GREMLIN Database
GLVA - Maltose-6'-phosphate glucosidase
UniProt: P54716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 449 (417)
Sequences: 1742 (992)
Seq/√Len: 48.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_E137_K5.4871.00
77_F139_S3.9341.00
82_F332_A3.9321.00
73_P134_Y3.7381.00
192_E213_E3.7211.00
104_K429_D3.3821.00
135_M165_S3.2601.00
135_M144_M3.2501.00
51_A69_A3.0901.00
365_G370_E3.0181.00
404_F428_E2.9941.00
208_S216_D2.9801.00
330_A337_E2.9741.00
408_W427_L2.9321.00
72_D75_E2.9311.00
74_E134_Y2.9021.00
107_V426_I2.8081.00
93_A290_M2.7771.00
36_K66_E2.7211.00
44_K48_D2.7101.00
108_V276_V2.6491.00
136_E162_R2.6481.00
36_K68_A2.6271.00
341_L364_V2.6201.00
215_N220_K2.5891.00
51_A55_D2.5371.00
188_S192_E2.5191.00
7_S38_K2.5061.00
283_H291_E2.4701.00
188_S191_K2.4501.00
350_A376_T2.3891.00
377_I385_M2.3871.00
242_S269_Y2.3661.00
212_Q217_L2.3221.00
407_L427_L2.3111.00
168_L369_P2.2971.00
38_K68_A2.2631.00
348_A358_V2.2611.00
401_E406_K2.2501.00
133_D136_E2.2221.00
118_I395_T2.2171.00
89_V127_G2.1761.00
96_A287_N2.1561.00
135_M139_S2.1321.00
48_D52_G2.1181.00
132_L158_T2.0771.00
346_N354_P2.0711.00
341_L362_C2.0591.00
130_E133_D2.0351.00
160_R397_E2.0291.00
105_Y425_L1.9990.99
105_Y429_D1.9910.99
107_V115_P1.9890.99
352_F385_M1.9680.99
351_N382_K1.9490.99
291_E295_A1.9310.99
136_E164_N1.9260.99
125_I157_A1.9230.99
217_L220_K1.8540.99
31_E329_R1.8490.99
48_D51_A1.8470.99
347_G354_P1.8300.99
295_A311_E1.8280.99
143_W166_K1.8240.99
74_E138_Y1.8150.99
75_E78_T1.7940.99
159_R344_E1.7920.99
22_V37_L1.7830.99
97_L433_A1.7460.99
397_E401_E1.7450.99
58_I67_F1.7350.99
125_I153_I1.7330.99
329_R333_Y1.7160.98
205_W270_L1.7060.98
38_K70_T1.7020.98
129_L157_A1.6980.98
100_Q287_N1.6880.98
82_F331_I1.6830.98
397_E406_K1.6730.98
331_I334_N1.6710.98
96_A286_A1.6610.98
363_I372_I1.6510.98
7_S36_K1.6110.98
336_G365_G1.6110.98
68_A75_E1.5940.97
403_S406_K1.5860.97
406_K409_Q1.5490.97
115_P417_V1.5320.97
192_E212_Q1.5280.97
141_D166_K1.5020.96
196_R208_S1.4940.96
124_S127_G1.4880.96
161_L400_A1.4850.96
223_E227_Q1.4820.96
365_G368_G1.4750.96
128_V158_T1.4690.96
118_I391_V1.4530.96
239_V247_F1.4530.96
52_G55_D1.4480.95
158_T167_I1.4460.95
244_N247_F1.4450.95
351_N375_G1.4320.95
350_A375_G1.4290.95
93_A96_A1.4270.95
185_L221_L1.4260.95
32_F328_A1.4260.95
220_K224_H1.4240.95
81_D141_D1.4100.95
9_V80_V1.3880.94
243_W247_F1.3750.94
294_E298_F1.3740.94
426_I430_L1.3690.94
338_R363_I1.3560.93
239_V243_W1.3520.93
14_G41_D1.3520.93
113_C388_Q1.3460.93
350_A354_P1.3360.93
234_T237_E1.3250.93
105_Y426_I1.3230.93
365_G369_P1.3140.92
132_L135_M1.3090.92
