GREMLIN Database
CADE - Catechol-2,3-dioxygenase
UniProt: P54721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (272)
Sequences: 778 (617)
Seq/√Len: 37.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_G147_V5.1281.00
82_D85_E5.1281.00
107_V142_M5.0681.00
23_S117_D4.2091.00
134_R140_Y3.9201.00
106_A143_T3.8621.00
24_L43_A3.6991.00
176_H223_G3.1941.00
119_N235_G2.9591.00
87_G152_L2.8581.00
83_R109_E2.7701.00
25_Q29_N2.7601.00
89_A123_M2.7251.00
184_K198_N2.6691.00
134_R196_V2.6591.00
44_E52_V2.5961.00
207_V218_L2.5741.00
76_F170_I2.4991.00
245_H248_E2.4321.00
253_A270_F2.3361.00
185_A189_D2.3171.00
87_G156_A2.3131.00
10_I170_I2.2080.99
17_I23_S2.2070.99
148_D151_G2.1140.99
24_L28_C2.1050.99
35_V43_A2.0690.99
26_F114_S2.0630.99
243_L252_V2.0450.99
36_L46_T2.0360.99
107_V140_Y2.0260.99
252_V282_T2.0170.99
80_L123_M1.9210.98
20_L43_A1.8860.98
178_S276_V1.8700.98
89_A93_L1.8560.98
147_V152_L1.8470.98
196_V208_S1.8330.98
87_G151_G1.7660.97
54_L78_I1.7660.97
17_I56_L1.7540.97
33_F78_I1.7270.96
90_L149_I1.7080.96
125_A131_T1.6830.96
24_L38_K1.6670.96
31_I113_L1.6370.95
59_N62_A1.6000.94
179_D182_E1.5780.94
220_I224_R1.5670.94
243_L282_T1.5520.94
261_Y272_V1.5380.93
173_I239_Y1.5320.93
76_F176_H1.5100.93
106_A145_T1.4910.92
182_E185_A1.4730.92
107_V134_R1.4570.91
31_I164_L1.4500.91
85_E165_P1.4470.91
180_L205_L1.4400.91
140_Y196_V1.4240.90
20_L56_L1.4160.90
184_K205_L1.3960.89
134_R142_M1.3730.88
78_I170_I1.3690.88
87_G147_V1.3470.87
45_L56_L1.3440.87
246_Q250_D1.3380.87
16_T57_E1.3110.86
132_W213_H1.3050.86
66_P176_H1.2980.85
17_I117_D1.2890.85
13_A170_I1.2830.85
223_G226_A1.2800.85
254_N258_H1.2790.85
175_L236_L1.2710.84
129_R211_G1.2690.84
46_T49_G1.2500.83
241_V282_T1.2390.83
126_D212_Y1.2350.82
251_L255_R1.2330.82
117_D234_S1.2260.82
142_M196_V1.2220.82
105_H112_Y1.2210.82
208_S215_H1.2160.81
24_L117_D1.2090.81
212_Y215_H1.2060.81
75_H172_H1.1940.80
140_Y197_G1.1930.80
16_T237_D1.1900.80
92_R161_K1.1900.80
271_R281_I1.1900.80
26_F100_I1.1850.80
238_Y281_I1.1800.79
71_T178_S1.1660.79
270_F282_T1.1640.78
21_E38_K1.1580.78
223_G227_P1.1520.78
105_H172_H1.1500.78
255_R259_A1.1310.76
266_T269_S1.1000.74
12_Y55_I1.0960.74
263_I270_F1.0910.74
126_D132_W1.0860.73
67_E70_V1.0860.73
174_H221_W1.0850.73
35_V38_K1.0840.73
103_G144_T1.0790.73
75_H105_H1.0750.73
31_I123_M1.0750.73
42_Q57_E1.0740.73
151_G154_E1.0720.72
90_L152_L1.0720.72
132_W212_Y1.0680.72
194_D211_G1.0600.72
84_K155_E1.0600.72
184_K195_I1.0520.71
22_R117_D1.0480.71
133_Q141_V1.0470.71
33_F164_L1.0470.71
85_E88_I1.0390.70
106_A127_R1.0340.70
97_G100_I1.0270.69
24_L45_L1.0250.69
105_H122_E1.0210.69
52_V55_I1.0170.68
126_D213_H1.0170.68
178_S227_P1.0140.68
63_V232_N1.0140.68
71_T229_K1.0130.68
100_I113_L1.0120.68
83_R151_G1.0110.68
80_L168_T1.0070.68
77_A172_H0.9950.67
193_F241_V0.9950.67
90_L100_I0.9830.66
104_D112_Y0.9820.66
93_L123_M0.9770.65
124_Y215_H0.9700.65
