GREMLIN Database
CATD - Putative oxidoreductase CatD
UniProt: P54720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (120)
Sequences: 3443 (2475)
Seq/√Len: 225.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_H97_E2.5821.00
76_A103_L2.4441.00
20_F75_F2.2591.00
15_I104_L2.1491.00
12_L108_H2.0751.00
21_F63_F1.9801.00
75_F106_S1.9791.00
16_T105_T1.9701.00
67_A70_I1.9611.00
34_T38_F1.9611.00
17_G59_G1.9161.00
17_G63_F1.8881.00
118_A121_P1.8681.00
25_L56_L1.8431.00
108_H112_T1.7731.00
87_K99_D1.7571.00
66_L120_D1.7351.00
61_L71_V1.7211.00
79_L82_A1.6851.00
70_I74_L1.6821.00
9_T112_T1.6811.00
31_M52_A1.6791.00
83_I103_L1.6701.00
19_I102_L1.6521.00
68_T114_S1.6311.00
96_A100_Y1.6271.00
25_L29_Q1.6191.00
58_G71_V1.6111.00
98_F102_L1.5561.00
37_F41_I1.5381.00
49_Y53_A1.5171.00
12_L105_T1.5021.00
19_I92_F1.4991.00
72_G106_S1.4701.00
37_F40_S1.4621.00
10_L117_L1.4521.00
57_I61_L1.4471.00
51_I78_T1.4461.00
60_V64_F1.4231.00
10_L14_V1.4131.00
58_G75_F1.4101.00
31_M49_Y1.3831.00
6_E116_F1.3751.00
21_F60_V1.3621.00
62_V75_F1.3611.00
54_I71_V1.3011.00
53_A57_I1.2831.00
101_L105_T1.2581.00
21_F59_G1.2421.00
84_I88_L1.2421.00
10_L116_F1.2401.00
19_I101_L1.2381.00
109_L112_T1.2081.00
28_F52_A1.2031.00
54_I78_T1.1991.00
72_G76_A1.1821.00
8_G111_L1.1741.00
27_K55_E1.1671.00
50_V54_I1.1461.00
36_Q39_G1.1121.00
22_V93_M1.1021.00
21_F25_L1.0841.00
8_G112_T1.0811.00
77_L81_G1.0801.00
39_G45_S1.0771.00
9_T108_H1.0671.00
73_V110_A1.0561.00
114_S118_A1.0531.00
62_V109_L1.0481.00
76_A110_A1.0351.00
114_S120_D1.0191.00
46_F49_Y1.0091.00
54_I74_L1.0041.00
87_K90_A0.9411.00
15_I19_I0.9361.00
61_L66_L0.9181.00
66_L119_L0.9090.99
55_E78_T0.8950.99
31_M35_I0.8850.99
7_I117_L0.8840.99
71_V74_L0.8840.99
68_T109_L0.8700.99
83_I88_L0.8620.99
71_V75_F0.8570.99
80_I84_I0.8480.99
33_G37_F0.8470.99
97_E100_Y0.8470.99
19_I22_V0.8410.99
83_I99_D0.8330.99
52_A59_G0.8250.99
119_L124_F0.8200.99
107_I111_L0.8180.99
64_F119_L0.8140.99
14_V63_F0.8110.99
98_F101_L0.8070.99
21_F56_L0.7960.99
35_I48_A0.7860.98
83_I100_Y0.7820.98
43_L47_M0.7690.98
32_E35_I0.7640.98
24_G59_G0.7630.98
69_R110_A0.7590.98
103_L106_S0.7340.98
26_S30_G0.7300.98
51_I81_G0.7270.97
119_L123_V0.7260.97
62_V106_S0.7160.97
54_I58_G0.7140.97
8_G108_H0.7130.97
34_T37_F0.7110.97
8_G12_L0.6960.97
29_Q32_E0.6960.97
96_A99_D0.6920.97
38_F41_I0.6890.96
99_D103_L0.6890.96
23_H95_N0.6810.96
35_I39_G0.6740.96
48_A52_A0.6710.96
79_L102_L0.6710.96
16_T106_S0.6680.96
100_Y103_L0.6680.96
34_T48_A0.6610.96
47_M51_I0.6600.96
18_I63_F0.6380.95
68_T120_D0.6360.95
56_L60_V0.6300.94
73_V77_L0.6240.94
31_M48_A0.6230.94
56_L59_G0.6230.94
78_T81_G0.6220.94
81_G85_T0.6160.94
78_T82_A0.6160.94
32_E36_Q0.6090.93
62_V68_T0.6070.93
28_F56_L0.6070.93
72_G110_A0.6070.93
51_I54_I0.5980.93
98_F105_T0.5970.93
26_S29_Q0.5970.93
19_I98_F0.5940.92
100_Y104_L0.5920.92
6_E9_T0.5910.92
37_F94_G0.5880.92
30_G33_G0.5850.92
14_V18_I0.5850.92
121_P124_F0.5840.92
24_G57_I0.5800.91
74_L77_L0.5710.91
69_R77_L0.5690.91
25_L52_A0.5680.91
9_T114_S0.5650.90
70_I110_A0.5610.90
7_I116_F0.5550.90
44_P58_G0.5550.90
35_I45_S0.5550.90
76_A107_I0.5540.89
31_M34_T0.5520.89
79_L99_D0.5510.89
102_L106_S0.5480.89
22_V59_G0.5440.89
52_A56_L0.5410.88
16_T102_L0.5390.88
75_F78_T0.5340.88
5_F9_T0.5330.88
95_N98_F0.5270.87
64_F67_A0.5210.86
80_I103_L0.5210.86
72_G109_L0.5170.86
10_L109_L0.5150.86
40_S43_L0.5140.86
31_M45_S0.5110.85
49_Y52_A0.5110.85
90_A95_N0.5090.85
15_I101_L0.5090.85
6_E117_L0.5060.85
24_G56_L0.5060.85
91_P97_E0.5050.85
116_F121_P0.5030.84
36_Q40_S0.5010.84
41_I85_T0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rgxA 5 0.1716 10 0.931 Contact Map
4htmA 1 0.1493 4.2 0.942 Contact Map
2l16A 1 0.3209 2.4 0.949 Contact Map
2lzrA 1 0.3134 2.4 0.949 Contact Map
2mi2A 1 0.3134 2.2 0.95 Contact Map
2mn6B 2 0.2985 1.9 0.952 Contact Map
4c5cA 2 0.2239 1.6 0.954 Contact Map
3ogkQ 1 0.097 1.5 0.955 Contact Map
2i71A 2 0.2537 1.4 0.955 Contact Map
3ld9A 3 0.2537 1.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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