9_V38_K1.2990.92
432_E435_K1.2980.92
399_W402_K1.2970.92
382_K386_E1.2870.92
58_I65_I1.2860.92
70_T76_A1.2820.91
398_A407_L1.2680.91
8_I32_F1.2670.91
298_F301_C1.2650.91
31_E335_T1.2610.91
97_L434_N1.2610.91
101_I433_A1.2590.91
125_I399_W1.2570.91
285_R289_V1.2470.90
339_M364_V1.2420.90
35_R66_E1.2350.90
129_L400_A1.2210.89
9_V77_F1.2190.89
107_V422_V1.2160.89
367_N370_E1.2090.89
85_A128_V1.1940.88
411_L430_L1.1860.88
237_E244_N1.1720.87
83_V135_M1.1530.86
286_A290_M1.1500.86
79_D141_D1.1480.86
198_Y207_T1.1470.86
234_T247_F1.1470.86
234_T238_A1.1460.86
310_S313_S1.1430.86
78_T138_Y1.1410.86
194_K210_Q1.1340.85
83_V142_A1.1340.85
48_D69_A1.1310.85
198_Y377_I1.1280.85
299_S311_E1.1270.85
273_D422_V1.1230.85
351_N386_E1.1210.85
126_G399_W1.1160.84
338_R372_I1.1150.84
96_A100_Q1.1040.84
77_F138_Y1.1020.84
203_F388_Q1.1010.84
411_L423_A1.0910.83
6_F332_A1.0840.83
55_D59_R1.0770.82
287_N290_M1.0740.82
128_V154_V1.0690.82
43_D91_K1.0630.81
350_A373_T1.0600.81
119_A431_V1.0550.81
162_R165_S1.0530.81
87_I131_I1.0520.81
102_P430_L1.0480.81
99_E109_G1.0480.81
98_D123_R1.0480.81
391_V411_L1.0420.80
284_T287_N1.0420.80
412_I420_A1.0310.79
380_F409_Q1.0260.79
348_A360_V1.0250.79
40_Y76_A1.0190.79
246_T424_R1.0120.78
203_F384_L1.0110.78
118_I411_L1.0100.78
87_I151_A1.0080.78
107_V418_P1.0070.78
95_R109_G1.0040.78
379_Q390_S1.0040.78
132_L164_N1.0010.77
102_P105_Y1.0000.77
404_F427_L0.9990.77
152_A392_E0.9970.77
88_R95_R0.9960.77
11_A144_M0.9960.77
54_C67_F0.9930.77
220_K223_E0.9930.77
273_D277_K0.9910.77
134_Y138_Y0.9900.77
219_P259_D0.9900.77
349_I358_V0.9800.76
44_K71_T0.9790.76
133_D162_R0.9760.76
216_D219_P0.9750.75
187_L212_Q0.9730.75
237_E241_A0.9710.75
119_A434_N0.9640.75
96_A290_M0.9630.75
156_E393_K0.9630.75
301_C308_Q0.9600.74
95_R99_E0.9590.74
26_L58_I0.9570.74
404_F431_V0.9570.74
47_Q69_A0.9490.73
208_S218_M0.9420.73
338_R361_P0.9410.73
176_G180_R0.9390.73
363_I370_E0.9380.73
197_Y206_W0.9380.73
305_T308_Q0.9380.73
275_M279_S0.9370.73
334_N366_S0.9370.73
178_E195_V0.9370.73
11_A131_I0.9330.72
93_A97_L0.9330.72
407_L431_V0.9230.71
226_S245_D0.9180.71
343_V362_C0.9140.71
9_V40_Y0.9120.70
408_W424_R0.9050.70
115_P411_L0.9020.70
412_I423_A0.9010.70
171_C202_H0.8980.69
168_L331_I0.8970.69
408_W423_A0.8940.69
6_F35_R0.8930.69
326_D337_E0.8910.69
411_L426_I0.8910.69
194_K338_R0.8890.68
402_K440_E0.8890.68
154_V157_A0.8880.68
237_E247_F0.8880.68
117_G123_R0.8870.68
103_L276_V0.8860.68
80_V139_S0.8850.68
82_F328_A0.8810.68
304_I307_E0.8800.68
112_T117_G0.8800.68
417_V423_A0.8740.67
18_T86_H0.8740.67
173_M264_T0.8720.67
351_N358_V0.8710.67
418_P422_V0.8690.67
