GREMLIN Database
YHCV - CBS domain-containing protein YhcV
UniProt: P54606 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (119)
Sequences: 13341 (10247)
Seq/√Len: 939.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_Q23_E2.7441.00
35_A99_R2.6331.00
17_P69_S2.2941.00
81_P104_D2.2861.00
79_G102_I2.2251.00
77_V95_H2.1571.00
83_M87_D2.0931.00
79_G83_M2.0161.00
16_S19_Q1.9791.00
80_N83_M1.9271.00
66_T70_E1.8781.00
24_A68_V1.7771.00
17_P45_K1.7701.00
15_V19_Q1.7671.00
15_V38_V1.7621.00
81_P109_V1.7171.00
4_V88_A1.7041.00
15_V24_A1.6861.00
15_V36_I1.6801.00
13_A31_H1.6481.00
37_P44_L1.6371.00
17_P40_E1.5871.00
79_G88_A1.5501.00
101_P108_L1.4991.00
67_P70_E1.4991.00
77_V97_I1.4791.00
98_R114_L1.4781.00
24_A48_L1.4421.00
27_L31_H1.4281.00
26_S30_Q1.4241.00
91_L95_H1.3911.00
88_A100_L1.3791.00
40_E43_V1.3761.00
48_L53_I1.3741.00
80_N105_Q1.3581.00
5_K81_P1.3131.00
19_Q27_L1.3071.00
40_E45_K1.3031.00
78_S103_V1.2981.00
15_V68_V1.2911.00
22_Q64_G1.2861.00
18_N69_S1.2651.00
35_A47_M1.2491.00
14_T39_V1.2431.00
13_A27_L1.2381.00
83_M91_L1.2331.00
77_V91_L1.2311.00
20_T23_E1.2181.00
23_E26_S1.2181.00
44_L108_L1.2141.00
24_A36_I1.2131.00
79_G100_L1.1941.00
50_D54_A1.1711.00
21_I71_V1.1671.00
22_Q26_S1.1411.00
104_D107_N1.1401.00
38_V72_M1.1251.00
66_T71_V1.1211.00
5_K82_N1.1191.00
48_L71_V1.1111.00
47_M101_P1.1111.00
84_S87_D1.1061.00
90_Q94_Q1.1051.00
7_T85_L1.0771.00
48_L68_V1.0751.00
34_G50_D1.0491.00
7_T112_V1.0331.00
52_D73_S1.0291.00
25_A53_I1.0231.00
9_T116_D1.0211.00
79_G91_L1.0101.00
39_V45_K0.9891.00
87_D91_L0.9721.00
88_A112_V0.9721.00
42_G107_N0.9701.00
54_A98_R0.9611.00
80_N104_D0.9581.00
33_V36_I0.9561.00
37_P108_L0.9511.00
50_D98_R0.9471.00
104_D109_V0.9331.00
91_L100_L0.9221.00
85_L117_L0.9171.00
23_E27_L0.9131.00
4_V79_G0.9071.00
99_R111_I0.9071.00
13_A33_V0.9031.00
16_S40_E0.9011.00
16_S39_V0.8971.00
35_A98_R0.8951.00
15_V27_L0.8911.00
44_L76_L0.8801.00
27_L30_Q0.8731.00
46_G72_M0.8691.00
64_G67_P0.8551.00
93_A119_V0.8521.00
44_L101_P0.8311.00
56_R59_A0.8121.00
87_D90_Q0.8111.00
8_M102_I0.7901.00
27_L36_I0.7901.00
22_Q65_Q0.7891.00
68_V72_M0.7891.00
43_V107_N0.7821.00
92_M100_L0.7761.00
98_R115_G0.7721.00
99_R113_A0.7521.00
28_M36_I0.7451.00
39_V42_G0.7391.00
69_S72_M0.7291.00
103_V108_L0.7241.00
34_G99_R0.7221.00
12_V37_P0.7111.00
51_R98_R0.7091.00
34_G98_R0.7081.00
18_N67_P0.7081.00
80_N106_N0.7081.00
35_A111_I0.7071.00
39_V44_L0.7051.00
81_P105_Q0.6791.00
37_P101_P0.6791.00
7_T120_N0.6781.00
29_K60_Q0.6601.00
24_A28_M0.6581.00
115_G119_V0.6501.00
33_V37_P0.6491.00
49_T52_D0.6431.00
47_M99_R0.6231.00
4_V112_V0.6141.00
50_D99_R0.6131.00
76_L101_P0.6111.00
43_V106_N0.6081.00
8_M109_V0.6081.00
58_T61_G0.6081.00
13_A36_I0.6031.00
53_I57_T0.6031.00
9_T12_V0.6021.00
14_T42_G0.5981.00
37_P45_K0.5981.00
45_K72_M0.5931.00
34_G51_R0.5931.00
34_G114_L0.5911.00
47_M73_S0.5891.00
83_M88_A0.5881.00
21_I57_T0.5871.00
25_A50_D0.5861.00
86_E90_Q0.5851.00
116_D119_V0.5831.00
114_L118_A0.5811.00
5_K8_M0.5811.00
50_D115_G0.5801.00
112_V117_L0.5751.00
35_A49_T0.5731.00
80_N103_V0.5721.00
34_G37_P0.5711.00
99_R114_L0.5701.00
4_V8_M0.5621.00
101_P111_I0.5581.00
92_M114_L0.5541.00
60_Q66_T0.5501.00
40_E69_S0.5501.00
89_S118_A0.5471.00
82_N105_Q0.5391.00
5_K104_D0.5381.00
19_Q36_I0.5371.00
34_G52_D0.5241.00
57_T61_G0.5171.00
118_A122_M0.5161.00
61_G64_G0.5091.00
57_T62_R0.5071.00
47_M76_L0.5051.00
74_T77_V0.5051.00
120_N123_S0.5031.00
51_R56_R0.5031.00
115_G118_A0.5011.00
4_V7_T0.5001.00
25_A48_L0.5001.00
56_R62_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.8214 99.9 0.284 Contact Map
2rc3A 3 0.8786 99.8 0.295 Contact Map
4cooA 2 0.8857 99.8 0.298 Contact Map
3orgA 2 0.8214 99.8 0.305 Contact Map
3fhmA 2 0.8857 99.8 0.308 Contact Map
2o16A 2 0.9429 99.8 0.313 Contact Map
3pc3A 2 0.8929 99.8 0.318 Contact Map
1y5hA 2 0.8643 99.8 0.32 Contact Map
2ef7A 3 0.9071 99.8 0.322 Contact Map
4fryA 2 0.9357 99.8 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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