GREMLIN Database
GLVR - HTH-type transcriptional regulator GlvR
UniProt: P54717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (235)
Sequences: 9233 (6517)
Seq/√Len: 425.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_D162_N4.6301.00
193_S206_T3.7451.00
109_L190_P3.0181.00
182_R205_L3.0111.00
173_E201_V2.9371.00
167_I181_A2.7761.00
118_V129_A2.6371.00
11_Y23_K2.5661.00
114_D160_K2.4601.00
106_M208_H2.4391.00
60_F69_F2.4221.00
10_H13_K2.4191.00
106_M192_I2.3491.00
38_D57_K2.3301.00
89_D93_A2.2611.00
185_S207_P2.2061.00
132_L136_F2.1661.00
181_A191_F2.1491.00
28_H31_T2.1281.00
165_F184_L2.1131.00
160_K163_D2.0361.00
183_M186_A2.0141.00
159_F189_I2.0021.00
114_D163_D1.9481.00
221_D224_E1.9481.00
23_K27_N1.9241.00
164_L192_I1.9021.00
118_V132_L1.8851.00
59_G62_G1.8841.00
109_L208_H1.8651.00
24_Y28_H1.8541.00
113_A164_L1.8361.00
181_A202_L1.8291.00
190_P207_P1.8151.00
118_V166_I1.7811.00
88_L92_E1.7731.00
99_R102_D1.7561.00
129_A168_I1.7431.00
107_C241_A1.7251.00
167_I177_L1.7241.00
22_L54_L1.7201.00
169_S202_L1.7001.00
168_I194_I1.6351.00
115_R142_Y1.6011.00
102_D105_D1.5941.00
184_L189_I1.5451.00
18_D57_K1.5411.00
40_L53_R1.5371.00
35_L43_A1.5341.00
193_S209_N1.5261.00
105_D208_H1.5201.00
190_P208_H1.5201.00
55_A66_F1.5121.00
108_Q245_Y1.5091.00
61_S65_E1.4741.00
191_F206_T1.4551.00
65_E73_E1.4511.00
119_Y165_F1.4301.00
193_S202_L1.4281.00
108_Q112_A1.4001.00
40_L56_Q1.3861.00
109_L164_L1.3801.00
63_Y67_R1.3781.00
238_L242_Y1.3771.00
130_R147_E1.3731.00
165_F189_I1.3711.00
21_I54_L1.3631.00
115_R144_I1.3451.00
133_Q145_L1.3451.00
11_Y19_F1.3391.00
68_V71_K1.3341.00
40_L57_K1.3331.00
62_G65_E1.3191.00
203_A209_N1.3161.00
167_I191_F1.3031.00
64_S67_R1.2621.00
62_G66_F1.2561.00
175_P179_P1.2551.00
115_R163_D1.2521.00
19_F23_K1.2291.00
116_I141_R1.2171.00
74_D82_M1.1961.00
69_F72_W1.1891.00
216_P220_S1.1731.00
106_M109_L1.1711.00
75_Q78_E1.1701.00
185_S205_L1.1661.00
179_P182_R1.1531.00
65_E69_F1.1531.00
69_F73_E1.1381.00
60_F66_F1.1331.00
126_K130_R1.1291.00
63_Y66_F1.1291.00
37_I52_L1.1221.00
166_I194_I1.1181.00
94_N213_T1.1001.00
60_F63_Y1.0991.00
31_T43_A1.0921.00
111_D242_Y1.0911.00
127_I130_R1.0911.00
17_N20_H1.0841.00
67_R71_K1.0741.00
65_E68_V1.0721.00
92_E96_K1.0611.00
159_F163_D1.0581.00
153_N179_P1.0481.00
167_I184_L1.0441.00
24_Y44_C1.0361.00
31_T35_L1.0341.00
17_N50_S1.0321.00
110_I164_L1.0251.00
105_D109_L1.0241.00
112_A190_P1.0121.00
84_F91_I1.0011.00
9_Q13_K0.9951.00
163_D189_I0.9951.00
102_D208_H0.9941.00
117_F163_D0.9881.00