156_E160_R0.8690.67
431_V435_K0.8680.67
102_P426_I0.8670.67
130_E134_Y0.8640.66
356_A389_V0.8590.66
160_R393_K0.8580.66
95_R285_R0.8580.66
388_Q414_S0.8570.66
404_F424_R0.8540.65
16_T297_I0.8530.65
113_C414_S0.8520.65
291_E294_E0.8520.65
133_D137_K0.8490.65
89_V124_S0.8430.64
234_T239_V0.8400.64
127_G130_E0.8360.64
425_L428_E0.8340.63
24_M172_D0.8330.63
197_Y204_G0.8280.63
263_N266_L0.8280.63
343_V364_V0.8270.63
241_A245_D0.8260.63
45_E347_G0.8250.63
121_G125_I0.8240.63
121_G357_M0.8230.62
45_E301_C0.8220.62
419_N422_V0.8220.62
293_R296_F0.8210.62
404_F408_W0.8210.62
136_E165_S0.8200.62
362_C371_P0.8200.62
235_E238_A0.8190.62
100_Q284_T0.8150.62
356_A393_K0.8110.61
402_K439_P0.8110.61
288_E292_G0.8100.61
238_A243_W0.8080.61
286_A289_V0.8030.61
133_D161_L0.7960.60
109_G262_P0.7930.60
394_L409_Q0.7920.59
129_L161_L0.7910.59
55_D66_E0.7910.59
102_P116_G0.7890.59
151_A174_P0.7870.59
196_R374_V0.7850.59
390_S393_K0.7810.58
188_S212_Q0.7810.58
10_I84_M0.7800.58
364_V369_P0.7800.58
329_R335_T0.7790.58
37_L65_I0.7700.57
349_I375_G0.7700.57
143_W331_I0.7680.57
293_R300_Q0.7660.57
147_Y324_I0.7660.57
178_E206_W0.7640.57
430_L433_A0.7640.57
242_S424_R0.7630.57
224_H228_Y0.7620.57
273_D419_N0.7600.56
83_V139_S0.7580.56
55_D75_E0.7570.56
293_R297_I0.7540.56
88_R99_E0.7540.56
101_I429_D0.7540.56
187_L192_E0.7520.56
13_G423_A0.7510.55
281_P286_A0.7510.55
99_E285_R0.7500.55
20_G320_H0.7480.55
113_C269_Y0.7470.55
147_Y152_A0.7470.55
118_I407_L0.7450.55
103_L279_S0.7410.54
50_I54_C0.7410.54
21_I86_H0.7400.54
7_S80_V0.7380.54
156_E389_V0.7350.54
361_P378_P0.7340.54
234_T244_N0.7320.54
403_S440_E0.7310.53
120_Y269_Y0.7300.53
407_L439_P0.7290.53
58_I63_P0.7290.53
115_P426_I0.7270.53
119_A430_L0.7270.53
271_F274_D0.7270.53
45_E354_P0.7250.53
223_E277_K0.7220.53
54_C58_I0.7180.52
307_E310_S0.7150.52
75_E274_D0.7150.52
340_L361_P0.7130.52
175_V327_L0.7130.52
301_C304_I0.7110.51
112_T269_Y0.7110.51
70_T75_E0.7100.51
88_R285_R0.7100.51
39_L54_C0.7080.51
29_L64_D0.7080.51
97_L101_I0.7070.51
181_M209_I0.7060.51
145_L328_A0.7060.51
77_F83_V0.7050.51
198_Y374_V0.7050.51
408_W411_L0.7040.51
282_N286_A0.7040.51
95_R262_P0.7020.50
275_M419_N0.7020.50
102_P119_A0.7000.50
48_D277_K0.6990.50
155_A169_N0.6990.50
98_D117_G0.6980.50
387_Q413_L0.6980.50
177_I204_G0.6980.50
238_A244_N0.6970.50
236_A244_N0.6960.50
351_N376_T0.6930.50
147_Y323_Y0.6920.49
203_F414_S0.6910.49
188_S304_I0.6890.49
144_M158_T0.6880.49
184_I221_L0.6880.49
50_I69_A0.6850.49
274_D369_P0.6850.49
180_R235_E0.6830.49
25_L372_I0.6830.49
73_P77_F0.6810.48
228_Y231_I0.6800.48
19_P111_E0.6790.48
185_L212_Q0.6790.48
60_E306_R0.6770.48
