GREMLIN Database
YFIH - Uncharacterized protein YfiH
UniProt: P54724 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (251)
Sequences: 11708 (8220)
Seq/√Len: 518.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_W271_E3.1491.00
20_N65_R3.0071.00
195_G222_H2.9961.00
59_S63_E2.9571.00
93_D158_K2.9541.00
97_E162_C2.8281.00
97_E158_K2.5881.00
60_Q64_K2.4371.00
29_T284_E2.4351.00
215_R275_V2.4191.00
16_E61_A2.3231.00
228_D261_G2.3101.00
148_A189_A2.2751.00
14_P17_D2.2641.00
184_F216_E2.2601.00
168_A222_H2.2201.00
304_V308_K2.1921.00
185_R189_A2.1711.00
100_G162_C2.1631.00
166_K195_G2.1421.00
166_K222_H2.0941.00
301_R305_E1.9971.00
20_N24_K1.9881.00
61_A65_R1.9251.00
209_D212_I1.9151.00
96_M162_C1.8741.00
56_K101_L1.8131.00
62_L69_L1.8061.00
61_A64_K1.7881.00
106_K168_A1.7551.00
275_V278_M1.7511.00
215_R278_M1.7451.00
157_K192_P1.7381.00
54_K57_E1.7371.00
55_R101_L1.7261.00
144_W185_R1.7141.00
156_V194_V1.6581.00
52_S101_L1.6551.00
224_V276_V1.6461.00
270_K274_S1.6331.00
168_A197_N1.6281.00
96_M159_A1.6281.00
86_K90_D1.6201.00
158_K162_C1.6021.00
158_K161_A1.6021.00
160_E192_P1.5701.00
160_E193_M1.5631.00
262_C302_T1.5601.00
184_F188_N1.5411.00
99_A104_V1.5171.00
90_D93_D1.5091.00
157_K161_A1.5051.00
90_D94_K1.5021.00
200_P272_F1.4941.00
142_Y145_E1.4911.00
16_E64_K1.4901.00
84_L87_S1.4821.00
94_K97_E1.4811.00
93_D154_K1.4731.00
145_E189_A1.4581.00
150_P153_K1.4511.00
96_M158_K1.4461.00
148_A153_K1.4411.00
57_E60_Q1.4381.00
89_R154_K1.4381.00
145_E150_P1.4371.00
274_S278_M1.4281.00
23_A65_R1.4081.00
19_L65_R1.3991.00
17_D20_N1.3901.00
21_F297_E1.3741.00
228_D263_G1.3651.00
25_L304_V1.3641.00
218_G279_M1.3331.00
85_G151_Y1.3331.00
179_N182_T1.3231.00
19_L62_L1.3161.00
212_I216_E1.3151.00
275_V279_M1.3101.00
60_Q63_E1.3081.00
89_R93_D1.3071.00
183_L196_L1.3031.00
153_K190_V1.2971.00
211_I271_E1.2871.00
144_W189_A1.2711.00
139_I142_Y1.2441.00
163_G193_M1.2371.00
298_A302_T1.2361.00
27_I287_L1.2361.00
86_K154_K1.2351.00
106_K166_K1.2301.00
21_F24_K1.2271.00
57_E61_A1.2221.00
195_G220_A1.2191.00
156_V190_V1.2171.00
259_A262_C1.2171.00
23_A66_N1.2161.00
92_T155_L1.2161.00
154_K157_K1.2121.00
146_D150_P1.2071.00
93_D161_A1.2051.00
20_N61_A1.1871.00
148_A190_V1.1811.00
93_D97_E1.1711.00
56_K60_Q1.1521.00
184_F217_L1.1501.00
215_R279_M1.1501.00
16_E57_E1.1461.00
29_T70_C1.1421.00
29_T68_T1.1311.00
27_I304_V1.1271.00
4_S286_S1.1231.00
178_Y182_T1.1091.00
214_A275_V1.1071.00
21_F25_L1.1071.00
87_S90_D1.1001.00
55_R98_L1.0961.00
157_K160_E1.0711.00
93_D162_C1.0661.00
105_K166_K1.0661.00
180_P216_E1.0631.00
196_L217_L1.0611.00
291_D295_S1.0461.00
181_E216_E1.0431.00
5_Y22_A1.0381.00
291_D294_M1.0341.00
267_Q272_F1.0311.00
