GREMLIN Database
PSPA - Phage shock protein A homolog
UniProt: P54617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (216)
Sequences: 1628 (1068)
Seq/√Len: 72.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_L84_E5.5821.00
76_M222_K4.4941.00
68_M101_L3.4281.00
65_Q105_Q2.9001.00
105_Q109_Q2.8911.00
58_K62_H2.8451.00
88_R213_D2.8131.00
72_E76_M2.8101.00
61_Y105_Q2.8071.00
142_K180_L2.6091.00
31_Q35_N2.5721.00
214_D217_A2.4751.00
150_E182_Q2.4611.00
147_K151_R2.3531.00
94_K215_E2.3411.00
2_S5_G2.3321.00
135_R173_E2.2871.00
61_Y101_L2.1601.00
84_E220_K2.1471.00
71_M74_Y2.1171.00
54_E112_A2.1161.00
30_D136_K2.1081.00
70_K74_Y2.0931.00
76_M80_Q2.0331.00
44_K126_V2.0231.00
217_A221_A1.9351.00
61_Y65_Q1.9311.00
76_M219_L1.9301.00
109_Q113_T1.9261.00
65_Q101_L1.9211.00
98_E102_S1.8481.00
131_E135_R1.8281.00
218_A222_K1.8271.00
72_E222_K1.8191.00
6_R23_E1.7911.00
8_K12_S1.7891.00
37_N133_E1.7821.00
102_S105_Q1.7561.00
213_D217_A1.7441.00
68_M98_E1.7131.00
72_E218_A1.6911.00
146_A183_A1.6871.00
218_A221_A1.6811.00
196_D199_D1.6771.00
14_N27_K1.6260.99
31_Q34_R1.6150.99
75_A219_L1.6150.99
47_T118_M1.6060.99
95_T211_Q1.5850.99
213_D223_M1.5720.99
65_Q69_E1.5650.99
215_E218_A1.5370.99
69_E73_S1.5280.99
70_K73_S1.5140.99
178_K182_Q1.5080.99
113_T117_Q1.4640.99
197_M200_L1.4460.99
20_D23_E1.4220.99
197_M201_S1.4120.99
54_E115_A1.4010.98
199_D202_A1.3940.98
202_A205_D1.3900.98
201_S205_D1.3880.98
86_D204_Y1.3740.98
30_D140_K1.3430.98
61_Y108_N1.3290.98
79_L219_L1.3220.98
102_S106_A1.2930.97
200_L203_K1.2930.97
54_E58_K1.2800.97
47_T122_H1.2560.97
112_A116_A1.2530.97
56_R60_E1.2250.96
94_K98_E1.2220.96
99_S102_S1.2090.96
12_S35_N1.1950.96
20_D34_R1.1780.95
88_R212_V1.1740.95
66_A70_K1.1710.95
79_L220_K1.1710.95
22_A27_K1.1710.95
33_L129_I1.1670.95
76_M223_M1.1590.95
121_M124_K1.1570.95
35_N38_S1.1460.95
214_D218_A1.1200.94
201_S204_Y1.1180.94
171_R174_D1.1110.94
79_L223_M1.1070.94
73_S76_M1.0820.93
13_A17_A1.0720.93
165_S169_F1.0680.92
185_A189_L1.0450.92
92_E96_S1.0430.91
139_I176_V1.0430.91
77_K81_A1.0390.91
62_H65_Q1.0250.91
197_M203_K1.0250.91
143_W147_K1.0090.90
62_H66_A1.0070.90
111_A115_A0.9990.90
127_S131_E0.9960.89
58_K108_N0.9920.89
83_N200_L0.9920.89
17_A27_K0.9850.89
28_M31_Q0.9700.88
35_N39_D0.9680.88
128_D131_E0.9610.88
150_E154_K0.9560.87
198_A201_S0.9530.87
174_D178_K0.9410.87
85_S200_L0.9410.87
68_M94_K0.9320.86
54_E108_N0.9310.86
84_E178_K0.9180.85
40_L129_I0.9150.85
71_M93_R0.9140.85
64_C97_L0.9100.85
11_M18_L0.8990.84
15_I18_L0.8990.84
29_V169_F0.8990.84
17_A21_K0.8980.84
116_A120_K0.8860.83
123_D127_S0.8850.83
140_K144_A0.8790.83
24_N27_K0.8790.83
125_L132_L0.8750.82
75_A91_L0.8630.81
26_E144_A0.8610.81
10_I29_V0.8540.81
200_L204_Y0.8470.80
93_R96_S0.8420.80
9_D168_A0.8340.79
67_D97_L0.8250.78
9_D12_S0.8210.78
64_C100_K0.8200.78
150_E183_A0.8120.77
86_D197_M0.8090.77
38_S42_K0.8050.77
72_E94_K0.8040.77
219_L223_M0.8040.77
13_A21_K0.7990.76
61_Y109_Q0.7970.76
84_E88_R0.7940.76
129_I168_A0.7910.76
15_I22_A0.7870.75
199_D214_D0.7860.75
18_L22_A0.7860.75
99_S211_Q0.7850.75
74_Y77_K0.7850.75
91_L94_K0.7790.74
39_D43_V0.7760.74
89_K92_E0.7740.74
60_E63_E0.7710.74
57_A61_Y0.7700.74
19_L23_E0.7630.73
151_R154_K0.7630.73
37_N129_I0.7610.73
9_D28_M0.7610.73
106_A109_Q0.7600.73
109_Q112_A0.7550.72
29_V136_K0.7530.72
9_D136_K0.7480.71
12_S31_Q0.7480.71
63_E69_E0.7450.71
101_L209_S0.7450.71
39_D187_A0.7390.70
137_N146_A0.7360.70
108_N112_A0.7360.70
