YFIH - BACSU - GREMLIN Contacts

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YFIH - Uncharacterized protein YfiH

UniProt:	P54724	Sequences: MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLNLDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLLGVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAEACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELGSAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVVKMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	313 (251)
Sequences:	11708 (8220)
Seq/√Len:	518.8

ECOLI - FRLC SGBU ULAE YCJR HYI YGBM YIHM
BACSU - YFIH IOLI IOLH IOLE
SULSO - Q97UI8 Q97UG9 Q97UI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
268_W	271_E	3.149	1.00
20_N	65_R	3.007	1.00
195_G	222_H	2.996	1.00
59_S	63_E	2.957	1.00
93_D	158_K	2.954	1.00
97_E	162_C	2.828	1.00
97_E	158_K	2.588	1.00
60_Q	64_K	2.437	1.00
29_T	284_E	2.435	1.00
215_R	275_V	2.419	1.00
16_E	61_A	2.323	1.00
228_D	261_G	2.310	1.00
148_A	189_A	2.275	1.00
14_P	17_D	2.264	1.00
184_F	216_E	2.260	1.00
168_A	222_H	2.220	1.00
304_V	308_K	2.192	1.00
185_R	189_A	2.171	1.00
100_G	162_C	2.163	1.00
166_K	195_G	2.142	1.00
166_K	222_H	2.094	1.00
301_R	305_E	1.997	1.00
20_N	24_K	1.988	1.00
61_A	65_R	1.925	1.00
209_D	212_I	1.915	1.00
96_M	162_C	1.874	1.00
56_K	101_L	1.813	1.00
62_L	69_L	1.806	1.00
61_A	64_K	1.788	1.00
106_K	168_A	1.755	1.00
275_V	278_M	1.751	1.00
215_R	278_M	1.745	1.00
157_K	192_P	1.738	1.00
54_K	57_E	1.737	1.00
55_R	101_L	1.726	1.00
144_W	185_R	1.714	1.00
156_V	194_V	1.658	1.00
52_S	101_L	1.655	1.00
224_V	276_V	1.646	1.00
270_K	274_S	1.633	1.00
168_A	197_N	1.628	1.00
96_M	159_A	1.628	1.00
86_K	90_D	1.620	1.00
158_K	162_C	1.602	1.00
158_K	161_A	1.602	1.00
160_E	192_P	1.570	1.00
160_E	193_M	1.563	1.00
262_C	302_T	1.560	1.00
184_F	188_N	1.541	1.00
99_A	104_V	1.517	1.00
90_D	93_D	1.509	1.00
157_K	161_A	1.505	1.00
90_D	94_K	1.502	1.00
200_P	272_F	1.494	1.00
142_Y	145_E	1.491	1.00
16_E	64_K	1.490	1.00
84_L	87_S	1.482	1.00
94_K	97_E	1.481	1.00
93_D	154_K	1.473	1.00
145_E	189_A	1.458	1.00
150_P	153_K	1.451	1.00
96_M	158_K	1.446	1.00
148_A	153_K	1.441	1.00
57_E	60_Q	1.438	1.00
89_R	154_K	1.438	1.00
145_E	150_P	1.437	1.00
274_S	278_M	1.428	1.00
23_A	65_R	1.408	1.00
19_L	65_R	1.399	1.00
17_D	20_N	1.390	1.00
21_F	297_E	1.374	1.00
228_D	263_G	1.365	1.00
25_L	304_V	1.364	1.00
218_G	279_M	1.333	1.00
85_G	151_Y	1.333	1.00
179_N	182_T	1.323	1.00