271_E275_V1.0311.00
297_E301_R1.0301.00
97_E100_G1.0271.00
96_M164_V1.0261.00
140_L143_Q1.0171.00
59_S101_L1.0131.00
188_N220_A1.0121.00
156_V193_M1.0101.00
295_S298_A1.0081.00
198_L203_L1.0011.00
171_N203_L0.9971.00
302_T305_E0.9931.00
97_E101_L0.9921.00
141_N145_E0.9901.00
211_I215_R0.9891.00
62_L67_M0.9781.00
190_V194_V0.9761.00
156_V192_P0.9731.00
276_V279_M0.9711.00
226_G285_V0.9701.00
24_K297_E0.9641.00
141_N185_R0.9631.00
159_A167_I0.9621.00
16_E20_N0.9601.00
144_W182_T0.9561.00
153_K191_G0.9561.00
19_L61_A0.9431.00
80_D84_L0.9351.00
31_E223_H0.9341.00
199_D288_E0.9271.00
153_K157_K0.9251.00
142_Y146_D0.9241.00
31_E71_A0.9231.00
227_K290_E0.9231.00
185_R188_N0.9211.00
99_A107_V0.9151.00
13_L21_F0.9061.00
22_A30_L0.9041.00
230_R258_V0.8951.00
230_R264_Q0.8801.00
302_T306_A0.8781.00
226_G269_W0.8751.00
150_P154_K0.8721.00
72_L99_A0.8631.00
52_S56_K0.8611.00
298_A301_R0.8611.00
28_D308_K0.8571.00
100_G164_V0.8561.00
211_I275_V0.8541.00
214_A279_M0.8521.00
55_R59_S0.8451.00
108_I197_N0.8441.00
20_N64_K0.8401.00
170_E288_E0.8391.00
51_S54_K0.8381.00
166_K193_M0.8341.00
212_I215_R0.8341.00
214_A218_G0.8341.00
106_K222_H0.8281.00
153_K189_A0.8251.00
53_E57_E0.8231.00
16_E65_R0.8221.00
152_W194_V0.8221.00
55_R102_L0.8201.00
260_V303_S0.8181.00
184_F220_A0.8131.00
271_E274_S0.8131.00
70_C284_E0.8081.00
62_L65_R0.8071.00
152_W186_L0.8051.00
27_I300_I0.8031.00
69_L104_V0.8021.00
213_A217_L0.7961.00
144_W148_A0.7941.00
201_S229_V0.7931.00
273_F277_K0.7921.00
201_S227_K0.7891.00
4_S29_T0.7881.00
214_A221_I0.7881.00
273_F285_V0.7851.00
143_Q146_D0.7811.00
155_L167_I0.7791.00
28_D68_T0.7781.00
98_L102_L0.7711.00
23_A28_D0.7701.00
187_R220_A0.7691.00
32_M69_L0.7641.00
187_R196_L0.7631.00
85_G150_P0.7621.00
202_H227_K0.7621.00
19_L30_L0.7571.00
305_E308_K0.7561.00
18_M22_A0.7521.00
299_G302_T0.7471.00
231_I264_Q0.7471.00
170_E225_H0.7461.00
269_W273_F0.7451.00
73_N110_M0.7451.00
68_T284_E0.7411.00
109_M112_G0.7401.00
159_A164_V0.7391.00
56_K59_S0.7331.00
198_L214_A0.7321.00
182_T185_R0.7301.00
83_E86_K0.7291.00
180_P208_A0.7281.00
68_T105_K0.7281.00
17_D21_F0.7241.00
292_L296_P0.7231.00
59_S103_G0.7221.00
214_A272_F0.7211.00
223_H286_S0.7201.00
112_G115_A0.7121.00
22_A27_I0.7111.00
91_I94_K0.7091.00
218_G221_I0.7091.00
153_K192_P0.7031.00
31_E286_S0.6991.00
200_P269_W0.6921.00
177_V183_L0.6911.00
204_L264_Q0.6891.00
226_G273_F0.6881.00
197_N223_H0.6851.00
13_L17_D0.6851.00
224_V285_V0.6821.00
226_G307_L0.6791.00
214_A276_V0.6771.00
230_R256_N0.6761.00
280_G283_G0.6741.00
77_N80_D0.6721.00
75_S95_T0.6681.00
177_V186_L0.6681.00
180_P212_I0.6661.00
157_K193_M0.6651.00
227_K257_Y0.6651.00
106_K223_H0.6641.00
219_S279_M0.6611.00