8_I25_L0.6770.48
119_A139_S0.6770.48
113_C203_F0.6760.48
383_G390_S0.6720.47
159_R167_I0.6650.47
15_S20_G0.6590.46
170_I263_N0.6590.46
330_A339_M0.6590.46
353_D356_A0.6580.46
312_N316_K0.6570.46
144_M167_I0.6570.46
112_T153_I0.6570.46
77_F134_Y0.6560.46
234_T243_W0.6560.46
212_Q215_N0.6550.46
395_T411_L0.6550.46
426_I429_D0.6540.46
425_L429_D0.6530.46
70_T263_N0.6520.45
171_C201_N0.6520.45
58_I64_D0.6520.45
292_G296_F0.6510.45
37_L215_N0.6510.45
320_H392_E0.6510.45
44_K137_K0.6510.45
59_R193_M0.6500.45
111_E120_Y0.6500.45
80_V83_V0.6490.45
331_I335_T0.6480.45
152_A203_F0.6470.45
186_G215_N0.6460.45
351_N377_I0.6460.45
219_P223_E0.6440.45
298_F435_K0.6430.45
218_M222_K0.6410.44
17_F86_H0.6370.44
179_D189_S0.6370.44
158_T164_N0.6360.44
182_A187_L0.6350.44
195_V206_W0.6340.44
31_E328_A0.6330.44
172_D320_H0.6330.44
289_V293_R0.6330.44
303_M306_R0.6310.43
149_N201_N0.6300.43
26_L92_Y0.6300.43
12_G15_S0.6300.43
57_F142_A0.6270.43
239_V244_N0.6270.43
37_L428_E0.6270.43
205_W409_Q0.6270.43
167_I357_M0.6260.43
13_G51_A0.6240.43
380_F385_M0.6240.43
48_D370_E0.6240.43
45_E48_D0.6220.42
94_M434_N0.6220.42
197_Y340_L0.6210.42
179_D183_Q0.6210.42
424_R428_E0.6200.42
312_N315_I0.6200.42
99_E111_E0.6200.42
144_M165_S0.6190.42
16_T293_R0.6170.42
348_A355_T0.6160.42
222_K244_N0.6140.42
389_V392_E0.6120.41
55_D141_D0.6120.41
427_L431_V0.6120.41
329_R337_E0.6120.41
236_A239_V0.6110.41
124_S399_W0.6090.41
243_W424_R0.6050.41
295_A299_S0.6050.41
135_M162_R0.6040.41
73_P130_E0.6020.41
121_G157_A0.6010.40
436_D439_P0.6010.40
301_C305_T0.6010.40
183_Q186_G0.6000.40
56_V305_T0.5980.40
104_K425_L0.5970.40
113_C153_I0.5970.40
8_I106_G0.5960.40
17_F331_I0.5950.40
124_S154_V0.5950.40
20_G321_A0.5940.40
191_K215_N0.5940.40
329_R362_C0.5930.40
27_D322_S0.5930.40
78_T133_D0.5920.40
355_T373_T0.5890.39
198_Y260_T0.5870.39
55_D68_A0.5870.39
328_A375_G0.5860.39
157_A399_W0.5850.39
47_Q71_T0.5850.39
11_A42_N0.5850.39
152_A388_Q0.5840.39
207_T378_P0.5830.39
113_C391_V0.5830.39
411_L417_V0.5820.39
84_M166_K0.5820.39
17_F323_Y0.5810.38
194_K208_S0.5810.38
161_L397_E0.5800.38
115_P159_R0.5800.38
210_Q216_D0.5800.38
99_E110_Q0.5790.38
24_M322_S0.5790.38
379_Q386_E0.5780.38
243_W246_T0.5780.38
285_R392_E0.5770.38
272_P276_V0.5770.38
145_L168_L0.5760.38
35_R64_D0.5750.38
385_M409_Q0.5750.38
242_S245_D0.5750.38
52_G69_A0.5740.38
131_I144_M0.5740.38
334_N365_G0.5730.38
147_Y320_H0.5730.38
118_I121_G0.5730.38
434_N437_F0.5710.38
173_M204_G0.5690.37
29_L330_A0.5690.37
11_A77_F0.5680.37
86_H321_A0.5670.37
173_M177_I0.5670.37
11_A73_P0.5660.37
112_T123_R0.5630.37
64_D409_Q0.5620.37