118_V136_F0.9841.00
136_F236_E0.9791.00
228_F231_F0.9661.00
14_L40_L0.9661.00
115_R145_L0.9661.00
70_L73_E0.9511.00
217_V220_S0.9501.00
117_F159_F0.9481.00
24_Y43_A0.9471.00
38_D48_R0.9451.00
94_N212_A0.9441.00
93_A96_K0.9441.00
20_H52_L0.9441.00
37_I41_A0.9411.00
35_L39_A0.9411.00
116_I164_L0.9381.00
68_V72_W0.9371.00
203_A211_Y0.9361.00
24_Y31_T0.9331.00
178_I201_V0.9311.00
184_L191_F0.9271.00
133_Q137_I0.9261.00
136_F239_F0.9251.00
132_L166_I0.9221.00
21_I44_C0.9131.00
164_L190_P0.9071.00
24_Y35_L0.9051.00
132_L235_G0.9001.00
195_T203_A0.9001.00
66_F70_L0.8911.00
77_E81_S0.8881.00
123_N221_D0.8831.00
128_C235_G0.8831.00
182_R186_A0.8751.00
33_Y37_I0.8731.00
40_L51_I0.8671.00
10_H14_L0.8631.00
88_L91_I0.8571.00
40_L63_Y0.8521.00
94_N97_F0.8511.00
81_S95_L0.8491.00
55_A62_G0.8441.00
183_M187_K0.8431.00
89_D92_E0.8431.00
133_Q143_L0.8421.00
168_I232_F0.8401.00
101_K104_T0.8401.00
108_Q111_D0.8361.00
52_L62_G0.8331.00
114_D142_Y0.8321.00
131_D135_M0.8291.00
159_F165_F0.8291.00
14_L56_Q0.8191.00
63_Y73_E0.8191.00
11_Y22_L0.8181.00
228_F232_F0.8151.00
113_A163_D0.8111.00
20_H45_S0.8081.00
238_L241_A0.8061.00
178_I182_R0.8051.00
81_S85_E0.8041.00
91_I230_P0.7921.00
107_C111_D0.7911.00
111_D245_Y0.7861.00
39_A42_K0.7851.00
22_L26_L0.7821.00
36_G39_A0.7821.00
169_S172_G0.7791.00
66_F73_E0.7731.00
83_S87_L0.7651.00
49_S52_L0.7611.00
110_I166_I0.7611.00
128_C168_I0.7611.00
105_D108_Q0.7591.00
90_D227_A0.7581.00
112_A162_N0.7581.00
15_N18_D0.7571.00
118_V133_Q0.7551.00
146_I155_M0.7551.00
106_M210_L0.7551.00
198_K211_Y0.7541.00
79_G83_S0.7481.00
138_P156_R0.7461.00
133_Q144_I0.7441.00
48_R52_L0.7441.00
79_G82_M0.7431.00
150_N176_E0.7431.00
208_H211_Y0.7401.00
115_R160_K0.7391.00
25_I66_F0.7381.00
50_S53_R0.7381.00
21_I50_S0.7351.00
93_A97_F0.7341.00
104_T241_A0.7331.00
51_I73_E0.7311.00
17_N56_Q0.7291.00
32_C70_L0.7281.00
98_L234_V0.7261.00
14_L57_K0.7251.00
109_L112_A0.7241.00
141_R158_D0.7211.00
104_T245_Y0.7191.00
62_G67_R0.7151.00
230_P233_L0.7121.00
110_I113_A0.7061.00
168_I235_G0.7061.00
117_F165_F0.7061.00
212_A231_F0.7061.00
166_I192_I0.7051.00
58_L72_W0.7041.00
216_P223_T0.7011.00
102_D106_M0.6981.00
118_V143_L0.6971.00
215_K218_T0.6961.00
130_R133_Q0.6951.00
141_R156_R0.6911.00
15_N57_K0.6881.00
132_L135_M0.6801.00
121_S174_T0.6781.00
201_V205_L0.6771.00
59_G63_Y0.6751.00
77_E100_T0.6751.00
21_I46_V0.6751.00
76_P85_E0.6731.00
97_F213_T0.6721.00
110_I116_I0.6691.00
206_T209_N0.6681.00
33_Y36_G0.6681.00
116_I166_I0.6641.00
147_E155_M0.6630.99
118_V168_I0.6630.99