19_L	62_L	1.316	1.00
212_I	216_E	1.315	1.00
275_V	279_M	1.310	1.00
60_Q	63_E	1.308	1.00
89_R	93_D	1.307	1.00
183_L	196_L	1.303	1.00
153_K	190_V	1.297	1.00
211_I	271_E	1.287	1.00
144_W	189_A	1.271	1.00
139_I	142_Y	1.244	1.00
163_G	193_M	1.237	1.00
298_A	302_T	1.236	1.00
27_I	287_L	1.236	1.00
86_K	154_K	1.235	1.00
106_K	166_K	1.230	1.00
21_F	24_K	1.227	1.00
57_E	61_A	1.222	1.00
195_G	220_A	1.219	1.00
156_V	190_V	1.217	1.00
259_A	262_C	1.217	1.00
23_A	66_N	1.216	1.00
92_T	155_L	1.216	1.00
154_K	157_K	1.212	1.00
146_D	150_P	1.207	1.00
93_D	161_A	1.205	1.00
20_N	61_A	1.187	1.00
148_A	190_V	1.181	1.00
93_D	97_E	1.171	1.00
56_K	60_Q	1.152	1.00
184_F	217_L	1.150	1.00
215_R	279_M	1.150	1.00
16_E	57_E	1.146	1.00
29_T	70_C	1.142	1.00
29_T	68_T	1.131	1.00
27_I	304_V	1.127	1.00
4_S	286_S	1.123	1.00
178_Y	182_T	1.109	1.00
214_A	275_V	1.107	1.00
21_F	25_L	1.107	1.00
87_S	90_D	1.100	1.00
55_R	98_L	1.096	1.00
157_K	160_E	1.071	1.00
93_D	162_C	1.066	1.00
105_K	166_K	1.066	1.00
180_P	216_E	1.063	1.00
196_L	217_L	1.061	1.00
291_D	295_S	1.046	1.00
181_E	216_E	1.043	1.00
5_Y	22_A	1.038	1.00
291_D	294_M	1.034	1.00
267_Q	272_F	1.031	1.00
271_E	275_V	1.031	1.00
297_E	301_R	1.030	1.00
97_E	100_G	1.027	1.00
96_M	164_V	1.026	1.00
140_L	143_Q	1.017	1.00
59_S	101_L	1.013	1.00
188_N	220_A	1.012	1.00
156_V	193_M	1.010	1.00
295_S	298_A	1.008	1.00
198_L	203_L	1.001	1.00
171_N	203_L	0.997	1.00
302_T	305_E	0.993	1.00
97_E	101_L	0.992	1.00
141_N	145_E	0.990	1.00
211_I	215_R	0.989	1.00
62_L	67_M	0.978	1.00
190_V	194_V	0.976	1.00
156_V	192_P	0.973	1.00
276_V	279_M	0.971	1.00
226_G	285_V	0.970	1.00
24_K	297_E	0.964	1.00
141_N	185_R	0.963	1.00
159_A	167_I	0.962	1.00
16_E	20_N	0.960	1.00
144_W	182_T	0.956	1.00
153_K	191_G	0.956	1.00
19_L	61_A	0.943	1.00
80_D	84_L	0.935	1.00
31_E	223_H	0.934	1.00
199_D	288_E	0.927	1.00
153_K	157_K	0.925	1.00
142_Y	146_D	0.924	1.00
31_E	71_A	0.923	1.00
227_K	290_E	0.923	1.00
185_R	188_N	0.921	1.00
99_A	107_V	0.915	1.00
13_L	21_F	0.906	1.00
22_A	30_L	0.904	1.00
230_R	258_V	0.895	1.00
230_R	264_Q	0.880	1.00
302_T	306_A	0.878	1.00
226_G	269_W	0.875	1.00
150_P	154_K	0.872	1.00
72_L	99_A	0.863	1.00
52_S	56_K	0.861	1.00
298_A	301_R	0.861	1.00
28_D	308_K	0.857	1.00
100_G	164_V	0.856	1.00
211_I	275_V	0.854	1.00
214_A	279_M	0.852	1.00
55_R	59_S	0.845	1.00
108_I	197_N	0.844	1.00
20_N	64_K	0.840	1.00
170_E	288_E	0.839	1.00
51_S	54_K	0.838	1.00
166_K	193_M	0.834	1.00
212_I	215_R	0.834	1.00