124_Y174_H0.9650.64
132_W206_F0.9650.64
126_D206_F0.9620.64
183_A276_V0.9590.64
199_Y203_S0.9390.62
16_T62_A0.9380.62
88_I157_G0.9310.61
17_I20_L0.9210.61
77_A105_H0.9050.59
8_T242_V0.9000.59
117_D235_G0.8960.58
124_Y221_W0.8870.58
152_L155_E0.8870.58
135_D139_N0.8860.58
93_L98_I0.8860.58
164_L168_T0.8830.57
107_V127_R0.8830.57
102_H147_V0.8820.57
74_Y176_H0.8820.57
93_L121_I0.8790.57
124_Y213_H0.8780.57
177_V183_A0.8760.57
101_G126_D0.8760.57
54_L173_I0.8750.57
252_V263_I0.8710.56
134_R208_S0.8700.56
31_I43_A0.8680.56
35_V50_K0.8680.56
180_L220_I0.8670.56
37_K44_E0.8660.56
101_G132_W0.8600.55
46_T53_L0.8570.55
81_P165_P0.8560.55
14_K238_Y0.8530.55
108_S132_W0.8530.55
184_K189_D0.8500.54
104_D127_R0.8490.54
77_A122_E0.8480.54
253_A282_T0.8450.54
21_E25_Q0.8430.54
272_V280_Y0.8420.54
112_Y172_H0.8270.52
125_A152_L0.8270.52
206_F213_H0.8230.52
207_V217_G0.8220.52
39_T42_Q0.8210.52
135_D141_V0.8210.52
30_V98_I0.8160.51
273_K279_A0.8120.51
56_L245_H0.8120.51
101_G213_H0.8060.50
183_A282_T0.8050.50
13_A76_F0.8040.50
74_Y103_G0.7940.49
120_G126_D0.7940.49
215_H244_P0.7930.49
78_I117_D0.7880.49
77_A219_N0.7870.49
75_H219_N0.7850.49
18_R234_S0.7840.49
178_S225_N0.7820.48
86_L126_D0.7800.48
174_H217_G0.7750.48
91_A156_A0.7740.48
80_L89_A0.7690.47
101_G204_A0.7690.47
77_A120_G0.7680.47
74_Y217_G0.7660.47
205_L218_L0.7650.47
10_I239_Y0.7620.47
48_D74_Y0.7610.47
104_D172_H0.7590.46
172_H214_H0.7580.46
137_E273_K0.7570.46
54_L76_F0.7550.46
108_S124_Y0.7540.46
230_P233_A0.7530.46
75_H112_Y0.7500.46
38_K43_A0.7480.45
150_E154_E0.7460.45
105_H221_W0.7450.45
190_V259_A0.7420.45
7_D244_P0.7400.45
134_R278_G0.7400.45
120_G213_H0.7370.44
24_L35_V0.7280.44
126_D215_H0.7250.43
204_A213_H0.7190.43
87_G91_A0.7170.43
206_F212_Y0.7170.43
77_A108_S0.7130.42
90_L239_Y0.7120.42
34_Q38_K0.7070.42
18_R117_D0.7070.42
269_S281_I0.7070.42
128_P259_A0.7070.42
111_L147_V0.7060.42
106_A142_M0.7060.42
28_C35_V0.7060.42
105_H219_N0.7060.42
102_H149_I0.7050.42
74_Y174_H0.7040.42
166_N190_V0.7030.41
92_R123_M0.7020.41
46_T229_K0.7020.41
111_L125_A0.7000.41
53_L128_P0.6970.41
80_L165_P0.6950.41
191_L282_T0.6940.41
29_N96_H0.6910.40
19_S273_K0.6910.40
74_Y117_D0.6890.40
109_E152_L0.6880.40
73_L120_G0.6860.40
105_H110_A0.6840.40
102_H144_T0.6830.40
176_H234_S0.6820.40
70_V229_K0.6810.40
122_E172_H0.6750.39
10_I209_A0.6710.39
30_V170_I0.6710.39
96_H99_A0.6690.39
112_Y221_W0.6690.39
122_E213_H0.6680.38
10_I78_I0.6620.38
248_E251_L0.6610.38
23_S76_F0.6600.38
18_R23_S0.6590.38
203_S216_I0.6570.38
71_T206_F0.6530.37
101_G212_Y0.6520.37
174_H214_H0.6520.37
20_L24_L0.6510.37
105_H174_H0.6500.37
103_G110_A0.6480.37
127_R206_F0.6460.37
176_H226_A0.6430.36
176_H222_A0.6410.36
11_G240_T0.6390.36
124_Y212_Y0.6380.36
169_I241_V0.6380.36
260_G272_V0.6380.36
120_G171_G0.6370.36
110_A204_A0.6370.36
101_G206_F0.6350.36
72_G171_G0.6340.36
17_I24_L0.6330.36
96_H137_E0.6320.35
141_V145_T0.6320.35