126_K145_L0.6620.99
215_K219_L0.6570.99
215_K220_S0.6570.99
181_A205_L0.6450.99
101_K105_D0.6450.99
137_I155_M0.6380.99
153_N183_M0.6370.99
36_G41_A0.6360.99
30_H33_Y0.6320.99
171_S174_T0.6310.99
53_R57_K0.6270.99
32_C35_L0.6260.99
193_S200_N0.6220.99
59_G66_F0.6200.99
195_T209_N0.6200.99
218_T221_D0.6190.99
157_D183_M0.6170.99
224_E227_A0.6160.99
107_C242_Y0.6150.99
113_A190_P0.6140.99
107_C245_Y0.6130.99
178_I202_L0.6110.99
156_R187_K0.6100.99
167_I180_Q0.6080.99
25_I32_C0.6030.99
9_Q12_S0.6000.99
85_E92_E0.5940.99
84_F87_L0.5910.99
178_I205_L0.5900.99
64_S68_V0.5900.99
229_A233_L0.5890.99
120_G124_A0.5890.99
167_I193_S0.5860.99
212_A227_A0.5850.99
131_D228_F0.5840.99
162_N190_P0.5820.99
216_P219_L0.5810.99
200_N203_A0.5800.99
78_E81_S0.5790.99
94_N230_P0.5770.99
55_A60_F0.5750.99
136_F242_Y0.5750.99
87_L91_I0.5740.99
241_A245_Y0.5740.99
88_L95_L0.5730.99
195_T200_N0.5720.99
15_N40_L0.5710.99
156_R183_M0.5700.98
179_P183_M0.5700.98
233_L236_E0.5690.98
173_E196_N0.5670.98
21_I51_I0.5660.98
29_K32_C0.5660.98
116_I136_F0.5650.98
14_L18_D0.5650.98
25_I54_L0.5620.98
132_L232_F0.5620.98
39_A43_A0.5610.98
80_E84_F0.5580.98
12_S19_F0.5570.98
210_L231_F0.5560.98
67_R70_L0.5540.98
119_Y180_Q0.5540.98
126_K147_E0.5540.98
126_K148_D0.5530.98
94_N98_L0.5520.98
80_E100_T0.5500.98
181_A206_T0.5470.98
84_F233_L0.5470.98
55_A69_F0.5440.98
18_D21_I0.5430.98
20_H51_I0.5430.98
237_A240_R0.5410.98
161_V188_G0.5400.98
20_H23_K0.5380.98
66_F69_F0.5380.98
53_R56_Q0.5320.98
196_N212_A0.5320.98
60_F65_E0.5310.98
117_F146_I0.5310.98
33_Y71_K0.5290.98
76_P104_T0.5290.98
137_I143_L0.5290.98
119_Y167_I0.5280.98
121_S176_E0.5260.97
35_L40_L0.5250.97
152_F180_Q0.5250.97
135_M233_L0.5200.97
136_F144_I0.5200.97
135_M236_E0.5160.97
128_C212_A0.5160.97
120_G126_K0.5150.97
58_L62_G0.5140.97
94_N231_F0.5130.97
100_T104_T0.5070.97
141_R242_Y0.5070.97
170_L223_T0.5070.97
170_L212_A0.5060.97
29_K33_Y0.5050.97
185_S191_F0.5020.97
106_M238_L0.5010.97
41_A53_R0.5000.97
20_H48_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ivnA 2 0.9882 100 0.138 Contact Map
3shoA 4 0.685 100 0.522 Contact Map
3fxaA 4 0.7244 100 0.532 Contact Map
2xhzA 4 0.6772 99.9 0.535 Contact Map
3etnA 4 0.7087 99.9 0.543 Contact Map
1vimA 4 0.6811 99.9 0.55 Contact Map
1m3sA 4 0.6772 99.9 0.55 Contact Map
1jeoA 4 0.6496 99.9 0.563 Contact Map
2pocA 4 0.6929 99.9 0.579 Contact Map
1x92A 4 0.6654 99.9 0.585 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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