GREMLIN Database
YHCW - Uncharacterized protein YhcW
UniProt: P54607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (204)
Sequences: 29799 (23680)
Seq/√Len: 1658.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_K160_E4.1321.00
139_E143_N2.8111.00
120_K125_F2.8081.00
149_L153_N2.7711.00
112_Y116_S2.6461.00
174_A181_C2.6111.00
165_E170_G2.6111.00
95_N127_D2.4551.00
4_A156_V2.4331.00
105_G130_V2.3021.00
91_E95_N2.2951.00
149_L152_K2.2431.00
103_K129_E2.2211.00
112_Y136_D2.2151.00
107_A146_L2.1671.00
7_F104_I2.1511.00
139_E145_E2.0961.00
202_E206_E2.0701.00
151_A161_C2.0681.00
175_K198_D2.0371.00
30_E72_L2.0321.00
130_V153_N2.0201.00
171_S181_C1.9891.00
108_S115_V1.9251.00
180_K198_D1.9241.00
172_I176_R1.8591.00
96_A100_L1.8581.00
5_L102_L1.7961.00
157_S160_E1.7481.00
26_E76_R1.7351.00
98_K127_D1.7291.00
151_A179_M1.7141.00
163_A174_A1.6771.00
162_L182_V1.6761.00
36_P39_V1.6751.00
98_K129_E1.6711.00
6_I163_A1.6671.00
6_I150_A1.6341.00
104_I128_F1.6251.00
90_V204_M1.5431.00
4_A154_L1.5341.00
116_S125_F1.5151.00
151_A158_P1.4951.00
156_V161_C1.4941.00
6_I107_A1.4831.00
185_P202_E1.4821.00
105_G154_L1.4591.00
87_R186_N1.4091.00
5_L164_F1.3991.00
168_V172_I1.3971.00
31_H72_L1.3961.00
5_L97_A1.3901.00
182_V201_L1.3661.00
9_F106_L1.3331.00
9_F115_V1.3261.00
144_P148_L1.2891.00
93_Y204_M1.2851.00
72_L76_R1.2831.00
96_A99_D1.2601.00
12_L164_F1.2531.00
9_F14_L1.2501.00
13_I90_V1.2451.00
185_P200_R1.2441.00
116_S120_K1.2411.00
72_L75_E1.2391.00
132_Q153_N1.2361.00
30_E76_R1.2001.00
89_G92_A1.1911.00
147_Y163_A1.1831.00
182_V199_H1.1811.00
26_E30_E1.1791.00
115_V133_T1.1791.00
76_R79_K1.1781.00
203_S206_E1.1691.00
26_E80_R1.1681.00
6_I161_C1.1391.00
132_Q150_A1.1341.00
4_A161_C1.1211.00
80_R83_S1.1201.00
22_E80_R1.1061.00
92_A205_A1.1001.00
147_Y173_A1.0991.00
10_D16_T1.0951.00
9_F110_S1.0951.00
106_L128_F1.0931.00
147_Y179_M1.0901.00
161_C179_M1.0851.00
4_A103_K1.0791.00
27_I31_H1.0791.00
145_E149_L1.0771.00
22_E26_E1.0771.00
148_L152_K1.0771.00
98_K104_I1.0651.00
29_E34_V1.0591.00
71_Q75_E1.0511.00
86_A124_L1.0381.00
123_G126_D1.0341.00
95_N99_D1.0301.00
22_E84_E1.0271.00
107_A150_A1.0181.00
54_E58_E1.0171.00
117_G121_Q1.0161.00
51_R54_E1.0141.00
94_L128_F1.0001.00
150_A154_L0.9991.00
130_V154_L0.9961.00
4_A105_G0.9891.00
112_Y133_T0.9891.00
10_D110_S0.9891.00
82_E117_G0.9871.00
175_K181_C0.9851.00
91_E127_D0.9831.00
25_Q29_E0.9811.00
148_L177_A0.9771.00
145_E148_L0.9761.00
65_N68_E0.9761.00
26_E29_E0.9711.00
10_D108_S0.9711.00
75_E79_K0.9691.00
108_S133_T0.9651.00
163_A179_M0.9641.00
173_A177_A0.9631.00
147_Y165_E0.9611.00
117_G120_K0.9601.00
68_E72_L0.9431.00
76_R80_R0.9351.00
6_I179_M0.9321.00
162_L180_K0.9321.00
180_K199_H0.9281.00
22_E25_Q0.9251.00
92_A95_N0.9111.00
86_A91_E0.9101.00
137_V149_L0.8991.00
95_N126_D0.8991.00
112_Y135_D0.8981.00
6_I154_L0.8871.00
58_E61_G0.8771.00
132_Q149_L0.8751.00
171_S197_Y0.8741.00
55_Y58_E0.8731.00
115_V118_H0.8731.00
87_R184_V0.8721.00
70_T74_R0.8681.00
148_L158_P0.8651.00
164_F182_V0.8601.00
169_N172_I0.8591.00
28_F33_S0.8571.00
25_Q37_L0.8511.00
73_R77_F0.8451.00
97_A102_L0.8431.00
175_K196_D0.8401.00
37_L41_G0.8401.00
89_G203_S0.8321.00
105_G150_A0.8321.00
54_E66_H0.8301.00
47_A51_R0.8291.00
87_R90_V0.8291.00
53_F56_L0.8251.00