93_A436_D0.5620.37
178_E209_I0.5600.36
358_V361_P0.5600.36
59_R301_C0.5600.36
101_I426_I0.5590.36
421_R425_L0.5590.36
53_A196_R0.5570.36
112_T265_Y0.5560.36
109_G285_R0.5550.36
360_V374_V0.5540.36
185_L220_K0.5540.36
262_P266_L0.5530.36
88_R392_E0.5530.36
16_T289_V0.5520.36
386_E390_S0.5510.36
399_W438_W0.5510.36
153_I334_N0.5500.36
149_N202_H0.5500.36
384_L394_L0.5490.35
75_E432_E0.5490.35
173_M323_Y0.5480.35
78_T346_N0.5470.35
88_R120_Y0.5470.35
153_I399_W0.5470.35
260_T381_Q0.5460.35
394_L410_A0.5440.35
95_R112_T0.5440.35
336_G366_S0.5440.35
196_R330_A0.5430.35
133_D164_N0.5420.35
56_V309_S0.5420.35
360_V371_P0.5410.35
18_T21_I0.5410.35
274_D421_R0.5410.35
198_Y349_I0.5390.35
17_F92_Y0.5380.34
382_K385_M0.5380.34
196_R207_T0.5370.34
391_V395_T0.5370.34
88_R109_G0.5360.34
95_R434_N0.5360.34
68_A137_K0.5350.34
382_K393_K0.5340.34
85_A144_M0.5340.34
181_M221_L0.5340.34
238_A246_T0.5340.34
153_I396_V0.5340.34
246_T405_Q0.5330.34
29_L65_I0.5320.34
119_A386_E0.5320.34
355_T399_W0.5280.34
379_Q409_Q0.5280.34
49_R402_K0.5280.34
149_N171_C0.5270.33
264_T279_S0.5260.33
346_N373_T0.5250.33
120_Y124_S0.5250.33
378_P381_Q0.5240.33
173_M263_N0.5240.33
132_L342_I0.5230.33
30_E52_G0.5230.33
84_M328_A0.5230.33
49_R300_Q0.5230.33
271_F421_R0.5230.33
7_S79_D0.5220.33
237_E243_W0.5220.33
143_W168_L0.5220.33
55_D245_D0.5210.33
99_E392_E0.5210.33
172_D322_S0.5210.33
191_K213_E0.5190.33
354_P376_T0.5180.33
81_D143_W0.5170.33
353_D393_K0.5170.33
198_Y385_M0.5160.32
333_Y349_I0.5140.32
405_Q409_Q0.5140.32
85_A148_S0.5140.32
54_C86_H0.5140.32
174_P340_L0.5140.32
240_E424_R0.5110.32
394_L413_L0.5100.32
27_D133_D0.5100.32
169_N415_K0.5100.32
362_C369_P0.5100.32
25_L37_L0.5080.32
85_A167_I0.5080.32
336_G363_I0.5080.32
225_V245_D0.5080.32
154_V399_W0.5070.32
7_S35_R0.5070.32
109_G260_T0.5070.32
110_Q262_P0.5060.32
355_T428_E0.5060.32
79_D307_E0.5060.32
373_T376_T0.5060.32
131_I134_Y0.5060.32
89_V131_I0.5050.32
182_A193_M0.5050.32
273_D412_I0.5050.32
331_I353_D0.5040.31
159_R355_T0.5030.31
51_A67_F0.5030.31
388_Q392_E0.5020.31
212_Q220_K0.5000.31
46_R265_Y0.5000.31
125_I395_T0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u8xX 1 0.9666 100 0.354 Contact Map
1s6yA 1 0.9131 100 0.362 Contact Map
1obbA 2 0.951 100 0.371 Contact Map
1up7A 3 0.922 100 0.373 Contact Map
3fefA 3 0.9042 100 0.418 Contact Map
3u95A 2 0.9555 100 0.433 Contact Map
1pzgA 4 0.7016 100 0.719 Contact Map
4rorA 4 0.6882 100 0.727 Contact Map
3p7mA 4 0.686 100 0.731 Contact Map
2hjrA 4 0.6682 100 0.734 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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