214_A	218_G	0.834	1.00
106_K	222_H	0.828	1.00
153_K	189_A	0.825	1.00
53_E	57_E	0.823	1.00
16_E	65_R	0.822	1.00
152_W	194_V	0.822	1.00
55_R	102_L	0.820	1.00
260_V	303_S	0.818	1.00
184_F	220_A	0.813	1.00
271_E	274_S	0.813	1.00
70_C	284_E	0.808	1.00
62_L	65_R	0.807	1.00
152_W	186_L	0.805	1.00
27_I	300_I	0.803	1.00
69_L	104_V	0.802	1.00
213_A	217_L	0.796	1.00
144_W	148_A	0.794	1.00
201_S	229_V	0.793	1.00
273_F	277_K	0.792	1.00
201_S	227_K	0.789	1.00
4_S	29_T	0.788	1.00
214_A	221_I	0.788	1.00
273_F	285_V	0.785	1.00
143_Q	146_D	0.781	1.00
155_L	167_I	0.779	1.00
28_D	68_T	0.778	1.00
98_L	102_L	0.771	1.00
23_A	28_D	0.770	1.00
187_R	220_A	0.769	1.00
32_M	69_L	0.764	1.00
187_R	196_L	0.763	1.00
85_G	150_P	0.762	1.00
202_H	227_K	0.762	1.00
19_L	30_L	0.757	1.00
305_E	308_K	0.756	1.00
18_M	22_A	0.752	1.00
299_G	302_T	0.747	1.00
231_I	264_Q	0.747	1.00
170_E	225_H	0.746	1.00
269_W	273_F	0.745	1.00
73_N	110_M	0.745	1.00
68_T	284_E	0.741	1.00
109_M	112_G	0.740	1.00
159_A	164_V	0.739	1.00
56_K	59_S	0.733	1.00
198_L	214_A	0.732	1.00
182_T	185_R	0.730	1.00
83_E	86_K	0.729	1.00
180_P	208_A	0.728	1.00
68_T	105_K	0.728	1.00
17_D	21_F	0.724	1.00
292_L	296_P	0.723	1.00
59_S	103_G	0.722	1.00
214_A	272_F	0.721	1.00
223_H	286_S	0.720	1.00
112_G	115_A	0.712	1.00
22_A	27_I	0.711	1.00
91_I	94_K	0.709	1.00
218_G	221_I	0.709	1.00
153_K	192_P	0.703	1.00
31_E	286_S	0.699	1.00
200_P	269_W	0.692	1.00
177_V	183_L	0.691	1.00
204_L	264_Q	0.689	1.00
226_G	273_F	0.688	1.00
197_N	223_H	0.685	1.00
13_L	17_D	0.685	1.00
224_V	285_V	0.682	1.00
226_G	307_L	0.679	1.00
214_A	276_V	0.677	1.00
230_R	256_N	0.676	1.00
280_G	283_G	0.674	1.00
77_N	80_D	0.672	1.00
75_S	95_T	0.668	1.00
177_V	186_L	0.668	1.00
180_P	212_I	0.666	1.00
157_K	193_M	0.665	1.00
227_K	257_Y	0.665	1.00
106_K	223_H	0.664	1.00
219_S	279_M	0.661	1.00
108_I	172_F	0.661	1.00
5_Y	300_I	0.658	1.00
105_K	163_G	0.656	1.00
97_E	161_A	0.654	1.00
82_G	86_K	0.650	1.00
100_G	163_G	0.649	1.00
291_D	296_P	0.648	1.00
94_K	98_L	0.647	1.00
62_L	66_N	0.644	1.00
204_L	267_Q	0.644	1.00
223_H	281_Y	0.642	1.00
183_L	187_R	0.642	1.00
89_R	155_L	0.641	1.00
83_E	87_S	0.637	1.00
184_F	187_R	0.636	1.00
25_L	301_R	0.635	1.00
110_M	113_L	0.633	1.00
218_G	275_V	0.632	1.00
85_G	146_D	0.631	1.00
89_R	151_Y	0.629	1.00
44_N	47_E	0.627	1.00
156_V	160_E	0.624	1.00
20_N	23_A	0.622	1.00
171_N	183_L	0.621	1.00
72_L	104_V	0.621	1.00
4_S	70_C	0.620	1.00
8_D	11_G	0.620	1.00