81_M84_E0.8191.00
104_I127_D0.8181.00
158_P179_M0.8141.00
97_A104_I0.8141.00
5_L162_L0.8131.00
21_Y25_Q0.8091.00
80_R84_E0.8071.00
133_T136_D0.8001.00
110_S115_V0.7951.00
138_E145_E0.7921.00
9_F118_H0.7911.00
94_L127_D0.7821.00
3_K102_L0.7791.00
14_L122_I0.7721.00
67_E71_Q0.7711.00
156_V160_E0.7671.00
201_L207_M0.7571.00
91_E123_G0.7511.00
10_D166_D0.7501.00
57_E60_I0.7481.00
191_T202_E0.7471.00
147_Y170_G0.7441.00
91_E126_D0.7431.00
89_G205_A0.7411.00
86_A122_I0.7331.00
39_V42_K0.7321.00
181_C198_D0.7301.00
171_S183_I0.7281.00
183_I200_R0.7251.00
172_I175_K0.7221.00
20_E24_L0.7211.00
119_L125_F0.7201.00
14_L118_H0.7171.00
44_I47_A0.7161.00
136_D153_N0.7131.00
164_F207_M0.7121.00
11_G17_E0.7111.00
62_K65_N0.7091.00
78_A113_K0.7041.00
15_D85_K0.7031.00
92_A96_A0.6971.00
146_L150_A0.6921.00
12_L170_G0.6891.00
183_I194_F0.6861.00
109_S140_V0.6851.00
6_I105_G0.6811.00
45_G49_G0.6791.00
53_F57_E0.6771.00
3_K103_K0.6751.00
89_G93_Y0.6701.00
201_L204_M0.6691.00
144_P176_R0.6681.00
186_N204_M0.6681.00
79_K82_E0.6661.00
10_D118_H0.6631.00
104_I129_E0.6621.00
163_A170_G0.6621.00
23_V76_R0.6611.00
137_V146_L0.6591.00
113_K117_G0.6541.00
115_V131_I0.6541.00
158_P161_C0.6511.00
134_A146_L0.6511.00
116_S131_I0.6501.00
18_T85_K0.6491.00
20_E110_S0.6481.00
182_V207_M0.6481.00
109_S142_P0.6471.00
41_G44_I0.6441.00
132_Q146_L0.6421.00
52_P55_Y0.6411.00
71_Q74_R0.6361.00
23_V27_I0.6361.00
107_A163_A0.6331.00
130_V150_A0.6331.00
82_E121_Q0.6321.00
93_Y164_F0.6311.00
7_F93_Y0.6301.00
146_L173_A0.6301.00
90_V94_L0.6301.00
15_D87_R0.6291.00
103_K156_V0.6291.00
3_K156_V0.6261.00
151_A177_A0.6241.00
55_Y59_Q0.6231.00
16_T110_S0.6221.00
163_A173_A0.6211.00
46_T51_R0.6201.00
15_D18_T0.6181.00
151_A156_V0.6151.00
21_Y40_W0.6091.00
109_S169_N0.6061.00
12_L184_V0.6051.00
70_T73_R0.6041.00
52_P56_L0.6031.00
61_G65_N0.6001.00
98_K126_D0.6001.00
31_H68_E0.5991.00
69_L73_R0.5971.00
115_V119_L0.5951.00
148_L151_A0.5911.00
20_E73_R0.5901.00
77_F81_M0.5901.00
128_F131_I0.5891.00
38_S41_G0.5881.00
38_S42_K0.5851.00
95_N98_K0.5841.00
78_A117_G0.5831.00
43_V46_T0.5771.00
107_A132_Q0.5771.00
57_E62_K0.5761.00
110_S114_W0.5741.00
51_R55_Y0.5741.00
75_E78_A0.5731.00
184_V204_M0.5731.00
20_E77_F0.5721.00
46_T55_Y0.5591.00
90_V93_Y0.5551.00
18_T22_E0.5551.00
6_I147_Y0.5541.00
44_I48_A0.5531.00
111_D114_W0.5531.00
147_Y174_A0.5531.00
79_K83_S0.5481.00
88_P205_A0.5421.00
74_R78_A0.5421.00
169_N173_A0.5411.00
89_G186_N0.5411.00
172_I195_E0.5381.00
93_Y96_A0.5371.00
86_A90_V0.5341.00
35_L39_V0.5341.00
27_I72_L0.5341.00
93_Y97_A0.5311.00
183_I197_Y0.5281.00
21_Y37_L0.5271.00
110_S165_E0.5261.00
10_D14_L0.5251.00
151_A157_S0.5241.00
130_V133_T0.5241.00
168_V183_I0.5221.00
40_W43_V0.5201.00
73_R76_R0.5161.00
132_Q154_L0.5151.00
5_L104_I0.5131.00
68_E71_Q0.5111.00
110_S133_T0.5091.00
13_I106_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw9A 1 0.9318 100 0.266 Contact Map
3l5kA 1 0.9864 100 0.276 Contact Map
3s6jA 2 0.9773 100 0.286 Contact Map
2hdoA 1 0.9318 100 0.287 Contact Map
3e58A 2 0.95 100 0.288 Contact Map
3kbbA 1 0.9682 100 0.29 Contact Map
1te2A 2 0.9636 100 0.29 Contact Map
3nasA 2 0.9227 100 0.29 Contact Map
4uasA 1 0.9773 100 0.3 Contact Map
2hoqA 2 0.9955 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.