208_S216_I0.6320.35
178_S226_A0.6280.35
74_Y221_W0.6270.35
126_D214_H0.6250.35
101_G144_T0.6210.35
10_I216_I0.6200.35
110_A172_H0.6200.35
257_K272_V0.6180.34
137_E146_A0.6180.34
19_S63_V0.6170.34
86_L101_G0.6150.34
50_K239_Y0.6130.34
8_T241_V0.6120.34
181_K185_A0.6120.34
102_H151_G0.6110.34
105_H124_Y0.6110.34
101_G110_A0.6100.34
26_F90_L0.6080.34
79_L127_R0.6060.33
99_A114_S0.6040.33
105_H204_A0.6020.33
105_H120_G0.6020.33
76_F117_D0.6020.33
104_D109_E0.6010.33
120_G212_Y0.6010.33
108_S172_H0.5990.33
50_K170_I0.5930.32
129_R209_A0.5920.32
37_K41_R0.5900.32
109_E127_R0.5870.32
208_S211_G0.5850.32
139_N197_G0.5820.32
124_Y204_A0.5810.31
110_A213_H0.5780.31
229_K278_G0.5780.31
28_C45_L0.5760.31
24_L33_F0.5750.31
101_G108_S0.5750.31
72_G212_Y0.5750.31
14_K55_I0.5750.31
101_G120_G0.5730.31
251_L254_N0.5730.31
106_A133_Q0.5720.31
107_V196_V0.5710.31
206_F217_G0.5710.31
125_A150_E0.5690.31
272_V279_A0.5680.30
112_Y174_H0.5680.30
120_G221_W0.5670.30
172_H219_N0.5670.30
72_G75_H0.5670.30
120_G124_Y0.5660.30
175_L239_Y0.5660.30
248_E252_V0.5650.30
117_D175_L0.5640.30
78_I176_H0.5640.30
85_E184_K0.5610.30
31_I121_I0.5550.30
127_R140_Y0.5550.30
257_K268_N0.5550.30
34_Q268_N0.5550.30
75_H108_S0.5550.30
41_R58_E0.5530.29
87_G90_L0.5530.29
103_G152_L0.5520.29
226_A229_K0.5520.29
184_K188_T0.5470.29
75_H174_H0.5460.29
120_G172_H0.5450.29
274_D277_S0.5440.29
81_P113_L0.5400.28
120_G215_H0.5400.28
125_A155_E0.5390.28
75_H110_A0.5350.28
11_G242_V0.5350.28
134_R197_G0.5340.28
145_T199_Y0.5340.28
82_D130_S0.5340.28
31_I280_Y0.5330.28
50_K150_E0.5330.28
77_A214_H0.5310.28
69_S226_A0.5300.28
128_P211_G0.5300.28
190_V261_Y0.5280.28
272_V282_T0.5260.27
209_A243_L0.5250.27
106_A140_Y0.5250.27
273_K278_G0.5250.27
37_K173_I0.5230.27
132_W204_A0.5200.27
71_T217_G0.5190.27
223_G229_K0.5190.27
188_T195_I0.5180.27
16_T203_S0.5160.27
71_T223_G0.5160.27
262_S271_R0.5150.27
178_S211_G0.5150.27
112_Y122_E0.5150.27
44_E55_I0.5140.27
78_I218_L0.5140.27
76_F226_A0.5130.26
79_L213_H0.5130.26
126_D204_A0.5120.26
193_F207_V0.5120.26
143_T271_R0.5090.26
272_V281_I0.5060.26
206_F214_H0.5060.26
54_L208_S0.5060.26
214_H217_G0.5050.26
70_V230_P0.5050.26
101_G172_H0.5050.26
177_V226_A0.5050.26
180_L195_I0.5040.26
191_L220_I0.5030.26
103_G197_G0.5030.26
10_I241_V0.5020.26
128_P182_E0.5020.26
271_R279_A0.5020.26
109_E163_S0.5010.26
79_L132_W0.5000.26
212_Y219_N0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e0rA 1 0.8386 100 0.549 Contact Map
3vb0A 1 0.8491 100 0.667 Contact Map
2zyqA 2 0.8456 100 0.679 Contact Map
3oajA 2 0.8912 100 0.679 Contact Map
4huzA 2 0.9018 100 0.683 Contact Map
1zswA 1 0.9053 100 0.684 Contact Map
3b59A 5 0.8281 100 0.685 Contact Map
2wl9A 5 0.8596 100 0.689 Contact Map
3lm4A 4 0.8947 100 0.693 Contact Map
2ehzA 5 0.8596 100 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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