170_E	202_H	0.615	1.00
19_L	23_A	0.614	1.00
214_A	217_L	0.610	1.00
217_L	221_I	0.608	1.00
299_G	303_S	0.606	1.00
52_S	55_R	0.605	1.00
52_S	102_L	0.604	1.00
198_L	213_A	0.600	1.00
151_Y	154_K	0.597	0.99
19_L	67_M	0.597	0.99
181_E	185_R	0.596	0.99
276_V	281_Y	0.595	0.99
154_K	158_K	0.592	0.99
221_I	224_V	0.592	0.99
95_T	107_V	0.590	0.99
144_W	186_L	0.588	0.99
224_V	281_Y	0.587	0.99
224_V	272_F	0.584	0.99
180_P	184_F	0.579	0.99
199_D	227_K	0.579	0.99
23_A	67_M	0.579	0.99
15_F	61_A	0.578	0.99
204_L	210_P	0.576	0.99
46_D	94_K	0.573	0.99
172_F	227_K	0.571	0.99
200_P	226_G	0.570	0.99
292_L	295_S	0.570	0.99
168_A	195_G	0.566	0.99
109_M	167_I	0.566	0.99
69_L	102_L	0.565	0.99
191_G	220_A	0.564	0.99
10_L	21_F	0.563	0.99
108_I	168_A	0.563	0.99
260_V	306_A	0.562	0.99
44_N	48_L	0.561	0.99
71_A	108_I	0.560	0.99
287_L	303_S	0.557	0.99
6_V	9_S	0.556	0.99
85_G	89_R	0.555	0.99
109_M	115_A	0.555	0.99
15_F	19_L	0.554	0.99
22_A	67_M	0.548	0.99
85_G	88_H	0.547	0.99
203_L	213_A	0.547	0.99
214_A	224_V	0.547	0.99
171_N	177_V	0.546	0.99
187_R	191_G	0.545	0.99
215_R	271_E	0.544	0.99
172_F	290_E	0.543	0.99
30_L	67_M	0.542	0.99
180_P	217_L	0.538	0.99
19_L	58_F	0.537	0.99
207_G	210_P	0.536	0.99
259_A	299_G	0.534	0.99
147_V	186_L	0.533	0.99
107_V	164_V	0.533	0.99
85_G	154_K	0.532	0.99
7_T	30_L	0.532	0.99
24_K	301_R	0.530	0.99
6_V	11_G	0.530	0.99
88_H	91_I	0.529	0.99
188_N	191_G	0.527	0.99
87_S	91_I	0.526	0.99
262_C	306_A	0.526	0.99
146_D	151_Y	0.526	0.99
70_C	286_S	0.524	0.99
108_I	223_H	0.524	0.99
301_R	304_V	0.523	0.99
89_R	92_T	0.522	0.99
76_G	88_H	0.522	0.99
304_V	307_L	0.521	0.99
287_L	307_L	0.519	0.99
200_P	224_V	0.519	0.99
73_N	108_I	0.516	0.99
4_S	284_E	0.516	0.99
107_V	159_A	0.515	0.98
63_E	101_L	0.515	0.98
277_K	280_G	0.514	0.98
303_S	307_L	0.510	0.98
303_S	306_A	0.507	0.98
99_A	164_V	0.507	0.98
58_F	61_A	0.506	0.98
78_P	151_Y	0.506	0.98
223_H	284_E	0.505	0.98
59_S	102_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zdsA	5	0.9361	100	0.249	Contact Map
1i60A	1	0.8498	100	0.271	Contact Map
3dx5A	2	0.8658	100	0.282	Contact Map
3u0hA	3	0.8403	100	0.283	Contact Map
3cqjA	2	0.8435	100	0.286	Contact Map
3qc0A	2	0.8211	100	0.291	Contact Map
4ovxA	1	0.8019	100	0.294	Contact Map
3cnyA	1	0.8914	100	0.294	Contact Map
3wqoA	2	0.8115	100	0.303	Contact Map
3kwsA	2	0.8115	100	0.305	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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