71_M90_F0.7290.69
80_Q223_M0.7280.69
3_I15_I0.7240.69
9_D19_L0.7220.69
13_A28_M0.7220.69
16_N34_R0.7210.69
110_I114_N0.7190.68
77_K80_Q0.7180.68
111_A114_N0.7120.68
40_L56_R0.7090.67
49_A67_D0.7080.67
63_E66_A0.7080.67
32_Y71_M0.7070.67
219_L222_K0.7050.67
16_N149_Q0.7050.67
29_V172_M0.7040.67
29_V36_M0.7040.67
167_S202_A0.7010.66
72_E98_E0.7010.66
47_T50_V0.6990.66
6_R25_P0.6970.66
26_E132_L0.6960.66
157_A160_S0.6940.66
9_D14_N0.6910.65
71_M201_S0.6840.64
66_A209_S0.6820.64
55_Q184_N0.6810.64
106_A217_A0.6800.64
72_E79_L0.6790.64
86_D200_L0.6760.64
63_E116_A0.6720.63
83_N86_D0.6680.63
30_D138_M0.6630.62
191_S203_K0.6630.62
130_G134_A0.6620.62
15_I99_S0.6610.62
75_A185_A0.6600.62
40_L48_A0.6590.62
169_F179_A0.6590.62
141_A188_E0.6550.61
58_K112_A0.6550.61
46_E144_A0.6510.61
99_S103_E0.6510.61
168_A172_M0.6460.60
64_C104_L0.6430.60
26_E30_D0.6430.60
107_A111_A0.6410.59
95_T212_V0.6410.59
74_Y144_A0.6390.59
114_N117_Q0.6380.59
59_R181_D0.6370.59
47_T148_T0.6350.59
154_K174_D0.6330.59
6_R13_A0.6300.58
40_L126_V0.6280.58
91_L95_T0.6280.58
26_E128_D0.6270.58
20_D28_M0.6250.58
152_M161_S0.6240.57
33_L37_N0.6240.57
104_L107_A0.6230.57
72_E92_E0.6230.57
36_M132_L0.6210.57
153_N156_G0.6210.57
48_A56_R0.6170.57
50_V168_A0.6140.56
79_L213_D0.6140.56
28_M176_V0.6100.56
84_E87_A0.6080.56
51_M119_R0.6020.55
169_F173_E0.6020.55
14_N22_A0.6010.55
124_K127_S0.5960.54
76_M218_A0.5940.54
74_Y90_F0.5940.54
154_K186_M0.5930.54
55_Q58_K0.5920.54
3_I10_I0.5920.54
114_N121_M0.5920.54
19_L22_A0.5880.53
11_M15_I0.5870.53
95_T215_E0.5870.53
90_F201_S0.5870.53
77_K187_A0.5860.53
60_E171_R0.5850.53
112_A130_G0.5840.53
66_A127_S0.5800.52
68_M103_E0.5790.52
69_E106_A0.5790.52
143_W172_M0.5760.52
102_S205_D0.5750.51
90_F128_D0.5740.51
102_S203_K0.5730.51
88_R91_L0.5710.51
51_M183_A0.5710.51
40_L43_V0.5700.51
39_D153_N0.5660.50
52_A197_M0.5650.50
98_E101_L0.5640.50
120_K163_S0.5620.50
176_V181_D0.5610.50
203_K209_S0.5600.50
96_S100_K0.5540.49
9_D35_N0.5530.49
64_C101_L0.5510.48
92_E212_V0.5480.48
198_A202_A0.5470.48
78_A128_D0.5470.48
87_A91_L0.5460.48
12_S19_L0.5460.48
220_K223_M0.5460.48
199_D203_K0.5460.48
50_V145_V0.5450.48
4_I210_S0.5440.48
89_K200_L0.5420.47
46_E53_E0.5410.47
47_T51_M0.5380.47
25_P90_F0.5380.47
23_E28_M0.5360.47
170_G221_A0.5350.47
57_A111_A0.5350.47
216_L220_K0.5350.47
44_K179_A0.5330.46
170_G174_D0.5320.46
2_S108_N0.5310.46
51_M115_A0.5290.46
9_D129_I0.5290.46
206_T214_D0.5280.46
88_R95_T0.5280.46
174_D177_N0.5280.46
89_K93_R0.5250.45
14_N17_A0.5210.45
142_K146_A0.5200.45
74_Y83_N0.5170.44
33_L133_E0.5160.44
179_A182_Q0.5140.44
117_Q121_M0.5130.44
36_M48_A0.5130.44
106_A110_I0.5130.44
20_D99_S0.5120.44
50_V111_A0.5110.44
95_T209_S0.5110.44
105_Q108_N0.5100.43
120_K148_T0.5090.43
175_K178_K0.5080.43
135_R202_A0.5080.43
32_Y168_A0.5060.43
65_Q68_M0.5050.43
40_L44_K0.5040.43
79_L87_A0.5030.43
91_L183_A0.5030.43
33_L136_K0.5020.42
69_E72_E0.5010.42
32_Y172_M0.5010.42
121_M180_L0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.4273 94.2 0.882 Contact Map
2gd5A 2 0.6784 88.1 0.9 Contact Map
3frtA 1 0.6123 86.9 0.901 Contact Map
4iloA 3 0.7048 86.4 0.902 Contact Map
3ojaB 1 0.5374 81.7 0.908 Contact Map
4abmA 2 0.348 81.6 0.908 Contact Map
3ghgA 2 0.6652 81.3 0.908 Contact Map
1c1gA 2 0.9295 78 0.911 Contact Map
4cgkA 3 0.6564 77.9 0.911 Contact Map
3mq9A 4 0.5419 64 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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