108_I172_F0.6611.00
5_Y300_I0.6581.00
105_K163_G0.6561.00
97_E161_A0.6541.00
82_G86_K0.6501.00
100_G163_G0.6491.00
291_D296_P0.6481.00
94_K98_L0.6471.00
62_L66_N0.6441.00
204_L267_Q0.6441.00
223_H281_Y0.6421.00
183_L187_R0.6421.00
89_R155_L0.6411.00
83_E87_S0.6371.00
184_F187_R0.6361.00
25_L301_R0.6351.00
110_M113_L0.6331.00
218_G275_V0.6321.00
85_G146_D0.6311.00
89_R151_Y0.6291.00
44_N47_E0.6271.00
156_V160_E0.6241.00
20_N23_A0.6221.00
171_N183_L0.6211.00
72_L104_V0.6211.00
4_S70_C0.6201.00
8_D11_G0.6201.00
170_E202_H0.6151.00
19_L23_A0.6141.00
214_A217_L0.6101.00
217_L221_I0.6081.00
299_G303_S0.6061.00
52_S55_R0.6051.00
52_S102_L0.6041.00
198_L213_A0.6001.00
151_Y154_K0.5970.99
19_L67_M0.5970.99
181_E185_R0.5960.99
276_V281_Y0.5950.99
154_K158_K0.5920.99
221_I224_V0.5920.99
95_T107_V0.5900.99
144_W186_L0.5880.99
224_V281_Y0.5870.99
224_V272_F0.5840.99
180_P184_F0.5790.99
199_D227_K0.5790.99
23_A67_M0.5790.99
15_F61_A0.5780.99
204_L210_P0.5760.99
46_D94_K0.5730.99
172_F227_K0.5710.99
200_P226_G0.5700.99
292_L295_S0.5700.99
168_A195_G0.5660.99
109_M167_I0.5660.99
69_L102_L0.5650.99
191_G220_A0.5640.99
10_L21_F0.5630.99
108_I168_A0.5630.99
260_V306_A0.5620.99
44_N48_L0.5610.99
71_A108_I0.5600.99
287_L303_S0.5570.99
6_V9_S0.5560.99
85_G89_R0.5550.99
109_M115_A0.5550.99
15_F19_L0.5540.99
22_A67_M0.5480.99
85_G88_H0.5470.99
203_L213_A0.5470.99
214_A224_V0.5470.99
171_N177_V0.5460.99
187_R191_G0.5450.99
215_R271_E0.5440.99
172_F290_E0.5430.99
30_L67_M0.5420.99
180_P217_L0.5380.99
19_L58_F0.5370.99
207_G210_P0.5360.99
259_A299_G0.5340.99
147_V186_L0.5330.99
107_V164_V0.5330.99
85_G154_K0.5320.99
7_T30_L0.5320.99
24_K301_R0.5300.99
6_V11_G0.5300.99
88_H91_I0.5290.99
188_N191_G0.5270.99
87_S91_I0.5260.99
262_C306_A0.5260.99
146_D151_Y0.5260.99
70_C286_S0.5240.99
108_I223_H0.5240.99
301_R304_V0.5230.99
89_R92_T0.5220.99
76_G88_H0.5220.99
304_V307_L0.5210.99
287_L307_L0.5190.99
200_P224_V0.5190.99
73_N108_I0.5160.99
4_S284_E0.5160.99
107_V159_A0.5150.98
63_E101_L0.5150.98
277_K280_G0.5140.98
303_S307_L0.5100.98
303_S306_A0.5070.98
99_A164_V0.5070.98
58_F61_A0.5060.98
78_P151_Y0.5060.98
223_H284_E0.5050.98
59_S102_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zdsA 5 0.9361 100 0.249 Contact Map
1i60A 1 0.8498 100 0.271 Contact Map
3dx5A 2 0.8658 100 0.282 Contact Map
3u0hA 3 0.8403 100 0.283 Contact Map
3cqjA 2 0.8435 100 0.286 Contact Map
3qc0A 2 0.8211 100 0.291 Contact Map
4ovxA 1 0.8019 100 0.294 Contact Map
3cnyA 1 0.8914 100 0.294 Contact Map
3wqoA 2 0.8115 100 0.303 Contact Map
3kwsA 2 0.8115 100 0.305 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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