.5800.22
11_L14_A0.5800.22
12_A23_F0.5770.22
17_I49_R0.5730.22
6_A108_D0.5730.22
44_I94_Y0.5720.22
44_I70_E0.5590.21
21_L87_K0.5580.21
90_A94_Y0.5550.21
19_G24_H0.5550.21
44_I110_V0.5490.21
76_A95_V0.5420.20
10_V28_T0.5410.20
56_T93_K0.5370.20
39_D104_E0.5330.20
43_Q95_V0.5330.20
103_F112_S0.5260.20
41_Y58_Y0.5250.20
36_H91_K0.5190.19
13_A78_K0.5180.19
42_V100_E0.5160.19
87_K109_S0.5100.19
30_R106_M0.5100.19
70_E94_Y0.5090.19
41_Y44_I0.5070.19
104_E109_S0.5050.19
18_C26_D0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nppA 4 0.7565 100 0.318 Contact Map
2k5qA 1 0.7478 99.9 0.391 Contact Map
2k5wA 1 0.7739 99.9 0.394 Contact Map
4qflA 1 0.7391 46.2 0.909 Contact Map
3j46n 1 0.6696 30.2 0.918 Contact Map
2mmpA 1 0.5478 18.6 0.925 Contact Map
4ff5A 1 0.5913 17.7 0.926 Contact Map
2j5lA 1 0 10.5 0.933 Contact Map
4pj0U 1 0.513 10.5 0.933 Contact Map
3vmtA 1 0.4696 10.1 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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